• Clinical and Experimental Pediatrics
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• 제57권6호
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• pp.287-291
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• 2014

Moyamoya disease is a cerebrovascular condition that results in the narrowing of the vessels of the circle of Willis and collateral vessel formation at the base of the brain. Although relationships between Graves' disease and cerebrovascular accidents in Moyamoya disease are obscure, the coexistence of the two diseases is noteworthy. Moyamoya disease has been rarely reported in adolescent patients with thyrotoxicosis. Recently, we encountered two adolescent Korean patients with Moyamoya disease associated with Graves' disease who presented with episodic right-sided hemiparesis and syncope. These two girls who had Graves' disease had no history of other diseases or head trauma. A thyroid function test revealed a euthyroid state and a high thyroid-stimulating hormone (TSH) receptor antibody titer at that time. The patients were diagnosed with Moyamoya disease based on brain magnetic resonance angiography and cerebral four-vessel angiography. The patients underwent cranial revascularization by encephalo-duroarterio-synangiosis as soon as a diagnosis was made, which resulted in successful symptom resolution. They fared well and had no additional neurological symptoms as of their last follow-up visits. Here, we report these two cases of confirmed Moyamoya disease complicated by Graves' disease with a review of the literature, and discuss the possible association between the two diseases. To our knowledge, this is the first report in South Korea on Moyamoya disease associated with Graves' disease in adolescents with a euthyroid.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2010년도 춘계학술대회
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• pp.117-125
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• 2010

Cerebrovascular and cardiovascular diseases (CVDs) are a major cause of deaths among workers as well as in general population in Korea. Occupational stress like long working hours or overwork can cause sudden unexpected death in a worker who had been suffering from an aggravated preexisting condition such as hypertensive or arteriosclerotic diseases, The Korean government has compensated the cases of cerebrovascular disease and cardiovascular disease due to overwork, but neither a resonable definition of overwork nor detailed evaluation guideline has been officially provided to verify overwork, so that the prevention of, as well as compensation for workers' occupational stress-related cardiovascular attacks, cannot be carried out efficiently. A thorough understanding of the etiopathology of WR-CVDs can be very helpful in developing a prevention strategy.

• Nuclear Medicine and Molecular Imaging
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• 제41권2호
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• pp.85-90
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• 2007

Acute event in cerebrovascular disease is the second most common cause of death in Korea following cancer, and it can also cause serious neurologic deficits. Understanding of perfusion status is important for clinical applications in management of patients with cerebrovascular diseases, and then the attacks of ischemic neurologic symptoms and the risk of acute events can be reduced. Therefore, the normal vascular anatomy of brain, various clinical applications of acetazolamide-enhanced brain perfusion SPECT, including meaning and role of assessment of vascular reserve in carotid stenosis before procedure, in pediatric Moyamoya disease before and after operation, in prediction of development of hyperperfusion syndrome before procedure, and in prediction of vasospasm and of prognosis in subarachnoid hemorrahge were reviewed in this paper.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제25권3호
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• pp.180-193
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• 2022

Pediatric inflammatory bowel disease (PIBD) is a multisystem disorder characterized by intestinal and extraintestinal manifestations and complications. Cerebrovascular events (CVE) are rare extraintestinal complications in patients with PIBD. Statistics show that 3.3% patients with PIBD and 1.3-6.4% adult patients with inflammatory bowel disease (IBD) experience CVE during the course of the disease. Therefore, this study aimed to review the records of children with IBD who developed CVE during the course of the disease. We retrospectively reviewed 62 cases of PIBD complicated by CVE. The mean patient age at the time of thrombotic events was 12.48±4.13 years. The incidence of ulcerative colitis was significantly higher than that of Crohn's disease (43 [70.5%] vs. 13 [21.3%] patients). Most patients (87.93%) were in the active phase of IBD at the time of CVE. The mean time interval between the onset of IBD and CVE was 20.84 weeks. Overall, 11 (26.83%) patients showed neurological symptoms of CVE at disease onset. The most frequent symptom on admission was persistent and severe headaches (67.85%). The most common site of cerebral venous thrombosis was the transverse sinuses (n=23, 53.48%). The right middle cerebral artery (n=3, 33.34%) was the predominant site of cerebral arterial infarction. Overall, 41 (69.49%) patients who were mostly administered unfractionated heparin or low-molecular-weight heparin (56.09%) recovered completely. Patients with IBD are at a risk of thromboembolism. CVE may be the most common type of thromboembolism. Based on these findings, the most common risk factor for CVE is IBD flares. In patients with CVE, anticoagulant therapy with heparin, followed by warfarin, is necessary.

• 한국방사선학회논문지
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• 제1권1호
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• pp.17-23
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• 2007

연구배경: 뇌혈관 질환은 지역 및 인종에 따라 발생양상의 차이를 보이는 것으로 알려져 있다. 그러므로 뇌혈관질환의 진단, 치료, 및 예방적인 목적에 활용하기 위한 특정지역의 발생양상을 파악하는 것은 매우 중요하다. 본 논문에서는 계절별, 성별, 연령별, 출혈성 뇌혈관질환과 허혈성뇌혈관질환 발생양상을 정량적으로 분석하고자 한다. 방 법: 연구대상은 일개 대학교병원 신경외과와 신경과에 출혈성 뇌혈관질환과 허혈성뇌혈관질환으로 입원한 환자 1603명을 대상으로 하였다. 연구대상 환자에 대해서 뇌혈관질환의 유형, 발생연도, 성별, 뇌혈관질환이 발생한 계절을 조사하였다. 자료의 산술적인 분석은 마이크로소프트사의 엑셀 2003을 이용하였고, t-test는 MICROCAL사에서 제공하는 ORIGIN 6.0을 이용하였다. 결 과: 연구대상 기간인 4년 동안의 출혈성 뇌혈관질환과 허혈성뇌혈관질환의 발생비는 38.55%, 61.45%이었다. 출혈성 뇌혈관질환의 발병 연령의 평균과 표준편차 $58.20{\pm}12.60$이었고, 40대, 50대, 60대, 70대에서 각각 20% 정도로 비슷하게 발병하였다. 이에 비하여 허혈성뇌혈관질환은 발병 연령의 평균과 표준편차는 $65.01{\pm}13.59$이었고, 출혈성뇌질환에 비하여 평균 연령이 높게 나타났고, 발생 연령분포에서도 60대 15.53%, 70대 37.06%, 80대 27.72%이었다. 출혈성 뇌혈관질환이 발병이 많이 나타난 계절은 겨울, 여름, 봄, 가을 순이었고, 출혈성 뇌혈관질환이 발병이 많이 나타난 계절은 봄, 여름, 겨울, 가을이었다. 일반적으로 알려진 겨울철 출혈성 뇌혈관질환 많이 나타났다. 출혈성 뇌혈관질환과 허혈성뇌혈관질환 환자의 남녀비율은 52.09% 47.91%로 나타났다. 결 론: 연구대상을 출혈성 뇌혈관질환과 허혈성뇌혈관질환으로 일개 대학교병원에 입원한 환자만을 대상으로 하였으므로 전체 뇌혈관 질환에 대한 결과를 대변한다고 볼 수 없다. 그러나 의료종사자에게서 일반적으로 알려진 계절별, 성별, 연령별, 출혈성 뇌혈관질환과 허혈성뇌혈관질환 발생비를 통계적으로 분석하였다는데 연구논문의 의의가 있다. 본 논문에서 출혈성 뇌혈관질환과 허혈성뇌혈관질환의 발생률은 38.55%, 61.45%로 허혈성뇌혈관질환의 비중이 높아지고 있다. 적절한 뇌혈관질환의 예방 및 질환관리계획을 세우기 위해서는 장기적인 뇌혈관질환의 역학조사가 필요할 것이다.

• 보건행정학회지
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• 제30권1호
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• pp.26-36
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• 2020

Background: The purpose of this study was to analyze the relationship between the regional characteristics and the age-adjusted cardio-cerebrovascular disease mortality rates (SCDMR) in 229 si·gun·gu administrative regions. Methods: SCDMR of man and woman was used as a dependent variable using the statistical data of death cause in 2017. As a representative index of regional characteristics, health behavior factors, socio-demographic and economic factors, physical environment factors, and health care factors were selected as independent variables. Ordinary least square (OLS) regression and geographically weighted regression (GWR) were performed to identify their relationship. Results: OLS analysis showed significant factors affecting the mortality rates of cardio-cerebrovascular disease as follows: high-risk drinking rates, the ratio of elderly living alone, financial independence, and walking practice rates. GWR analysis showed that the regression coefficients were varied by regions and the influence directions of the independent variables on the dependent variable were mixed. GWR showed higher adjusted R² and Akaike information criterion values than those of OLS. Conclusion: If there is a spatial heterogeneity problem as Korea, it is appropriate to use the GWR model to estimate the influence of regional characteristics. Therefore, results using the GWR model suggest that it needs to establish customized health policies and projects for each region considering the socio-economic characteristics of each region.

• 문화기술의 융합
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• 제7권3호
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• pp.105-113
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• 2021

본 연구는 중년여성 근로자를 대상으로 모바일 앱을 활용한 심뇌혈관질환 예방관리 프로그램 참여 경험에 대한 의미를 파악하기 위해 일대일 심층면담 및 포커스 그룹 인터뷰(Focus Group Interview, FGI)를 실시한 질적 연구이다. 본 연구의 대상자는 일 백화점에서 모바일 앱을 활용하여 심뇌혈관질환 예방프로그램에 참여하고 있는 50세 이상의 여성 근로자 26명을 대상으로 하였다. 연구결과 도출된 참여경험은 '알아가는 것에 대한 즐거움', '상호 우호적 관계의 활성화', '건강에 대한 관심이 나를 관리하게 함', '익숙하지 않은 문화를 받아들임', '어디서나 상담을 받는 듯한 편리함'의 주제가 도출되었다. 이러한 결과를 통해 모바일 앱이 건강행위 실천의지를 향상시키는 것으로 나타났고, 모바일 앱을 설치 시 낯선 프로그램에 대한 불안을 감소하기 위해 안전한 프로그램임을 보증할 수 있는 인증기준이 필요함을 제언한다.

• 성인간호학회지
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• 제18권3호
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• pp.436-445
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• 2006

Purpose: The purpose of this study was to examine the effect of the discharge education program on compliance with the sick role behavior for patients having undergone cerebrovascular surgery. Method: Research was done using a posttest only design. The subjects were 60 patients who were admitted to the neurosurgery unit at C.N.U. Hospital in G. City and were divided into the experimental and control groups. The discharge education program were intervened two times in the experimental group by the researcher; the first one was at the time of discharge using a booklet about knowledge related to disease and compliance, and the other one was a telephone education session after a week from discharge. Data were collected two times by interview and telephone using questionnaires from January 19, to June 10, 2000. The first one was at hospital before discharge, and the other one was one month later from discharge. Data were analysed by $\chi^{2}$, t-test, ANOVA, and Pearson's correlation. Results: The experimental group showed a higher score of compliance(t=2.772, p=.008) than those of the control group, but knowledge about CVD was not significant between the two groups(p>.05). Conclusion: The discharge education program was effective on the compliance of the patients having undergone cerebrovascular surgery.

• 사상체질의학회지
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• 제20권2호
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• pp.145-154
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• 2008

1. Objectives The purpose of this study is to evaluate the effect of Gihwangbaekho-tang which is based on the Sasang Constitutional Medicine for the cerebrovascular accident patient who has suffered from dysphasia and dysphagia. 2. Methods The subject is about 69-year-old cerebrovascular accident patient suffering from dysphasia and dysphagia who was diagnosed as Soyangin interior overheated disease based on his nature & emotion, physical chracteristics, symptoms, and we have prescribed Gihwangbaekho-tang. 3. Results and Conclusions Cerebrovascular accident parient is suffering from dysphagia, dysphasia, insomnia, constipation, quadroparesis treated with Gihwangbaekho-tang were improved. This study describes the improvement of dysphagia, dysphasia and other general sypmtoms using Gihwangbaekho-tang. Gihwangbaekho-tang takes effect Soyangin interior overheated disease.

• 치위생과학회지
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• 제17권4호
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• pp.375-381
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• 2017

2002~2013년도 국민건강보험공단 표본 코호트자료를 활용하여 만 40세 이상 치주질환 환자를 대상으로 CVD 누적 치료 경험률 및 개인의 소득과 지역의 CDI의 차이에 따른 치료 경험률을 파악한 본 연구의 결론은 다음과 같다. 첫째, 치주질환이 있는 대상자에서 고혈압은 34.3%, 뇌졸중은 12.6%의 누적 치료 경험률이 확인되었다. 둘째, 치주질환이 있는 대상자에서 지역적 차이(CDI)에 따른 고혈압의 치료 경험률의 차이는, CDI가 높은 집단이 낮은 집단에 비해 치료 경험률이 높은 것으로 나타났다(p<0.001). 셋째, 치주질환이 있는 대상자에서 소득분위에 따른 고혈압 치료 경험률의 차이는, 소득분위가 낮은 집단에서 치료 경험률이 높은 것으로 확인되었다(p<0.001). 넷째, 치주질환이 있는 대상자에서 지역적 차이(CDI)에 따른 뇌졸중 치료 경험률의 차이는, CDI가 높을수록 뇌졸중 치료 경험률이 높은 것으로 나타났다(p<0.001). 다섯째, 치주질환이 있는 대상자에서 소득분위에 따른 뇌졸중 치료 경험률의 차이는, 소득분위가 높아질수록 뇌졸중의 치료 경험률이 낮은 것으로 조사되었다(p<0.001). CVD와 치주질환의 관계에 지역의 CDI와 개인의 소득은 역의 관계를 보이는 것으로 나타났다. 향후 국민의 구강 및 보건의료 소비에 있어 사회경제적, 지역간 격차 해소에 대한 정책적 대안으로, 사회경제적 취약계층에 대한 보건의료서비스 제공으로 보건의료에 대한 접근성 개선과, 공공의료기관의 확충으로 보건의료서비스의 지리적 접근성 취약지를 해결하고 동시에 보건의료서비스의 이용 가능성을 높이는 등 다각적 노력을 기울여야 할 것으로 생각된다.