• Title/Summary/Keyword: cerebroside D

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Phytochemical Studies on Lonicerae Flos (1) - Isolation of Iridoid Glycosides and other Constituents

  • Lee, Eun-Ju;Lee, Joo-Young;Kim, Ju-Sun;Kang, Sam-Sik
    • Natural Product Sciences
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    • v.16 no.1
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    • pp.32-38
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    • 2010
  • From the polar fractions of a 70% EtOH extract of the flower buds of Lonicera japonica (Caprifoliaceae), ten constituents were isolated and identified as iridoid glycosides 7-dehydrologanin (7-ketologanin, 2), secologanin dimethyl acetal (3), (E)-aldosecologanin (centauroside, 5), dimethyl secologanoside (6), secoxyloganin (7) and epivogeloside (8). Other identified constituents were 1-O-$\beta$-D-glucopyranosyl-(2S,3S,4R,8E/Z)-2-[(2R)-2-hydroxy(docosanoyl, tricosanoyl, tetracosanoyl, pentacosanoyl)amino]-8-octadecene-1,3,4-triol (1), uracil (4), D-mannitol (9), and sucrose (10). Among them, 1, 2, 4, and 10 were isolated for the first time from this plant.

Effect of Long-Term Pyridoxine Depletion on Lipid Composition in the Developing Rat Brain (장기간의 Pyridoxine 부족이 새끼쥐 뇌의 지방조성에 미치는 영향)

  • 김정희
    • Journal of Nutrition and Health
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    • v.20 no.5
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    • pp.318-329
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    • 1987
  • Weanling female Sprague Dawley rate were fed 1.2mg pyridoxine' HCl/kg diet Cdepleted diet) and 2 22mg pyridoxine' HCI/kg dietCcontrol diet). The control and one depleted group were fed their diets throughout growth, gestation, and lactation. Other three depleted groups were fed the depleted diet throught growth and gestation, and then pyridoxine w was supplemented by feeding control diet at 5, 10, and 21 days postpartum. The brains were analyzed for proteolipid protein, cholesterol, and cerebrosi­d de. Percentage stimulation of erythrocyte alanine aminotransferase activity was also determined. Body and brain weight were significantly lower at all ages in depleted group than the control and depleted group showed inadequacy of B6 at all ages. PProteolipid protein and cholesterol were significa­n ntlylower in the depleted group at 10, 21, 35 and 5 50 days. The postnatal development of cerebroside in brain was delayed in depleted groups suppleme­I nted at 5, 10, and 21 days. When supplementation was initiateo at 5 days postparturn, contents of cho­lesterol proteolipid protein were reversed. But some differences in brain development of pups we­re evident when supplementation of dams was de­layed to 10 days or 21 days.

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Phytochemical Studies on Rehmanniae Radix (지황 (地黃)의 성분연구)

  • Lee, So-Young;Yean, Min-Hye;Kim, Ju-Sun;Lee, Je-Hyun;Kang, Sam-Sik
    • Korean Journal of Pharmacognosy
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    • v.42 no.2
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    • pp.127-137
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    • 2011
  • Twenty-four compounds were isolated from the 70% ethanolic extract of Rehmanniae Radix (Scrophulariaceae) cultivated in Ubo-myeon, Gunwi-gun, Gyeongbuk province, Korea and their structures were identified as four iridoids [6-O-(4''-O-${\alpha}$-L-rhamnopyranosyl) vanilloyl ajugol (17), ajugol (18), aucubin (19), and catalpol (20)], three phenethyl alcohol glycosides [decaffeoyl acteoside (15), isoacteoside (16), and acteoside (21)], five sugar derivatives [ethyl ${\beta}$-D-fructofuranoside (7), eleutheroside C (14), mannitol (22), raffinose (23), and stachyose (24)], two terpenoids [remophilanetriol (4) and glutinolic acid (11)], a lignan, paulownin (2), and eight others [${\beta}$-sitosterol (1), daucosterol (6), monopalmitin (3), pinellic acid (9), uracil (5), adenosine (12), jio-cerebroside (10), aeginetic acid 5-O-${\beta}$-D-quinovoside (8), aeginetoyl ajugol 5''-O-${\beta}$-D-quinovoside (13)]. The chemical structures of these compounds were identified on the basis of spectroscopic methods and comparison with literature values. Among these compounds, paulownin (2), monopalmitin (3), uracil (5), daucosterol (6), ethyl ${\beta}$-D-fructo-furanoside (7), and eleutheroside C (14) were isolated from this plant for the first time.

Phytochemical Studies on Rehmanniae Radix Preparata (숙지황(熟地黃)의 성분연구)

  • Lee, Joo-Young;Lee, Eun-Ju;Kim, Ju-Sun;Lee, Je-Hyun;Kang, Sam-Sik
    • Korean Journal of Pharmacognosy
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    • v.42 no.2
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    • pp.117-126
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    • 2011
  • Twenty-two compounds were isolated from the 70% ethanolic extract of Rehmanniae Radix Preparata (Scrophulariaceae) and their structures were identified as three triterpenoids [oleanolic acid (1), pomonic acid (2) and ursolic acid (5)], an iridoid, catalpol (13), four furan derivatives [5-hydroxymethyl-2-furaldehyde acetate (3), 5-hydroxymethyl-2-furfural (6), 5-hydroxymethyl-2-furancarboxylic acid (7), and 5-(${\alpha}$-D-galactopyranosyloxymethyl)-2-furancarboxaldehyde (15)], three phenethyl alcohol glycosides [darendoside B (14), phenethyl alcohol 2-O-${\beta}$-D-xylopyranosyl(1${\rightarrow}$6)-${\beta}$-D-glucopyranoside (17), and salidroside (19)], four sugar derivatives [L-arabinose (11), raffinose (20), stachyose (21), and mannitol (22)], and seven others [2,5-dihydroxyacetophenone (4), succinic acid (8), daucosterol (9), ${\beta}$-sitosterol (10), adenosine (16), uridine (18) jio-cerebroside (12)]. The chemical structures of these compounds were identified on the basis of spectroscopic methods and comparison with literature values. This is the first report of the triterpenoids oleanolic acid (1), pomonic acid (2), and ursolic acid (5) from the genus Rehmannia, as well as the first report of compounds 5-hydroxymethyl-2-furaldehyde acetate (3), 2,5-dihydroxyacetophenone (4), daucosterol (9), darendoside B (14), 5-(${\alpha}$-D-galactopyranosyloxymethyl)-2-furancarboxaldehyde (15), adenosine (16), phenethyl alcohol 2-O-${\beta}$-D-xylopyranosyl(1${\rightarrow}$6)-${\beta}$-D-glucopyranoside (17), and salidroside (19) from the Rehmanniae Radix Preparata.

Lipids and Fatty Acids Composition of Korean Native Goat's Bone Marrow (한국 재래산양 골수의 지질 및 지방산 조성)

  • Lee, Y.Y.;Ha, J.K.;Ahn, B.H.;Kang, D.H.;Ki, W.K.;Kim, J.K.
    • Applied Biological Chemistry
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    • v.31 no.2
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    • pp.177-181
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    • 1988
  • Korean native goat's bone marrow was low in triglycerides high in phospholipids and glycolipids. In the fatty acid composition, goat's bone marrow was high in $C_{18:1}$ and low in $C_{18:0}$. Goat's bone marrow also contained more unsaturated fatty acid than saturated fatty acid. Triglyceride and sterylester were more than others in the neutral lipids. Esterified glycoside and monogalactosyl diglyceride were higher than others in the glycolipids. Diphosphatidyl glycerol and phosphatidyl ethanolamine were higher than others in the phospholipids. In the fatty acid composition of triglycerides, Humerus and Radius, Femur and Os coxae and Lumbar vertebra were all higher in $C_{16:0}$, $C_{18:0}$ and $C_{18:1}$ than others in the 1-position of triglycerides and higher in $C_{18:0}$, $C_{18:2}$ and $C_{18:3}$ than others in the 2-position of triglycerides.

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