• The Journal of Internal Korean Medicine
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• v.38 no.5
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• pp.744-752
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• 2017

Objectives: In this report, we describe two patients with central dizziness and cerebellar ataxia who were treated with traditional Korean medicine. Methods: We applied traditional Korean medicine treatments of herbal medication (Banhabaekchulcheonma-tang and Bojungikki-tang), acupuncture, and moxibustion. Results: After 31 days of treatment, we observed improvement in the central dizziness on a numeric rating scale and in the cerebellar ataxia based on the patient's ambulation state. Conclusions: Traditional Korean medicine may be effective in the treatment of central dizziness and cerebellar ataxia.

• Journal of Sasang Constitutional Medicine
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• v.26 no.2
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• pp.194-204
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• 2014

Objectives The aim of this study was to examine significant improvement of gait ataxia, vertigo and tremor after treatment with Sipyimigwanjung-tang, Hyangsayangwi-tang in a Soeumin Greater Yin Symptomatology patient Diagnosed as Cerebellar ataxia. Methods The patient was diagnosed with Soeumin Greater Yin Symptomatology and treated with Soeumin's constitutional medications and acupuncture. The primary outcome measures for this study were the Unified Multiple System Atrophy Rating Scale(UMSARS) and Cerebellar function test to assess the overall function of patient. Secondary outcome assessment included Global Assessment Scale(GAS), change of patient's sleep, stool and digestion. Results The symptoms of gait ataxia, vertigo and tremor decreased from GAS 100 to GAS 0~40 after treatment, and the UMSARS score decreased in Part I, II. Conclusions This case showed that Sasang Constitutional medicine treatment can be effective treatment method for cerebellar ataxia. We consider that consistent treatment can contribute to improve the patient's quality of life.

• The Journal of Korean Physical Therapy
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• v.27 no.2
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• pp.112-117
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• 2015

Purpose: The purpose of this study was to examine the effects of a task-specific obstacle crossing rehabilitation program on functional gait ability in patients with cerebellar ataxia. Overall, we sought to provide ataxia-specific locomotor rehabilitation guidelines for use in clinical practice based on quantitative evidence using relevant analysis of gait kinematics including valid clinical tests. Methods: Patients with cerebellar disease (n=13) participated in obstacle crossing training focusing on maintenance of dynamic balance and posture, stable transferring of body weight, and production of coordinated limb movements for 8 weeks, 2 times per week, 90 minutes per session. Throughout the training of body weight transfer, the instructions emphasized conscious perception and control of the center of body stability, trunk and limb alignment, and stepping kinematics during the practice of each walking phase. Results: According to the results, compared with pre-training data, foot clearance, pre-&post-obstacle distance, delay time, and total obstacle crossing time were increased after intervention. In addition, body COM measures indicated that body sway and movement variability, therefore posture stability during obstacle crossing, showed improvement after training. Based on these results, body sway was reduced and stepping pattern became more consistent during obstacle crossing gait after participation in patients with cerebellar ataxia. Conclusion: Findings of this study suggest that task-relevant obstacle crossing training may have a beneficial effect on recovery of functional gait ability in patients with cerebellar disease.

• Korean Journal of Acupuncture
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• v.19 no.2
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• pp.79-85
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• 2002

Objective : In 1983 Autosomal dominent spinocerebellar ataxia(ADCA) has been classified to four types by a useful clinical features according to Harding. Since 1993 ADCA referred to as SCA by molecular genetic characteristics. We focused on the improvement of clinical symptoms in SCA patient through oriental medical treatment. Methods ＆ Results : The assessment included neurophysiological examination and clinical symptoms. For example slow saccade, gaze limitation, upward and lateral, nystagmus, truncal and gait ataxia. The patient(M/30) was clinically charaterized by ocular abnormalities, trunkal and gait ataxia and the MRI showed atrophy of cerebellar vermis. The patient was taken both common acupuncture and Dong-Si venepuncture on Hwasan with herbal medicine. Before the treatment Rt. ocular movement were slowed and a significant eye fixation was observed always in abduction and intermittently presented trunkal and gait ataxia. During the treatment trunkal and gait ataxia has not been presented and ocular obnomalities changed to normal state. This case suggests the possibility of oriental medical treatment on SCA but further observation is needed on this patient.

• Journal of Genetic Medicine
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• v.14 no.2
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• pp.71-74
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• 2017

Mutations in the DNA methyltransferase 1 gene (DNMT1) were reported to cause two phenotypes: OMIM 604121 and OMIM 614116. The first phenotype includes autosomal dominant cerebellar ataxia, deafness, and narcolepsy, which were reported to be caused by mutations in exon 21. The second phenotype includes hereditary sensory and autonomic neuropathy type 1E, which was suggested to be caused by mutations in exon 20 and 21. In this article, we report a novel heterozygous missense variant c.898A>C, p.(Lys300Gln) in exon 12 of DNMT1 in a young woman who presented with pure cerebellar ataxia. This report indicates that a mutation in exon 12 may lead to pure cerebellar ataxia. Another possibility is that the patient is currently in an early stage of the disease, and as the disease progresses, she will have more manifestations. To confirm or exclude this possibility, a subsequent follow-up study reporting the disease progression in this patient may be needed. Further reports of cases with the same mutation are needed to confirm the phenotype of this mutation.

• The Journal of Internal Korean Medicine
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• v.37 no.5
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• pp.806-814
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• 2016

Objective: To describe the effect of Korean medicine on gait disturbance in a patient with multiple system atrophy and cerebellar ataxia. Methods: We observed a 75-year-old female patient who had multiple system atrophy and cerebellar ataxia. The patient was treated with Korean medicine, including acupuncture, moxibustion, and herbal medicine (Yukmijihwang-tang-gamibang and Boyanghwano-tang-gamibang) for 38 days. We evaluated the patient with the Korean version of the Berg Balance Scale (K-BBS), the Unified Multiple System Atrophy Rating Scale (UMSARS), and the Numeric Rating Scale-11 (NRS-11). Results: After treatment, the patient’s symptoms were improved. The K-BBS score increased from 9 to 19, while the UMSARS score decreased from 16 to 12 in Part I, from 15 to 7 in part Ⅱ, and from 4 to 3 in part Ⅳ. The NRS-11 score of gait disturbance decreased from 10 to 5. Conclusions: Korean medicine may be an effective treatment for gait disturbance in multiple system atrophy with cerebellar ataxia.

• The Journal of the Society of Stroke on Korean Medicine
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• v.9 no.1
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• pp.33-39
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• 2008

Ataxia and vertigo are frequent clinical findings in cerebellar infarction patients. In severe cases, they cannot achieve normal activity in daily life. A 65-year-old man was admitted with ataxia and vertigo diagnosed as acute cerebellar infarction. We prescribed for Chukdam-tang to treat the phlegm disease. After this treatment, ataxia and vertigo improved. We suggest Chukdam-tang is significantly effective on the treatment of cerebellar infarction.

• The Journal of Internal Korean Medicine
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• v.25 no.2
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• pp.335-343
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• 2004

The two case reports here presented are based on an inpatient with lateral medullary infarction, known as Wallenberg's syndrome with chief complains of central dizziness and cerebellar ataxia, and an inpatient with infarctions of cerebellar, pontine, and lacunar thalamic region. QSCCII was performed while the patient was hospitalized and, by consultation with the Dept. of Sasang Constitutional Medicine, the patient was diagnosed with Taeumin. Thus, an oriental medical therapy of Cheongsimyeonjatang, acupuncture, and moxibustion was carried out. As a result the degree of dizziness decreased noticeably while other symptoms improved as well. Before leaving the hospital, the degree of cerebellar ataxia also improved and the patient was able to go on foot by himself. In conclusion, significant improvements were observed in cerebellar and a pontine infarction patients who suffered central dizziness and cerebellar ataxia through Sasang medical therapy.

• The Journal of Internal Korean Medicine
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• v.35 no.3
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• pp.373-382
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• 2014

Objectives: This study is a report of the clinical application of traditional Korean medicine on ataxia with cerebellar atrophy. Methods: The ataxia in this case occurred 5 years ago. The symptoms had been getting worse until the patient came to hospital. The MRI of this patient showed atrophy of the cerebellum. We measured the state of this case with the Korean version of the Berg Balance Scale (K-BBS), before and after treatment and Numeric Rating Scale-11 (NRS-11) of the symptoms, every week. We treated the case with traditional Korean medicine such as acupuncture and Gamiyukmijihwang-tang. Results: After treatment, the score of K-BBS increased, while the score of NRS-11 decreased. Conclusions: According to this study, traditional Korean medicine is effective for controlling ataxia caused by cerebellar atrophy.

• The Journal of Internal Korean Medicine
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• v.42 no.2
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• pp.165-174
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• 2021

This study reported on the effect of traditional Korean medicine on ataxia, gait disturbance, tremor, and dizziness with cerebellar atrophy. The patient was treated with traditional Korean medicines, such as acupuncture, moxibustion, and herbal medicine (Kuibiondam-tang-gami). The effectiveness of the treatment was evaluated with the scale for the assessment and rating of ataxia (SARA). After treatment, the symptoms had improved. The SARA score decreased by 18 points after Korean medicine treatment. According to this study, traditional Korean medicine can be effective to treat ataxia, gait disturbance, tremor, and dizziness in patients with cerebellar atrophy.