• 동의신경정신과학회지
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• 제34권2호
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• pp.95-113
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• 2023

Objectives: To review studies evaluating effects of acupuncture on pain and depressive symptoms in fibromyalgia. Methods: Quantitative evidences (RCTs) were systematically reviewed. Literature were searched for a combination of fibromyalgia and depression (The Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, medline (via PubMed), Kmbase, KISS, ScienceON, OASIS, CiNii, CNKI). Quantitative research findings were critically appraised by Cochrane risk of bias (RoB) tool and pooled. Meta-analysis was then conducted using Review Manager (RevMan) 5.4. Results: Eighteen studies were selected. American College of Rheumatology (ACR) classification criteria for Fibromyalgia Syndrome was most frequently used as diagnostic criteria for fibromyalgia. As for outcome measurement, Hamilton Rating Scale for Depression (HAMD), Visual Analog Scale (VAS), and Total Effective Rate (TER) were used most commonly. Meta-analysis of ten studies revealed that both Depression and VAS scores of the Acupuncture+Western Medicine group were significantly lower than those of Western Medicine group (Depression: SMD, -0.94, 95% CI, -1.17 to -0.70; VAS: MD, -1.51, 95% CI, -1.83 to -1.19). Also, TERs of both Acupuncture group and Acupuncture+Western Acupuncture+Western Medicine group were significantly higher than those of the Western Medicine group (OR: 2.38, 95% CI: 1.29 to 4.41; and OR: 7.40, 95% CI: 3.41 to 16.07). There was no significant difference in Depression or VAS score between the Acupuncture Group and the Western Medicine Group. Conclusions: Acupuncture might be an effective option for pain and depressive symptoms of fibromyalgia when it is combined with Western Medicine treatment. For more accurate results, more types of Korean medicine treatment should be conducted.

• 정신신체의학
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• 제31권2호
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• pp.118-124
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• 2023

연구목적 우울장애와 불안장애는 흔히 공존하며 임상전단계에서도 흔히 공존한다. 본 연구는 일반인구 집단에서 우울장애와 불안장애가 공존시의 복합 네트워크를 구성하여 중심 증상과 중개 증상을 밝히고자 했다. 방 법 2022년 아산시 청년 정신건강실태조사 데이터를 활용하여 진행하였다. 일반 인구집단 810명의 성인을 대상으로 PHQ-9과 GAD-7을 이용하여 각각 우울과 불안증상의 정도를 측정하였고, 각 증상에 대해 Isingfit model을 기반으로 네트워크 구조를 도출하였다. 주요 증상 및 중개 증상을 찾기 위해 네트워크 지표 중 강도 중심성과 bridge expected influence를 활용하였다. 결 과 우울한 기분, 안절부절 못함과 초조함이 네트워크에서 가장 높은 강도중심성을 보였으며, 불안증상과 우울증상 간의 높은 중개 역할을 하는 증상은 안절부절 못함과 과민성이었다. 결 론 일반 인구집단에서 우울증상과 불안증상이 공존할 때의 중심증 상과 중개증상을 규명하였고 치료적 중재의 목표가 되면 두 질환의 동반이환율을 감소시키는데 기여할 수 있을 것으로 기대된다.

• 한국지구물리탐사학회:학술대회논문집
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• 한국지구물리탐사학회 2005년도 공동학술대회 논문집
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• pp.139-144
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• 2005

남극 웨델해 북부에 위치한 남스코시아해령을 가로지르는 측선에 대하여 다중채널 탄성파 탐사를 수행하였다. 남스코시아해령은 남극반도의 연장선에 존재하는 대륙지각으로 각각 해양지각인 스코시아해와 포웰분지와 접하고 있다. 남스코시아해령은 스코시아 판의 남쪽 가장자리를 이루고 있는 동-서 방향의 좌선 변환단층을 따라 횡장력에 의해 만들어졌다. 남스코시아해령 중앙에 위치한 중앙 함몰대는 경사부정합이 존재하며 남스코시아해령의 확장과정에 나타난 구조로 해석된다.

• 지구물리
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• 제8권4호
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• pp.215-219
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• 2005

남극 웨델해 북부에 위치한 남스코시아해령을 가로지르는 측선에 대하여 다중채널 탄성파 탐사를 수행하였다. 남스코시아해령은 남극반도의 연장선에 존재하는 대륙지각으로 각각 해양지각인 스코시아해와 포웰분지와 접하고 있다. 남스코시아해령은 스코시아 판의 남쪽 가장자리를 이루고 있는 동-서 방향의 좌선 변환단층을 따라 횡장력에 의해 만들어졌다. 남스코시아해령 중앙에 위치한 중앙 함몰대는 경사부정합이 존재하며 남스코시아해령의 확장과정에 나타난 구조로 해석된다.

• Asian-Australasian Journal of Animal Sciences
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• 제17권5호
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• pp.594-597
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• 2004

A pedigree file of 4,628 records of Muzaffarnagari sheep, maintained at Central Institute for Research on Goats (CIRG), Makhdoom, was used to calculate the inbreeding coefficient of the flock. The flock had been closed for about 25 years (1978 to 2002). The investigation was aimed to study the effects of inbreeding on survivability of lambs. The cumulative survivability of lambs i.e., lambs survived up to 3, 7 and 15 days, 1, 2, 3, 6, 9 and 12 months after birth was considered for the study. The average level of inbreeding of lambs was 1.60%, ranging from 0 to 26.4%. The average inbreeding coefficient of dam over the periods was 1.00% and it ranged from 0 to 25.0%. Significant (p<0.05) adverse effect of lamb's inbreeding was observed on survivability of lambs at all ages except up to 3 and 7 days after birth. On an average, 1% increase in individual inbreeding coefficient should reduce the 0.31, 0.34, 0.32, 0.31, 0.33, 0.44 and 0.49 percent lamb survival up to the age of 15 day and 1, 2, 3, 6, 9 and 12 months, respectively. Ewes inbreeding had non-significant effects on lamb survival at all ages.

• Journal of Microbiology and Biotechnology
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• 제22권5호
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• pp.708-720
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• 2012

In this study, we assessed the effects of ginsenoside Re (GRe) administration on repeated immobilization stress-induced behavioral alterations using the forced swimming test (FST), the elevated plus maze (EPM), and the active avoidance conditioning test (AAT). Additionally, we examined the effect of GRe on the central adrenergic system by observing changes in neuronal tyrosine hydroxylase (TH) immunoreactivity and brain-derived neurotrophic factor (BDNF) mRNA expression in the rat brain. Male rats received 10, 20, or 50 mg/kg GRe (i.p.) 30 min before daily exposures to repeated immobilization stress (2 h/day) for 10 days. Activation of the hypothalamic-pituitary-adrenal (HPA) axis in response to repeated immobilization was confirmed by measuring serum levels of corticosterone (CORT) and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Repeated immobilization stress increased immobility in the FST and reduced open-arm exploration in the EPM test. It also increased the probability of escape failures in the AAT test, indicating a reduced avoidance response. Daily administration of GRe during the repeated immobilization stress period significantly inhibited the stress-induced behavioral deficits in these behavioral tests. Administration of GRe also significantly blocked the increase in TH expression in the locus coeruleus (LC) and the decrease in BDNF mRNA expression in the hippocampus. Taken together, these findings indicate that administration of GRe prior to immobilization stress significantly improved helpless behaviors and cognitive impairment, possibly through modulating the central noradrenergic system in rats. These findings suggest that GRe may be a useful agent for treating complex symptoms of depression, anxiety, and cognitive impairment.

• The Korean Journal of Pain
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• 제33권3호
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• pp.226-233
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• 2020

Background: We aimed to compare interlaminar epidural steroid injections (ILESI) and bilateral transforaminal epidural steroid injections (TFESI) on pain intensity, functional status, depression, walking distance, and the neuropathic component in patients with lumbar central spinal stenosis (LCSS). Methods: The patients were divided into either the ILESI or the bilateral TFESI groups. Prime outcome measures include the numerical rating scale (NRS), Oswestry disability index (ODI), Beck depression inventory (BDI), and pain-free walking distance. The douleur neuropathique en 4 questions score was used as a secondary outcome measure. Results: A total of 72 patients were finally included. NRS, ODI, and BDI scores showed a significant decline in both groups in all follow-ups. Third-month NRS scores were significantly lower in the ILESI group (P = 0.047). The percentages of decrease in the ODI and BDI scores between the baseline and the third week and third month were significantly higher in the ILESI group (P = 0.017, P = 0.001 and P = 0.048, P = 0.030, respectively). Pain-free walking distance percentages from the baseline to the third week and third month were significantly higher in the ILESI group (P = 0.036, P < 0.001). The proportion of patients with neuropathic pain in the bilateral TFESI group significantly decreased in the third week compared to the baseline (P = 0.020). Conclusions: Both ILESI and TFESI are reliable treatment options for LCSS. ILESI might be preferred because of easier application and more effectiveness. However, TFESI might be a better option in patients with more prominent neuropathic pain.

• 대한물리의학회지
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• 제13권1호
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• pp.137-146
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• 2018

PURPOSE: This study examine the effect of community ambulation training on gait, depression and self - efficacy of stroke patients in order to develop more effective training methods of community rehabilitation. METHODS: In the experimental group, community ambulation training combined with indoor and outdoor walking was performed for 30 minutes three times a week for six weeks. In the control group, general indoor walking training was performed. The physical factors were assessed by a 10-meter walking test, six-minute walking test and community gait test. Psychological factors were assessed by the Korean version of the Epidemiology Center Depression Scale and Activity-Specific Balance Confidence Scale. RESULTS: In the 10-meter walking test, the normal walking speed was significantly improved after the intervention in both the experimental group and the control group (p<.05). However, the fast walking speed was significantly improved only in the experimental group (p <.05). ln the community gait test, the experimental group showed significant improvement (p<.05), but the control group did not. Depression and self-efficacy were significantly improved in the experimental group (p<.05) but not in the control group. CONCLUSION: Community ambulation training may improve the gait ability of stroke patients and reduce their depression and improve self-efficacy.

• 한국환경생태학회지
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• 제35권4호
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• pp.424-434
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• 2021

고령화 시대에 퇴직을 맞이하는 사람들은 회복탄력성과 심리적 우울의 변화를 경험하게 된다. 한국 사회의 경제사회분야에서 중심적 역할을 주도해 온 베이비부머 세대의 퇴직이 시작되면서 이들의 퇴직 이후의 삶에도 관심이 높아지고 있다. 본 연구에서는 생태숲이 가지고 있는 산림치유인자들을 활용한 산림치유 프로그램을 통해 베이비부머 은퇴자들의 회복탄력성, 우울에 미치는 영향을 알아보고자 하였다. 실험은 베이비부머 세대 58명을 대상으로 3그룹으로 구분하여 그룹 간 차이를 검정하였다. 그 결과 산림치유 프로그램에 참여한 그룹(FHPG)은 자율적인 숲 활동 그룹(FHNG)과 일상생활 그룹(DLG)에 비하여 회복탄력성이 매우 유의미하게 증가되었고, 우울감도 통계적으로 유의하게 감소되었다. 따라서 은퇴자들의 자율적인 숲 활동 보다도 산림치유 프로그램에 참여하는 것이 매우 효과적이라고 할 수 있다. 본 연구 결과가 향후 은퇴자들의 회복탄력성과 우울 연구에 기초자료로 활용되기를 기대한다.

• 대한약리학회지
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• 제18권1호
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• pp.17-22
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• 1982

Zizyphus seed(Zizyphus vulgaris Lamark var. Spinosus Bunge) has long been used as hypnotics and sedatives in oriental medicine, and it is reported that the Zizyphus seed elicited a variety of pharmacologic actions besides CNS depression. Present study was undertaken to investigate the effects of Zizyphus seed on the central nervous system and on the blood pressure. The effect of Zizyphus seed on the central nervous system was measured by the influence of thiopental sleeping time and by inhibition of chemical convulsion (strychnine and pentylenetetrazol induced). Blood pressure changes by Zizyphus extract and its mode of action were investigated. The ground Zizyphus seed was extracted with hexane and methanol, consecutively and the supernatants were discarded. The precipitate was re-extracted with distilled water and the supernatant was evaporated to a dark-brownish sticky liquid, which was used as Zizyphus seed extract in this study after dissolving in saline prior to experiment. The results are as follows. 1) Zizyphus seed extract caused marked prolongation of the thiopental sleeping time in mice. 2) The chemical convulsion by strychnine and pentylenetetrazol, and the mortality by them in chicks were not affected by pretreatment of Zizyphus seed extract. 3) Zizyphus seed extract produced transient fall of blood pressure in the cat, and this hypotentive effect was blocked partially by atropine but not affected by bilateral vagotomy and/or hexamethonium, nor propranolol and, chlorpheniramine and/or cimetidine. With the above results, it may be suggested that the water extract of Zizyphus seeds contains components producing CNS depression and hypotension. Furthermore it is felt that the cholinergic effect, but not the adrenergic or histaminergic, is partly responsible for the hypotensive effect of Zizyphus seed extract.