• Bulletin of the Korean Chemical Society
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• v.26 no.5
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• pp.769-775
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• 2005

An efficiency of Monte Carlo (MC) docking simulations was examined for the prediction of chiral discrimination by cyclodextrins. Docking simulations were performed with various computational parameters for the chiral discrimination of a series of 17 enantiomers by $\beta$-cyclodextrin ($\beta$-CD) or by 6-amino-6-deoxy-$\beta$-cyclodextrin (am-$\beta$-CD). A total of 30 sets of enantiomeric complexes were tested to find the optimal simulation parameters for accurate predictions. Rigid-body MC docking simulations gave more accurate predictions than flexible docking simulations. The accuracy was also affected by both the simulation temperature and the kind of force field. The prediction rate of chiral preference was improved by as much as 76.7% when rigid-body MC docking simulations were performed at low-temperatures (100 K) with a sugar22 parameter set in the CHARMM force field. Our approach for MC docking simulations suggested that the conformational rigidity of both the host and guest molecule, due to either the low-temperature or rigid-body docking condition, contributed greatly to the prediction of chiral discrimination.

• Journal of Korean Society of Steel Construction
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• v.18 no.5
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• pp.563-574
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• 2006

The objective of this study is to determine the effect of the loading size on displacements of stiffened plates with open ribs using the orthotropic rigidity ratio as the parameter. To analyze the displacement behavior of stiffened plates according to the loading size, a concentrated load and three types of uniform distributed loads were applied on the rib at the center of some plates. The results of the analysis of various stiffened plates show that the central displacement ratio of the distributed load to the concentrated load increased according to the decrease in the loading size, and that the ratio can be expressed as a function of the rigidity ratio for each rib space. The maximum displacement of the stiffened plate subjected to the distributed load did not appear at the center of the plate due to the local behavior, and the increasing ratio of the maximum displacement to the central displacement can be expressed as a function of the rigidity ratio for each rib space. Orthotropic plate analysis can achieve more accurate results using the proposed functions, and the application of the functions to examples of a different aspect ratio and support condition shows good accuracy. Therefore, using the functions proposed in this study, the central and maximum displacements can easily be achieved in the orthotropic plate analysis of stiffened plates subjected to the distributed load.

• Journal of Korean Society of Steel Construction
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• v.19 no.6
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• pp.621-632
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• 2007

The purpose of this study was the estimation and formulation of orthotropic flexural rigidities considering the deformed shape for a plate stiffened with rectangular ribs. Analytical results of methods modifying the flexural rigidity of the x-direction, the y-direction or both directions were compared at the center, the x-directional quarter point and the y-directional quarter point of stiffened plates loaded at the center. The composite method modifying the flexural rigidity of both directions improves the accuracy compared with the other methods. Moreover, the ratio of modified coefficients for each directional rigidity can be expressed as a function corresponding to each dimension of stiffened plates. The application of modified coefficient functions to various types of stiffened plates with different boundary conditions, aspect ratios and rib arrangement shows that the increment of the error ratio is small compared with examples of this study and the application of proposed functions shows more accurate results than previous methods modifying the flexural rigidity. Therefore, by using the modified coefficient functions proposed in this study, the orthotropic plate analysis of plates stiffened with rectangular ribs can easily achieve more accurate displacement results.

• Korean Journal of Food Science and Technology
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• v.28 no.6
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• pp.1052-1058
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• 1996

The effect of varietal differences of rice starches by amylose content and gel consistency on the retrogradation behavior was studied. Setback viscosity of rice flour measured in a Brabender amylograph was significantly affected by amylose content as well as gel consistency. Increase in the rigidity modulus (E) of rice starch gels during storage determined by using texture analyzer indicated that amylose content was an important factor in terms of hardness increase. Kinetics of retrogradation showed that time constant of rice starch gels was influenced by amylose content, but not by gel consistency.

• Elastomers and Composites
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• v.35 no.2
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• pp.138-148
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• 2000

In order to investigate the possibility of EPDM micro cellular pad (MCP) as an impact sound insulation product, we studied static/dynamic properties and vibration transfer characteristics of EPDM MCP depending on shape, thickness, degrees of foaming by using material test system (MTS) and lab scale mock-up test apparatus. Static/dynamic rigidity is increased when shape is simple. thickness and degrees of foaming low. We could see that dynamic stiffness is proportional to the transmissibility of EPDM MCP. When dynamic stiffness is increased, characteristic peak at transmissibility curve moves high frequency range or snows increase of maximum value of transmissibility. For lab scale mock-up test and finite element method, EPDM MCP shows low vibration velocity and superior mode shape to just concrete plus slab structure. We could confirm that possibility of EPDM MCP as a impact sound insulation product is high.

• IMMUNE NETWORK
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• v.12 no.3
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• pp.71-83
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• 2012

T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, the immunological synapse leads to sustained T cell receptor-mediated signalling and stabilized adhesion. High resolution microscopy indeed had a great impact in understanding the function and dynamic structure of immunological synapse. Trends of recent research are now moving towards understanding the mechanical part of immune system, expanding our knowledge in mechanosensitivity, force generation, and biophysics of cell-cell interaction. Actin cytoskeleton plays inevitable role in adaptive immune system, allowing it to bear dynamic and precise characteristics at the same time. The regulation of mechanical engine seems very complicated and overlapping, but it enables cells to be very sensitive to external signals such as surface rigidity. In this review, we focus on actin regulators and how immune cells regulate dynamic actin rearrangement process to drive the formation of immunological synapse.

• Journal of the Korean Mathematical Society
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• v.57 no.6
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• pp.1335-1345
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• 2020

We will show a rigidity of a Kähler potential of the Poincaré metric with a constant length differential.

• Bulletin of the Korean Mathematical Society
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• v.57 no.4
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• pp.1049-1060
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• 2020

We prove rigidity theorems for ancient solutions of geometric flows of immersed submanifolds. Specifically, we find conditions on the second fundamental form that characterize the shrinking sphere among compact ancient solutions for the mean curvature flow in codimension two surfaces, which is different from the conditions of Risa and Sinestrari in [26] and we also remove the condition that the second fundamental form is uniformly bounded when t ∈ (-∞, -1).

• Earthquakes and Structures
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• v.7 no.1
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• pp.39-55
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• 2014

A modified procedure is presented for assessing the seismic response of elastic non-proportionate multistory buildings. This procedure retains the simplicity of the methodology presented by the author in earlier papers, but it presents higher accuracy in buildings composed by very dissimilar types of bents. As a result, not only frequencies and peak values of base resultant forces are determined with higher accuracy, but also the location of the first mode center of rigidity (m1-CR). The closeness of m1-CR with the axis passing through the centers of floor masses (mass axis) implies a reduced rotational response and it is demonstrated that in elastic systemsa practically translational response is obtained when this point lies on the mass axis.Besides, when common types of buildings are detailed as planar structures under a code load, this response is maintained in the inelastic phase of their response as a result of the almost concurrent yielding of all the resisting bents. This property of m1-CR can be used by the practicing engineer as a guideline to form a structural configuration which will sustain minimum rotational response, simply by allocating the resisting elements in such a way that this point lies close to the mass axis. Inelastic multistory building structures, detailed as above, may be regarded as torsionally balanced multistory systems and this is demonstrated in eight story buildings, composed by dissimilar bents, under the ground motions of Kobe 1995 (component KJM000) and Friuli 1976 (component Tolmezzo E-W).

• Structural Engineering and Mechanics
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• v.66 no.5
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• pp.637-648
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• 2018

When the centers of mass and stiffness of a building do not coincide, the structure experiences torsional responses. Such systems can consist of the underlying soil and the super-structure. The underlying soil may modify the earthquake input motion and change structural responses. Specific effects of the input motion shall also not be ignored. In this study, seismic demands of asymmetric buildings considering soil-structure interaction (SSI) under near-fault ground motions are evaluated. The building is modeled as an idealized single-story structure. The soil beneath the building is modeled by non-linear finite elements in the two states of loose and dense sands both compared with the fixed-base state. The infinite boundary conditions are modelled using viscous boundary elements. The effects of traditional and yield displacement-based (YDB) approaches of strength and stiffness distributions are considered on seismic demands. In the YDB approach, the stiffness considered in seismic design depends on the strength. The results show that the decrease in the base shear considering soft soil induced SSI when the YDB approach is assumed results only in the center of rigidity to control torsional responses. However, for fixed-base structures and those on dense soils both centers of strength and rigidity are controlling.