• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2007년도 춘계학술대회 논문집
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• pp.217-218
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• 2007

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제12권4호
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• pp.1854-1868
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• 2018

A wireless body-sensor network (WBSN) refers to a network-configured environment in which sensors are placed on both the inside and outside of the human body. The sensors are much smaller and the energy is more constrained when compared to traditional wireless sensor network (WSN) environments. The critical nature of the energy-constraint issue in WBSN environments has led to numerous studies on the reduction of energy consumption of WBSN sensors. The transmission-power-control (TPC) technique adjusts the transmission-power level (TPL) of sensors in the WBSN and reduces the energy consumption that occurs during communications. To elaborate, when transmission sensors and reception sensors are placed in various parts of the human body, the transmission sensors regularly send sensor data to the reception sensors. As the reception sensors receive data from the transmission sensors, real-time measurements of the received signal-strength indication (RSSI), which is the value that indicates the channel status, are taken to determine the TPL that suits the current-channel status. This TPL information is then sent back to the transmission sensors. The transmission sensors adjust their current TPL based on the TPL that they receive from the reception sensors. The initial TPC algorithm made linear or binary adjustments using only the information of the current-channel status. However, because various data in the WBSN environment can be utilized to create a more efficient TPC algorithm, many different types of TPC algorithms that combine human movements or fuse TPC with other algorithms have emerged. This paper defines and discusses the design and development process of an efficient TPC algorithm for WBSNs. We will describe the WBSN characteristics, model, and closed-loop mechanism, followed by an examination of recent TPC studies.

• 한국환경농학회지
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• 제28권4호
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• pp.462-467
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• 2009

Exposure of formaldehyde (FA), one of the major compounds in pesticides and in the onset of sick house syndrome, has been implicated in the development of diverse diseases. Liver is a very important organ to body metabolism and drug detoxification. Apotosis of hepatocytes is associated with the onset of liver diseases such as hepatitis. However, the apoptotic effect of FA in hepatocytes is not clear. Therefore, this study was conducted to investigate the effect of FA on the apoptosis in HepG2 cells, a human hepatocyte cell line. As a result, FA (> $500\;{\mu}M$) decreased cell viability and increased lactate dehydrogenase activity in HepG2 cells, which was blocked by the treatment of vitamin E and N-acetylcysteine (NAC). In addition, FA decreased glutathione (GSH) contents and Bcl-2 levels, while increasing lipid peroxide formation and Bax levels. It also cleaved caspase-3 form, which was blocked by the treatment of vitamin E and NAC. It is insisted that FA induced apoptosis via oxidative stress in human hepatocytes.

• Nutrition Research and Practice
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• 제9권4호
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• pp.433-438
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• 2015

BACKGROUND/OBJECTIVES: Breast milk is the best available food for optimum growth and development of infants and the breastfeeding rate is increasing in Korea. The purpose of this study is to measure the concentrations of macronutrients and to evaluate their changes according to lactation period in breast milk from lactating Korean women. SUBJECTS/METHODS: Milk samples were obtained from 2,632 healthy lactating women (mean age; $32.0{\pm}3.3years$), where the lactating period was up to a period of 8 months, who also volunteered to participate in the Human Milk Macronutrient Analysis Research. Lactose, protein, fat and water content in the breast milk samples were analyzed with infrared spectrometry using MilkoScan FT-2. RESULTS: The mean macronutrient composition per 100 mL of mature breast milk was 7.1 g for lactose, 1.4 g for protein and 3.0 g for fat, and energy content was 61.1 kcal. The protein concentration was significantly lower in milk samples at 1-2 weeks (2.0 g/dL) to 2-3 months (1.4 g/dL) than those at 0-1 week (2.2 g/dL), but it was similar among samples from 3-4 months to 7-8 months (1.3 g/dL). Mean lipid levels varied among different lactational period groups (2.7-3.2 g/dL), but presented no significant difference. Lactose concentration in the milk samples did not differ with lactation period. Maternal body mass index was positively related to protein and lipid breast milk contents, but was negatively related to lactose content. General linear models examining the associations between maternal variables and milk macronutrient content revealed that lactation period had a major impact on protein and lipid, but not on lactose content in breast milk. CONCLUSIONS: These results warrant future studies to explore factors that may be associated with changes in macronutrient content in human milk.

• 비교문화연구
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• 제21권
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• pp.165-188
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• 2010

One of the things that should be done first in establishing the cosmic life culture is to reflect on the old human-oriented culture. If the cosmic life culture absolutizes everything except for humans according to the logic of reason, its foundation will weaken or eventually get lost. Separating humans from the universe is just like separating life from it. Given that all life, whether it is humans or the earth, originated from the universe, such an effort for separation merely values an individual life by excluding all life or whole life. When the human body and the cosmic chi' blood are not in an active flow, it means there is a problem with life. What is in the greatest need in such a case is the sincere human mind that follows the principle of cosmic life. It is like the sincerity found in the pasonri singer, who mellows all the hardships and difficulties in the world out and create songs out of them like the shadow. It is the pansori singer's shadow that changes the universe. It is only when the extreme force of human mind communicates with that of the universe that the cosmic life or cosmic life culture can be created. In that sense, it is urgent to create life out of the universe inside me and create a universe out of all life in and outside me. It is such a grave plan in human history in that it involves finding the "Sanal" which is the core of life living hidden inside the body whose life force gradually goes away or inside the universe, and creating the culture of Bokseung in which it bursts out. The most important thing in life is the flow, and the mankind is currently standing in the life flow of the massive universe's chaosmos. The greatest task the mankind is currently faced with is to think over how to deal with the period of Big Chaos in the massive universe's chaosmos reversely and establish the cosmic life culture anew.

• International Journal of Oral Biology
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• 제42권2호
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• pp.71-78
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• 2017

BMP-2 is a well-known TGF-beta related growth factor, having a significant role in bone and cartilage formation. It has been employed to promote bone formation in some clinical trials, and to differentiate mesenchymal stem cells into osteoblasts. However, it is difficult to obtain this protein in its soluble and active form. hBMP-2 is expressed as an inclusion body in the bacterial system. To continuously supply hBMP-2 for research, we optimized the refolding of recombinant hBMP-2 expressed in E. coli, and established an efficient method by using detergent and alkali. Using a heparin column, the recombinant hBMP-2 was purified with the correct refolding. Although combinatorial refolding remarkably enhanced the solubility of the inclusion body, a higher yield of active dimer form of hBMP-2 was obtained from one-step refolding with detergent. The refolded recombinant hBMP-2 induced alkaline phosphatase activity in mouse myoblasts, at $ED_{50}$ of 300-480ng/ml. Furthermore, the expressions of osteogenic markers were upregulated in hPDLSCs and hDPSCs. Therefore, using the process described in this study, the refolded hBMP-2 might be cost-effectively useful for various differentiation experiments in a laboratory.

• 대한가정학회지
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• 제20권3호
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• pp.9-18
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• 1982

In this study, we attempted to make an original pattern of clothing for an abnormal type of figure, especially for the type of kyphosis. We measured the curvature of the spine of a woman with kyphosis with a Martin measuring instrument and a silhouetter in the following ways. First, we counted the rate of shrinkage of the standard lines drawn on the surface of the body according as the body moved. Secondly, placing the front and back darts, the front and back shoulder darts and the side darts according to“Munhwa”pattern, we made cubic cuttings of four moving postures as well as the standing one. Thirdly, we superposed the developed patterns of the standing and the moving postures, measuring the position change and the amount of the chaange of the darts, and compared them. The results are as follows: 1) In the developed pattern of a cubic cutting of the basic pattern and the standing posture, the neckhole became larger than that of the basic pattern, and the waist line was lowered than that of the basic pattern because the center back line was shortened due to the curved backbone. 2) As for the change of the standard line according to the movement, we found that the waist line, the center front line, the center back line, the bust width line, the upper back width line and the back width line became longer. Special consideration must be given to the function of the clothing for an abnormal type of figure. 3) The difference of the measurements between the cubic cutting and the body measurement regardless of the body movement is due to a gap by an acute angle at the jutted place between the developed pattern and the body surface. We found that the body measurement of the upper back width line, the back width line and the bust line became larger. Consequently, in making an original clothing pattern, it is desirable that we must not place the front and the back waist darts at the jutted place on the back from the functional and the aesthetic viewpoint of clothing. It is also desirable that we must widen the neckhole because the shoulder angle is close to a straight line due to a jut of the upper back width line.

• 한국염색가공학회:학술대회논문집
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• 한국염색가공학회 2009년도 학술발표대회
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• pp.205-206
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• 2009

The trouble with small & medium dyeing company is balance and transfer of the chemical by man. And due to manual operation occur various environmental issues, and harmful elements in the human body. And the price of imported equipment (CCK) is very high. To solve these problems, this equipment was developed.

• 한국방사선학회논문지
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• 제14권5호
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• pp.651-660
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• 2020

본 연구에서는 보급형 3D 프린터를 이용하여 인체 Femur와 유사한 HU 값을 가진 팬텀을 제작하여 기존 돼지 뼈를 대체할 수 있는지 분석하고자 하였다. 인체 Femur의 HU 값을 알아보기 위해 연령별 총 372명의 데이터를 분석하였다. 보급형 3D 프린터를 이용하여 PLA-Cu 20%를 이용하여 인체 뼈 모형 팬텀을 제작하여 CT 검사하였다. 돼지 뼈는 생후 6개월 된 돼지로 도축된 지 2일이 지난 뼈를 이용하였다. 검사결과 내부채움 80%로 제작한 3D 프린팅 팬텀이 인체의 모든 데이터와 유사한 값이 나타났고(p<0.05) 돼지뼈와는 차이가 있었다(p>0.05). 또한 연령대별 Femur의 HU 값의 경우 연령대가 증가할수록 HU의 값은 줄어드는 것으로 확인 되었다(p<0.05). 3D 프린팅과 HU 값은 적층 높이에 대해서는 약한 음의 상관성을 확인 하였지만 내부 채움에서는 182.13±1.290으로 강한 양의 상관성(R²=0.996)을 확인하였다(p<0.05). 결론적으로 3D 프린팅을 이용한 인체 모형 팬텀이 기존 돼지뼈 팬텀에 비해 인체와 유사한 정도의 HU 값을 나타낼 수 있음을 확인할 수 있었으며 이에 본 연구가 3D 프린터를 이용한 인체 모형 팬텀의 제작에 기초자료를 제공할 수 있을 것이라 사료된다.

• Journal of Veterinary Science
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• 제22권1호
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• pp.7.1-7.13
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• 2021

Background: Niemann-Pick disease type C (NPC) is caused by the mutation of NPC genes, which leads to the abnormal accumulation of unesterified cholesterol and glycolipids in lysosomes. This autosomal recessive disease is characterized by liver dysfunction, hepatosplenomegaly, and progressive neurodegeneration. Recently, the application of induced neural stem cells (iNSCs), converted from fibroblasts using specific transcription factors, to repair degenerated lesions has been considered a novel therapy. Objectives: The therapeutic effects on NPC by human iNSCs generated by our research group have not yet been studied in vivo; in this study, we investigate those effects. Methods: We used an NPC mouse model to efficiently evaluate the therapeutic effect of iNSCs, because neurodegeneration progress is rapid in NPC. In addition, application of human iNSCs from NPC patient-derived fibroblasts in an NPC model in vivo can give insight into the clinical usefulness of iNSC treatment. The iNSCs, generated from NPC patientderived fibroblasts using the SOX2 and HMGA2 reprogramming factors, were transplanted by intracerebral injection into NPC mice. Results: Transplantation of iNSCs showed positive results in survival and body weight change in vivo. Additionally, iNSC-treated mice showed improved learning and memory in behavior test results. Furthermore, through magnetic resonance imaging and histopathological assessments, we observed delayed neurodegeneration in NPC mouse brains. Conclusions: iNSCs converted from patient-derived fibroblasts can become another choice of treatment for neurodegenerative diseases such as NPC.