• 한국통신학회논문지
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• 제28권10A호
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• pp.788-795
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• 2003

We analyze the performance of a truncated power controlled CDMA(code division multiple access) cellular systems with base station antenna arrays. Erlang capacity and the channel capacity which is a maximum date rate to maintain almost error free communication are analytically derived. The numerical results show there can be a substantial increase in Erlang capacity and in channel capacity by antenna arrays incorporating with the truncated power control scheme.

• 한국시스템다이내믹스연구
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• 제1권1호
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• pp.133-157
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• 2000

This paper deals with the social system from the point of system thinking consisting the fundamental construct of system dynamics. The Bertalanffy's general system theory, having been criticized because of its ambiguity, and the complex science theory, emerging system theory, are integrated by using the system thinking which is characterized with three concepts, 'feedback thinking', 'dynamic thinking', 'operational thinking'. In the integration, system thinking suggests the dynamic pattern of the social system have not only an equilibrium status but also complex status. The science of complexity gives an implication to system dynamics the important of the uncertainty and complexity if we interpret the social system as an open system. To show more concrete description, I simulate the cooperation model based on the iterated prisoner dilemma. The simulation results show the diverse patterns of cooperation and betrayal. Especially the sensitivity of initial payoff will cause the chaotic strategic landscapes as the game gose on. These results mean that we should not give the hasty prescription to control social system artificially. Because social system retains the self-organizing force in itself.

• 한국지능시스템학회논문지
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• 제11권5호
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• pp.426-432
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• 2001

본 논문은 진화형 하드웨어를 이용하여 생물의 정보처리 시스템인 셀룰라 오토마타 신경망의 구현에 관한 연구이다. 셀룰라 오토마타 신경망은 진화 및 발생을 기반으로 한 신경망 모델이다. 진화는 다양성을 주요 근원을 제공하는 돌연변이 및 재 조합 비율에 의하여 비결정론이며, 발생은 결정론 적이며 지역적인 무리현상을 따른다. 셀룰라 오토마타 신경망은 셀룰라 오토마타에 의해 신경망 내부의 각 셀의 상태를 발생시키고, 초기 셀을 유전자 알고리즘의 개체로 간주하여 초기 셀이 진화 알고리즘을 통해 진화함으로써 신경망이 진화하는 시스템이다. 본 논문은 이 시스템을 진화형 하드웨어 이용하여 하드웨어로 구현하였다. 진화형 하드웨어는 진화 알고리즘과 재구성하드웨어의 결합체이다. 즉, 재구성 하드웨어의 구성에 필요한 bit를 유전자 알고리즘의 개체로 간주한 것이다. 진화 알고리즘을 수행하기 위해 유전자 알고리즘 프로세서를 설계하였으며, 셀룰라 오토마타 신경망이 유전자 알고리즘의 개체와 셀룰라 오토마타 룰에 의해 자동적으로 신경망을 생성하기 위해 신경망을 이루는 셀들로 설계하였다. 제안된 시스템의 효율성을 검증하기 위해 Exclusive-OR 문제에 적용하였다.

• 한국컴퓨터정보학회지
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• 제14권2호
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• pp.123-127
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• 2006

이 논문에서는 현재 모바일 단말기 중 국내에 가장 많이 보급되어 있는 휴대폰을 이용하여 가정 내에 위치하고 있는 여러 가전 기기를 원격에서 또는 가정 내에서 안전하게 모니터링하고 제어할 수 있는 원격 제어 홈 게이트웨이 시스템을 설계 및 구현하였다. 제안한 시스템은 디지털 가전기기 및 디바이스들과의 Zigbee 통신을 지원하며 Linux 환경의 셋톱박스 내의 흠 서버는 네트워크를 통해 외부 휴대폰과 통신하여 원격지에서 가정내의 디바이스들의 상황 정보를 확인하고 상태를 변경할 수 있도록 설계함으로써 홈 오토메이션 홈 네트워크, 스마트오피스 등의 실내 환경 및 다양한 유비쿼터스 환경에서 홈 네트워크 미들웨어로 적용될 수 있을 것으로 보인다.

• 대한의용생체공학회:의공학회지
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• 제13권3호
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• pp.181-188
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• 1992

This paper provides an overview of system analysis of immunology. The theoretical research in this area is aimed at an understanding of the precise manner by which the immune system controls Infec pious diseases, cancer, and AIDS. This can provide a systematic plan for immunological experimentation by means of an integrated program of immune system analysis, mathematical modeling and computer simulation. Biochemical reactions and cellular fission are naturally modeled as nonlinear dynamical processes to synthesize the human immune system! as well as the complete organism it is intended to protect. A foundation for the control of tumors is presented, based upon the formulation of a realistic, knowledge based mathematical model of the interaction between tumor cells and the immune system. Ordinary bilinear differential equations which are coupled by such nonlinear term as saturation are derived from the basic physical phenomena of cellular and molecular conservation. The parametric control variables relevant to the latest experimental data are also considered. The model consists of 12 states, each composed of first-order, nonlinear differential equations based on cellular kinetics and each of which can be modeled bilinearly. Finally, tumor control as an application of immunotherapy is analyzed from the basis established.

• 전자공학회논문지A
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• 제33A권4호
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• pp.37-46
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• 1996

In this paper, we analyzed the performance improvement of the DS-CDMA/dPSK cellular mobile communication system with CCI canceller and RAKE receiver techniques in mobile radio channel which is characterized by AWGN, Multi-user interference (mUI) and frequency-selective rayleigh fading. System capacity i.e., number of user per cell has been derived and the evaluated results are shown in figuraes as a function of PN code sequence length, number of RAKE receiver tap, BER and E$_{b}$/N$_{o}$. The voice activity factor is assumed to be 3/8 the number of sectors in a cell 3 and MUI is modeled as gaussian process. From the results, the capacity of the DS-CDMA/DPSK cellular mobile communication system is improved by adopting CCI canceller. When we adopt the RAKE receiver to mitigate the multipath fading, the error performance is improved and the amount of improvement is proportional ot the number of taps L in the case that each tap contains a signal component and the better of improvement can be obtained, the smaller of the SNR difference in each tap. The system capacity is more increased when the CCI canceller and the RAKE receiver is used in cascade.

• BMB Reports
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• 제36권2호
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• pp.207-213
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• 2003

Peroxisome proliferator-activated receptors (PPARs) are orphan nuclear hormone receptors that are known to control the expression of genes that are involved in lipid homeostasis and energy balance. PPARs activate gene transcription in response to a variety of compounds, including hypolipidemic drugs. Most of these compounds have high affinity to the ligand-binding domain (LBD) of PPARs and cause a conformational change within PPARs. As a result, the receptor is converted to an activated mode that promotes the recruitment fo co-activators such as the steroid receptor co-activator-1 (SRC-1). Based on the activation mechanism of PPARs (the ligand binding to $PPAR{\gamma}$ induces interactions of the receptor with transcriptional co-activators), we performed Western blot and ELISA. These showed that the indomethacin, a $PPAR{\gamma}$ ligand, increased the binding between $PPAR{\gamma}$ and SRC-1 in a ligand dose-dependent manner. These results suggested that the in vitro conformational change of $PPAR{\gamma}$ by ligands was also induced, and increased the levels of the ligand-dependent interaction with SRC-1. Collectively, we developed a novel and useful ELISA system for the mass screening of $PPAR{\gamma}$ ligands. This screening system (based on the interaction between $PPAR{\gamma}$ and SRC-1) may be a promising system in the development of drugs for metabolic disorders.

• Asian-Australasian Journal of Animal Sciences
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• 제28권3호
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• pp.420-427
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• 2015

It is necessary to understand the cellular uptake and cytotoxicity of food-grade delivery systems, such as ${\beta}$-lactoglobulin (${\beta}$-lg) nanoparticles, for the application of bioactive compounds to functional foods. The objectives of this study were to investigate the relationships between the physicochemical properties of ${\beta}$-lg nanoparticles, such as particle size and zeta-potential value, and their cellular uptakes and cytotoxicity in Caco-2 cells. Physicochemical properties of ${\beta}$-lg nanoparticles were evaluated using particle size analyzer. Flow cytometry and confocal laser scanning microscopy were used to investigate cellular uptake and cytotoxicity of ${\beta}$-lg nanoparticles. The ${\beta}$-lg nanoparticles with various particle sizes (98 to 192 nm) and zeta-potential values (-14.8 to -17.6 mV) were successfully formed. A decrease in heating temperature from $70^{\circ}C$ to $60^{\circ}C$ resulted in a decrease in the particle size and an increase in the zeta-potential value of ${\beta}$-lg nanoparticles. Non-cytotoxicity was observed in Caco-2 cells treated with ${\beta}$-lg nanoparticles. There was an increase in cellular uptake of ${\beta}$-lg nanoparticles with a decrease in particle size and an increase in zeta-potential value. Cellular uptake ${\beta}$-lg nanoparticles was negatively correlated with particle size and positively correlated with zeta-potential value. Therefore, these results suggest that the particle size and zeta-potential value of ${\beta}$-lg nanoparticles play an important role in the cellular uptake. The ${\beta}$-lg nanoparticles can be used as a delivery system in foods due to its high cellular uptake and non-cytotoxicity.

• Molecular & Cellular Toxicology
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• 제1권3호
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• pp.179-188
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• 2005

To develop the novel anti-allergic drug, many sophoricoside derivatives were synthesized. Among these derivatives, JSH-II-3, VI-3, VII-3, VIII-3, VII-20 and VII-20 (sodium salt) were selected and subjected to high throughput toxicity screening (HTTS) because they revealed strong IL-5 inhibitory activity and limitation of quantity. Single cell gel electrophoresis (Comet) assay, mouse lymphoma thymidine kinase ($tk^{+/-}$) gene assay (MOLY), chromosomal aberration assay in mammalian cells and Ames reverse mutation assay in bacterial system were used as simplified, inexpensive, short-term in vitro screening tests in our laboratory. Through the primary screening using the comet assay, we could choose the first candidates of sophoricoside derivatives with no genotoxic potentials as JSH-VI-3, VII-3, VII-20 and VII-20 (sodium salt). Also JSH-VII-3, VII-20 and VII-20 (sodium salt) are non-mutagenic in MOLY assay, while JSH-II-3 is mutagenic at high concentration with the presence of metabolic activation system in both comet assay and MOLY assay. The selected derivatives (JSH-VI-3, VII-3, VII-20 and VII-20 (sodium salt) are not mutagenic in S. typhimurium TA98 and TA100 strains both in the presence and absence of metabolic activation. From results of chromosomal aberration assay, 6 h treatment of JSH-VI-3, VII-3 and VII-20 (sodium salt) were not revealed clastogenicity both in the presence and absence of S-9 mixture. Therefore, we suggests that JSH-VI-3, VII-3, VII-20 and VII-20 (sodium salt), as the optimal candidates with both no genotoxic potential and IL-5 inhibitory effects must be chosen. To process the development into new anti-inflammatory drug of these derivatives, further investigation will need.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제4권1호
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• pp.5-10
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• 2015

LTE-A 네트워크에서 D2D 통신은 시스템의 용량 및 스펙트럼의 효율성을 향상시키는 유망한 기술이다. 전체 스펙트럼의 효율성을 향상시킬 수 있는 이유는 기지국이 이미 셀룰러 단말에 할당한 무선 자원을 D2D 통신에 할당하여 자원을 재사용할 수 있기 때문이다. 하지만 동일한 자원을 셀룰러 및 D2D 통신이 공유하여 사용함으로써 셀 내에 간섭이 발생할 수 있다. 따라서 동일한 자원을 사용하는 셀룰러 통신과 D2D 통신 간에 간섭 조정을 위한 적절한 자원 할당 기법이 필요하다. 특히, LTE-A 환경에 D2D 통신을 적용하기 위해서는 셀 내 간섭뿐만 아니라 셀 간 간섭 조정이 반드시 필요하다. 본 논문에서는 셀 간 간섭 완화를 위해서 주파수 재사용 패턴 기법 중 하나인 FFFR 기법을 사용하고, 셀 내 간섭 완화를 위해서는 기지국이 셀룰러 사용자가 이미 사용 중인 자원을 랜덤하게 선택하여 D2D 통신에 할당하는 D2D 자원 할당 알고리즘을 제안한다. 제안된 자원 할당 알고리즘의 성능평가를 위해 시뮬레이션을 수행하였으며, 셀 내 간섭 완화, 시스템 처리량 및 계산복잡도 등이 향상되는 것을 확인하였다.