• Proceedings of the Korea Concrete Institute Conference
• /
• 2009.05a
• /
• pp.489-490
• /
• 2009

In this study, the experiment was carried out to investigate the effect of metakaolin on the compressive strength of lightweight aggregate cellular concrete. For this purpose, five level replacement ratio of metakaolin were selected.

• Proceedings of the IEEK Conference
• /
• 2002.06a
• /
• pp.85-88
• /
• 2002

Maintaining a proper level of cell lead, system throughput can be maximized by a transmission rate control over the uplink in DS/CDMA cellular system to support integrated services of real-time and delay-tolerant traffic. We find that the cell load-based rate control scheme can be further enhanced by taking the varying channel condition into account In conjunction with some fair scheduling algorithm. Our simulation results show that the proposed scheme outperforms the original cell load-based rate control with the round-robin sharing scheduling scheme.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.6 no.2
• /
• pp.183-188
• /
• 2005

Two mammalian receptors are reported (MT1A and MT1B). In this experiments, MT1A is expressed at a little enhanced level (about 8 times) in hypothalamus of the 9 hours exposed mice. In other part of the brain, the expression level of the MT1A and MT1B is elevated at nearly same level: 16 times in cerebellum, 128 times in hippocampus and in thalamus, respectively. But MT1B is expressed at very high level (about thousand times) in hypothalamus of the 9 hours exposed mice.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.9
• /
• pp.5317-5323
• /
• 2013

Breast cancer is the most prevalent cancer and one of the leading causes of death among women in the world. Plants and herbs may play an important role in complementary or alternative treatment. The aim of this study was to evaluate the antioxidant and anti-proliferative potential of Urtica dioica. The anti oxidant activity of an aqueous extract of Urtica dioica leaf was measured by MTT assay and the FRAP method while its anti-proliferative activity on the human breast cancer cell line (MCF-7) and fibroblasts isolated from foreskin tissue was evaluated using MTT assay. Mechanisms leading to apoptosis were also investigated at the molecular level by measuring the amount of anti and pro-apoptotic proteins and at the cellular level by studying DNA fragmentation and annexin V staining by flow cytometry. The aqueous extract of Urtica dioica showed antioxidant effects with a correlation coefficient of $r^2$=0.997. Dose-dependent and anti-proliferative effects of the extract were observed only on MCF-7 cells after 72 hrs with an $IC_{50}$ value of 2 mg/ml. This anti proliferative activity was associated with an increase of apoptosis as demonstrated by DNA fragmentation, the appearance of apoptotic cells in flow cytometry analysis and an increase of the amount of calpain 1, calpastatin, caspase 3, caspase 9, Bax and Bcl-2, all proteins involved in the apoptotic pathway. This is the first time such in vitro antiproliferative effect of aqueous extract of Urtica dioica leaf has been described for a breast cancer cell line. Our findings warrant further research on Urtica dioica as a potential chemotherapeutic agent for breast cancer.

• Journal of Embryo Transfer
• /
• v.30 no.4
• /
• pp.305-313
• /
• 2015

Xenotransplantation of pig islet regarded as a good alternative to allotransplantation. However, cellular death mediated by hypoxia-reoxygenation injury after transplantation disturb success of this technique. In the present study, we produce transgenic pig expressing human heme oxygenase 1 (HO1) genes to overcome cellular death for improving efficiency of islet xenotransplantation. Particularly, Korean miniature pig breed, Micro-Pig, was used in the present study. Somatic cell nuclear transfer (SCNT) technique was used to produce the HO1 transgenic pig. Six alive transgenic piglets were produced and all the transgenic pigs were founded to have transgene in their genomic DNA and the gene was expressed in all tested organs. Also, in vitro cultured fibroblasts derived from the HO1 transgenic pig showed low reactive oxygen species level, improved cell viability and reduced apoptosis level.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.24 no.1
• /
• pp.42-46
• /
• 2011

Light can be divided into ultraviolet rays, visible rays, and infrared rays depending on the wavelengths. Visible rays with specific wavelength are those predominantly used for would treatment. Especially low level laser irradiates into cells, effectively stimulating cellular tissues and activating cellular function. This study was intended to verify the effect of white LED irradiation therapy on wound recovery in animal tests by applying white LED irradiator, which was independently designed and developed to emit beams of similar wavelength to that of a laser. The designed LED Irradiator was used to find out how white LED light source affected the skin wound of SD-Rat(Sprague-Dawley Rat). We divided the participants into two groups; white LED irradiation group which was irradiated 1 hour a day for 9 consecutive days, and none irradiation group. The results showed that the study group had lower incidence of inflammation and faster recovery, compared with the control group.

• Journal of the Korea Society of Computer and Information
• /
• v.23 no.3
• /
• pp.25-31
• /
• 2018

In this paper, we consider the game theoretic approach to investigate the transmit power optimization problem where D2D users share the uplink of the cellular system. Especially, we formulate the transmit power optimization problem as a non cooperative power control game. In the user wide sense, each user may try to select its transmit power level so as to maximize its utility in a selfish way. In the system wide, the transmit power levels of all users eventually converge to the unique point, called Nash Equilibrium. We first formulate the transmit power optimization problem as a non cooperative power control game. Next, we examine the existence of Nash Equilibrium. Finally, we present the numerical example that shows the convergence to the unique transmit power level.

• Journal of Korea Multimedia Society
• /
• v.17 no.11
• /
• pp.1279-1285
• /
• 2014

In this paper, we propose on image encryption method which uses NC(Non-linear Cycle) and 2D CAT(Two-Dimensional Cellular Automata Transform) in sequence to encrypt medical images. In terms of the methodology, we use NC to generate a pseudo noise sequence equal to the size of the original image. We then conduct an XOR operation of the generated sequence with the original image to conduct level 1 NC encryption. Then we set the proper Gateway Values to generate the 2D CAT basis functions. We multiply the generated basis functions by the altered NC encryption image to conduct the 2nd level 2D CAT encryption. Finally, we verify that the proposed method is efficient and extremely safe by conducting an analysis of the key spatial and sensitivity analysis of pixels.

• Journal of Microbiology and Biotechnology
• /
• v.20 no.12
• /
• pp.1677-1680
• /
• 2010

The harmful effects of succinic acid and oxidative stress on cell growth were determined during batch fermentation with Mannheimia succiniciproducens LPK7, a powerful succinic acid-producing strain, and conditions were optimized to minimize these effects. In terms of toxicity, the cell concentration decreased as the concentration of succinic acid increased. By changing the pH from 6.5 to 7 during fermentation, the cell concentration increased by about 10%, and the level of succinic acid production was 6% higher than that of the control. In addition, by introducing protectants, the cell concentration increased by about 10%, and the level of succinic acid produced was increased by 3%.

• Molecular & Cellular Toxicology
• /
• v.1 no.3
• /
• pp.149-156
• /
• 2005

Di (n-ethylhexyl) phthalate (DEHP) is thought to mimic estrogens in their action, and are called endocrine disrupting chemicals. DEHP is used in numerous consumer products, especially those made of flexible polyvinyl chloride and have been reported to be weakly estrogenic. In this study, DEHP were tested for estrogenic properties in vitro models and with microarray analysis. First, the E-screen assay was used to measure the proliferation of DEHP in MCF-7 cells, a human breast cancer cell line. DEHP induced an increase in MCF-7 cell proliferation at concentration of $10^{-4}M$. Second, we carried out a microarray analysis of MCF-7 cells treated with DEHP using human c-DNA microarray including 401 endocrine system related genes. Of the genes analyzed, 60 genes were identified showing significant changes in gene expression resulting from DEHP. Especially, 4 genes were repressed and 4 genes were induced by DEHP compared to $17{\beta}-estradiol$. Among these genes, trefoil factor 3 (intestinal), breast cancer 1, early onset and CYP1B1 are involved in estrogen metabolism and regulation. Therefore it suggests that these genes may be associated with estrogenic effect of the DEHP on transcriptional level. The rationale is that, as gene expression is a sensitive endpoint, alterations of these genes may act as useful biomarkers to define more precisely the nature and level of exposure to kinds of phthalates.