• 제목/요약/키워드: cell-based

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전위쎌에 기초한 미세조직 구성모델을 이용한 ECAP 공정 시 변형과 미세조직의 진화 해석 (Analysis of Deformation and Microstructural Evolution during ECAP Using a Dislocation Cell Related Microstructure-Based Constitutive Model)

  • 김형섭
    • 한국소성가공학회:학술대회논문집
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    • 한국소성가공학회 2004년도 추계학술대회논문집
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    • pp.207-210
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    • 2004
  • The deformation behavior of copper during equal channel angular pressing (ECAP) was calculated using a three-dimensional version of a constitutive model based on the dislocation density evolution. Finite element simulations of the variation of the dislocation density and the dislocation cell size with the number of ECAP passes are reported. The calculated stress, strain and cell size are compared with the experimental data for Cu deformed by ECAP in a modified Route C regime. The results of FEM analysis were found to be in good agreement with the experiments. After a rapid initial decrease down to about 200 nm in the first ECAP pass, the average cell size was found to change little with further passes. Similarly, the strength increased steeply after the first pass, but tended to saturate with further pressings. The FEM simulations also showed strain non-uniformities and the dependence of the resulting strength on the location within the workpiece.

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제조 셀 구현을 위한 군집분석 기반 방법론 (Cluster Analysis-based Approach for Manufacturing Cell Formation)

  • 심영학;황정윤
    • 산업경영시스템학회지
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    • 제36권1호
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    • pp.24-35
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    • 2013
  • A cell formation approach based on cluster analysis is developed for the configuration of manufacturing cells. Cell formation, which is to group machines and parts into machine cells and the associated part families, is implemented to add the flexibility and efficiency to manufacturing systems. In order to develop an efficient clustering procedure, this paper proposes a cluster analysis-based approach developed by incorporating and modifying two cluster analysis methods, a hierarchical clustering and a non-hierarchical clustering method. The objective of the proposed approach is to minimize intercellular movements and maximize the machine utilization within clusters. The proposed approach is tested on the cell formation problems and is compared with other well-known methodologies available in the literature. The result shows that the proposed approach is efficient enough to yield a good quality solution no matter what the difficulty of data sets is, ill or well-structured.

Enhanced delivery of protein fused to cell penetrating peptides to mammalian cells

  • Moon, Jung-Il;Han, Min-Joon;Yu, Shin-Hye;Lee, Eun-Hye;Kim, Sang-Mi;Han, Kyuboem;Park, Chang-Hwan;Kim, Chun-Hyung
    • BMB Reports
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    • 제52권5호
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    • pp.324-329
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    • 2019
  • Recent progress in cellular reprogramming technology and lineage-specific cell differentiation has provided great opportunities for translational research. Because virus-based gene delivery is not a practical reprogramming protocol, protein-based reprogramming has been receiving attention as a safe way to generate reprogrammed cells. However, the poor efficiency of the cellular uptake of reprogramming proteins is still a major obstacle. Here, we reported key factors which improve the cellular uptake of these proteins. Purified red fluorescent proteins fused with 9xLysine (dsRED-9K) as a cell penetrating peptide were efficiently delivered into the diverse primary cells. Protein delivery was improved by the addition of amodiaquine. Furthermore, purified dsRED-9K was able to penetrate all cell lineages derived from mouse embryonic stem cells efficiently. Our data may provide important insights into the design of protein-based reprogramming or differentiation protocols.

시뮬레이션 기반 연료전지/2차전지 하이브리드 미니버스의 설계 및 성능 평가 (Design and Performance Evaluation for a Fuel Cell/Battery Hybrid Mini-Bus Based on a Simulation)

  • 김민진;공낙원;이원용;김창수
    • 한국수소및신에너지학회논문집
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    • 제18권1호
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    • pp.60-66
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    • 2007
  • In terms of the vehicle efficiency, a fuel cell hybrid system has advantages compared to a conventional internal combustion engine and a fuel cell alone-powered system. The efficiency of the fuel cell hybrid vehicle mainly depends on the maximum power of the fuel cell and therefore it is important to decide the design value of the fuel cell maximum power. In this paper, to estimate the performance of the fuel cell hybrid mini-bus in the design phase the simulator based on the models for the fuel cell stack, the electric battery, the fuel cell balance of plant, the controller, and the vehicle itself is proposed. Additionally, the hybrid mini-bus efficiencies with several different fuel cell powers are simulated for a city driving schedule and are compared on another. Consequently, the proposed simulation scheme is useful to determine the best design value of the fuel cell hybrid vehicles.

GPS와 Pico-cell ID접속 확률을 이용한 위치 추정 방법 (Positioning Mechanism Using GPS and Pico-cell ID Access Probability)

  • 정원영;이태진
    • 한국통신학회논문지
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    • 제36권12B호
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    • pp.1459-1467
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    • 2011
  • 무선 측위 방법 중 하나인 Cell-ID 기반 측위 방법은 정확도가 낮은 단점이 있지만 다른 방법들에 비해 저렴하고 용이하게 구현이 가능한 장점이 있어 널리 사용되고 있다. 본 논문에서는 Cell-ID 기반 측위 방법의 단점인 낮은 정확도를 개선하고자 새로운 방법을 제안한다. 본 논문은 실내 네트워크로 관심을 모으고 있는 Pico-Cell 네트워크에서 MS가 접속할 수 있는 여러 BS들 중 BS별로 MS가 접속될 수 있는 확률을 이용하고 더불어 Cell-ID 기반 측위 방법을 응용한 새로운 접근 방법을 제시한다. 그리고 기존의 다른 측위 방법과 제안 방법에 대한 성능 평가를 통해 제안 방법의 성능이 향상됨을 확인 할 수 있다.

확산 모형을 이용한 줄기 세포 기술의 수명 주기 분석 : 연구 단계를 중심으로 (Life Cycle Analysis of Stem Cell Technology Based on Diffusion Model : Focused on the Research Stage)

  • 장인영;홍정식;김태구
    • 대한산업공학회지
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    • 제41권5호
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    • pp.488-498
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    • 2015
  • Research on stem cells can be divided into three categories : pluripotent stem cell, adult stem cell, and induced pluripotent stem cell. Technology life cycle (TLC) on research stage is analyzed for the three stem cell categories based on diffusion model. Three diffusion models-logistic, Bass, and Bass model with integration constant (BMIC)-are applied to the number of articles related to each stem cell category in SCOPUS lists. Two different parameter estimation methods is used for each of logistic and Bass model. Results show that (1) the current year, 2015, lies in growth period at pluripotent stem cell and adult stem cell, and lies in growth period or maturity period at induced pluripotent stem cell. (2) Model fitness is the highest at BMIC model. (3) Imitation effect works best at the research area of induced pluripotent stem cell.

Light Trapping in Silicon Based Tandem Solar Cell: A Brief Review

  • Iftiquar, Sk Md;Park, Hyeongsik;Dao, Vinh Ai;Pham, Duy Phong;Yi, Junsin
    • Current Photovoltaic Research
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    • 제4권1호
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    • pp.1-7
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    • 2016
  • Among the various types of solar cells, silicon based two terminal tandem solar cell is one of the most popular one. It is designed to split the absorption of incident AM1.5 solar radiation among two of its component cells, thereby widening the wavelength range of external quantum efficiency (EQE) spectra of the device, in comparison to that of a single junction solar cell. In order to improve the EQE spectra further and raise short circuit current density ($J_{sc}$) an optimization of the tradeoff between the top and bottom cell is needed. In an optimized cell structure, the $J_{sc}$ and hence efficiency of the device can further be enhanced with the help of light trapping scheme. This can be achieved by texturing front and back surface as well as a back reflector of the device. In this brief review we highlight the development of light trapping in the silicon based tandem solar cell.

Detection of the cell wall-affecting antibiotics at sublethal concentrations using a reporter Staphylococcus aureus harboring drp35 promoter - lacZ transcriptional fusion

  • Mondal, Rajkrishna;Chanda, Palas K.;Bandhu, Amitava;Jana, Biswanath;Lee, Chia-Y.;Sau, Subrata
    • BMB Reports
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    • 제43권7호
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    • pp.468-473
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    • 2010
  • Previously, various inhibitors of cell wall synthesis induced the drp35 gene of Staphylococcus aureus efficiently. To determine whether drp35 could be exploited in antistaphylococcal drug discovery, we cloned the promoter of drp35 ($P_d$) and developed different biological assay systems using an engineered S. aureus strain that harbors a chromosomally-integrated $P_d$ - lacZ transcriptional fusion. An agarose-based assay showed that $P_d$ is induced not only by the cell wall-affecting antibiotics but also by rifampicin and ciprofloxacin. In contrast, a liquid medium-based assay revealed the induction of $P_d$ specifically by the cell wall-affecting antibiotics. Induction of $P_d$ by sublethal concentrations of cell wall-affecting antibiotics was even assessable in a microtiter plate assay format, indicating that this assay system could be potentially used for high-throughput screening of new cell wall-inhibiting compounds.

인공 면역계 기반 자율분산로봇 시스템의 협조 전략과 군행동 (Cooperative Strategies and Swarm Behavior in Distributed Autonomous Robotic Systems Based on Artificial Immune System)

  • 심귀보;이동욱;선상준
    • 제어로봇시스템학회논문지
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    • 제6권12호
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    • pp.1079-1085
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    • 2000
  • In this paper, we propose a method of cooperative control (T-cell modeling) and selection of group behavior strategy (B-cell modeling) based on immune system in distributed autonomous robotic system (DARS). An immune system is the living bodys self-protection and self-maintenance system. these features can be applied to decision making of the optimal swarm behavior in a dynamically changing environment. For applying immune system to DARS, a robot is regarded as a B-cell, each environmental condition as an antigen, a behavior strategy as an antibody, and control parameter as a T-cell, respectively. When the environmental condition (antigen) changes, a robot selects an appropriate behavior strategy (antibody). And its behavior strategy is stimulated and suppressed by other robots using communication (immune network). Finally, much stimulated strategy is adopted as a swarm behavior strategy. This control scheme is based on clonal selection and immune network hypothesis, and it is used for decision making of the optimal swarm strategy. Adaptation ability of the robot is enhanced by adding T-cell model as a control parameter in dynamic environments.

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A Novel Air-cell Mattress Based on Approximate Anthropometric Model for Preventing Pressure Ulcer

  • Moon, In-Hyuk;Kang, Sung-Jae;Kim, Gyu-Seok;Mun, Mu-Seong
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 2005년도 ICCAS
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    • pp.1278-1282
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    • 2005
  • Air mattress is now used widely to prevent the pressure ulcer by reducing the localized pressure peaks. In this paper an air-cell mattress and its pressure control method based on an approximate anthropometric model are presented. The air-cell mattress has eighteen cylindrical air cells made of porous material allowing air leakage to contribute in reducing the development of pressure ulcer by lowering the pressure peak, temperature and humidity. To determine an optimal air-cell pressure appropriate for each user, we divide the parts of the body into four sections such as head, trunk, hip, and leg. Then, the pressure of each section is independently calculated from the weight of each part based on the individual body height and weight and the approximate anthropometric model. Air supply system for the air-cell mattress is implemented by using four electronic solenoid valves and an air compressor, and it is driven by a real-time micro-controller. The experimental results with seven subjects shows that the proposed air-cell mattress is effective for the prevention of the pressure ulcer.

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