• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 1996년도 춘계공동학술대회논문집; 공군사관학교, 청주; 26-27 Apr. 1996
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• pp.121-124
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• 1996

In general, cellular manufacturing system can be constructed by the following two steps. The first step forms machine cells and part families, and the second step determines cell layout based on the result of first step. Cell layout has to be considered when cell is formed becauese the result of cell formation affects it. This paper presents a cell formation algorithm and proposes an integrated mathematical model for cell formation and cell layout. The cell formation algorithm minimizes the number of exceptional element in cellular manufacturing system. New concept for similarity and incapability is introduced, based on machine-operation incidence matrix and part-operation incidence matrix. One is similarity between the machines, the other is similarity between preliminary machine cells and machines. The incapability identifies relations between machine cells and parts. In this procedure, only parts without an exceptional element are assigned to machine cell. Bottleneck parts are considered with cell layout design in an integrated mathematical model. The integrated mathematical model determines cell layout and assigns bottleneck parts to minimize the number of exceptional element and intercell moving distance, based on linearixed 0-1 integer programming. The proposed algorithm is illustrated by using numerical examples.

• Journal of Electrical Engineering and Technology
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• 제12권5호
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• pp.1812-1820
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• 2017

This paper analyzes a symmetric active cell balancer for a battery management system. The considered cell balancer uses a forward converter in which the circuit structure is symmetric. This cell-balancing method uses fewer switches and is simpler than the previously proposed active cell-balancing circuits. Active power switches of this cell-balancing circuit operate simultaneously with the same pulse width modulation signals. Therefore, this cell-balancing circuit requires less time to be balanced than a previous bidirectional-forward-converter-based cell balancer. This paper analyzes the operational principles and modes of this cell balancer with computer-based circuit simulation results as well as experimental results in which each unbalanced cell is equalized with this cell balancer. The maximum power transfer efficiency of the investigated cell balancer was 87.5% from the experimental results. In addition to the experimental and analytical results, this paper presents the performance of this symmetric active cell-balancing method.

• 경영과학
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• 제12권1호
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• pp.51-60
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• 1995

This paper presents a workload based model and cell design support system (CDSS) in manufacturing cell design. The proposed model consider manufacturing factor such as machine capacity, production volume, process time, and cell size. Based on those information, workload is calculated and according to the workload, the relationship between machine and part is represented by the workload matrix. To form the manufacturing cell, correlation similarity coefficient (CSC) among machines are calculated and a pair of machines that has the highest value of CSC is assigned to a machine cell. Repeat the above steps until the desired manufacturing cells are obtained. Finally, a cell design support system that could increase the efficiency in the application of a proposed model is developed. The proposed model and CDSS are illustrated by a numerical example.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 1996년도 추계학술대회 학술발표 논문집
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• pp.315-318
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• 1996

The machine-part cell formation means the grouping of similar parts and similar machines into families in order to minimize bottleneck machines, bottleneck parts, and inter-cell part movements in cellular manufacturing systems and flexible manufacturing systems. The cell formation problem is knows as a kind of NP complete problems. This paper briefly introduces the cell-formation problem and proposes a cell formation method based on the Kohonen's self-organizing feature map which is a neural network model. It also shows some experiment results using the proposed method. The proposed method can be easily applied to the cell formation problem compared to other meta-heuristic based methods. In addition, it can be used to solve large-scale cell formation problems.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4797-4800
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• 2015

Background: This analysis was conducted to evaluate the efficacy and safety of crizotinib based regimens in treating Chinese patients with EML4-ALK positive non-small-cell lung cancer. Materials and Methods: Clinical studies evaluating the efficacy and safety of crizotinib based regimens on response and safety for Chinese patients with EML4-ALK positive non-small-cell lung cancer were identified by using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. Results: In crizotinib based regimens, 3 clinical studies which including 128 Chinese patients with EML4-ALK positive non-small-cell lung cancer and treated with crizotinib based regimen were considered eligible for inclusion. Pooled analysis suggested that, in all patients, the pooled RR was 59.3% (76/128) in crizotinib based regimens. ALT/AST mild visual disturbances, nausea, and vomiting were the main side effects. No treatment related death occurred in these crizotinib based treatments. Conclusions: This pooled analysis suggests that crizotinib based regimens are associated with good response rate and accepted toxicities in treating Chinese patients with EML4-ALK positive non-small-cell lung cancer.

• Journal of Electrical Engineering and Technology
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• 제10권2호
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• pp.641-646
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• 2015

In this paper, a zinc electrowinning cell is fully optimized to achieve a uniform current distribution at electrode surfaces. To effectively deal with an electromagnetically coupled problem with multi-dimensional design variables, a sampling-based sensitivity approach is combined with a highly tuned multiphysics simulation model. The model involves the interrelation between electrochemical reactions and electromagnetic phenomena so as to predict accurate current distributions in the electrowinning cell. In the sampling-based sensitivity approach, Kriging-based surrogate models are generated in a local window, and accordingly their sensitivity values are extracted. Such unique design strategy facilitates optimizing very complicated multiphysics and multi-dimensional design problems. Finally, ten design variables deciding the electrolytic cell structure are optimized, and then the uniformity of current distribution in the optimized cell is examined through the comparison with existing cell designs.

• 대한의용생체공학회:의공학회지
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• 제43권2호
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• pp.94-101
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• 2022

Recent advancement of micro/nano technology enables the development of diverse micro/nano particle-based delivery systems. Due to the multi-functionality and engineerability, particle-based delivery system are expected to be a promising method for delivery to the target cell. Since the particle-based delivery system should be delivered to the various kinds of target cell, including the cardiovascular system, cancer cell etc., it is frequently decorated with multiple kinds of targeting molecule(s) to induce specific interaction to the target cell. The surface decorated molecules interact with the cell surface expressed molecule(s) to specifically form a firm adhesion. Thus, in this study, the probability of adhesion is estimated to predict the possibility to form a firm adhesion for the multi-ligand decorated particle-based delivery system.

• IMMUNE NETWORK
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• 제16권1호
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• pp.33-43
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• 2016

Cell-penetrating peptides (CPPs) are short amino acids that have been widely used to deliver macromolecules such as proteins, peptides, DNA, or RNA, to control cellular behavior for therapeutic purposes. CPPs have been used to treat immunological diseases through the delivery of immune modulatory molecules in vivo. Their intracellular delivery efficiency is highly synergistic with the cellular characteristics of the dendritic cells (DCs), which actively uptake foreign antigens. DC-based vaccines are primarily generated by pulsing DCs ex vivo with various immunomodulatory antigens. CPP conjugation to antigens would increase DC uptake as well as antigen processing and presentation on both MHC class II and MHC class I molecules, leading to antigen specific CD4⁺ and CD8⁺ T cell responses. CPP-antigen based DC vaccination is considered a promising tool for cancer immunotherapy due to the enhanced CTL response. In this review, we discuss the various applications of CPPs in immune modulation and DC vaccination, and highlight the advantages and limitations of the current CPP-based DC vaccination.

• 한국정밀공학회지
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• 제15권12호
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• pp.72-80
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• 1998

In this study, a design approach based on genetic algorithm is proposed to solve the manufacturing cell design problem considering alternative process plans and alternative machines. The problem is formulated as a 0-1 integer programming model which considers several manufacturing parameters, such as demand and processing time of part, machine capacity, manufacturing cell size, and the number of machines in a machine cell. A genetic algorithm is used to determine process plan for each part, part family and machine cell simultaneously.

• KSBB Journal
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• 제13권3호
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• pp.272-278
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• 1998

Cell recovery from high cell density broths of Alcaligenes eutrophus by pretreatment with aluminum-based coagulants such as aluminum sulfate, polyaluminum hydrooxide chloride silicate (PACS), and polyaluminum hydrooxide chloride (Hi-PAX) was carried out. Cells coagulated with coagulants could be successfully recovered above 95-99% by centrifugation or filtration. The optimum initial pH of fermentation broths for cell recovery was in the range of 10 to 12. Optimum coagulants dosage for cell recovery increased with increasing of cell concentrations (21-160 g/L). The optimum coagulant dosages to recover cells with more than 95% cell recovery by centrifugation for the cell concentrations ranged 21-160 g/L were as follows: aluminum sulfate, 416-1708 mg Al/L; PACS, 211-826 mg Al/L; Hi-PAX, 320-960 mg Al/L. At optimum conditions for the coagulation of cells, centrifugal forces for 95% of cell recovery were dependent on the cell concentration. The centrifugal forces at 82 g/L and 160 g/L of cell concentration were only 45${\times}$g and 1600${\times}$g, respectively.