• BMB Reports
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• v.47 no.12
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• pp.655-659
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• 2014

Integrin-mediated cell adhesion is important for development, immune responses, hemostasis and wound healing. Integrins also function as signal transducing receptors that can control intracellular pathways that regulate cell survival, proliferation, and cell fate. Conversely, cells can modulate the affinity of integrins for their ligands a process operationally defined as integrin activation. Analysis of activation of integrins has now provided a detailed molecular understanding of this unique form of "inside-out" signal transduction and revealed new paradigms of how transmembrane domains (TMD) can transmit long range allosteric changes in transmembrane proteins. Here, we will review how talin and mediates integrin activation and how the integrin TMD can transmit these inside out signals.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.3
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• pp.886-900
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• 2015

Small cells are deployed in Heterogeneous Networks (HetNet) to improve overall performance. These access points can provide high-rate mobile services at hotspots to users. In a Small Cell Network (SCN), the good deployment of small cells can guarantee the performance of users on the basis of average and cell edge spectrum efficiency. In this paper, the performance of small cell deployment is analyzed by using system-level simulations. The positions of small cells can be adjusted according to the deployment radius and angle. Moreover, different Inter-Cell Interference Coordination (ICIC) techniques are also studied, which can be implemented either in time domain or in frequency domain. The network performances are evaluated under different ICIC techniques when the locations of Small evolved Nodes (SeNBs) vary. Simulation results show that the average throughput and cell edge throughput can be greatly improved when small cells are properly deployed with the certain deployment radius and angle. Meanwhile, how to optimally configure the parameters to achieve the potential of the deployment is discussed when applying different ICIC techniques.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.10a
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• pp.29-30
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• 2001

MAP kinase/ AP-1 signal transduction components are rapidly initiated by many extracellular stimuli, especially environmental carcinogens. We have investigated the role of MAP kinases (Erks, JNKs, and p38 kinases) and AP-1 signal transduction pathways in the process of cell transformation and carcinogenesis. Incubation of Cl 41 cells with tumor promoters such as TPA, EGF, arsenic, or TNF-$\alpha$ led to cell transformation and activation of MAP kinases.(omitted)

• BMB Reports
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• v.50 no.10
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• pp.496-503
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• 2017

The human body loses several billions of cells daily. When cells die in vivo, the corpse of each dead cell is immediately cleared. Specifically, dead cells are efficiently recognized and cleared by multiple types of neighboring phagocytes. Early research on cell death focused more on molecular mechanisms of cell death regulation while the cellular corpses were merely considered cellular debris. However, it has come to light that various biological stimuli following cell death are important for immune regulation. Clearance of normal dead cells occurs silently in immune tolerance. Exogenous or mutated antigens of malignant or infected cells can initiate adaptive immunity, thereby inducing immunogenicity by adjuvant signals. Several pathogens and cancer cells have strategies to limit the adjuvant signals and escape immune surveillance. In this review, we present an overview of the mechanisms of dead cell clearance and its immune regulations.

• Biomolecules & Therapeutics
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• v.18 no.4
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• pp.402-410
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• 2010

Although the overproduction of prostaglandin $E_2$ ($PGE_2$) in intestinal epithelial cells has been considered to be highly correlated with the colorectal carcinogenesis, the precise mechanism of action remains poorly elucidated. Accumulating evidence suggests that the PGE receptor (EP)-mediated signal transduction pathway might play an important role in this process. In the present study, we investigated the mechanism of action underlying $PGE_2$-mediated cell proliferation and the effect of resveratrol on the proliferation of human colon cancer cells in terms of the modulating $PGE_2$-mediated signaling pathway. $PGE_2$ stimulated the proliferation of several human colon cancer cells and activated growth-stimulatory signal transduction, including Akt and ERK. $PGE_2$ also increased the phosphorylation of GSK-$3{\beta}$, the translocation of ${\beta}$-catenin into the nucleus, and the expressions of c-myc and cyclin D1. Resveratrol, a cancer chemopreventive phytochemical, however, inhibited $PGE_2$-induced growth stimulation and also suppressed $PGE_2$-mediated signal transduction, as well as ${\beta}$-catenin/T cell factor-mediated transcription in human colon cancer cells. These findings present an additional mechanism through which resveratrol affects the regulation of human colon cancer cell growth.

• Journal of Acupuncture Research
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• v.18 no.4
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• pp.101-115
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• 2001

Objective : To characterize the antitumorigenic potential of Apamin, one of the major components of bee venom, its effects on cell proliferation and the mitogen-activated protein kinase (MAPK) signal transduction pathway were characterized using the human melanoma cell line SK-MEL-2. Methods & Results : Cell counting analysis for cell death demonstrated that consistent with a previous results, SK-MEL-2 cells treated with $0.5-2.0{\mu}g/ml$ of Apamin showed no recognizable cytotoxic effect whereas detectable induction of cell death was identified at concentrations over $5.0{\mu}g/ml$. [3H]thymidine incorporation assay for cell proliferation demonstrated that DNA replication of SK-MEL-2 cells is inhibited by Apamin in a dose- and time-dependent manner. To explore whether Apamin-induced growth suppression is associated with the MAPK signaling pathway, phosphorylation of Erk, a function mediator of MAPK growth-stimulating signal, was examined Western blot assay using a phospho-specific Erkl/2 antibody. A significant increase of Erkl/2 phosphorylation level was observed in Apamin-treated cells compared with untreated control cells. Qantitative RT-PCR analysis revealed that Apamin inhibit expression of MAPK downstream genes such as c-Jun, c-Fos, and cyclin D1 but not expression of MAPK pathway component genes including Ha-Ras, c-Raf-1, MEK1, and Erk. Conclusion : It is strongly suggested that the antitumorigenic activity of Apamin might result in part from its inhibitory effect on the MAPK signaling pathway in human melanoma cells SK-MEL-2.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.8 no.3
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• pp.945-964
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• 2014

In this paper, we investigate the performance of Signal to Leakage and Noise Radio (SLNR) based user scheduling in uplink of multi-cell with large-scale antenna system. Large antenna array is desired to improve the performance in future system by providing better beamforming capability. However, some studies have found that the signal channel is 'hardened' (becomes invariant) when the antenna number goes extremely large, which implies that the signal channel aware user scheduling may have no gain at all. With the mathematic tool of order statistics, we analyzed the signal and interference terms of SLNR in a homogeneous multicell network. The derived distribution function of signal and interference shows that the leakage channel's variance is much more influential than the signal channel's variance in large-scale antenna regime. So even though the signal channel is hardened, the SLNR-based scheduling can achieve remarkable multiuser diversity (MUD) gain due to the fluctuation of the uplink leakage channel. By providing the final SINR distribution, we verify that the SLNR-based scheduling can leverage MUD in a better way than the signal channel based scheduling. The Monte Carlo simulations show that the throughput gain of SLNR-based scheduling over signal channel based scheduling is significant.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.609-617
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• 2013

Renal cell carcinomas make up 3% of all cancers and one in four patients is metastatic at time of diagnosis. This cancer is one of the most resistant to cytotoxic chemotherapy. Studies have shown that the efficiency of interferon-alpha and/or interleukin-2 based immune therapies is limited in patients with metastatic renal cell carcinoma but latest advances in molecular biology and genetic science have resulted in better understanding of its biology. Tumor angiogenesis, tumor proliferation and metastasis develop by the activation of signal message pathways playing a role in the development of renal cell carcinomas. Better definition of these pathways has caused an increase in preclinic and clinical studies into target directed treatment of renal cell carcinoma. Many recent studies have shown that numerous anti-angiogenic agents have marked clinical activity. In this article, the focus is on general characteristics of molecular pathways playing a major role in renal cell carcinoma, reviewing clinical information onagents used in the target directed treatment of metastatic lesions.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.10a
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• pp.693-696
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• 2008

The systems for mobile communication services of fourth generation use OFDM (Orthogonal Frequency Division Multiplexing) scheme that ran transmit large amounts of data to support the multimedia services, and consist of several types of cell, such as Macro Cell, Pico Cell, Femto Cell to improve the qualify of service. According to subdivision of communication region, superposition of cells in co-channel different from conventional single cell is used, but it cause inter band interference between systems. In particular, an OFDM signal consists of a number of independently modulated subcarriers, and superposition of these subcarriers causes a problem that ran give a large PAPR. Increased PAPR induces signal distortion passing through components such as power amplifier so that inter band interference is caused by out-of-band spectrum radiation. In order to minimize the inter band interference, this paper applies PAPR reduction scheme and analyzes the out-of-band spectrum radiation when the signal passes through nonlinear components such an power amplifier.

• Journal of electromagnetic engineering and science
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• v.18 no.1
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• pp.70-72
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• 2018

We propose a microwave signal generation system for brain stimulation. The existing brain stimulation system uses a signal of several tens of kHz, and the magnetic field distribution is wide. Microwave is used to locally limit the distribution of the electromagnetic field and to change the action potential of the cell with less power. The switch modulates the microwave signal to obtain a pulse envelope. The action potential of the cell can be controlled to the excitation/inhibition state by adjusting the repetition frequency. These results are confirmed by measuring the cell potential of the mouse brain.