• YAKHAK HOEJI
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• v.42 no.1
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• pp.101-107
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• 1998

The antiparkinsonian agent l-deprenyl, a selective monoamine oxidase (MAO)-B inhibitor, is metabolized in part to l-methamphetamine and l-amphetamine. l< /I>-Deprenyl was evaluated for amphetamine and methamphetamine-like discriminative stimulus effects in rats and its mechanism of action was investigated. Rats were trained under a 5-response, fixed ratio schedule of stimulus-shock termination or a 10-response. Fixed-ratio schedule of food-presentation which discriminate between d-amphetamine (1mg/kg, i.p.) and saline or d-methamphetamine (1mg/kg, i.p.) and saline in a two-lever, operant conditioning procedure. Full generalization was obtained to d-amphetamine (1~3mg/kg). d-methamphetamine (1~3mg/kg) and l-deprenyl (17~30mg/kg) under both the food presentation and stimulus shock termination schedule. l-Deprenyl has dose-dependent amphetamine-and methamphetamine-like discriminative stimulus properties in rats only at doses of 17 and 30mg/kg. Reversible MAO-B inhibitor, RO 16-6491 didn`t show any amphetamine-like discriminative properties. Aromatic amino acid decarboxylase inhibitor, NSD 1015 decreased % responding of l-deprenyl in the methamphetamine-trained rats under the stimulus-shock termination schedule. SKF-525A produced partial inhibition of methamphetamine-like discriminative effects of l-deprenyl under the food presentation schedule. These results suggest that l-deprenyl has no abuse liability at the therapeutic range but there needs some caution at high doses and furthermore, drug discrimination studies under the food presentation and shock termination schedule are useful for the assessment of abuse liability of psychostimulants.

• Journal of Korean Foot and Ankle Society
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• v.22 no.3
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• pp.95-99
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• 2018

Purpose: The purpose of this study was to evaluate the radiologic outcomes of distal fibular fractures and to analyze the risk factors associated with nonunion. Materials and Methods: Between January 2009 and March 2016, 13 patients who had final nonunion with ankle fracture were included. In the control group, 370 patients who had undergone bony union and removed metal implants were included. All patients underwent the same surgical procedure and had the same treatment method, ultimately achieving satisfactory open reduction results with less than 2 mm fracture gap. Surgical treatment of fracture was considered to have the same effect on nonunion, and factors that might be associated with nonunion were evaluated. SPSS ver. 13.0 (SPSS Inc., USA) was used for all statistical analyses. Pearson's chi-square test and multi-variate regression analysis were performed to determine the factors affecting nonunion of distal fibular fracture. A p-value less than 0.05 was considered statistically significant, and relative risk was assessed. Results: The mean age of 13 patients was 46.9 years (range, 16~57 years); there were 8 men and 5 women. Among the 13 patients with nonunion, atrophic was the most common (12 cases). The association between the injury mechanism and the Lauge-Hansen classification and diabetes mellitus was not statistically significant. Distal fibular fractures with tibia shaft fracture (p=0.015) and Danis-Weber type C fracture (p=0.023), open fracture (p=0.011), and smoking (p=0.023) were significantly associated with nonunion. Conclusion: In this study, the combined injury of the ipsilateral tibia shaft fracture, open fracture, and Danis-Weber type C fracture may increase the possibility of nonunion. Therefore, caution is advised to prevent nonunion.

• Journal of Dental Anesthesia and Pain Medicine
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• v.19 no.4
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• pp.181-189
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• 2019

Local anesthetic systemic toxicity (LAST) refers to the complication affecting the central nervous system (CNS) and cardiovascular system (CVS) due to the overdose of local anesthesia. Its reported prevalence is 0.27/1000, and the representative symptoms range from dizziness to unconsciousness in the CNS and from arrhythmias to cardiac arrest in the CVS. Predisposing factors of LAST include extremes of age, pregnancy, renal disease, cardiac disease, hepatic dysfunction, and drug-associated factors. To prevent the LAST, it is necessary to recognize the risk factors for each patient, choose a safe drug and dose of local anesthesia, use vasoconstrictor, confirm aspiration and use incremental injection techniques. According to the treatment guidelines for LAST, immediate application of lipid emulsion plays an important role. Although lipid emulsion is commonly used for parenteral nutrition, it has recently been widely used as a non-specific antidote for various types of drug toxicity, such as LAST treatment. According to the recently published guidelines, 20% lipid emulsion is to be intravenously injected at 1.5 mL/kg. After bolus injection, 15 mL/kg/h of lipid emulsion is to be continuously injected for LAST. However, caution must be observed for >1000 mL of injection, which is the maximum dose. We reviewed the incidence, mechanism, prevention, and treatment guidelines, and a serious complication of LAST occurring due to dental anesthesia. Furthermore, we introduced lipid emulsion that has recently been in the spotlight as the therapeutic strategy for LAST.

• Archives of Obesity and Metabolism
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• v.1 no.2
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• pp.78-82
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• 2022

Liraglutide (Saxenda^R) is prescribed to induce and sustain weight loss in obese patients. The starting dose of liraglutide is 0.6 mg/day for 1 week, which is increased by 0.6 mg/day every week until the full maintenance dose of 3 mg/day is achieved. Such dose titration is needed to prevent side effects, which primarily include gastrointestinal problems such as nausea, diarrhea, constipation, vomiting, dyspepsia, and abdominal pain. A 35-year-old, reportedly healthy obese man receiving liraglutide treatment for obesity visited the emergency room complaining of generalized weakness and dizziness accompanied by repeated diarrhea and vomiting. He reported over 20 episodes of diarrhea starting the day after liraglutide dose escalation from 1.2 mg/day to 1.8 mg/day. Laboratory findings suggested pre-renal acute kidney injury, including serum creatinine 4.77 mg/dl, blood urea nitrogen (BUN) 37 mg/dl, estimated glomerular filtration rate (eGFR) 15 ml/min/1.73 m², and Fractional excretion of sodium 0.08. After volume repletion therapy, his renal function recovered to a normal range with laboratory values of creatinine 1.08 mg/dl, BUN 14 mg/dl, and eGFR 88 ml/min/1.73 m². This case emphasizes the need for caution when prescribing glucagon-like peptide-1 receptor agonists, including liraglutide, given the risk of serious renal impairments induced by volume depletion and dehydration through severe-grade diarrhea and vomiting.

• Journal of Advanced Navigation Technology
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• v.26 no.5
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• pp.358-364
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• 2022

The Inter Communication System for avionics is in charge of processing all voice signals that internal calls between Pilot and Co-pilot, internal calls between Pilots and Crews, external calls through communication equipment such as Ultra/Very High Frequency Receiver/Transmitter(U/VHF RT), audio signal monitoring for navigation and mission equipment such as VHF Omnidirectional Range/Instrument Landing System(VOR/ILS), Tactical Air Navigation(TACAN), audio signal output for voice recording to Flight Data Recorder(FDR) and Data Transfer System(DTS), and warning/caution audio signal generate about the status and threat of aircraft. Because Inter Communication System for avionics is sensitive to noise in the case of analog audio signals, a redundant design that can protect audio signal from electromagnetic noise inside/outside of aircraft is required for the mission of pilots and crews. In this paper, Normal/Back-up operation mode and redundancy design plan based on digital method for the redundancy of the digital Inter Communication System for avionics and manufacturing, verification results are described.

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.38.2-38.2
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• 2020

Horizon Run 5 (HR5) is a cosmological hydrodynamical simulation which captures the properties of the Universe on a Gpc scale while achieving a resolution of 1 kpc. This enormous dynamic range allows us to simultaneously capture the physics of the cosmic web on very large scales and account for the formation and evolution of dwarf galaxies on much smaller scales. Inside the simulation box. we zoom-in on a high-resolution cuboid region with a volume of 1049 × 114 × 114 Mpc3. The subgrid physics chosen to model galaxy formation includes radiative heating/cooling, reionization, star formation, supernova feedback, chemical evolution tracking the enrichment of oxygen and iron, the growth of supermassive black holes and feedback from active galactic nuclei (AGN) in the form of a dual jet-heating mode. For this simulation we implemented a hybrid MPI-OpenMP version of the RAMSES code, specifically targeted for modern many-core many thread parallel architectures. For the post-processing, we extended the Friends-of-Friend (FoF) algorithm and developed a new galaxy finder to analyse the large outputs of HR5. The simulation successfully reproduces many observations, such as the cosmic star formation history, connectivity of galaxy distribution and stellar mass functions. The simulation also indicates that hydrodynamical effects on small scales impact galaxy clustering up to very large scales near and beyond the baryonic acoustic oscillation (BAO) scale. Hence, caution should be taken when using that scale as a cosmic standard ruler: one needs to carefully understand the corresponding biases. The simulation is expected to be an invaluable asset for the interpretation of upcoming deep surveys of the Universe.

• Atmosphere
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• v.33 no.5
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• pp.549-560
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• 2023

This study evaluates three distinct observation methods, CRDS, OA-ICOS, and OF-CEAS, in greenhouse gas monitoring equipment for atmospheric CO₂ and CH₄ concentrations. The assessment encompasses fundamental performance, high-concentration measurement accuracy, calibration methods, and the impact of atmospheric humidity on measurement accuracy. Results indicate that within a range of approximately 500 ppm, all three devices demonstrate high accuracy and linearity. However, beyond 1000 ppm, CO₂ accuracy sharply declines (84%), emphasizing the need for caution when interpreting high-concentration CO₂ data. An analysis of calibration methods reveals that both CO₂ and CH₄ measurements achieve high accuracy and linearity through 1-point calibration, suggesting that multi-point calibration is not imperative for precision. In dynamic atmospheric conditions with significant CO₂ and CH₄ concentration variations, a 1-point calibration suffices for reliable data (99% accuracy). The evaluation of humidity impact demonstrates that humidity removal devices significantly reduce air moisture levels, yet this has a negligible effect on dry CO₂ concentrations (less than 0.5% relative error). All three observation method instruments, which have integrated humidity correction to calculate dry CO₂ concentrations, exhibit minor sensitivity to humidity removal devices, implying that additional removal devices may not be essential. Consequently, this study offers valuable insights for comparing data from different measurement devices and provides crucial information to consider in the operation of monitoring sites.

• Journal of the Korean Institute of Gas
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• v.27 no.3
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• pp.108-115
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• 2023

Although hydrazine is an excellent liquid propellant, caution is required during storage and handling due to its high toxicity and reactivity. Safety guidelines should be established in consideration of the chemical reactivity by unintended leakage. In this study, the status of hydrazine facilities at launch site and safety standards for storing and handling were investigated and then, the reactivity between chemicals and hydrazine was analyzed. As a result of the analysis, hydrazine has reactivity with the exception of fuel oil. This paper emphasizes the imperative nature of constructing a dedicated hydrazine storage facility. Ensuring compatibility between hydrazine and the materials used in storage containers and handling equipment is crucial to prevent undesired reactions that could compromise safety. It was intended to be used as basic data to secure the range safety when handling hydrazine.

• Journal of Drive and Control
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• v.21 no.1
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• pp.22-30
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• 2024

Gearboxes designed for reciprocating motion operating mechanisms operate under conditions where both the load and speed undergo continuous variations. When conducting durability tests on gearboxes designed for such applications, operating the target gearbox under conditions similar to the intended usage is essential. The gearbox must be operated for the required number of cycles to validate its durability under conditions mirroring its intended usage. This study devised an accelerated test method for gearboxes, which reduces operating angles and operational strokes. The reliability of the accelerated test was verified by comparing the stresses imposed on the gears under general and acceleration conditions through multi-body dynamic simulations. The results confirmed that the maximum contact stress levels under normal and accelerated conditions were within a 0.1% error range, indicating a minimal difference in the gear damage rates. However, a difference in the maximum contact stress results between the normal and accelerated conditions was observed when inertial forces acted on the output shaft due to the operational acceleration of the gearbox. Therefore, when conducting this acceleration test, caution should be exercised to ensure that the operational load on the gearbox, which affects inertia, does not significantly deviate from the conditions observed under normal operating conditions.

• Korean Journal of Radiology
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• v.21 no.9
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• pp.1027-1035
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• 2020

Objective: To assess the appropriate follow-up interval, and rate and timepoint of cancer detection in women with Breast Imaging Reporting and Data System (BI-RADS) 3 lesions on screening ultrasonography (US) according to the type of institution. Materials and Methods: A total of 1451 asymptomatic women who had negative or benign findings on screening mammogram, BI-RADS 3 assessment on screening US, and at least 6 months of follow-up were included. The median follow-up interval was 30.8 months (range, 6.8-52.9 months). The cancer detection rate, cancer detection timepoint, risk factors, and clinicopathological characteristics were compared between the screening and tertiary centers. Nominal variables were compared using the chi-square or Fisher's exact test and continuous variables were compared using the independent t test or Mann-Whitney U test. Results: In 1451 women, 19 cancers (1.3%) were detected; two (0.1%) were diagnosed at 6 months and 17 (1.2%) were diagnosed after 12.3 months. The malignancy rates were both 1.3% in the screening (9 of 699) and tertiary (10 of 752) centers. In the screening center, all nine cancers were invasive cancers and diagnosed after 12.3 months. In the tertiary center, two were ductal carcinomas in situ and eight were invasive cancers. Two of the invasive cancers were diagnosed at 6 months and the remaining eight cancers newly developed after 13.1 months. Conclusion: One-year follow-up rather than 6-month follow-up may be suitable for BI-RADS 3 lesions on screening US found in screening centers. However, more caution is needed regarding similar findings in tertiary centers where 6-month follow-up may be more appropriate.