• Annals of Clinical Neurophysiology
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• v.6 no.2
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• pp.65-74
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• 2004

Limb-girdle muscular dystrophy (LGMD) is a heterogeneous group of inherited muscle disorders caused by the mutations of different genes encoding muscle proteins. In the past, when the molecular diagnostic techniques were not available, the subtypes of muscular dystrophies were classified by the pattern of muscle weakness and the mode of inheritance, and LGMD had been considered as a 'waste basket' of muscular dystrophy because many unrelated heterogeneous cases with 'limb-girdle' weakness were put into the category of LGMD. With the advent of molecular genetics at the end of the last century, it has been known that there are many subtypes of LGMD caused by the mutation of different genes, and now, LGMD is classified according to the results of the linkage analysis and the genes or proteins affected. Only small proportion (probably less than 10%) of LGMD is dominantly inherited, and autosomal dominant LGMD (AD-LGMD) consists of six subtypes (LGMD1A to 1F) so far. In autosomal recessive LGMD (AR-LGMD), more than 10 subtypes (LGMD2A to 2J) have been linked and most of the causative genes have been identified. Among AR-LGMDs, LGMD2A (calpain 3 deficiency), 2B (dysferlin deficiency), and sarcoglycanopathy (LGMD2C-2F) are major subtypes. The defective proteins in LGMDs are components of nuclear envelope, cytosol, sarcomere, or sarcolemma, and seem to play a different role in the pathogenesis of muscular dystrophy. It is notable that many causative genes of LGMDs are also responsible for other categories of muscular dystrophy or diseases affecting other tissue. However, by which mechanism they produce such a broad phenotypic variability is still unknown. The identification of mutation in the relevant gene is confirmative for the diagnosis, and is essential for genetic counseling and antenatal diagnosis of LGMD. Because many different genes are responsible for LGMD, differentiation of subtypes using immunohistochemistry and western blotting is the essential step toward the detection of mutation. For the effective research and medical care of the patients with muscular dystrophy in Korea, a research center with a medical facility supported by the government seems to be needed.

• Journal of Nutrition and Health
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• v.28 no.9
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• pp.914-922
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• 1995

A food frequency questionnaire (FFQ), which can be used in studies investigating relationship between diet and chronic diseases in a rural area of Korea, was developed and validated. Food items were selected from two sources ; (1) preliminary survey in a rural area by 24-hour recalls and (2) National Nutritional Survey of 1991. Sixty-five food items were finally selected based on the frequency of consumption and contributions to major nutrient intakes. Portion size of each food item was determined considering the mean and median values of the amounts consumed by subjects in the preliminary survey. Frequency of consumption was asked in nine categories ranging from 'more than three times a day' to 'almost never'. The newly developed FFQ was administered in 24-hour recalls conducted in different seasons in the same area after the administration of FFQ. Sixty-one subjects completed both FFQ and all three repeated 24-hour recalls. The results of the two different survey methods showed that mean daily intake levels of energy, carbohydrate, vitamin A and vitamin C were significantly higher in FFQ compared to 24-hour recalls(p<0.05). Intake levels of energy, protein, fat, carbohydrate and iron were significantly correlated by Pearson's correlation coefficients(p0.05). Ranking on nutrient intake of the subjects by two method were significantly correlated(Spearman's correlation coefficients) in all above nutrients plus Ca and vitamin A. Percentage of subjects in the lowest or in the highest quintile by 24-hour recalls who belong to the nearest two categories by FFQ ranged from 46% to 83%, while the percentage falling into the opposite category were below 10% in most of the nutrients. The proportion of subjects classfied into the same quintiles by the two methods were between 23% and 33%, with an average of 28%. From the results, FFQ developed in this study seems to be useful in evaluating nutrient intake pattern of 1 year in adults living in rural area of Kyonggi province.

• Journal of Korean Neurosurgical Society
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• v.59 no.6
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• pp.584-589
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• 2016

Objective : A rare subtype of meningioma, sclerosing meningioma is not included in the current World Health Organization classification of meningiomas and is classified into the category of other morphological variation subtypes. Sclerosing meningioma is often misdiagnosed to other non-benign meningioma or malignant neoplasm, so it is important to diagnose sclerosing type correctly. We analyzed the radiological and clinical characteristics of a series of sclerosing meningiomas. Methods : Twenty-one patients who underwent surgery in one institute with a histopathologically proven sclerosing meningioma were included from 2006 to 2014. Eighteen tumors were diagnosed as a pure sclerosing-type meningioma, and 3 as mixed type. Magnetic resonance image was taken for all patients including contrast enhancement image. Computed tomography (CT) scan was taken for 16 patients. One neuroradiologist and 1 neurosurgeon reviewed all images retrospectively. Results : In the all 16 patients with preoperative CT images, higher attenuation was observed in the meningioma than in the brain parenchyma, and calcification was observed in 11 (69%). In 15 of the 21 patients (71%), a distinctive very low signal intensity appeared as a dark color in T2-weighted images. Nine of these 15 tumors (60%) exhibited heterogeneous enhancement, and 6 (40%) exhibited homogeneous enhancement that was unlike the homogeneous enhancing pattern shown by conventional meningiomas. Ten patients had a clear tumor margin without peritumoral edema. Conclusion : Although these peculiar radiological characteristics are not unique to sclerosing meningioma, we believe that they are distinctive features that may be helpful for distinguishing sclerosing meningioma from other subtypes.

• The Journal of Korean Medicine
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• v.40 no.4
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• pp.29-40
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• 2019

Objectives: To analyze the prescription frequency of various herbs as either individual or major herbs (in terms of dosage) and their usage patterns in the treatment of different diseases for standardization of traditional Korean medicine. Methods: We analyzed the prescription database of patients at the Pusan National University Korean Medicine Hospital from the date of establishment of the hospital to February 2013. The complete prescription data were extracted from the electronic medical records of patients, and the prescription frequencies of individual herbs, particularly, of major herbs, were analyzed in terms of gender, age, and international classification of diseases (ICD) code. Results: The prescription frequency of individual herbs based on age and gender showed a similar pattern. Herbal mixtures were also distributed in a similar manner. The use of some herbs differed according to age and gender (Table 1.). The herbs that were used at high frequencies for a given ICD code had similar usage patterns in different categories. However, some major herbs in the "Jun (King)" category were used uniquely for a given ICD code (Table 2.). There was significant difference between male and female on ICD code E and N, but the other ICD codes had small differences. The ratio of herbal medicine by gender showed different usage patterns in each gender. Conclusions: The findings of our study provide fundamental data that reflect the real clinical conditions in South Korea, and therefore, can contribute to the standardization of TKM.

• 한국신재생에너지학회:학술대회논문집
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• 2011.05a
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• pp.113.1-113.1
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• 2011

PEMS (printed electro-mechanical system) is fabricated by means of various printing technologies. Passive and active compo-nents in 2D or 3D such as conducting lines, resistors, capacitors, inductors and TFT(Thin Film Transistor), which are printed withfunctional materials, can be classified in this category. And the issue of PEMS is applied to a R2R process in the manu-facturing process. In many electro-devices, the vacuum process is used as the manufacturing process. However, the vacuum process has a problem, it is difficult to apply to a continuous process such as a R2R(roll to roll) printing process. In this paper, we propose an ESD (electro static deposition) printing process has been used to apply an organic solar cell of thin film forming. ESD is a method of liquid atomization by electrical forces, an electrostatic atomizer sprays micro-drops from the solution injected into the capillary with electrostatic force generated by electric potential of about several tens kV. ESD method is usable in the thin film coating process of organic materials and continuous process as a R2R manufacturing process. Therefore, we experiment the thin films forming of PEDOT:PSS layer and active layer which consist of the P3HT:PCBM. The organic solar cell based on a P3HT/PCBM active layer and a PEDOT:PSS electron blocking layer prepared from ESD method shows solar-to-electrical conversion efficiency of 1.42% at AM 1.5G 1sun light illumination, while 1.86% efficiency is observed when the ESD deposition of P3HT/PCBM is performed on a spin-coated PEDOT:PSS layer.

• Journal of Oriental Neuropsychiatry
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• v.20 no.4
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• pp.1-13
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• 2009

Objectives : As depression falls into the category of Wuljeung, Gamiguibi-Tang(Jiaweiguipitang) is the standard prescription to cure Wuljeung. This study develops a questionnaire for building the guidelines to administer Gamiguibi-Tang to depression and evaluates reliability and validity of questionnaire. Methods : With extracting the text related to depression and Gamiguibi-Tang through total 9 Korean medicine books and consulting the experts, the study selected 80 items and converted them into a questionnaire. It surveyed the neuropsychiatry professors and the medical specialists three times by Delphi method, and lastly selected 21 final items of a questionnaire. On the basis of the questionnaire, it collected total 216 samples and tested their reliability and validity. Results : 21 items all didn't reduce total Cronbach alpha coefficient and satisfied test-retest reliability. As a result of factor analysis, totally 5 factors were extracted such as mental state, sleep, accompaniment, fatigue and weakness. Finally, in comparing a depression group with a normal control group, two groups all showed meaningful difference in each 21 items' point, the sum of factor 1 to 5 items' points, and the sum of 21 items' points. Conclusions : The questionnaire on the updated depression prescription guideline of Gamiguibi-Tang satisfied both of reliability and validity. Later it can help objectifying to apply Gamiguibi-Tang to depression cure.

• Korean Institute of Interior Design Journal
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• v.21 no.2
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• pp.92-100
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• 2012

This study was to examine the pattern of visual interpretation in the process of eye-tracking. I categorized the subjects' observation inclination for analysis so that I could find out which element the user observing the space concentrated and explored. First, for 2 minutes of observation, there occurred 171 times of eye-fixations and 9.8 times of observation frequency on average, which showed that the subject, through this observing fixation, spent 44.5% of the entire time performing the visual activity in order to acquire the "visual understanding" of the lobby-space. Second, I found out that there was a consistent observation type as the time passed. I could categorize the subjects observing the space into 6 concentrating types and 3 discontinuing ones of observation types, which category can be utilized as data for analyzing the subjects' characteristics at space-observation. Third, the type, which was so intensive as to get the visual understanding on the space, was mostly of the case that (1) the subject had a kind of high degree of observation type, exploring the space, again having high degree of the observation type [Type A], (2) the subject repeated the concentration from the early part to the latter [Type C], which can be considered to be the observation type generally shared. Fourth, in the case of observing the space, 45.8% of the subjects showed a high rate of concentration at the time of starting the observation and in less than two minutes. The subjects of type A can be considered to understand the space visually by distinctively repeating the concentration and exploration.

• Journal of the Korea Society of Computer and Information
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• v.17 no.11
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• pp.117-123
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• 2012

Smart devices are great tool to get a lot of information of user by variety sensors, application, web. The information is good clue to seize pattern of user. So, we can expect that customized content-service will be possible based on utilizing information of user. This expectation alters the type of content-service from just providing lots of contents to smart devices to recommendation contents which wanted, needed, favorite looking by user. For this customized content-service, a system model like a curator in galleries or museums is required. So, in this paper, we suggest Intelligent Contents Curation(ICCuration) model which has 3 sub modules with sensing, analysis and filtering information of user. The collected information of user are processed up to scenarios and the scenario is a clue for selecting contents which will be recommended to users. In the scenario has user's preferences and behaviors as well as devices informations as elements. So, contents can be optimized not only domain category but type of media for devices.

• Journal of Digital Contents Society
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• v.19 no.3
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• pp.445-451
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• 2018

Recently, transmedia is evolving constantly without clear theories and definitions. In this paper, we reviewed the previous researches on transmedia and summarized the transmedia concept studied before. Furthermore, we analyzed the cases of , and which are examples of the transmedia and researched whether these three cases belonged to the category of the transmedia concept discussed above. The pattern of is almost similar to definition and type of the previously discussed transmedia. However, the cases of and don't match on the concepts presented by existed researches perfectly. This paper includes the necessity of the expanded definition and redefinition on the evolving transmedia, in addition, presents the changed definition on transmedia, through reviewing the limitations of the existing transmedia storytelling concept based on these three cases.

• Journal of Navigation and Port Research
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• v.42 no.4
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• pp.277-282
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• 2018

Recently, the Vessel Traffic Service (VTS) coverage has expanded to include coastal areas following the increased attention on vessel traffic safety. However, it has increased the workload on the VTS operators. In some cases, when the traffic volume increases sharply during the rush hour, the VTS operator may not be aware of the risks. Therefore, in this paper, we proposed a new method to recognize ship movement anomalies automatically to support the VTS operator's decision-making. The proposed method generated traffic pattern model without any category information using the unsupervised learning algorithm.. The anomaly score can be calculated by classification and comparison of the trained model. Finally, we reviewed the experimental results using a ship-handling simulator and the actual trajectory data to verify the feasibility of the proposed method.