• Journal of Preventive Medicine and Public Health
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• 제39권2호
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• pp.177-183
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• 2006

Objectives : In this study we examined the association between the genetic markers ACE (A-240T, C-93T, I/D, A2350G), AGT (M235T), AT1R (A1166C), CYP11B2 (T344C, V386A), REN (G2646A), ADRB2 (G46A, C79G, T47C, T1641), GNB3 (C825T) and ADD1 (G460W) and the presence of essential hypertension in adolescents. Methods : The Kangwha Study is an 18-year prospective study that is aimed at elucidating the determinants of the blood pressure level from childhood to early adulthood. For this study, we constructed a case-control dataset of size of 277 and 40 family trios data from the Kangwha Study. For this purpose, we perform a single locus-based case-control association study and a single locus-based TDT (transmission/disequilibrium test) study. Results : In the case-control study, the single locus-based association study indicated that the ADD1 (G460W) (p=0.0403), AGT (M235T) (p=0.0002), and REN (G2646A) (p=0.0101) markers were significantly associated with the risk of hypertension. These results were not confirmed on the TDT study. This study showed that genetic polymorphisms of the ADD1, AGT and REN genes might be related to the hypertension in Korean adolescents. Conclusions : This study provided useful information on genetics markers related to blood pressure. Further study will be needed to confirm the effect of the alpha adducin gene, the angiotensinogen gene and the renin gene on essential hypertension.

• 농업생명과학연구
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• 제46권5호
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• pp.73-82
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• 2012

13종의 초위성체 마커를 이용해 분석한 대립유전자형을 $F_0$, $F_1$ 그리고 $F_2$로 세대 간 구분 하여 동일한 개체 출현확률 값을 추정한 결과 $F_2$의 무작위교배집단으로 가정한 경우 13종의 초위성체 마커는 $3.84{\times}10^{-23}$ 의 추정치를 나타내 37개의 SNP 마커를 이용할 경우와 유사한 동일개체 출현확률 추정치를 유추할 수 있었다. 본 연구에 사용한 실험축군은 2품종 상호교배로 만들어졌다. 친자감정확률 추정치를 전체집단을 대상으로 13종의 초위성체 마커와 37개의 SNP 마커를 이용하여 분석한 결과 부모를 동시에 찾을 수 있는 추정치인 $PE_{pu}$의 경우 초위성체 마커는 0.97897이고 SNP 마커는 0.99149였으며, 한쪽 부모를 찾을 수 있는 추정치인 PE의 경우 초위성체 마커는 0.99916이고 SNP 마커는 0.99949로 나타났다. 또한 가능한 후보 부모들로부터 가장 확률이 높은 부모를 찾을 추정치인 $PNE_{pp}$의 경우는 초위성체 마커와 SNP 마커 둘 다 1.00000으로 추정 되었다. 한정된 부모집단 내 한정된 대립유전자형을 통해 대량의 비육돈이 생산되는 국내의 양돈산업의 경우 DNA 마커의 특성, 분석집단의 크기, 유전자형 분석의 정확도와 비용, 분석된 자료 관리의 용이성 및 기존 분석 시스템과의 호환성 등을 고려하여 효율성과 경제성이 높은 마커를 선정해 마커 조합을 만드는 것이 필요할 것으로 사료된다.

• Animal cells and systems
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• 제8권1호
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• pp.41-47
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• 2004

The kallikrein-kinin system affects regulation of blood pressure, and genes encoding for the components of this system have been considered as good candidates for hypertension. To evaluate the relationship between genetic polymorphisms of candidate genes involved in this system and hypertension, we performed case-control studies using genetic markers in Korean normotensives and hypertensives, respectively. By association study, there was a marginal association with hypertension in AA genotype distribution of A1789G polymorphism in the hKLK1 gene (P=0.0754). Thus, this genetic polymorphism may weakly contribute to the susceptibility to hypertension in Koreans. We also observed that significant linkage disequilibrium exists among three polymorphic sites in the hKLK1 gene studied, suggesting that the three genetic polymorph isms can be useful as genetic markers in clinical association studies. Further studies using larger sample sizes and more genetic markers will be needed to clarify genetic influence of kallikrein-kinin system for hypertension.

• Journal of Korean Neurosurgical Society
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• 제62권4호
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• pp.487-491
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• 2019

Conservative therapy with appropriate antibiotics is essential for most patients with infectious spondylitis. Although most antibiotics do not cause problems if it used properly and serious side effects are rare, side effects can occur with any class of drugs and adverse reactions of antibiotics can range from mild allergic reactions to serious and fulminant adverse events. These side effects are also extremely variable from patient to patient and from antibiotic to antibiotic. A side effect of antibiotics may paradoxically increase inflammatory marker levels. Here, the author presents two cases of antibiotic-induced increase in inflammatory markers in cured infectious spondylitis. The patients were successfully treated after stopping the antibiotic therapy. The differential diagnosis between antibiotic side effects and infection should be considered very carefully because the treatment is completely different. Although the exact mechanisms underlying successful treatment without antibiotics are unclear, we should consider the side effects of antibiotics when following inflammatory markers during treatment of infectious spondylitis.

• 한국언어정보학회:학술대회논문집
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• 한국언어정보학회 2007년도 정기학술대회
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• pp.57-66
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• 2007

Case markers in Korean are omissible in colloquial speech. Previous discourse studies of Caseless bare NPs in Korean show that the information structure of zero Nominative not only differs from that of overt Nominative but it also differs from that of zero Accusative in many respects. This paper aims to provide a basis for these semantic/pragmatic properties of Caseless NPs through the syntactic difference between bare subjects and bare objects: namely, the former are left-dislocated NPs, whereas the latter form complex predicates with the subcategorizing verbs. Our analysis will account for the facts that (i) the distribution of bare subject NPs are more restricted than that of bare object NPs; (ii) bare subject NPs must be specific or topical; (iii) Acc-marked NPs in canonical position tend to be focalized.

• 대한수의학회지
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• 제52권2호
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• pp.147-151
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• 2012

Radiography, ultrasonography with hydrogram, and contrast studies using radiopaque markers were applied to evaluate alimentary lymphoma in two cats. The hydrogram facilitated the differentiation of pseudo-thickening from true wall thickening, and enabled an evaluation of wall layering and lymph nodes. In case 1, mechanical obstruction of the duodenum was confirmed with barium-impregnated polyethylene spheres (BIPS), a radiopaque marker; however, results obtained in case 2 were not as definitive. We expect that hydrograms and BIPS can be used as valuable alternative methods to evaluate the gastrointestinal (GI) tract although further studies in cases involving GI tumors are needed.

• 한국물환경학회지
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• 제23권3호
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• pp.391-396
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• 2007

공기와 모래를 이용한 건식 식기세척기를 주방에 설치하여 운전하였다. 실험을 위하여 30여종의 양념(Dirt 마커) 과 14종의 접시를 사용하였으며 세척효율은 COD-MN에 의해 평가하였다. 건식 공기세척은 일부 양념에는 효과적이었으나 일부 양념에는 전혀 효과가 없는 것으로 분석되었다. 또한 건식공기세척을 통해서 양념의 완벽한 제거는 불가능하였다. 접시의 형태에 따라 세척효율에 큰 차이를 보였다. 모래와 공기에 의한 세척은 COD-MN 제거에 탁월한 성능을 보였다. 본 연구를 통하여 물을 사용하지 않고 모래와 공기에 의한 건식세척 방법이 가능함이 입증되었다.

• 대한의생명과학회지
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• 제28권3호
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• pp.157-169
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• 2022

DNA typing is the typical technology in the forensic science and plays a significant role in the personal identification of victims and suspects. Short tandem repeat (STR) is the short tandemly repeated DNA sequence consisting of 2~7 bp DNA units in specific loci. It is disseminated across the human genome and represents polymorphism among individuals. Because polymorphism is a key feature of the application of DNA typing STR analysis, STR analysis becomes the standard technology in forensics. Therefore, the DNA database (DNA-DB) was first introduced with 4 essential STR markers for the application of forensic science; however, the number of STR markers was expanded from 4 to 13 and 13 to 20 later to counteract the continuously increased DNA profile and other needed situations. After applying expanded STR markers to the South Korean DNA-DB system, it positively affected to low copy number analysis that had a high possibility of partial DNA profiles, and especially contributed to the theft cases due to the high portion of touch DNA evidence in the theft case. Furthermore, STR marker expansion not only contributed to the resolution of cold cases but also increased kinship index indicating the potential for improved kinship test accuracy using extended STR markers. Collectively, the expansion of the STR locus was considered to be necessary to keep pace with the continuously increasing DNA profile, and to improve the data integrity of the DNA-DB.

• 한국의류산업학회지
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• 제8권3호
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• pp.303-309
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• 2006

This study intended to compare and analyze marking efficiencies of basic slacks, based on different cloth and production conditions, the width of cloth, the number of marking pieces and the direction for marking deployment and proposed an efficient marking method. The results were as follows. On the whole, the marking efficiencies increased with increasing cloth widths. In the case of small number of marking pieces, the efficiency increased with increasing cloth widths, while, for large number of marking pieces, there was no differences in the efficiency with the cloth widths. From the result of the comparison of the marking efficiencies with the number of marking pieces, it was shown that, in the case of small cloth width, the efficiency increased considerably with increasing number of marking pieces, while, in the case of large cloth width over two markers, there was no distinct effect of the number of markers on the marking efficiency. Thought there were some differences of the marking efficiencies with the marker directions, bi-direction marker was the most efficient marker, followed by one-direction for each size marker and one-direction marker.

• 음성과학
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• 제13권3호
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• pp.207-219
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• 2006

The present study was designed to investigate the comprehension of 'who' and 'what' questions in 2- to 3-year-old normal children. Sixty children were divided into 3 groups depending on their ages, i.e., age groups 2;6-2;11, 3;0-3:5, and 3;6-3;11. Three types of 'who' questions and 2 types of 'what' questions were generated depending on the attached case markers, i.e., who-nominative, who-accusative, who-dative, what-nominative, and what-accusative. The children watched 36 cuts of short video recordings. After watching each cut, they were asked to answer one of the 5 types of wh-questions. For the 'who-nominative' and 'what-accusative' questions, even the late 2-year-old children performed with over 70% of accuracy, and the late 3-year-old children performed with over 95% of accuracy. For the 'who-accusative' and 'who-dative' questions, the late 2-year olds exhibited difficulty in comprehension with performance accuracy of 41% and 33%, respectively. However, the late 3-year olds could comprehend those questions correctly with over 90% of accuracy. On the other hand, in answering 'what-nominative' questions, the children did not show rapid development across the age groups, as the mean performance accuracies of the 3 groups were 39%, 49%, and 59%, respectively. The results indicated that children's understanding of a wh- question is largely affected by the case of the interrogative.