• Journal of Chest Surgery
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• 제37권3호
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• pp.279-281
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• 2004

베체트병은 구강 생식기의 궤양, 안구와 피부 병변을 주 증상으로하고 심혈관계, 호흡기계, 소화기계, 중추신경계, 비뇨기계를 침범하여 다양한 증상을 나타낼 수 있다. 베체트병에서 경동맥류와 장천공의 동반은 드문 경우로, 병리소견과 병력상 베체트병으로 진단 받은 환자에서 상기 병증에 대한 수술을 시행하였기에 보고하는 바이다.

• Molecular & Cellular Toxicology
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• 제3권4호
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• pp.246-253
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• 2007

Doxorubicin and daunorubicin are excellent chemotherapeutic agents utilized for several types of cancer but the irreversible cardiac damage is the major limitation for its use. The biochemical mechanisms of doxorubicin- and daunorubicin- induced cardiotoxicity remain unclear. There are many reports on toxicity of doxorubicin and doxorubicin in cardiomyocytes, but effects in cardiovascular system by these drugs are almost not reported. In this study, we investigated gene expression profiles in human umbilical vein endothelial cells (HUVECs) to better understand the causes of doxorubicin and doxorubicininduced cardiovascular toxicity and to identify differentially expressed genes (DEGs). Through the clustering analysis of gene expression profiles, we identified 124 up-regulated common genes and 298 down-regulated common genes changed by more than 1.5-fold by all two cardiac toxicants. HUVECs responded to doxorubicin and doxorubicin damage by increasing levels of apoptosis, oxidative stress, EGF and lipid metabolism related genes. By clustering analysis, we identified some genes as potential markers on apoptosis effects of doxorubicin and doxorubicin. Six genes of these, BBC3, APLP1, FAS, TP53INP, BIRC5 and DAPK were the most significantly affected by doxorubicin and doxorubicin. Thus, this study suggests that these differentially expressed genes may play an important role in the cardiovascular toxic effects and have significant potential as novel biomarkers to doxorubicin and doxorubicin exposure.

• Journal of Chest Surgery
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• 제31권3호
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• pp.336-338
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• 1998

다한증은 감염이나 일부 종양 등에서 볼 수 있으나, 원인질환이 없이 원발성으로 발생하는 경우도 있다. 원발성 다한증의 경우 땀이 많이 나는 부위는 주로 손바닥이며 안면부에서 땀이 과다하게 나는 경우도 있다. 최근 흉강경을 이용한 흉부교감신경절제술이 다한증의 외과적 치료로 이용되고 있는데, 안면부다한증의 경우에는 성상신경절의 일부를 절제하기 때문에 호너증후군 등의 합병증 발생 가능성이 높다. 저자들은 최근 안면부다한증 3례의 환자에서 흉강경을 이용하여 성상신경절의 일부를 포함한 흉부교감신경절제술를 시행하였다. 수술후 모두에서 증상호전이 있었으며 호너증후군 등의 합병증은 없었다.

• BMB Reports
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• 제47권10호
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• pp.552-557
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• 2014

The main purpose of this study was to investigate whether type 3 muscarinic acetylcholine receptor (M3R) dysfunction induced vascular hyperpermeability. Transwell system analysis showed that M3R inhibition by selective antagonist 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP) and small interfering RNA both increased endothelial permeability. Using coimmunoprecipitation and Western blot assay, we found that M3R inhibition increased VE-cadherin and ${\beta}$-catenin tyrosine phosphorylation without affecting their expression. Using PTP1B siRNA, we found that PTP1B was required for maintaining VE-cadherin and ${\beta}$-catenin protein dephosphorylation. In addition, 4-DAMP suppressed PTP1B activity by reducing cyclic adenosine monophosphate (cAMP), but not protein kinase $C{\alpha}$ ($PKC{\alpha}$). These data indicate that M3R preserves the endothelial barrier function through a mechanism potentially maintaining PTP1B activity, keeping the adherens junction proteins (AJPs) dephosphorylation.

• Journal of Chest Surgery
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• 제47권1호
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• pp.63-65
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• 2014

Ameloblastomas are rare odontogenic epithelial tumors that occur mainly in the mandible. Despite their benign histologic appearance, they are locally aggressive with a high recurrence rate. However, a metastasizing ameloblastoma has been rarely reported. According to the current World Health Organization classification system, the definitive diagnosis of metastasizing ameloblastoma can only be carried out in retrospect, after the event of metastasis. This case report describes a patient with metastatic pulmonary ameloblastoma, 17 years after the surgical excision of an odontogenic tumor, preoperatively misdiagnosed as primary squamous cell carcinoma.

• 대한한의진단학회지
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• 제16권3호
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• pp.33-40
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• 2012

Objectives: Existing cardiovascular simulators are used to evaluate artificial organs such as artificial hearts, prosthetic valves, and artificial blood vessels, and pulses are typically triggered using artificial hearts. However, the forms of pulse waves vary according to the location of arteries, and for precise assessment of artificial blood vessels, the development of simulators that generate diverse pressure pulse waves is necessary. This study developed a novel cardiovascular simulator that generates different forms of pulse waves. Methods: This simulator consists of a stepping motor, a slider-crank mechanism that transforms the rotation movement of a motor into the straight-line motion of a piston, a piston that generates pulsatile flows, a water tank that supplies fluids, an elastic tube made of silicon, and a device that adjusts the terminal resistance of fluids. Results & Conclusion: This study examined motor rotation and its operation under conditions similar to the physiological conditions of the heart. The simulator developed in this study produced diverse forms of waves, and the generated pressure waves well satisfied physiological conditions.

• Physical Therapy Rehabilitation Science
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• 제10권3호
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• pp.320-327
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• 2021

Objective: The community has implemented a variety of exercise programs for the elderly population. However, studies comparing changes in the cardiovascular system through body composition and blood analysis after applying aqua aerobic exercise are insufficient. The purpose of this study was to investigate the effect of a 12 weeks aqua exercise on body composition and cardiovascular index in elderly women. Design: Non-equivalence pre-post design. Methods: Thirty elderly women were assigned to aquarobic group(n=15) and control group(n=15). The aquarobic exercise was 60 minutes per every session, 2times per week, for 12weeks. Weight, skeletal muscle mass, body fat percentage, total cholesterol, triglyceride, HDL cholesterol, and LDL cholesterol were measured before and after the exercise program. Paired and independent t-tests were performed using SPSS program. Results: The result showed was weight(p<0.05), body fat percentage(p<0.05), total cholesterol(p<0.05), triglyceride(p<0.05), HDL cholesterol(p<0.05), and LDL cholesterol(p<0.05) were significantly decreased and skeletal muscle mass(p>0.05) was not significantly increased after aquatic exercise program. Conclusions: According to the study result, aqua exercise program made a positive effect in the improvement of obesity and cardiovascular function in elderly women. Therefore, we suggest that you actively consider implementing the Aquarobic exercise program when operating the community health promotion program in the future. In addition, in future studies, comparative studies according to various ages and genders and studies on the effects of aqua aerobic exercise as a community exercise program for chronically illness patients are needed.

• 대한의용생체공학회:의공학회지
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• 제25권6호
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• pp.565-573
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• 2004

본 연구에서는 심혈관시스템 내의 압력 변화를 감지하는 압수용체 중 가장 대표적인 대동맥 압수용체의 시뮬레이션을 위한 심활성도 압반사 제어모델을 제안하였다. 그리고 제안된 모델은 압반사 조절, 시간지연을 포함한 전기회로 모델들로 구성하였으며, 대동맥동의 압반사 조절시 시간지연이 심주기와 일회 심박출량에 주는 영향을 관찰할 수 있도록 하였다. 심활성도 압수용체 제어 모델에서 시간지연의 기전은 대동맥동 압수용체에서 감지된 압력 정보가 구심성 신경으로 전달되고, 이 정보는 중추신경을 거쳐 원심성 신경으로 전달되어 제어 기능을 수행한다. 제안된 모델의 시뮬레이션 결과 시간지연에 따라 심혈관시스템 변이성의 세가지 패턴을 관찰할 수 있었다. 먼저 시간지연이 2.5초 이상일 경우에는 대동맥압, 일회심박출량, 심박동수가 비주기적으로 발생하고 불규칙인 것을 관찰할 수 있었고, 시간지연이 0.1초에서 2.5초 사이일 경우에는 주기적인 진동이 발생함을 관찰할 수 있었다. 그리고 시간지연이 0.1초 이하인 경우에는 심박동수와 동맥압-심박동수의 궤적은 안정상태를 유지함을 관찰할 수 있었다.

• Journal of Pharmaceutical Investigation
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• 제40권6호
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• pp.333-337
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• 2010

Combining cell- and gene-based therapy is a promising therapeutic strategy in regenerative medicine. The aim of this study was to develop genetically modified mesenchymal stem cell (MSC) aggregates using a poly(ethylene glycol) (PEG) hydrogel micro-well array technique. Stable PEG hydrogel micro-well arrays with diameters of 200 to $500\;{\mu}m$ were fabricated and used to generate genetically engineered MSC aggregates. Rat bone marrow-derived MSCs were transfected with a green fluorescent protein (GFP) plasmid as a reporter gene, and aggregated by culturing in the PEG hydrogel micro-well arrays. The resultant cell aggregates had a mean diameter of less than $200\;{\mu}m$, and maintained the mesenchymal phenotype even after genetic modification and cell aggregation. Transplantation of MSC aggregates that are genetically modified to express therapeutic or cell-survival genes may be a potential therapeutic approach for regenerative medicine.

• Journal of Chest Surgery
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• 제43권2호
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• pp.168-171
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• 2010

말초혈관 삽관을 통한 체외막형산화장치가 도입된 후, 국내에서도 체외막형산화장치의 적용 사례가 빠르게 증가하고 있다. 하지만 소아에서는 아직까지 그 사용이 제한적인데, 그 이유는 소아에 적합한 장비가 공급되지 않고, 소아의 특성 상 말초혈관을 통한 삽관으로 충분히 보조하기 어렵기 때문이다. 이로 인해 국내에서 발표된 소아의 체외막형산화장치 적용 사례는 주로 심장수술 후 보조 목적으로, 정맥-동맥 간에 사용된 것이었다. 최근 저자들은 호흡부전증후군 소아를 대상으로 하나의 이중관 캐뉼라를 경피적으로 내경정맥에 삽관하여 성공적으로 정맥간 체외막형산화장치를 시행하였기에 이를 보고하는 바이다.