• Journal of Chest Surgery
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• 제48권1호
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• pp.95-97
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• 2015

We report the case of a 69-year-old woman who was diagnosed with intracardiac schwannoma without symptoms. Preoperative echocardiography and cardiac magnetic resonance imaging showed a mass attached to the interatrial septum. The initial diagnosis was a myxoma or a bronchogenic cyst. The tumor was successfully excised under cardiopulmonary bypass. However, the pathology of the excised tumor was consistent with schwannoma. We suggest that cardiovascular surgeons consider schwannoma to be a possible differential diagnosis for a mass close to the interatrial septum.

• Journal of Chest Surgery
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• 제41권3호
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• pp.369-372
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• 2008

심장에 발생하는 원발성 악성 림프종은 매우 드물다. 68세 남자 환자가 점점 심해지는 호흡곤란으로 본원 흉부외과에 입원하였다. 심장 초음파, 흉부컴퓨터단층촬영 후, 우심방과 우심실에 걸쳐 있는 거대 종양을 발견하였다. 뇌경색 등의 위험과 혈역학적 불안정으로 응급수술을 결정하였다. 우측 심장에 있는 거대 종양을 심방 중격의 일부와 전외측 우심방 벽을 함께 포함하여 제거하고, 우형 심내막 패치로 재건하였다. 최종 조직검사상 원발성 악성 림프종으로 진단되었으며, 환자와 보호자가 경제적 이유 등으로 항암치료를 거부하고 귀가 퇴원을 하였다.

• Tuberculosis and Respiratory Diseases
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• 제77권1호
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• pp.28-33
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• 2014

We report a case of invasive pulmonary aspergillosis invading the mediastinum and the left atrium. A 70-year-old woman was hospitalized for dyspnea. She had been well controlled for her diabetes mellitus and hypertension. The chest X-ray disclosed mediastinal widening, and the computed tomography scan of the chest showed that there was a large mediastinal mass and this lesion extended into the left atrium and right bronchus. The cardiac echocardiography showed that a huge mediastinal cystic mass compressed in the right atrium and a hyperechoic polypoid lesion in the left. The pathology from the bronchoscopic biopsy observed abundant fungal hyphae which was stained with periodic acid-Schiff and Gomori's methenamine silver. Despite the treatment with antifungal agents, she died from cardiac tamponade after three months. Invasive pulmonary aspergillosis, which involves the mediastinum and the heart, is very rare in immunocompetent patients.

• 대한핵의학회지
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• 제15권2호
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• pp.75-79
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• 1981

A Case of main pulmonary artery aneurysm in a 9-year-old boy with patent ductus arteriosus is presented. In this case presented with a huge mass density on the chest X-ray, radionuclide cardiac angiography showed a vascular lesion, which was confirmed as an aneurysm of the main pulmonary artery at roentgenologic angiogram. The aneurysm appeared following an episode of bacterial endocarditis and pulmonary hypertension. A successful aneurysmectomy with multiple ligation of ductus arteriosus was performed.

• Journal of Chest Surgery
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• 제38권4호
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• pp.316-318
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• 2005

유두상 섬유탄력종은 원발성 종양 중 두 번째로 많이 호발하는 양성종양으로 주로 심장판막에 발생한다. 본원에서는 심계항진과 호흡곤란을 주소로 내원한 51세 여자환자를 검사하던 중 우연히 대동맥 판막에 위치한 유두상 섬유탄력종이 발견되었다. 수술시 대동맥 판막의 손상 없이 대동맥 판막에 부착된 종양만 제거하는 것이 가능하였다.

• Journal of Chest Surgery
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• 제39권11호
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• pp.858-860
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• 2006

유두상 섬유탄력종은 원발성 종양 중 두 번째로 많이 호발하는 양성종양으로 주로 심장판막에 발생한다. 본원에서는 흉통과 호흡곤란을 주소로 내원한 61세 여자 환자에서 발견된 대동맥 판막에 위치한 유두상 섬유탄력종을 경험하였다. 대동맥 판막의 손상 없이, 개심술 하에서 대동맥 판막에 부착된 종양을 제거한 치험을 문헌고찰과 함께 보고하는 바이다.

• Reproductive and Developmental Biology
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• 제35권2호
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• pp.159-165
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• 2011

To explore the role of histone deactylase (HDAC) activation in an in vivo model of hypertrophy, we studied the effects of Trichostatin A (TSA). TSA subjected to thoracic aortic banding (TAB)-induced pressure stress in mice. In histological observations, TAB in treated mice showed a significant hypertrophic response, whereas the sham operation remained nearly normal structure with partially blunted hypertrophy. TSA treatment had no effect (measured as HW/BW) on sham-operated animals. TAB animals treated with vehicle manifested a robust ~50% hypertrophic response (p<0.05 vs sham). TAB mice treated with 2 mg/kg/day TSA manifested a blunted growth responses, which was significantly diminished (p<0.05) compared with vehicle-treated TAB mice. TAB mice treated with a lower dose of TSA (0.5 mg/kg/day) manifested a similar blunting of hypertrophic growth (~25% increase in heart mass). Furthermore, to determine activity duration of TSA in vitro, 1 nM TSA was added to H9c2 cells. Histone acetylation was initiated at 4 hr after treatment, and it was peak up to 18 hr, then followed by significantly reduced to 30 hr. We also analyzed the expression of p53 following TSA treatment, wherein p53 expression was elevated at 4 hr, and it was maintained to 24 hr after treatment. ERK was activated at 8 hr, and maintained till 30 hr after treatment suggesting an intracellular signaling interaction between TSA and p53 expression Taken together, it is suggested that HDAC activation is required for pressure-overload growth of the heart. Eventually, these data suggest that histone acetylation may be a novel target for therapeutic intervention in pressure-overloaded cardiac hypertrophy.

• 대한임상검사과학회지
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• 제45권3호
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• pp.96-101
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• 2013

Increased waist circumference has shown to be more strongly associated with cardiovascular disease risk factors. The purpose of this study is to investigate the association between exercise capacity and cardiovascular risk factors among obese types in adult men. The subjects of this study were a total fifty-four obese persons and obesity criteria is body mass index $(BMI){\geq}25kg/m^2$. Diagnostic criteria for obesity was defined as a waist circumference of ${\geq}90cm$. The BMI in the obese subjects, as judged by the presence or absence of abdominal obesity, were classified into two groups (non-AO: without abdominal obesity group, AO: with abdominal obesity group). AO presented lower total exercise time, metabolic equivalents (METs) than Non-AO. AO showed slow HRR (heart rate recovery) response. HRR was negative correlated with BMI, body fat mass, waist circumference. AO had a high heart rate and a low cardiac output in submaximal exercise stage 1~2. In conclusion, AO's (with abdominal obesity groups) total exercise time, METs and HRR are lower than Non-AO. HRR is related with BMI, body fat mass and waist circumference.

• Tuberculosis and Respiratory Diseases
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• 제39권4호
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• pp.366-369
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• 1992

A chest x-ray of 68 year old male showed pneumonic consolidation of right lower lung field with blunting of right cardiac border. Computerized tomography of chest revealed infiltrative mass with V-shaped calcification just below right main bronchus. This finding has to be made into differential diagnosis of numerous pulmonary diseases including, mycobacterial disease, neoplasm, lymphadenopathies, and foreign bodies. Initial bronchoscopic findings suggest endobronchial mass lesion on right intermediate bronchus but endobronchial biopsy fail to prove malignant cell or underlying illness. But repeated endobronchial biopsy shows metallic material in the right Intermediate bronchus and we remove it with alligator jaws forcep under bronchoscopy. He was well after discharge.

• Journal of Chest Surgery
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• 제39권4호
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• pp.320-322
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• 2006

60세 남자 환자가 호흡곤란 및 협심증을 의심케 하는 흉통을 주소로 내원하였다. 시행한 비침습성 검사상 좌심방 후면에 종양이 발견되었다. 심폐기하에서 종양제거술을 시행하였다. 종양은 좌심방에서 기시하였으며 다른 장기로의 침범은 없었다. 조직검사상 부분 괴사를 동반한 성숙 지방 세포였으며 지방종으로 확진되었다. 이에 심낭 내 좌심방에서 기원한 드문 심장 지방종을 발표하는 바이다.