• Journal of the Korean association of regional geographers
• /
• v.12 no.3
• /
• pp.364-381
• /
• 2006

Strategies for regional development has been implemented by facilitating the cultural industry since the mid 1990s. The government of Gyeongbuk attempted to establish the cluster of cultural industries and to enhance the capability of cultural industries. However, infrastructure of the industries is still weak. The most cultural industries are small-sized enterprises and are in low value-added production link in the value chain. This research examines the situation of cultural industries and then to recommend the direction of cluster of cultural industries in Gyeongbuk. The cluster of cultural industries in Gyeongbuk needs to be decentralized integration. Cultural industries in Gyeongbuk are found in dispersed regions with own cultural and industrial characteristics. The hub of cluster of cultural industries should be formulated to promote network among cultural industrial complexes in dispersed regions; thus, the hub is able to provide knowledge and information for the cultural industrial firms in Gyeongbuk. The supporting center as the hub of cluster has to input more energy to establish the on-line and off-line network among firms, and between firms and innovation agencies such as universities, cultural industrial organizations, and local governments. The cultural industrial cluster should be linked with IT cluster in Gumi and cluster of Daegu cultural industries to upgrade the value chain of cultural industries.

• Korean Journal of Applied Biomechanics
• /
• v.15 no.3
• /
• pp.143-152
• /
• 2005

The purpose of this study was to predict the failure or success of the Snatch-lifting trial as a consequence of the stand-up phase simulated in Kane's equation of motion that was effective for the dynamic analysis of multi-segment. This experiment was a case study in which one male athlete (age: 23yrs, height: 154.4cm, weight: 64.5kg) from K University was selected The system of a simulation included a multi-segment system that had one degree of freedom and one generalized coordinate for the shank segment angle. The reference frame was fixed by the Nonlinear Trans formation (NLT) method in order to set up a fixed Cartesian coordinate system in space. A weightlifter lifted a 90kg-barbell that was 75% of subject's maximum lifting capability (120kg). For this study, six cameras (Qualisys Proreflex MCU240s) and two force-plates (Kistler 9286AAs) were used for collecting data. The motion tracks of 11 land markers were attached on the major joints of the body and barbell. The sampling rates of cameras and force-plates were set up 100Hz and 1000Hz, respectively. Data were processed via the Qualisys Track manager (QTM) software. Landmark positions and force-plate amplitudes were simultaneously integrated by Qualisys system The coordinate data were filtered using a fourth-order Butterworth low pass filtering with an estimated optimum cut-off frequency of 9Hz calculated with Andrew & Yu's formula. The input data of the model were derived from experimental data processed in Matlab6.5 and the solution of a model made in Kane's method was solved in Matematica5.0. The conclusions were as follows; 1. The torque motor of the shank with 246Nm from this experiment could lift a maximum barbell weight (158.98kg) which was about 246 times as much as subject's body weight (64.5kg). 2. The torque motor with 166.5 Nm, simulated by angular displacement of the shank matched to the experimental result, could lift a maximum barbell weight (90kg) which was about 1.4 times as much as subject's body weight (64.5kg). 3. Comparing subject's maximum barbell weight (120kg) with a modeling maximum barbell weight (155.51kg) and with an experimental maximum barbell weight (90kg), the differences between these were about +35.7kg and -30kg. These results strongly suggest that if the maximum barbell weight is decided, coaches will be able to provide further knowledge and information to weightlifters for the performance improvement and then prevent injuries from training of weightlifters. It hopes to apply Kane's method to other sports skill as well as weightlifting to simulate its motion in the future study.

• Korean Journal of Microbiology
• /
• v.53 no.4
• /
• pp.251-256
• /
• 2017

Some rhizobacteria were isolated, that have copper resistance and can confer copper resistance to plants allowing growth under copper stress. Isolated strains Pseudomonas veronii MS1 and P. migulae MS2 produced 0.13 and 0.26 mmol/ml of siderophore, that is a metal-chelating agent, and also showed 64.6 and 77.9% of biosorption ability for Cu in 20 mg/L Cu solution, respectively. Copper can catalyze a formation of harmful free radicals, which may cause oxidative stress in organisms. Removal activity of 1,1-diphenyl-2-picryl hydrazyl radical and antioxidant capacity of strains MS1 and MS2 increased up to 82.6 and 78.1%, respectively compared to those of control at 24 h of incubation. They exhibited 7.10 and $6.42{\mu}mol$ ${\alpha}$-ketobutyrate mg/h of 1-aminocyclopropane-1-carboxylic acid deaminase activity, respectively, which reduced levels of stress hormone, ethylene in plants, and also produced indole-3-acetic acid and salicyclic acid that can help plant growth under abiotic stress. All these results indicated that these copper-resistant rhizobacteria could confer copper resistance and growth promotion to plants.

• Experimental and Molecular Medicine
• /
• v.50 no.12
• /
• pp.12.1-12.14
• /
• 2018

Osteoporosis develops with high prevalence in both postmenopausal women and hypogonadal men. Osteoporosis results in significant morbidity, but no cure has been established. Mesenchymal stem cells (MSCs) critically contribute to bone homeostasis and possess potent immunomodulatory/anti-inflammatory capability. Here, we investigated the therapeutic efficacy of using an infusion of MSCs to treat sex hormone-deficient bone loss and its underlying mechanisms. In particular, we compared the impacts of MSC cytotherapy in the two genders with the aim of examining potential gender differences. Using the gonadectomy (GNX) model, we confirmed that the osteoporotic phenotypes were substantially consistent between female and male mice. Importantly, systemic MSC transplantation (MSCT) not only rescued trabecular bone loss in GNX mice but also restored cortical bone mass and bone quality. Unexpectedly, no differences were detected between the genders. Furthermore, MSCT demonstrated an equal efficiency in rectifying the bone remodeling balance in both genders of GNX animals, as proven by the comparable recovery of bone formation and parallel normalization of bone resorption. Mechanistically, using green fluorescent protein (GFP)-based cell-tracing, we demonstrated rapid engraftment but poor inhabitation of donor MSCs in the GNX recipient bone marrow of each gender. Alternatively, MSCT uniformly reduced the $CD3^+T$-cell population and suppressed the serum levels of inflammatory cytokines in reversing female and male GNX osteoporosis, which was attributed to the ability of the MSC to induce T-cell apoptosis. Immunosuppression in the microenvironment eventually led to functional recovery of endogenous MSCs, which resulted in restored osteogenesis and normalized behavior to modulate osteoclastogenesis. Collectively, these data revealed recipient sexually monomorphic responses to MSC therapy in gonadal steroid deficiency-induced osteoporosis via immunosuppression/anti-inflammation and resident stem cell recovery.

• Korean Journal of Clinical Laboratory Science
• /
• v.50 no.4
• /
• pp.391-398
• /
• 2018

Mesenchymal stem cells (MSCs) are an attractive resource for refractory patients because of their anti-inflammatory/immunomodulatory capability and multi-lineage differentiation potential. The transplantation of MSCs has led to positive results in preclinical and clinical application to various diseases, including autoimmune disease, cardiovascular disease, cancer, liver cirrhosis, and ischemic stroke. On the other hand, studies have shown that paracrine factors, not direct cell replacement for damaged cells or tissue, are the main contributors in MSC-based therapy. More recently, evidence has indicated that MSC-derived exosomes play crucial roles in regulating the paracrine factors that can mediate tissue regeneration via transferring nucleic acids, proteins, and lipids to the local microenvironment and cell-to-cell communication. The use of these exosomes is likely to be beneficial for the therapeutic application of MSCs because their use can avoid harmful effects, such as tumor formation involved in cell transplantation. Therefore, therapeutic applications using MSC-derived exosomes might be safe and efficient strategies for regenerative medicine and tissue engineering. This review summarizes the recent advances and provides a comprehensive understanding of the role of MSC-derived exosomes as a therapeutic agent.

• Management & Information Systems Review
• /
• v.37 no.4
• /
• pp.219-236
• /
• 2018

The purpose of this study is to investigate the effect of image of brand origin on brand related variables in the formation of attitude or loyalty of global brand, We tried to identify more influential relationships through sub-variables such as brand familiarity, brand identification, and brand attitude. This study presents the following results and implications. It is shown that the manufacturing ability image has no direct effect on brand identification, but the general image has a direct positive effect on brand identification. In addition, the manufacturing capability image and general image of brand origin have indirect effects on brand familiarity through brand identification without directly affecting brand familiarity. In addition, consumers are more likely to be more familiar with brands that they think are consistent with their own images, maintain a good attitude, and be more likely to be loyal to brands. Brand familiarity had a positive effect on brand attitude but not on brand loyalty. Familiarity showed a positive attitude, but it did not necessarily lead to strong repeat purchase or purchase.

• Journal of Space Technology and Applications
• /
• v.1 no.3
• /
• pp.319-336
• /
• 2021

This paper discusses the results of launch environment tests for the engineering qualification model (EQM) of nanosatellite Scale magNetospheric and Ionospheric Plasma Experiment (SNIPE) for scientific missions and lessons learned for the design of nanosatellites. SNIPE is a group of four formation-flying 6U nanosatellites with a range of payloads for missions including space weather measurement. We developed the EQM to verify the preliminary design prior to fabricating the flight model. Launch environment test of EQM was conducted for the first time in 2019, and all failures were corrected and verified at the second test conducted in 2021. A notable point of the two tests is that the nanosatellite deployer used in the first test is different from that of the second test. The second deployer has the capability to fix the internal satellite whereas the first deployer just contains and deploys the satellite. Thus actual mechanical loads the satellite receives is reduced for the second test compared to the first test. This work compares the mechanical responses of two tests and proposes general guidelines for structural design of nanosatellites.

• BMB Reports
• /
• v.55 no.2
• /
• pp.98-103
• /
• 2022

Increased mRNA levels of cancer upregulated gene (CUG)2 have been detected in many different tumor tissues using Affymetrix microarray. Oncogenic capability of the CUG2 gene has been further reported. However, the mechanism by which CUG2 overexpression promotes cancer stem cell (CSC)-like phenotypes remains unknown. With recent studies showing that pyruvate kinase muscle 2 (PKM2) is overexpressed in clinical tissues from gastric, lung, and cervical cancer patients, we hypothesized that PKM2 might play an important role in CSC-like phenotypes caused by CUG2 overexpression. The present study revealed that PKM2 protein levels and translocation of PKM2 into the nucleus were enhanced in CUG2-overexpressing lung carcinoma A549 and immortalized bronchial BEAS-2B cells than in control cells. Expression levels of c-Myc, CyclinD1, and PKM2 were increased in CUG2-overexpressing cells than in control cells. Furthermore, EGFR and ERK inhibitors as well as suppression of Yap1 and NEK2 expression reduced PKM2 protein levels. Interestingly, knockdown of β-catenin expression failed to reduce PKM2 protein levels. Furthermore, reduction of PKM2 expression with its siRNA hindered CSC-like phenotypes such as faster wound healing, aggressive transwell migration, and increased size/number of sphere formation. The introduction of mutant S37A PKM2-green fluorescence protein (GFP) into cells without ability to move to the nucleus did not confer CSC-like phenotypes, whereas forced expression of wild-type PKM2 promoted such phenotypes. Overall, CUG2-induced increase in the expression of nuclear PKM2 contributes to CSC-like phenotypes by upregulating c-Myc and CyclinD1 as a co-activator.

• Tunnel and Underground Space
• /
• v.33 no.4
• /
• pp.228-243
• /
• 2023

Bentonite is widely recognized and utilized as a buffer material in high-level radioactive waste repositories, mainly due to its favorable characteristics such as swelling capability and low permeability. Bentonite buffers play an important role in ensuring the safe disposal of radioactive waste by providing a low permeability barrier and effectively preventing the migration of radionuclides into the surrounding rock. However, the long-term performance of bentonite buffers still remains a subject of ongoing research, and one of the main concerns is the erosion of the buffer induced by swelling and groundwater flow. The erosion of the bentonite buffer can significantly impact repository safety by compromising the integrity of buffer and leading to the formation of colloids that may facilitate the transport of radionuclides through groundwater, consequently elevating the risk of radionuclide migration. Therefore, it is very important to numerically quantify the erosion of bentonite buffer to evaluate the long-term performance of bentonite buffer, which is crucial for the safety assessment of high-level radioactive waste disposal. In this technical note, Two-region model is introduced, a proposed model to simulate the erosion behavior of bentonite based on a dynamic bentonite diffusion model, and quantitative evaluation is conducted for the bentonite buffer erosion with this model.

• Korean small business review
• /
• v.40 no.1
• /
• pp.25-52
• /
• 2018

The purpose of this study is to investigate the relationship between supply chain sustainability antecedent, supply chain competence, and supply chain sustainability. The relationship between supply chain sustainability antecedence factor and supply chain competence, supply chain competence and supply chain sustainability and to identify the differences between sustainability antecedence factors, capacity and sustainability depending on the size of the firm. To accomplish this, each research hypothesis was established and the results are as follows. First, compliance with environmental regulations, NGO response activities, CSR activities, and trade fairness were found to have a significant positive impact on manufacturing agility, environmental management, and social capital. And manufacturing agility, environmental management, and social capital has been confirmed that most of the economic, environmental and social sustainability have a significant positive influence. In addition, it has been confirmed that there are differences in the factors of supply chain sustainability, capacity, and sustainability depending on the size of the company. According to the results of the study, environmental regulation compliance, NGO response activities, CSR activities, and fairness factors selected as the leading factors of supply chain sustainability play a role as fundamental prerequisites for supply chain competence to achieve sustainability. Manufacturing agility, environmental management, and the formation of social capital have confirmed that they can raise the level of economic, environmental and social sustainability. Therefore, it was confirmed that the enhancement of supply chain sustainability precedence factors can lead to enhancement of supply chain competence, and furthermore, sustainability of supply chain. Compared with large corporations, SMEs' supply chain sustainability precedence factor, capacity and sustainability should be further improved.