• Korean Journal of Pharmacognosy
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• v.21 no.1
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• pp.88-91
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• 1990

Potential antimutagenic activities of vegetable plants were investigated. 24 vegetables which are frequently consumed by Korean people were extracted with 70% ethyl alcohol to prepare the extract samples. Then those samples were added to the culture media containing mitomycin C($O.3\;{\mu}g/ml$) and the SOS-Chromotest was performed. Positive control, mitomycin C alone, showed about 330 units of ${\beta}$-galactosidase activities. Among 24 vegetable samples, Saxifraga oblougifolia Nakai (취나물, Saxifragaceae) and Platycodon grandiflorum A. De Candolle(도라지, Campanulaceae) showed 136 and 155 units, respectively when mitomycin C was treated. These results indicate that Saxifragae Herba and Platycodi Radix possess protecting action from mutagenic activity produced by mitomycin C.

• Korean Journal of Pharmacognosy
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• v.26 no.2
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• pp.164-167
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• 1995

The essential oils from the roots of Codonopsis lanceolata and the cultivated callus were analysed and compared by gaschromatography-mass spectrometry. In the experimental study of cell culture, it appeared that 2,4-dichlorophenoxy acetic acid in the culture medium induced higher production of essential oils in the callus than indole acetic acid. The growth of callus was inhibited by illumination of the light. The production of essential oil in cultured cells was increased by the addition of biosynthetic precursors. The essential oils from the roots of Codonopsis lanceolata and the cultured callus showed different compositions. Tetradecanoic acid, 1,1,-dimethoxyl 4-methoxy phenol, 9,12-octadecanoic acid and hexadecanoic acid were identified as main components of the cultured callus oil.

• Korean Journal of Medicinal Crop Science
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• v.22 no.1
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• pp.1-7
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• 2014

Codonopsis lanceolata (Campanulaceae) has been used in traditional medicines, as its roots contain several kinds of 3,28-bidesmosidic triterpenoid saponin with high medicinal values. In this study, we induced hairy root-derived transgenic plants of C. lanceolata and analyzed triterpenoid saponins from the leaf, stem and root. Transgenic plants were regenerated from the hairy roots via somatic embryogenesis. The saponins are lancemaside A, B and E, foetidissimoside A, and aster saponin Hb. Transgenic plants contained richer triterpenoids saponin than wild-type plants. Major saponin lancemaside A was the most abundant saponin in the stem from transgenic-plant, $4.76mg{\cdot}1^{-1}dry$ stem. These results suggest that transgenic plants of C. lanceolata could be used as medicinal materials for the production of triterpene saponins.

• Korean Journal of Plant Resources
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• v.3 no.1
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• pp.41-63
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• 1990

The plants medicinal resources of Mt. Chu-woL were investigated 21times from APril, 1975 to August , 1977 and from JuLy, 1988 to August 1989In orther to analyze the vegetation of Chu-woL mountain area , medical wildplants structure and distribution. MedicaL wild plants of Chu-woL moun-tain consisted of 113 familis, 428 species in alL. The resources of important herb drugs were Polypodiaceae, Graminea, Liliaceae , Polygonaceae,Ranunculaceae, Brassicaceae, Rosaceae , Fabaceae, Apiaceae, tabiatae, so-lanaceae, Scrophulariaceae, Campanulaceae, Compositae. The herb drugswere comparatively more than in other mountains in our country .

• Plant Resources
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• v.6 no.3
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• pp.188-194
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• 2003

Present studies were carried out to produce tetraploid plants by colchicine treatment using seeds, seedlings and shoot tips of Platycodon grandiflorum in Campanulaceae. The most successful colchicine treatment for tetraploid production in P. grandiflorum was soaking treatment using 0.01 and 0.5% colchicine solution for 1 hour and 12 hours, respectively. Morphological characteristics of both diploid and tetraploid were similar, but tetraploid plants had more leaves. Compared to diploid, tetraploid had the larger stomata, but less number of stomata. Fresh weight of tetraploids was 20∼40% heavier than that of diploid.

• Korean Journal of Environment and Ecology
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• v.15 no.4
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• pp.293-318
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• 2002

As one of the botanical hot spots of the Korean peninsula, the vascular plant species in the areas of Taebaeksan, Hambaeksan, Geumdaebong(Peak) and Maebongsan were summarized as 694 taxa, 89 families, 302 genus, 579 species. 102 varieties and 13 forms. Based on the list of rare and endangered plants from the Forest Research Institute and the Ministry of Environment, 22 species were recorded in the studied areas: Thuja koraiensis(Cupressaceae), Arisaema heterophyllum(Araceae), Disporum ovale(Liliaceae), Tricyrtis dialata(Liliaceae), Lilium distichum(Liliaceae), Anemone koraiensis(Ranunculaceae), Rodgersia podophylla(Saxifragaceae), Rosa marretii(Rosaceae), Viola diamantica(Violaceae), Viola albida(Violaceae), Echinopanax horridum(Araliaceae), Acanthopanax chiisannensis(Araliaceae), Lysimachia coreana(Prinmulaceae), Syringa velutina var. kamibayashii, Halenia corniculata(Gentianaceae), Partrinia saniculaefolia(Valerianaceae), Adenophora grandiflora(Campanulaceae), Cacalia pseudo-taimingasa(Compositae) Iris odaesanensis(Iridaceae), Leontice microrhyncha(Berberidaceae), Rpdgersia tabularis(Saxifragaceae), and Acanthopanax sentico년(Araliaceae), Among them the four species were recorded from the list of the Ministry of Environment. As most of the species were recorded from the mountain-trails, the long-term habitat monitoring for the species is required .

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.113.3-114
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• 2003

The increased deposition of extracellular matrix by hepatic stellate cells following liver injury in a process known as activation is considered a key mechanism for increased collagen content of liver during the development of liver fibrosis. In this study, we investigated the protective effects of an aqueous extract from the roots of Platycodon grandiflorum A. DC (Campanulaceae), Changkil (CK), on hepatic fibrosis in hepatic stellate cells. We report that CK reduces the accumulation of collagen in acetaldehyde-induced hepatic stellate cells. (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.221.3-222
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• 2003

Adenophorae Radix, the roots of Adenophora triphylla var. japonica Hara (Campanulaceae) is known to be an anti-inflammatory and antitussive drug used for the treatment of lung disease. However quality control method is not established yet. This study is to establish the quality control method of Adenophorae Radix.From the roots of this plant, we isolated (6R,7R)-E,E-tetradeca-4,12-diene-8,10-diyne-1,6,7-triol (1) as a marker compound for the quality control and determined its content by HPLC-UV detector. (omitted)

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.288.1-288.1
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• 2002

Herbal medicines are increasingly being utilized to treat a wide variety of disease processes. The aim of this study was to evaluate the ability of aqueous extract from the roots of Platycodon grandiflorum A. DC (Campanulaceae). Changkil (CK). to affect cellular response in primary cultures of rat hepatocytes to t-butyl hydroperoxide (t-BHP) induced oxidative stress and hepatotoxicity. CK-treated cells showed an increased resistance to oxidative challenge. as revealed by a higher percent of survival capacity in respect to control cells. CK added prior or simultaneously with I-BHP reduced enganced lipid peroxidation measured as production of malondialdehyde and enhnaced intracellular reduced glutathinoe depletion by t-BHP. Furhtermore. CK protected from the t-BHP-induced intracellular generation of reactive oxygen species assessde by montioting dichlorodihydrofluorescein fluorescence. it can be concluded that CK exerts an antioxidant action insice the cell. responsible for the abserved modulation of the cellular response to oxidative challenge. and CK have a marked anitioxdative and hepatoprotective potency.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.290.2-290.2
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• 2002

The protective effects of a Platycodi Radix (Changkil: CK), the root of Platycodon grandiflorum A. DC (Campanulaceae). on carbon tetrachloride-induced hepatotoxicity and the possible mechanisms involved in this protection were investigated in mice. Pretreatment with CK prior to the administration of carbon tetrachloride significantly prevented the increased serum enzymatic activities of alanine and aspartate aminotransferase in a dose-dependent manner. (omitted)