• Title/Summary/Keyword: c-SCM

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Association between Genetic Polymorphisms of the CYP2C19, CYP2D6 and Types of Sasang Constitutional Medicine (약물대사효소 CYP2C19, CYP2D6의 다형성과 사상체질의 관련성 연구)

  • Lee, Sang-Gyu;Kim, Hyun-Ju;Park, Hye-Jung;Lee, Jung-Ho;Kwon, Deog-Yun;Joo, Jong-Cheon;Choi, Sun-Mi;Lee, Hye-Suk;Kim, Yun-Kyung
    • The Journal of Korean Medicine
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    • v.28 no.1 s.69
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    • pp.51-62
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    • 2007
  • Objectives . The types of Sasang constitutional medicine (SCM) have definite effect on response to herbal drugs. The majority of human P45O dependent xenobiotic metabolism is carried out by polymorphic enzymes which can cause abolished, altered or enhanced metabolism. Therefore, we evaluated the relation of major CYP2C19, 2D6 polymorphism with Sasang types. Methods : 214 healthy subjects were recruited with informed consent; 172 among them had Sasang diagnosis by QSCC2. CYP2D6, 2C19 polymorphism were determined by PCR-RFLP method. Results : None of the Sasang types showed significant difference in CYP2D6, 2C19 polymorphism. However, the Tae-um type showed relatively low frequency of CYP2D6 $^{*}$10/$^{*}$10 polymorphisms with low activity (p=0.110). In the So-yang type, specific $^{*}$3/$^{*}$3 genotype which is a poor metabolizer of CYP2C19$^{*}$3 was detected (p=0.078).Conclusion . These results suggest that the Tae-um type which is said to have high liver function in SCM has the tendency of high drug-metabolizing enzyme activity. With further study, the CYP polymorphism could serve as a scientific tool for SCM diagnosis.

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A Study on Improvement and Estimation of Fatigue Strength in Sintering Spur Gear (소결치차의 성능향상과 강도평가에 관한 연구)

  • 류성기;문봉호
    • Journal of the Korean Society of Safety
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    • v.11 no.3
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    • pp.53-58
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    • 1996
  • This paper deals with the bending fatigue strength of sintering spur gears. The test specimens are used to sintering spur gear to be consisted of Fe-C-Ni-Mn and SCM415 spur gear. The fatigue test at a constant stress amplitude is performed by using an electrohydraulic servo-controlled pulsating tester. The S-N curves are obtained and the enhancement of fatigue strength due to carburized treatment is clarified, Accordingly, this study presents the fatigue strength of sintering spur gear, SCM415 spur gear and carburized gears of them. The strength enhancement due to the carburized treatment is discussed.

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Influence of Ambient Gas Composition on the Microstructure of Plasma Nitrocarburised SCM435 steel (플라즈마 질탄화처리된 SCM435강의 미세조직에 미치는 가스 조성의 영향)

  • Lee, In-Seop
    • Korean Journal of Materials Research
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    • v.12 no.6
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    • pp.427-430
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    • 2002
  • Plasma nitrocarburizing treatment was performed for SCM 435 steel by using a plasma ion nitriding system. The effects of the variation of nitrogen and methan contents upon the hardened layer was investigated. Both the thickness of the compound layer and the amount of $\varepsilon$ phase in the compound layer increased with increasing nitrogen content. However, the thickness of the compound layer decreased due to unstable plasma for an atmosphere containing 90% $N_2$ gas content in the gas mixture. The amount of $\varepsilon$phase in the compound layer increased with increasing $CH_4$ gas content. For $CH_4$ gas content more than 2% in the gas mixture, the thickness of the compound layer decreased due to the formation of $\theta$ phase.

The Effect of the Gas Ration on the Characteristics of Plasma Nitrided SCM440 Steel (SCM440강의 플라즈마 질화특성에 미치는 가스비율의 영향)

  • 김무길
    • Journal of Advanced Marine Engineering and Technology
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    • v.22 no.5
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    • pp.712-720
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    • 1998
  • The effect of H2:N2 gas ratio on the case thickness hardness and nitrides formation in the sur-face of SCM440 machine structural steel have been studied by micro-pulse plasma process. The thickness of compound layer increased with the increase of nitrogen content in the gas com-position. The maximum thickness of compound layer the maximum case depth and the maximum surface hardness were about 15.8${\mu}m$, 400${\mu}m$ and Hv765 respectively in the nitriding condition of 250Pa and 70% nitrogen content at $520^{\circ}C$ for 7hrs. Generally only nitride phases such as ${\'{\gamma}}$($Fe_4N$)$\varepsilon(Fe_2}{_3N}$ phases were detected in compound and diffusion layer by XRD analysis. The amount of $\varepsilon(Fe_2}{_3N}$ phase increased with the increase of nitrogen content. The relative amounts and kind of phases formed in the nitrided case changed with the change of nitrogen content in the gas composition.

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A Study on the Corrosion Fatigue Characteristics of Ion-nitrided SCM4 Steel in Rotationg Bending (이온질화처리한 SCM4 강의 회전굽힘 부식피로 특성에 관한 연구)

  • Lee, Du-Yong;Woo, Chang-Gi
    • Journal of the Korean Society for Precision Engineering
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    • v.6 no.1
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    • pp.75-84
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    • 1989
  • This paper deals with the effect of $N_2$ and $H_2$gas mixture ratio and ion-nitriding time in the corrosion fatigue fracture behavior of ion-nitrided SCM4 steel with notch subject to rotary bending stress. The specimens were treated rapid water cooling after ion-nitriding at $500^{\circ}C$ Torr for 1 hour and 3 hours in gas mixtures of 80% $N_2$and 50% $N_2$. The fatigue limit and the fracture strength of corrosion fatigue depended on $N_2$gas quantity and ion-nitriding time. The ion-nitrided specimens showed about 88 .approx. 158% increase in the fracture strength of corrosion fatigue in $10^6$ cycles than non-nitrided specimens. The corrosion failure is due to corrosion pitting of the surface, and the propargation of cracks started at the surface into the core.

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A Study on the Microstructures and Properties of Sulfnitrided SCM440 Steel by Micro-pulse Plasma (SCM440강에 형성된 플라즈마 침류질화층의 조직과 특성에 관한 연구)

  • 이재식
    • Journal of the Korean institute of surface engineering
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    • v.31 no.5
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    • pp.266-277
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    • 1998
  • The effects of $H_2S$ gas ratio, temperature and time on the case depth, hardness, and sulfide and nitride formation on the surface of sulfnitrided SCM440 steel have been studied by micro-pulse plasma technique. The thickness of compound layer of sulfide and nitride increased with the increase of time, temperautre and $H_2S$ gas ratio. But surface hardness decreased with the increase of soft sulfide layer because the hard nitride layer formed beneath the sulfide. The thickness of sulfide layer was about 10$\mu\textrm{m}$ abpve 0.0088% of $H_2S$ gas. The highest surface hardness of the compound layer was Hv835 at $530^{\circ}C$, 1hr and 0.06% of $H_2S$ gas. X-ray diffraction indicated that the surface products were $Fe_{1_x}S$, $Fe_{2.5}N$ and $Fe_4N$. It was confirmed by EPMA that sulfide only existed in the surface.

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AGS Distribution of Round-oval and Square-Diamond Rolling of SCM435 Steel (SCM435 강의 라운드-오발 및 스퀘어-다이아몬드 압연 공정에서의 AGS 분포)

  • Lee H. W.;Kwon H. C.;Zahiri S. H.;Hodgson P. D.;Im Y. T.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2004.08a
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    • pp.317-326
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    • 2004
  • This study investigated tile local austenite grain size (AGS) distribution In rolling of SCM435 steel which is commonly used for high strength bolt. To investigate AGS distribution, round-oval (R-O) and square-diamond (S-D) rolling experiments were carried out with pilot mill. In round-oval rolling, local AGS has a tendency to increase when it goes to outward. In square-diamond rolling, local AGS has a tendency to increase when it goes to free surface. To investigate relation between AGS and process parameter, three dimensional FE analysis was carried out along with rolling experiment. To validate accuracy of FE analysis, we compared deformed geometry with FE result. The AGS prediction combined AGS model with numerical analysis was also carried out for center node of S-D rolling. Although this study brought experimental observation and its qualitative analysis into focus and quantitative AGS prediction will be done as a further work.

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Gasification reactivity of Chinese Shinwha Coal Chars with Steam (스팀을 이용한 중국산 신화 석탄 촤 가스화 반응에 관한 연구)

  • Kang, Min-Woong;Seo, Dong-Kyun;Kim, Yong-Tak;Hwang, Jung-Ho
    • Journal of the Korean Society of Combustion
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    • v.15 no.1
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    • pp.22-29
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    • 2010
  • In this study, carbon conversion was measured using an electronic mass balance. In a lab scale furnace, each coal sample was pyrolyzed in a nitrogen environment and became coal char, which was then gasified with steam under isothermal conditions. The reactivity of coal char was investigated at various temperatures and steam concentrations. The VRM(volume reaction model), SCM(shrinking core model), and RPM(random pore model) were used to interpret experimental data. For each model the activation energy(Ea), pre-exponential factor (A), and reaction order(n) of the coal char-steam reaction were determined by applying the Arrhenius equation into the data obtained with thermo-gravimetric analysis(TGA). According to this study, it was found that experimental data agreed better with the VRM and SCM for 1,000 and $1,100^{\circ}C$, and the RPM for 1,200 and $1,300^{\circ}C$. The reactivity of chars increased with the increase of gasification temperature. The structure parameter(${\psi}$) of the surface area for the RPM was obtained.

The Effect of Tempering Temperature on Ultrasonic Velocity Property at the Quenched SCM 440 Steel (퀜칭한 SCM 440 강에서 초음파 전파특성에 미치는 템퍼링온도의 영향)

  • Lee, K.W.;Kim, M.I.;Park, U.S.
    • Journal of the Korean Society for Heat Treatment
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    • v.4 no.3
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    • pp.54-62
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    • 1991
  • The effect of tempering temperature on the ultrasonic propagation velocity at SCM 440 steel quenched from $870^{\circ}C$ and $1000^{\circ}C$ has been studied by metallurgical and crystallographical observation. The measurements of ultrasonic velocity were made on the specimen by appling an immersion ultrasonic pulse-echo technique with a constant frequency of 10 MHz. The quenched microstructure of this steel was a lath martensite. As the tempering temperature was increased, the martensite was transformed into the tempered martensite composed of cementite and carbide. The ultrasonic velocity increased with increasing the tempering temperature. It was thought that these were resulted from the microstructural transformation. The change of ultrasonic propagation velocity with quenching and tempering heat treatment was resulted from microstrain due to the change of internal stress. Considering these results concerning to the change of ultrasonic propagation velocity. the phenomena of microstructural transformation were estimated. Consequently, it was thought that the degree of quenching and tempered heat treatment of steel could be nondestructively evaluated with the change of ultrasonic propagation velocity.

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