약물대사효소 CYP2C19, CYP2D6의 다형성과 사상체질의 관련성 연구

Association between Genetic Polymorphisms of the CYP2C19, CYP2D6 and Types of Sasang Constitutional Medicine

  • 이상규 (원광대학교 한의과대학) ;
  • 김현주 (원광대학교 약학대학 한약학과) ;
  • 박혜정 (원광대학교 약학대학 한약학과) ;
  • 이정호 (원광대학교 약학대학 한약학과) ;
  • 권덕윤 (익산원광한의원) ;
  • 주종천 (원광대학교 한의과대학) ;
  • 최선미 (한국한의학연구원) ;
  • 이혜숙 (원광대학교 약학대학 한약학과) ;
  • 김윤경 (원광대학교 약학대학 한약학과)
  • 발행 : 2007.03.30

초록

Objectives . The types of Sasang constitutional medicine (SCM) have definite effect on response to herbal drugs. The majority of human P45O dependent xenobiotic metabolism is carried out by polymorphic enzymes which can cause abolished, altered or enhanced metabolism. Therefore, we evaluated the relation of major CYP2C19, 2D6 polymorphism with Sasang types. Methods : 214 healthy subjects were recruited with informed consent; 172 among them had Sasang diagnosis by QSCC2. CYP2D6, 2C19 polymorphism were determined by PCR-RFLP method. Results : None of the Sasang types showed significant difference in CYP2D6, 2C19 polymorphism. However, the Tae-um type showed relatively low frequency of CYP2D6 $^{*}$10/$^{*}$10 polymorphisms with low activity (p=0.110). In the So-yang type, specific $^{*}$3/$^{*}$3 genotype which is a poor metabolizer of CYP2C19$^{*}$3 was detected (p=0.078).Conclusion . These results suggest that the Tae-um type which is said to have high liver function in SCM has the tendency of high drug-metabolizing enzyme activity. With further study, the CYP polymorphism could serve as a scientific tool for SCM diagnosis.

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