• Composites Research
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• 제14권6호
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• pp.24-31
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• 2001

필라멘트 와인딩 연소관의 제작에 있어서 라이너 표면의 형상과 와인딩되는 섬유각도는 제작 공정상의 편의와 제작 후 구조물의 성능에 큰 영향을 미친다. 본 연구에서는 두 개의 반구를 합친 험상의 라이너 위에 와인딩된 로켓 연소관의 유한 요소 해석을 수행하였다. 32개의 스트레인 게이지를 표면에 부탁한 후 수압실험을 실시하여 유만 요소 해석 과정을 검증하였고, 웨이퍼(wafer)를 통한 국부적 보강 방법에 대한 해석을 수행하였다. 파손에 따른 재료의 비선형 거동을 고려한 점진적 파손 해석을 통해 연소관의 과열 압력과 취약부위에 대한 연구를 수행하였다.

• Journal of Pharmaceutical Investigation
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• 제29권1호
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• pp.21-27
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• 1999

Semi-solid poly(ortho esters) (POE) were prepared to provide bioerodible carriers for sustained drug delivery systems of naloxone (NLX) in the treatment of narcotic addiction. As the POE have viscous behavior at room temperature, a significant advantage of this polymer is that it can be injected without any surgical intervention. The POE was synthesized by a transesterification reaction between 1,2,6-hexanetriol and trimethyl orthoacetate, and the structure of the polymer was confirmed by IR. The in vitro release of the drug from POE was studied. The release rate of NLX decreased with increasing intrinsic viscosities of the polymer. In vivo biocompatibility studies were carried out in rats with NLX loaded POE. Histopathological analysis showed that NLX implants are well-tolerated by rats when used subcutaneously. Pharmacokinetic studies of POE-NLX implants of two different viscosities were carried out in rabbits. In all cases, plasma concentrations of NLX were maintained over 1 ng/ml for at least 168 hours, but initial burst effect was observed. Mean residence time(MRT) was found to depend on the viscosity of the polymer.

• Journal of Pharmaceutical Investigation
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• 제36권2호
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• pp.115-121
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• 2006

The aim of this study was to develop new protein/peptide depot system instead of poly(DL-lactic acid-coglycolic acid) (PLGA) microspheres. Pullulan was chemically modified by the addition of acetic anhydride (pullulan acetate; PA) and then investigated as new depot system for protein/peptide delivery. PA microspheres (PAM) with lysozyme as a model protein were prepared by w/o/w double emulsion method. The microspheres had a mean size of 10-50 mm with a spherical shape. The size distributions reduced with increasing the degree of acetylation. The loading efficiency of lysozyme was also increased. Lysozyme aggregation behavior in the microsphere was monitored to estimate the change of protein stability during preparation step. The ratios of protein aggregation in PAMs are lower than that of PLGA microsphere, in particular, PA 5 showed lowest as about 16%. The result indicated that the increase of acetylation suppressed the aggregation of protein. The release profiles of lysozyme from PAMs were significantly different. High acetylation effectively improved lysozyme release kinetics by reducing initial burst release and extending continuous release over a period of time. To check the effect of preservation for structural stability of lysozyme, the activity of lysozyme released from PA 5 was also observed. The activity of lysozyme was maintained almost 100% for 25 day. Therefore, PAM may become to a useful carrier for delivery of protein/peptide drugs, if it will be supported by biocompatibility and biodegradability results.

• 한국항행학회논문지
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• 제19권3호
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• pp.244-249
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• 2015

본 연구는 지구의 높은 고도에서 핵폭발로 발생된 HEMP (high-altitude electromagnetic pulse)가 발생 즉시 지면에 도달하면서 OFDM (orthogonal frequency division multiplexing) 시스템에 미치는 영향을 분석한다. HEMP가 미치는 영향은 BER (bit error rate) 특성으로 확인한다. 시스템의 Q-factor로 인해 간섭 영향의 지속시간이 변화가 발생한다. Q값이 작으면, 간섭으로부터의 회복이 빠르고, Q값이 크면 영향을 받는 지속시간이 길어져 회복이 300~600%까지 늦어짐을 확인하였다.

• 펄프종이기술
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• 제30권1호
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• pp.29-43
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• 1998

This study was to investigate the effect of .compressive load and cyclic humidity(2$0^{\circ}C$, 65% and 90% RH) on the physical and mechanical properties of corrugated board. Corrugated boards in the study were under compressive load and under cyclic humidity, and their properties were compared to those without load. Results were summarized as follows ; 1 Statistically significant correlation was shown between the ring crush of the boards and the compressive strength of cylinder specimen made from the boards. So we could study the compressive behavior of board with cylinder specimen. 2. The boards under the compressive load increased their moisture content and thickness much more than those without load both in constant and in cyclic RH. 3. The compressive and tensile strength of board samples were inversely and closely proportional to the sheet moisture content regardless of their load and humidity history. 4. The moisture content did not show any significant proportionality to the change of burst strength of boards within this experiment. 5. Board reconditioning in standard condition led to the recovery of the strength loss that had occurred under various load and humidity condition. 6. The handsheets prepared from the boards that had experienced compressive load and cyclic humidity, and those with no-load and 65% RH did not show any significant difference in strength properties. No physical damage or load-carrying properties of the wood fiber were observed by the compressive load and cyclic humidity history.

• Corrosion Science and Technology
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• 제3권6호
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• pp.233-239
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• 2004

Primary water stress corrosion cracking of steam generator tubings occur on many tubes in pressurized water reactors(PWRs), and they are repaired using sleeves or plugs. In order to develop proper repair criteria, it is necessary to know the leak behavior of the tubes, which have stress corrosion cracks. Crack development tests were carried out on the tubes at room temperature, and leak rate and burst pressure were measured on the degraded tubes at room temperature and a high temperature. No leakage was detected on the tubes where 100 % through wall crack developed, at 1560 psi, which is an operating pressure difference of pressurized water reactors(PWRs). In some tests, leak rates of the tubes increased with time at a constant internal water pressure. A test tube showed a very small amount of leakage at 2700 psi in a high temperature pressure test at $282^{\circ}C$, but it disappeared after the pressure increased slightly. Even cracks are 100 % through wall, they need to open in order to reach a certain amount of leak rate at the operating pressure difference.

• ETRI Journal
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• 제29권5호
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• pp.569-595
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• 2007

Particularly in wireless communications, link errors severely affect the quality of the services due to the high error probability and the specific error characteristics (burst errors) in the radio access part of the network. In this work, we show that thorough analysis and appropriate modeling of radio-link error behavior are essential to evaluate and optimize higher layer protocols and services. They are also the basis for finding network-aware cross-layer processing algorithms which are capable of exploiting the specific properties of the link error statistics, such as predictability. This document presents the analysis of the radio link errors based on measurements in live Universal Mobile Telecommunication System (UMTS) radio access networks as well as new link error models originating from that analysis. It is shown that the knowledge of the specific link error characteristics leads to significant improvements in the quality of streamed video by applying the proposed novel network- and content-aware cross-layer scheduling algorithms. Although based on live UMTS network experience, many of the conclusions in this work are of general validity and are not limited to UMTS only.

• International Journal of Industrial Entomology and Biomaterials
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• 제28권2호
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• pp.66-70
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• 2014

In order to the feasibility of silk materials as protein delivery system, silk beads incorporated with bovine serum albumin (BSA) were prepared by dropping silk fibroin extract into dope solution composed of ethanol and dichloromethane. Structural and morphological characteristics of silk beads were examined using scanning electron microscopy (SEM), infrared spectrometry, and X-ray diffractometry. Swelling ratio of silk beads was also measured. Release behavior of prototypical protein, BSA, was studied by observing the electropheretic phenomenon and release profile. SEM showed that silk beads are spherical with porous interior structure. Infrared spectrometry and X-ray diffraction confirm that the silk beads have a ${\beta}$-sheet conformation. The swelling capability of silk beads increased with the incorporation of the protein. The protein was released from the beads with slow release following an initial burst release. Therefore, silk beads show promise as materials for encasing protein drugs to be delivered to targets in the human body.

• Macromolecular Research
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• 제12권3호
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• pp.269-275
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• 2004

To graft N-isopropylacrylamide (NIPAAm) onto alginate, varying dosages of ${\gamma}$-rays were irradiated onto alginate films in deionized water and methanol media, which are non-solvents of alginate. We investigated the hydrogels graft ratio, mechanical strength, swelling kinetics and ratio, and behavior with respect to drug release. The graft yield of NIPAAm increased upon increasing the irradiation dose. The use of the aqueous solution increased the graft yield relative to that obtained in methanol. The mechanical strength of the grafted hydrogels increased after grafting with NIPAAm. In a study of the swelling kinetics, we found that all hydrogels reached an equilibrium swollen state within 3 h. The equilibrium swelling ratio of the hydrogels decreased upon increasing the irradiation dose. The swelling ratio of the hydrogels decreased dramatically between 30 and 35$^{\circ}C$ because phase separation of NIPAAm occurred at 32$^{\circ}C$. The swelling process, with respect to the temperature change, was repeatable. An NIPAAm-grafted alginate containing a drug sustained its release rate until 3 h after an initial high drug release caused by a burst effect.

• 천문학회보
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• 제46권1호
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• pp.51.2-51.2
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• 2021

Nuclear rings are sites of intense star formation at the center of barred spiral galaxies. A straightforward but unanswered question is what controls star formation rate (SFR) in nuclear rings. To understand how the ring SFR is related to mass inflow rate, gas content, and background gravitational field, we run a series of semi-global hydrodynamic simulations of nuclear rings, adopting the TIGRESS framework to handle radiative heating and cooling as well as star formation and supernova feedback. We find: 1) when the mass inflow rate is constant, star formation proceeds in a remarkably steady fashion, without showing any burst-quench behavior suggested in the literature; 2) the steady state SFR has a simple linear relationship with the inflow rate rather than the ring gas mass; 3) the midplane pressure balances the weight of the overlying gas and the SFR surface density is linearly correlated with the midplane pressure, consistent with the self-regulated star formation theory. We suggest that the ring SFR is controlled by the mass inflow rate in the first place, while the gas mass adjusts to the resulting feedback in the course of achieving the vertical dynamical equilibrium.