• Tuberculosis and Respiratory Diseases
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• 제44권3호
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• pp.505-515
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• 1997

배 경 : 폐암환자에서 기관지 침습에 관하여 CT의 정확도를 알아보고, 수술을 시행한 폐암환자에서 CT의 역할을 알아보기 위하여 본 연구를 시행하였다. 대상 및 방법 : 저자들은 폐절제술을 시행한 95명과 엽절제술을 시행한 61명의 수술전 CT를 분석하였다. 엽절제술을 시행 환자중 7명에서는 절제한 기관지 말단에서 암세포가 발견되어 폐절제술을 시행했다. 또한 저자들은 충분한 생검을 한 수술못한 60명의 수술전 CT도 분석하였다. 3mm 이상의 기관지벽의 비후, 불규칙한 기관지벽의 비후 그리고 기관지 직경의 감소를 기관지 침습으로 정하였다. 절제한 기관지 말단의 암세포 발견(20명), 수술한 기관지 말단에서의 폐암재발(6명) 그리고 기관지 생검상 양성(수술 안한군에서 34명)을 기관지 침습으로 생각하였다. 결 과 : 기관지 침습에 관하여 CT는 예민도 (11.5%), 낮은 양성기대치 (38%), 그러나 높은 특이도 (96%), 그리고 비교적 높은 정확도 (84%)를 나타냈으며, 수술 안한 군에서는 높은 예민도(62%), 양성 기대치를 보였다. 결 론 : 시행한 폐암환자에서 CT는 폐암의 기관지 침습에 대하여 예민도와 양성 기대치가 낮았다. 이와 같은 결과로 기관지 침습에 대한 CT의 유용성은 제한적이라 생각되며, 수술전 기관지경에 의한 기관지벽 생검이 필요하리라 생각된다.

• Journal of Chest Surgery
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• 제45권1호
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• pp.49-52
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• 2012

A coronary-bronchial artery fistula is a very rare congenital anomaly of the coronary artery whose etiology and pathogenesis have not yet been clarified. Most patients with coronary-bronchial fistulas are asymptomatic; however, some patients present with congestive heart failure, infective endocarditis, myocardial ischemia induced by a coronary steal phenomenon, or rupture of an aneurysmal fistula. Furthermore, patients with a coronary-bronchial artery fistula rarely manifest life-threatening hemoptysis due to the associated bronchiectasis. We report herein the case of a patient with a coronary-bronchial artery fistula who had bronchiectasis and a history of massive hemoptysis and myocardial ischemia.

• Journal of Chest Surgery
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• 제6권1호
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• pp.41-46
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• 1973

This is a report on four cases of atelectasis which were implicated as one case of mucoid impaction and three cases of blood clots in main bronchus. The 1st case was found to be massive atelectasis on Lt. entire lung due to mucoid impaction with pulmonary tuberculosis. This case was performed the Lt. pneumonectomy. There are contain-ing impacted yellowish-gray jelly like thick materials on the Lt. whole bronchial trees and pathologic findings were consistent with tuberculosis including caseation necrosis and multinucleated giant cell on whole left lung thoroughly in microscopic findings. The 2nd and 3rd case [25 years old female and 30 years old female] were diagnosed as one sided entire lung ateletasis which were led by accumulation of old blood clots on bronchus following incomplete expectoration of sudden massive hemoptysis from pulmonary tuberculosis lesion. These two cases were recovered by removal of blood clots and bronchial irrigation under bronchoscopy. Follow up chest film revealed well aeration. The 4th case [45 years old] was taken the removal of old blood clots and tissue debris under the bronchoscopy as bronchial obstruction following massive hemoptysis. The cytologic findings revealed the class III in fresh sputum and class 1V in bronchial irrigation which may suggest of malignancy. However, we could not found the causative lesions suggestive malignancy by the bronchography and other diagnostic measurements.

• Journal of Chest Surgery
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• 제25권11호
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• pp.1299-1304
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• 1992

We experienced 5 cases of tracheal stenosis and 7 cases bronchial stenosis treated surgically at the Department of Thoracic and Cardiovascular Surgery, School of Medicine, Hanyang University during 5 years. The causes of tracheal stenosis were prolonged endotracheal intubation 1 case, tracheostomy 1 case, the sequela of endobronchial tuberculosis 2 cases and tracheomalacia 1 case. The causes of bronchial stenosis were all endobronchial tuberculosis. The managements of tracheal stenosis were tracheal resection and end to end anastomosis. The resected lengths of trachea were 1.5cm, 3cm and 7.5cm. One case of suglottic stenosis was underwent the resection of trachea, 8cm in length, and the laryngotracheal anastomosis was done, but the re-stenosis of trachea was developed after 4 weeks post-operatively. One case of tracheomalacia was done permanent tracheostomy only, because the entire trachea was adhered to the surrounding tissue. The managements of bronchial stenosis were resection of involved lobe or one lung, in the 5 case. One case with Lt. main bronchial stenosis and atelectasis of Lt. upper lobe was done the lobectomy of Lt. upper lobe only and then, the Lt. pneumonectomy was done re-operatively because the atelectasis of Lt. lower lobe had continued. The other one case with stenosis of Rt. main bronchus, failed the insertion of metalic stent, was underwent the Rt. upper lobe lobectomy, sleeve resection and side to end anastomosis

• Tuberculosis and Respiratory Diseases
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• 제41권2호
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• pp.73-86
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• 1994

In addition to classic cholinergic and adrenergic pathways, the existence of a third division of autonomic control in the human airways has been proved. It is called a nonadrenergic noncholinergic(NANC) nervous system, and difficult to study in the absence of specific blockers. Neuropeptides are certainly suggested to be transmitters of this NANC nervous system. It is very frustrating to understand the pathophysiologic role of these peptides in the absence of any specific antagonists. However, further studies of neuropeptides might eventually lead to novel forms of treatment for bronchial asthma. Another study of the interaction between different components of the autonomic nervous system, either in ganglionic neurotransmission or by presynaptic modulation of neurotransmitters at the end-organ will elute neural control in airway disease, particularly in asthma. Studies of how autonomic control may be disordered in airway disease should lead to improvements in clinical management. Epithelial damage due to airway inflammation in asthma may induce bronchial hyperresponsiveness. Axon reflex mechanism is one of possible mechanisms in bronchial hyperresponsiveness. Epithelial damage may expose sensory nerve terminals and C-fiber nrve endings are stimulated by inflammatory mediators. Bi-directional communication between the nerves and mast cells may have important roles in allergic process. The psychological factors and conditioning of allergic reactions is suggested that mast cell activation might be partly regulated by the central nervous system via the peripheral nerves. Studies in animal models, in huamn airways in vitro and in patients with airway disease will uncover the interaction between allergic disease processes and psychologic factors or neural mechainsms.

• Journal of Chest Surgery
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• 제36권11호
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• pp.874-877
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• 2003

괴사성 기관지 국균증은 대부분 면역 기능이 저하된 환자에서 발생하며 국균이 기관지 상피를 침범하여 기관지 내에 종괴나 협착을 유발하는 질환이다. 당뇨병이 있는 78세 남자가 호흡곤란과 기침을 주소로 내원하여 시행한 단순 흉부 X-선 촬영과 흉부 전산화 단층 촬영 결과 좌상엽 기관지를 완전히 막고 있는 종괴와 좌상엽의 허탈이 발견되었고, 기관지 내시경을 통한 생검 결과 만성 염증 소견을 보였다. 확진과 치료를 위해 시험적 개흉술을 통해 좌상엽 소매 절제술을 시행하였고 치종 조직검사 상 괴사성 기관지 국균증으로 진단되었다. 저자들은 당뇨병이 있는 고령의 환자에서 발생한 괴사성 기관지 국균증 1예를 문헌 고찰과 함께 보고하는 바이다.

• 한방안이비인후피부과학회지
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• 제16권3호
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• pp.82-95
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• 2003

Chemokines are important for the recruitment of leukocytes to sites of infection, which is essential in host defense. The thymus and activation-regulated chemokine (TARC) is a CC chemokine which potentially plays a role via a paracrine mechanism in the development of allergic respiratory diseases. Objectives : The objective of this study is to investigate the effect of Youn-Gyo-Pae-Doc-San on the secretion of TARC of human bronchial epithelial cell Methods : Enzyme-linked immunosorbent assay (ELISA) was performed to detect the secretion of TARC. The cytotoxicity was measured by MTT assay. Results : Youn-Gyo-Pae-Doc-San significantly inhibited the secretion of TARC with a dose -dependant manner. The effective dosage did not have the cytotoxicity on human bronchial epithelial cell. Conclusions : Results of our study show that Youn-Gyo-Pae-Doc-San would play an important role in modulation of TARC in human bronchial epithelial cells.

• Tuberculosis and Respiratory Diseases
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• 제41권3호
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• pp.299-301
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• 1994

저자들은 폐결핵으로 우중엽절제술 후 발생한 기관지 단단 국균증을 기관지 내시경으로 진단, 치료한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Korean Journal of Acupuncture
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• 제22권1호
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• pp.23-32
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• 2005

Chemokines are important for the recruitment of leukocytes, which is essential in host defense to the sites of infection. The thymus and activation-regulated chemokine (TARC) is a CC chemokine which potentially plays a role via a paracrine mechanism in the development of allergic respiratory diseases. Objectives : The objective of this study is to investigate the effect of Ephedrae Herba Herbal Acupuncture Solution(EHS) on the secretion of TARC of human bronchial epithelial cell. Methods : Enzyme-linked immunosorbent assay (ELISA) was performed to detect the secretion of TARC. The cytotoxicity was measured by MTT assay. Results : EHS significantly inhibited the secretion of TARC with a dose-dependant manner. The effective dosage did not have the cytotoxicity on human bronchial epithelial cell. Conclusion : Results of our study imply that EHS would play an important role in modulation of TARC in human bronchial epithelial cells by MTT assay.

• Journal of Chest Surgery
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• 제24권5호
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• pp.480-484
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• 1991

Traumatic rupture of the main bronchus is comparatively very rare. With the advent of widespread mechanization and high-speed era, the incidence of traumatic rupture of the tracheobronchial tree has been increased considerably. Rupture of the bronchus is an unusual result of nonpenetrating trauma to the chest. Early recognition of bronchial rupture and emergency thoracotomy and management is essential for reducing of morbidity, mortality and late complications. We experienced 3 cases of bronchial rupture caused by nonpenetrating chest trauma with or without rib fracture. Patients were suffered from dyspnea and chest pain. After closed thoracostomy, corrective surgery was performed. Postoperative courses were uneventful and discharged without any complication.