• ETRI Journal
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• 제40권6호
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• pp.802-812
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• 2018

Disease discrimination using an electronic nose is achieved by measuring the presence of a specific gas contained in the exhaled breath of patients. Many studies have reported the presence of acetone in the breath of diabetic patients. These studies suggest that acetone can be used as a biomarker of diabetes, enabling diagnoses to be made by measuring acetone levels in exhaled breath. In this study, we perform a chemical sensor array optimization to improve the performance of an electronic nose system using Wilks' lambda, sensor selection based on a principal component (B4), and a stepwise elimination (SE) technique to detect the presence of acetone gas in human breath. By applying five different temperatures to four sensors fabricated from different synthetic materials, a total of 20 sensing combinations are created, and three sensing combinations are selected for the sensor array using optimization techniques. The measurements and analyses of the exhaled breath using the electronic nose system together with the optimized sensor array show that diabetic patients and control groups can be easily differentiated. The results are confirmed using principal component analysis (PCA).

• 한국운동역학회지
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• 제19권4호
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• pp.627-636
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• 2009

본 연구는 한국무용 시 내면의 아름다움뿐만 아니라, 외면으로 표현되고 기술적으로 한층 세분화된 한국무용의 호흡에 대한 중요성을 인식하는 연구의 필요성을 갖고, 호흡의 사용이 한국무용 걸음체 동작에 어떠한 영향을 미치는 가를 분석하여, 무용의 추상적인 아름다움을 과학적인 근거로 명확하게 제공하는 데 연구의 목적을 갖는다. 연구 결과, 호흡을 사용한 걸음체가 호흡을 사용하지 않는 걸음체 보다 신체중심과 골반이 이동변위가 낮게 나타났다. 슬관절과 족관절의 각변위에서 호흡을 사용하는 걸음체가 호흡을 사용하지 않는 걸음체보다 굴곡되어 굽힘이 많이 사용되었고, 이것은 굴신이 일어나고 있는 시전에서 나타났다. 호흡을 사용한 걸음체 동작은 수직지면반력에서 호흡을 사용하지 않은 걸음체에서 볼 수 없는 pre정점이 나타났고 이것은 한국무용 걸음체 시 호흡이 시작되는 들숨의 시점을 의미하며, 뒤꿈치 닿는 구간(1정점)에서 호흡을 사용한 걸음체의 부하 값이 날숨에 의해 호흡을 사용하지 않는 걸음체 보다 부하 값이 더 크게 나타났다. 전후지면반력 결과 호흡을 사용한 걸음체가 제동력이 더욱 크게 나타났다.

• 한국환경과학회지
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• 제7권3호
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• pp.301-310
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• 1998

Recently, bathes have been suspected to an Important source of indoor exposure to volatile organic compounds(VOCs). Two experiments were conducted to evaluate chloroform exposure and corresponding body burden by exposure routes while bathing. Another experiment was conducted to ekamine the chloro- form dose during dermal exposure and the chloroform decay In breath after dermal exposure. The chioroform dose was determined based on exhaled breath analysis. The ekamine breath concentration measured after normal baths (2.8 Vg/$m^3$) was approxidmately 13 tomes higher that measured prior to normal bathes (0.2 ug/$m^3$). Based on the means of the normalized post exposure chloroform breath concentration. the dermal exposure was estimated to contribute to 74% of total chloroform body burden while bathing. The Internal dose from bathing (Inhalation plus dermal) was comparable to the dose ostimated Srom dally water Ingestion. The rusk associated 10 a weekly, 30-min bath was estimated to be 1 x 10.5, while the rusk firom dally Ingestion of tap water was to be $0.5{\times}0^{-5} for 0.151 and 6.5{\times}10^{-5}$ for 2. 0 1. Chloroform breath concentration Increased gradually during the 60 minute dermal exposure. The breath decay after the dermal exposure showed two-phase mechanism, with early raped decay and the second slow decay. The mathematical model was developed to describe the relationship between water and air chloroform concentrations, with $R^2$ : 0.4 and p<0.02.

• 한국식품영양과학회:학술대회논문집
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• 한국식품영양과학회 2001년도 International Symposium on Food,Nutrition and Health for 21st Century
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• pp.140-151
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• 2001

This study was performed to examine a possible application of the beverage as a bad breath controlling food. To achieve this objective, methods of gas chromatography, electronic nose, sensory analysis and halimeter were used to detect reduction in odor intensities of bad breath caused by the functional beverage as well as its active ingredients. According to results of GC and electronic nose, adding green tea and champignon extracts to bad breath indicators, methylmercaptan and trimethylamine, resulted in significant reduction in headspace concentrations of two indicators. GC results revealed that headspace concentrations of 5 ug/ml of methylmercaptan and 30 ug/ml of trimethylamine added to various concentrations of two extracts were reduced up to $100\%$ after incubating mixtures at $37^{\circ}C$ for 5min. When the functional beverage was properly formulated with green tea extract, champignon extract and $\alpha$-cyclodextrin and evaluated for its deodorizing effect systematically, it also showed distinctive deodorizing activities against bad breath indicators. Conclusively, results obtained from this study might encourage introduction of a new type of bad breath control food in near future.

• 말소리와 음성과학
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• 제11권4호
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• pp.109-116
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• 2019

본 연구는 정상군과 음성장애 환자군의 문단낭독 시 휴지 및 호흡단락 특성을 파악해보고자 시행되었다. 정상군 40명과 기능적 음성장애 환자군 40명을 대상으로 PAS(Phonatory Aerodynamic System) 중 Running Speech를 이용하여 '가을' 문단을 낭독하게 하였다. 이를 통해 흡기 동반 및 미동반, 어절간 및 어절내 휴지와 호흡단락을 구분하고 이에 대한 기술통계 및 집단간 통계적 유의성을 검증하였다. 그 결과 흡기를 동반한 휴지횟수는 환자군이 더 높았으나 흡기를 동반하지 않은 휴지횟수는 정상군이 더 높은 수치를 보였다. 어절경계 중 휴지가 동반된 비율은 환자군이 더 높았고 호흡단락당 음절수는 정상군이 유의하게 더 높았다. 음성장애 화자군은 성대폐쇄부전으로 인한 호흡지지가 정상군보다 부족하므로 휴지 시 흡기를 동반하는 경우나 호흡단락의 수가 더 많은 것으로 사료된다. 이는 일상대화의 자연스러움을 저해할 수 있으므로 음성장애 화자의 중재 시 휴지와 호흡단락의 빈도를 적절히 조절하는 것도 평가 및 중재에 포함해야 할 것이다.

• 센서학회지
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• 제22권3호
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• pp.219-222
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• 2013

The exhaled breath contains gases generated from human body. When disease occurs in the body, exhaled breath may include gas components released from disease metabolism. If we can find specific elements through analysis of the exhaled gases, this approach is an effective way to diagnose the disease. The lung function has a close relationship with exhalation. Exhaled gases from COPD (Chronic Obstructive Pulmonary Disease) patients can be analyzed by gas chromatography-mass spectroscopy (GC-MS) and a gas sensor system. The exhaled breath for healthy person and COPD patients had different components. Significantly more benzendicarboxylic acid was detected from COPD patients than in healthy persons. In addition, patients had a variety of decane. Phosphorous compounds with different isomers were detected from patients. The results obtained by gas sensor system were processed by PCA (Principal Component Analysis). The PCA results revealed distinct difference between the patients and healthy people.

• 대한한의진단학회지
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• 제12권2호
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• pp.96-106
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• 2008

Background and purpose : Health is characterized by variability and a loss variability is associated with aging and disease. Normal healthy respiratory patterns are characterized by breath to breath variability. Cold-Heat score are quantified indices in Korean Medicine. The aim of this study is to analyze relations between 9 respiratory indices (including breath to breath variability) and cold-heat score by questionnaire. Method : Respiratory data were measured during 15 minutes and transferred to text file. We calculated 9 respiratory parameters in use of MATLAB7.1. After then we did correlation analysis of 9 respiratory indices and cold-heat score Results and conclusion : EIratio is showed significant correlation with Cold score and weighted Heat score.

• 한국환경과학회지
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• 제1권1호
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• pp.47-51
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• 1992

수중에 존재하는 휘발성 유기화합물은 샤워를 하는동안 공기로 방출되고 공기농도는 샤워 변수에 따라 달라지는데, 이는 휘발성 유기화합물의 호기농도의 변화를 야기 시킨다. 본 연구에서는 샤워를 하는 동안 공기중의 클로로포픔 노출에 영향을 미치는 주요한 샤워변수(물온다 및 노출시간)를 클로로포픔 호기농도를 측정하여 검토 하였다. 크롤로포름 호기농도는 물의 온도와 노출 시간이 증가함에 따라 증가 하였다. 가장 큰 클로로포름 호기농도 차이를 나타내는 두개의 흡기 노출 조건은 미지근한 물을 이용한 5분 동안의 노출과 더운 물을 이용한 15분 동안의 노출이었다. 클로로포름 호기농도는 후자의 노출후에 전자의 경우보다 거의 3배 정도 높았다. 주요 샤워변수와 수중농도로 조정된 호기농도 사이의 수학모델은 0.0001의 확률에서의 데이타와 훌륭한 일치되는 결과를 나타내었다.

• Biomolecules & Therapeutics
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• 제6권1호
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• pp.9-13
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• 1998

ln an attempt to define the effects of hyperbaric oxygen treatment on the lipid peroxidation and oxygen See radical reactions in rats exposed to carbon monoxide, we studied malondialdehyde(MDA) level and activities of catalase and superoxide dismutase in the heart of the rats exposed to carbon monoxide. Male Sprague-Dawley albino rats weighing 240 to 260gm were used. Experimental groups consist of Control group (=breathing with air), HBO group(=exposed to hyperbaric oxygen(HBO, 3ATA, 100%) after air breath), CO group(=exposed to CO(3,970 ppm) after air breath), CO-Air group(=exposed to CO after air breath followed by air breath) and CO-HBO group(=exposed to CO after ai. breath followed HBO treatment). The CO group showed significantly higher MDA level, catalase activity and SOD activity as compared to that of control group. The CO-HBO group showed significantly lower MDA level as compared to that of CO group, and did not show significantly lower catalase activity and SOD activity as compared to that of CO group. These results suggest that the excessive oxygen free radicals is an important determinant in pathogenesis of Co-induced cardiotoxicity and HBO inhibits the lipid peroxidation caused by excessive oxygen free radicals in the heart of the rats exposed to carbon monoxide.

• Biomolecules & Therapeutics
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• 제7권2호
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• pp.121-126
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• 1999

In an attempt to define the effects of hyperbaric oxygen treatment on the lipid peroxidation and oxygen free radical reactions in rats exposed to carbon monoxide, we studied malondialdehyde (MDA) level and activities of catalase and superoxide dismutase in the kidney of the rats exposed to carbon monoxide. Male Sprague-Dawley albino rats weighing 240 to 260 gm were used. Experimental groups consist of Control group (=breathing with air), HBO group (=exposed to hyperbaric oxygen 〔HBO, 3ATA, 100%〕 after air breath), CO group (=exposed to CO〔3,970 ppm〕after air breath), CO-Air group (=exposed to CO after air breath followed by air breath) and CO-HBO group (=exposed to CO after air breath followed HBO treatment). The CO group showed significantly higher MDA level, catalase activity and SOD activity as compared to that of control group. The CO-HBO group showed significantly lower MDA level as compared to that of CO group, and did not show significantly lower catalase activity and SOD activity as compared to that of CO group. These results suggest that the excessive oxygen free radicals is an important determinant in pathogenesis of CO-induced nephrotoxicity and HBO inhibits the lipid peroxidation caused by excessive oxygen free radicals in the kidney of the rats exposed to carbon monoxide.