• 제목/요약/키워드: breast carcinoma

검색결과 595건 처리시간 0.037초

SLC35B2 Expression is Associated with a Poor Prognosis of Invasive Ductal Breast Carcinoma

  • Chim-ong, Anongruk;Thawornkuno, Charin;Chavalitshewinkoon-Petmitr, Porntip;Punyarit, Phaibul;Petmitr, Songsak
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권15호
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    • pp.6065-6070
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    • 2014
  • Background: Breast cancer is the most common malignancy in women worldwide, including Thailand, and is a major cause of mortality and morbidity, despite advances in diagnosis and treatment. Novel gene expression in breast cancer is a focus in searches for prognostic biomarkers and new therapeutic targets. Materials and Methods: The mRNA expression of novel B4GALT4, SLC35B2, and WDHD1 genes in breast cancer were examined in invasive ductal breast carcinoma (IDC) patients using quantitative real-time reverse transcription polymerase chain reaction (QRT-PCR). Results: Among these genes, increased expression of SLC35B2 mRNA was significantly associated with TNM stage III + IV of IDC (p<0.001). Hence, up-regulation of SLC35B2 may serve as a prognostic biomarker for poor prognosis, and is also a potential therapeutic target in breast cancer.

Expression of DNA Methylation Marker of Paired-Like Homeodomain Transcription Factor 2 and Growth Receptors in Invasive Ductal Carcinoma of the Breast

  • Rahman, Wan Faiziah Wan Abdul;Fauzi, Mohd Hashairi;Jaafar, Hasnan
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권19호
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    • pp.8441-8445
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    • 2014
  • Background: Paired-like homeodomain transcription factor 2 (PITX2) is another new marker in breast carcinoma since hypermethylation at P2 promoter of this gene was noted to be associated with poor prognosis. We investigated the expression of PITX2 protein using immunohistochemistry in invasive ductal carcinoma and its association with the established growth receptors such as estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth receptor 2 (HER2). Methods: We conducted a cross sectional study using 100 samples of archived formalin-fixed paraffin embedded tissue blocks of invasive ductal carcinoma and stained them with immunohistochemistry for PITX2, ER, PR and HER2. All HER2 with scoring of 2+ were confirmed with chromogenic in-situ hybridization (CISH). Results: PITX2 protein was expressed in 53% of invasive ductal carcinoma and lack of PITX2 expression in 47%. Univariate analysis revealed a significant association between PITX2 expression with PR (p=0.001), ER (p=0.006), gland formation (p=0.044) and marginal association with molecular subtypes of breast carcinoma (p=0.051). Combined ER and PR expression with PITX2 was also significantly associated (p=0.003) especially in double positive cases. Multivariate analysis showed the most significant association between PITX2 and PR (RR 4.105, 95% CI 1.765-9.547, p=0.001). Conclusion: PITX2 is another potential prognostic marker in breast carcinoma adding significant information to established prognostic factors of ER and PR. The expression of PITX2 together with PR may carry a very good prognosis.

유방의 점액성 암종의 진단시 세침흡인 검사의 의의 (Value of Fine Needle Aspiration Cytology of Mucinous Carcinoma of the Breast)

  • 김윤정;공경엽;허주령;박정미;안세현;김온자
    • 대한세포병리학회지
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    • 제7권2호
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    • pp.157-162
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    • 1996
  • Fine needle aspiration(FNA) is an effective tool in diagnosing mammary carcinoma. We experienced 7 cases of histologically confirmed mammary mucinous carcinoma among 3,052 aspirated cases of breast from 1992 to 1996 in Asan Medical Center. The average age of the patient was 48(33-64) years. The mean size of the lesions was $1.6(0.7{\sim}3)cm$, and they were palpated as well-defined, firm to hard masses. The cytologic features that may be useful in making a FNA diagnosis of mucinous carcinoma of the breast were analysed. Mucinous background and tumor cell clusters with occasional single cells were observed in all cases. Among them, two cases showed abundant scattered single cells, whereas only few single cells were seen in the other two cases. Tumor cells exhibited mild pleomorphism in four cases and moderate pleomorphism in three cases. Nucleoli tended to be not prominent and are observed in three cases, rarely noted in other three cases and not seen in one. There was microcalcification in four cases(57%). In conclusion, mucinous background and clustered tumor cells showing mild to moderate pleomorphism with characteristic clinical findings allow us to diagnose mucinous carcinoma of the breast.

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유방촬영술에서 거친 석회화 종괴로 관찰된 점액 유방암: 증례 보고 (Mucinous Breast Carcinoma Presenting as a Coarse and Densely Calcified Mass on Mammography: A Case Report)

  • 신기원;박하영;박영미
    • 대한영상의학회지
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    • 제81권5호
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    • pp.1266-1271
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    • 2020
  • 저자들은 유방촬영술에서 밀도 높고 거친 석회화 종괴로 관찰된 점액 유방암 증례를 보고한다. 병변은 초음파 영상에서 4.6 cm 크기의 고에코성, 후방음영 증강 및 석회화를 동반한 종괴로 관찰되었다. 이러한 영상의학적 소견은 점액암의 비특징적인 소견으로서, 연골형 분화의 화생성 암, 유방의 골외성 골육종, 연골육종 등에서 나타날 수 있는 소견으로 알려져 있다. 이 병변은 4년간 서서히 증가되는 양상으로 관찰되었으며 당시에는 이형성 석회화 양상으로 관찰되었다. 점액암을 포함한 몇 가지의 드문 아형의 유방암이 거친, 밀도 높은 석회화 종괴로 관찰될 수 있으므로, 즉각적인 생검이 고려되어야 할 것이다.

유방의 표피낭종에서 발생한 편평세포암종: 영상 소견 및 문헌고찰 (Squamous Cell Carcinoma Arising from Epidermal Inclusion Cyst of Breast: Imaging Findings and Literature Review)

  • 한영주;김유미
    • 대한영상의학회지
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    • 제84권3호
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    • pp.776-781
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    • 2023
  • 표피낭종은 중층 편평상피로 구성되어 있는 진피층에서 흔하게 발생하는 양성질환으로, 유방을 포함한 신체 모든 부위에서 발생할 수 있다. 유방에서의 표피낭종은 임상에서 흔하게 볼 수 있으나, 임상적인 중요성이 떨어져 보고된 바가 적고, 표피낭종의 악성변형은 발생 빈도가 0.011%-0.045% 정도로 매우 드물다. 저자들은 침윤성 유관암의 과거력이 있는 환자에게서 발생한 유방의 표피낭종에서 기원한 편평세포암종에 대한 증례를 보고하고자 한다.

Current Progress in the Treatment of Metaplastic Breast Carcinoma

  • Hu, Qing;Chen, Wei-Xian;Zhong, Shan-Liang;Li, Jian;Luo, Zhou;Tang, Jin-Hai;Zhao, Jian-Hua
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권11호
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    • pp.6221-6225
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    • 2013
  • Metaplastic breast cancer (MBC) is a rare type of breast carcinoma, characterized by various combinations of mesenchymal, adenocarcinoma and other epithelial components. MBC often manifests as a large mass, with low axillary lymph node involvement and poor prognosis. Knowledge and treatment patterns about MBC demographics, presentation and tumor characteristics are very limited. In clinical practice, MBC is usually treated based on the guidelines developed for infiltrating ductal carcinoma (IDC). The ideal treatment paradigm for MBC is unknown due to its low incidence and pathological variability, so potential predictors of treatment efficacy need to be explored. This review summarizes the current models and strategies for MBC according to the published literature.

Myiasis in Ulcerated Breast Carcinoma: First Case Record in Myanmar

  • Wai, Aung Phyo;Maw, Win Win;Boonmars, Thidarut
    • Parasites, Hosts and Diseases
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    • 제60권2호
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    • pp.139-141
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    • 2022
  • Myiasis is an infestation of maggot, which is frequently associated with poor personal hygiene and environmental sanitation. A 78-year-old female breast cancer patient visited clinic complaining of irritation, itching, and pain within the ulcerous cancer lesion for 3 weeks. Many maggots were found in the lesion. A total of 30 maggots were removed and identified to be 3rd stage of larvae of metallic fly. This is the first case of wound myiasis in advanced breast carcinoma as a complication of untreated or drug-induced ulcer.

유방 섬유선종과 유방암종의 화상 계측에 관한 연구 - 세침 홉인 세포 검사와 조직 검사간의 비교를 중심으로 - (Nuclear Morphometry of Fibroadenoma and Carcinoma of Breast - Comparison between fine needle aspiration cytology and biopsy -)

  • 손진희;최영희;박영의
    • 대한세포병리학회지
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    • 제9권2호
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    • pp.161-168
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    • 1998
  • Primary breast lesions diagnosed by fine needle aspiration cytology, confirmed by histologic examination were analyzed by morphometry to evaluate the difference between benign and malignant lesions, and the methods obtaining the sample. four size factors and 5 form factors were evaluated in 22 fibroadenomas and 20 carcinomas by image analyzer(Zeiss Ibas 2000) using the H-E stained slides. Nuclear size was significantly larger in the carcinoma cells than fibroadenoma cells both in the cytology and biopsy specimens, but the form factors were not significantly different. Both fibroadencma and carcinoma cells were significantly larger in cytologic smear than histologic section. The cells in the cytology were more regular and round than those in histology, but not statistically significant. Fibroadenomas having cellular proliferation and atypism exhibited larger size and more irregular nuclei than non-proliferative fibroadenoma, but not statistically significant. Therefore nuclear morphometric analysis can be a helpful method to diagnose the questionable breast lesions and is a method appropriate for use as a quality control procedure in the fine needle aspiration cytology.

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유방암의 Imprint 표본에서 p53 단백 발현 (p53 Protein Expression in Imprint Cytology of Breast Carcinoma)

  • 김동석;이은희;김기권;김미진;이수정
    • 대한세포병리학회지
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    • 제6권1호
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    • pp.1-9
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    • 1995
  • This study was carried out to determine the usefulness of imprint cytology for detecting p53 protein in breast carcinoma. NCL-DO7 (Novocastra, U.K.) was used to detect p53 protein immunocytochemically. A total of 33 cases was studied, Immunostaining of imprint cytology with NCL-DO7 was positive in 64% (21/33) and showed relatively high coincident rate (80%) with immunostaining of formalin-fixed, paraffin-embedded specimen p53 protein was related to negative estrogen receptor status, but not to the nuclear grade, lymph node metastasis, or tumor size. The fact that p53 protein expression was not related to nuclear grade might be due to predominance of nuclear grade 3. It was easier to determine the nuclear grade is one of the most important prognostic factors, in imprint cytology than in tissue specimen. p53 protein tended to be stained more strongly in imprint cytology than in tissue. It is concluded that the application of imprint cytology in p53 protein detection can be performed easily, and that it may contribute to the evaluation of prognostic factors in breast carcinoma.

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유방의 침윤성 미세유두암종의 세침흡인 세포검사 (Fine Needle Aspiration Cytology of Invasive Micropapillary Carcinoma of the Breast)

  • 최현주;정지한;신정하;민기옥;강석진;이교영;유진영
    • 대한세포병리학회지
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    • 제18권1호
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    • pp.62-68
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    • 2007
  • Invasive micropapillary carcinoma (IMPC) of the breast is recently described rare variant of invasive ductal carcinoma. This variant has a distinctive histological features and aggressive biological behavior. We reviewed the cytologic features of eight cases of IMPC. The cytologic smears showed moderate to high cellularity and the tumor tissue was composed of atypical, angulated, cohesive clusters of neoplastic cells with a papillary to tubuloalveolar architecture, and a morular growth pattern without fibrovascular cores was seen on the histopathology. IMPC of the breast has distinctive cytologic features and it is important to make an early diagnosis via fine needle aspiration cytology due to this tumor's aggressive behavior.