Fine Needle Aspiration Cytology of Invasive Micropapillary Carcinoma of the Breast

유방의 침윤성 미세유두암종의 세침흡인 세포검사

  • Choi, Hyun-Joo (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Jung, Ji-Han (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Shin, Jung-Ha (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Min, Ki-Ouk (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Kang, Seok-Jin (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Lee, Kyo-Young (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Yoo, Jin-Young (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea)
  • 최현주 (가톨릭대학교 의과대학 병원병리학교실) ;
  • 정지한 (가톨릭대학교 의과대학 병원병리학교실) ;
  • 신정하 (가톨릭대학교 의과대학 병원병리학교실) ;
  • 민기옥 (가톨릭대학교 의과대학 병원병리학교실) ;
  • 강석진 (가톨릭대학교 의과대학 병원병리학교실) ;
  • 이교영 (가톨릭대학교 의과대학 병원병리학교실) ;
  • 유진영 (가톨릭대학교 의과대학 병원병리학교실)
  • Published : 2007.03.30

Abstract

Invasive micropapillary carcinoma (IMPC) of the breast is recently described rare variant of invasive ductal carcinoma. This variant has a distinctive histological features and aggressive biological behavior. We reviewed the cytologic features of eight cases of IMPC. The cytologic smears showed moderate to high cellularity and the tumor tissue was composed of atypical, angulated, cohesive clusters of neoplastic cells with a papillary to tubuloalveolar architecture, and a morular growth pattern without fibrovascular cores was seen on the histopathology. IMPC of the breast has distinctive cytologic features and it is important to make an early diagnosis via fine needle aspiration cytology due to this tumor's aggressive behavior.

Keywords

References

  1. Siriaunkgul S, Tavassoli FA. Invasive micropapillary carcinoma of the breast. Mod Pathol 1993;6:660-2
  2. Luna-More S, Gonzalez B, Acedo C, Redrigo I, Luna C. Invasive micropapillary carcinoma of the breast. A new special type of invasive mammary carcinoma. Path Res Pract 1994;190:668-74 https://doi.org/10.1016/S0344-0338(11)80745-4
  3. Paterakos M, Watkin WG, Edgerton SM, Moore I, Thor AD. Invasive micropapillary carcinoma of the breast. A prognostic study. Hum Pathol 1999;30:1459-63 https://doi.org/10.1016/S0046-8177(99)90168-5
  4. Nassar H, Wallis T, Andea A, Dey J, Adsay V, visscher D. Clinicopathologic analysis of invasive micropapillary differentiation in breast carcinoma. Mod Pathol 2001;14:836-41 https://doi.org/10.1038/modpathol.3880399
  5. Walsh MM, Bleiweiss IJ. Invasive micropapillary carcinoma of the breast: eighty cases of an underrecognized entity. Hum Pathol 2001;32:583-9 https://doi.org/10.1053/hupa.2001.24988
  6. Middleton LP, Tressera F, Sobel ME, Bryant BR, Alburquerque A, Grases P, Merino MJ. Infiltrating micropapillary carcinoma of the breast. Mod Pathol 1999;12:499-504
  7. Wong S, Cheung H, Tse G. Fine needle aspiration cytology of invasive micropapillary carcinoma of the breast. A case report. Acta Cytol 2000;44:1085-9 https://doi.org/10.1159/000328603
  8. Khurana K, Wilbur D, Dawson A. Fine needle aspiration cytology of invasive micropapillary carcinoma of the breast. A report of two cases. Acta Cytol 1997;41:1394-8 https://doi.org/10.1159/000333547
  9. Kumarasinghe MP, Rernando MS, Sheriffdeen AH, Weerasekera K. Cytohistologic features of invasive micropapillary carcinoma in a young female. Diagn Cytopathol 2000;23:196-8 https://doi.org/10.1002/1097-0339(200009)23:3<196::AID-DC11>3.0.CO;2-G
  10. Ng WK, Poon CS, Kong JH. Fine needle aspiration cytology of invasive micropapillary carcinoma of the breast. Review of cases in a three-year period. Acta Cytol 2001;45:973-9 https://doi.org/10.1159/000328373
  11. Jaffer S, Reid-Nicholson M, Bleiweiss IJ. Infiltrating micropapillary carcinoma of the breast. Cytologic findings. Acta Cytol 2002;46:1081-7 https://doi.org/10.1159/000327111
  12. Kwon SY, Jung HR, Kang YN, Kim SP, Kwon KY, Lee SS. Fine needle aspiration cytology of invasive micropapillary carcinoma of the breast: report of four cases. Korean J Cytopathol 2004;15:106-11
  13. Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 1991;19:403-10 https://doi.org/10.1111/j.1365-2559.1991.tb00229.x
  14. Pinder SE, Elston CW, Ellis IO. Invasive carcinoma-usual histologic types. In: Elston CW, Ellis IO, eds. The breast. Systemic pathology. 3rd ed. vol 13. Edinburgh: Churchill Livingstone. 1998;322-4
  15. Hind N, Tracy W, Aleodor A, Jyotirmoy D, Volkan A, Daniel V. Clinicopathologic analysis of invasive micropapillary differentiation in breast carcinoma. Mod Pathol 2001;14:836-41 https://doi.org/10.1038/modpathol.3880399
  16. Peterson JL. Breast carcinomas with an unexpected insideout growth pattern. Rotation of polarization associated with angioinvasion. Pathol Res Pract 1993;189:780A
  17. Nassar H, Pansare V, Zhang H, et al. Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoprotein. Mod Pathol 2004;17:1045-50 https://doi.org/10.1038/modpathol.3800166
  18. Milddleton LP, Tressera F, Sobel ME, et al. Infiltrating micropapillary carcinoma of the breast. Mod Pathol 1999;12:499-504
  19. Bayramoglu H, Zekioglu O, Erhan Y, Ciris M, Ozdemir N. Fine-needle aspiration biopsy of invasive micropapillary carcinoma of the breast: a report of five cases. Diagn Cytopathol 2002;27:214-7 https://doi.org/10.1002/dc.10176