• Journal of Music and Human Behavior
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• v.12 no.2
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• pp.19-36
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• 2015

The purpose of this study was to examine the effects of rhythmic auditory stimulation (RAS) on gait parameters, with and without the presence of a melody, for adolescents with traumatic brain injury (TBI). Three adolescents with TBI received a total of ten individual RAS training sessions. At pre and posttest, spatiotemporal parameters including cadence, velocity and kinematic parameters were measured using the VICON 370 Motion Analysis System. The results showed no significant difference in gait velocity between the two conditions, thus the presence of the melody condition did not impact the outcome of RAS gait training. On the other hand, all participants showed improvement in gait function after RAS training. The cadence, velocity, stride length, and symmetry were increased and the stride time was reduced after training. The motion analysis demonstrated that the movement patterns of hip and knee joints improved, as they were more similar to normal gait, which indicates that the walkings tance became more stable. The research findings indicate that rhythm is the primary factor in mediating gait functions via RAS training. This study also supports that RAS training can effectively improve the gait function for adolescents with TBI.

• 제어로봇시스템학회:학술대회논문집
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• 1991.10b
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• pp.1681-1686
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• 1991

In robotics and other fields of engineering, techniques for artificial reality or virtual reality are focused on and studied extensively, e.g., virtual existence for tele-operator systems in robotics, and virtual reality of designed objects in architecture. In order to realize the system we should create physical stimulations according to internal models created by experiences in a human brain. The internal model does not have to have direct connections to the real world, however, the stimulation must be signals such that the internal model are retrieved in a human brain. In this paper we propose a technique for tele-virtual reality of dynamic mechanical models, which means that one dynamic mechanical model can be shared by peoples in distant places. Since a stability issue due to time delays arises in the system, we employed a scattering technique developed for a tele-operator system and a kind of passive adaptive controllers. Furthermore, restrictions due to a simple digital implementation of the scattering transformation are discussed and some conditions for stability are shown. The proposed method is applied to a remote tug of war system and the effectiveness is verified.

• Journal of Biomedical Engineering Research
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• v.25 no.3
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• pp.195-200
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• 2004

The Auditory Brainstem Response (ABR) with a click stimulation in guinea pigs was used to examine the auditory neuro-pathway from the cochlear nucleus to brain. Using multi-channel active electrodes, the 3-dimensional auditory pathway was examined from the cochlea to the inferior colliculus through the brainstem. These results are similar to the well-known neuro-pathway. This study on the multi-channel ABR shows that the positions of the ABR generators move to the central brain and the contralateral pathway. It is generally agreed that the ABR is generated by some structures along the auditory pathway. This study provides some information on the neuro-pathway where the ABR peak is generated.

• Childhood Kidney Diseases
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• v.16 no.1
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• pp.9-14
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• 2012

The relationship between central nervous system (CNS) and enuresis has not been sufficiently elucidated despite the presence of several circumstantial evidences. Contrary to common belief, polysomnographic sleep analysis revealed that the disturbance of arousal rather than deep sleep was responsible for enuresis. Subsequent studies confirmed depressed sympathetic tone and retarded brainstem reflex indicating abnormal arousal threshold in enuretics. In accordance with the bladder-brain dialogue, chronic stimulation of bladder may modify the brainstem function elevating arousal threshold. Epidemiological studies have suggested the association between enuresis and various psychosomatic disorders like attention deficit hyperactivity disorder (ADHD), which has shown the abnormal brainstem reflex similar to enuresis. Taken together, CNS is assumed to play a crucial role in the pathogenesis of enuresis. Psychological assessment is vital to understand the psychodynamic effect of enuresis. Studies have shown that the prevalence of psychological problems was higher in enuretic children and externalization of the symptoms was usually found. Several explanations have been brought up regarding the development of enuresis and psychological problems. Enuresis may cause psychological problems and vice versa. Otherwise, both may be associated with other variables, such as socioeconomic status (SES).

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2003.05a
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• pp.36-40
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• 2003

근래에 들어 질병으로 인하여 의사표현이 곤란한 환자에게 뇌파에 기초한 BCI(Brain Computer Interface)와 같은 새로운 인터페이스를 제공하고자 하는 연구가 활발히 진행되고 있다. BCI를 위한 기초 연구로서 특정 자극에 대해 유발되는 뇌파의 측정과 분석은 BCI를 위한 뇌파의 패턴과 인터페이스의 설계에 중요한 역할을 한다. 이 연구의 목적은 시청각 자극 인가후 피험자의 반응 시간을 측정하는 시스템을 EEG와 같은 생체 신호 계측 시스템과 연동이 가능한 형태로 개발하는 것이다. 제안된 시스템은 기능적으로 자극 신호 발생부, 반응시간 측정부, 유발뇌파 측정부, 동기신호발생부로 나뉘어진다. 자극신호 발생부는 실험에 이용되는 자극신호를 제작하는 부분으로서 Flash를 사용하여 구현하였다. 반응시간 측정부는 문제에 대한 답 선택 요청시각으로부터 피험자의 반응까지의 시간을 측정하는 부분으로서 마이크로 컴퓨터(80C31)를 이용하여 구현하였다. 우발뇌파 측정부는 시판용 하드웨어와 소프트웨어를 그대로 사용하였다. 동기신호 발생부는 전체 시스템의 동기를 맞추기 위한 신호를 발생하는 부분으로서 문제제시, 답요구와 동기한 화면상의 명암 신호와 이를 검출하는 광센서로 구성하였다. 본 논문에서 제시한 방법에서는 기존의 유발진위 측정 및 자극시스템에 특정 모듈(반응시간 측정 장치, 동기신호 발생장치)만을 추가하여 실험자의 의도에 맞는 시스템을 설계할 수 있어 유발 뇌파 및 반응시간 측정을 필요로 하는 연구를 가속화 할 것이 기대된다.

• Journal of Biomedical Engineering Research
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• v.15 no.4
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• pp.481-488
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• 1994

In this paper a study of neuro-pathway estimation based on visual and somatosensory evoked potential is given. The evoked potentials which are caused by visual and somatosensory stimulation are detected by an average method. The forward problem that is estimating a scalp potential from a given electrical source in the brain is solved by using a triple concentric spherical shell model of the head and a single current dipole model of the neuron activity. The inverse problem which calculates a source position is solved by a least square fit between the model predicted potential and a given evoked potential measurement. The similarities between estimated sensory neuro-pathways and physiological brain function regions are verified.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.2
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• pp.121-127
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• 2014

Acupuncture is the process of stimulating skin regions called meridians or acupoints and has been used to treat pain-related symptoms. However, the pain-relieving effects of acupuncture may be different depending on acupoints. In the present study, the effects of acupuncture on behavioral responses and c-Fos expression were evaluated using a formalin test in male Sprague-Dawley rats in order to clarify the analgesic effects of three different acupoints. Each rat received manual acupuncture at the ST36 (Zusanli), SP9 (Yinlingquan) or BL60 (Kunlun) acupoint before formalin injection. Flinching and licking behaviors were counted by two blinded investigators. Fos-like immunoreactivity was examined by immunohistochemistry in the rat spinal cord. Manual acupuncture treatment at BL60 acupoint showed significant inhibition in flinching behavior but not in licking. Manual acupuncture at ST36 or SP9 tended to inhibit flinching and licking behaviors but the effects were not statistically significant. The acupuncture at ST36, SP9, or BL60 reduced c-Fos expression as compared with the control group. These results suggest that acupuncture especially at the BL60 acupoint is more effective in relieving inflammatory pain than other acupoints.

• Journal of Pharmacopuncture
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• v.23 no.1
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• pp.1-7
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• 2020

Nicotine, primary component of tobaco produces craving and withdrawal effect both in humans and animals. Nicotine shows a close resemblance to other addictive drugs in molecular, neuroanatomical and pharmacological, particularly the drugs which enhances the cognitive functions. Nicotine mainly shows its action through specific nicotinic acetylcholine receptors located in brain. It stimulates presynaptic acetylcholine receptors thereby enhancing Ach release and metabolism. Dopaminergic system is also stimulated by it, thus increasing the concentration of dopamine in nuclear accumbens. This property of nicotine according to various researchers is responsible for reinforcing behavioral change and dependence of nicotine. Various researchers have also depicted that some non dopaminergic systems are also involved for rewarding effect of nicotinic withdrawal. Neurological systems such as GABAergic, serotonergic, noradrenergic, and brain stem cholinergic may also be involved to mediate the actions of nicotine. Further, the neurobiological pathway to nicotine dependence might perhaps be appropriate to the attachment of nicotine to nicotinic acetylcholine receptors, peruse by stimulation of dopaminergic system and activation of general pharmacological changes that might be responsible for nicotine addiction. It is also suggested that MAO A and B both are restrained by nicotine. This enzyme helps in degradation dopamine, which is mainly responsible for nicotinic actions and dependence. Various questions remain uninsurable to nicotine mechanism and require more research. Also, various genetic methods united with modern instrumental analysis might result for more authentic information for nicotine addiction.

• The Korean Journal of Nuclear Medicine
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• v.36 no.3
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• pp.166-176
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• 2002

Purpose: The purpose of this study is to investigate the effects of visual activation and quantitative analysis of regional cerebral blood flow. Visual activation was known to increase regional cerebral blood flow in the visual cortex in occipital lobe. We evaluated that change in the distribution of $^{99m}Tc-HMPAO$ (Hexamethyl propylene amine oxime) to reflect in regional cerebral blood flow. Materials and Methods: The six volunteers were injected with 925 MBq (mean ages: 26.75 years, n=6, 3men, 3women) underwent MRI and $^{99m}Tc-HMPAO$ SPECT during a rest state with closed eyes and visual stimulated with 8 Hz LED. We delineate the legion of interest and calculated the mean count per voxel in each of the fifteen slices to quantitative analysis. The ROI to whole brain ratio and regional index was calculated pixel to pixel subtraction visual non-activation image from visual activation image and constructed brain map using a statistical parameter map (SPM99). Results: The mean regional cerebral blood flow was increased due to visual stimulation. The increase rate of the mean regional cerebral blood flow which of the activation region in primary visual cortex of occipital lobe was $32.50{\pm}5.67%$. The significant activation sites using a statistical parameter of brain constructed a rendering image and image fusion with SPECT and MRI. Conclusion: Visual activation was revealed significant increase through quantitative analysis in visual cortex. Activation region was certified in Talairach coordinate and primary visual cortex (Ba17),visual association area (Ba18,19) of Brodmann.

• Science of Emotion and Sensibility
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• v.6 no.1
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• pp.39-45
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• 2003

To investigate the changes of cortico-cortical connectivity during odor stimulation of subjects classified by occupations, the mutual information content of EEGs was examined, for general workers, perfume salespersons and professional perfume researchers. Analysis of the averaged-cross mutual information content (A-CMI) from the EEGs revealed that, among the professional perfume researchers,. changes in the A-CMI values during odor stimulation were more apparent in the frontal region of the brain, although for the general workers group and perfume salespersons group such changes were more conspicuous in the overall posterior temporal, parietal and frontal regions. These results indicate that the brains of professional perfume researchers respond to odors mainly in the frontal region, reflecting the function of the orbitofrontal cortex (OFC) due to the occupational requirement of these subjects to discriminate of identify odors. During odor stimulation, the perfume salespersons, although relatively more exposed to odors than the general workers, showed similar changes to the general workers. A-CMI value is in inverse proportion to psychological preferences of the professional perfume researchers and perfume salespersons, but this is not the case with the general workers. This suggests that functional coupling for people who are occupationally exposed to odors may be related to odors nay be related to psychological preference.