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Quantitative Evaluation of Regional Cerebral Blood Flow by Visual Stimulation in $^{99m}Tc-HMPAO$ Brain SPECT  

Juh, Ra-Hyeong (College of Medicine, The Catholic University of Seoul)
Suh, Tae-Suk (College of Medicine, The Catholic University of Seoul)
Kwark, Chul-Eun (College of Medicine, The Catholic University of Seoul)
Choe, Bo-Young (College of Medicine, The Catholic University of Seoul)
Lee, Hyoung-Koo (College of Medicine, The Catholic University of Seoul)
Chung, Yong-An (Department of Biomedical Engineering, Radiology The Catholic University of Seoul)
Kim, Sung-Hoon (Department of Biomedical Engineering, Radiology The Catholic University of Seoul)
Chung, Soo-Kyo (Department of Biomedical Engineering, Radiology The Catholic University of Seoul)
Publication Information
The Korean Journal of Nuclear Medicine / v.36, no.3, 2002 , pp. 166-176 More about this Journal
Abstract
Purpose: The purpose of this study is to investigate the effects of visual activation and quantitative analysis of regional cerebral blood flow. Visual activation was known to increase regional cerebral blood flow in the visual cortex in occipital lobe. We evaluated that change in the distribution of $^{99m}Tc-HMPAO$ (Hexamethyl propylene amine oxime) to reflect in regional cerebral blood flow. Materials and Methods: The six volunteers were injected with 925 MBq (mean ages: 26.75 years, n=6, 3men, 3women) underwent MRI and $^{99m}Tc-HMPAO$ SPECT during a rest state with closed eyes and visual stimulated with 8 Hz LED. We delineate the legion of interest and calculated the mean count per voxel in each of the fifteen slices to quantitative analysis. The ROI to whole brain ratio and regional index was calculated pixel to pixel subtraction visual non-activation image from visual activation image and constructed brain map using a statistical parameter map (SPM99). Results: The mean regional cerebral blood flow was increased due to visual stimulation. The increase rate of the mean regional cerebral blood flow which of the activation region in primary visual cortex of occipital lobe was $32.50{\pm}5.67%$. The significant activation sites using a statistical parameter of brain constructed a rendering image and image fusion with SPECT and MRI. Conclusion: Visual activation was revealed significant increase through quantitative analysis in visual cortex. Activation region was certified in Talairach coordinate and primary visual cortex (Ba17),visual association area (Ba18,19) of Brodmann.
Keywords
Visual activation; Statistical parametric mapping;
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