• Journal of Acupuncture Research
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• 제20권3호
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• pp.86-103
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• 2003

Objective : Recently, many studies have showed the evidences of the effect of the acupunture treatment through scientific methods. One of these methods is functional MRI. We performed electro-acupunture on Sp6 and observed the changes of brain activation using fMRI. Methods : To see the effect of electro-acupunture stimulation on Sp6, the experiment was carried out on 12 healthy volunteers, using the gradient echo sequence with the 3.0T whole-body MRI system(ISOL). After the needle insertion on right Sp6, 2Hz of electric stimulation was given for 30 seconds, repeated five times, with 30 seconds' intervals. The Image analysis including motion correction, talairach transformation, and smoothing was done with SPM99. Results : 1. Group averaged brain activation induced by bilateral eletro-acupunture stimulation on Sp6 activates Brodman Area 3, 7, 13. 2. Group averaged brain deactivation induced by bilateral eletro-acupunture stimulation on Sp6 activates Brodman Area 6, 38, 47. 3. Group averaged brain activation induced by unilateral(right side) eletro-acupunture stimulation on Sp6 activates Brodman Area 5, 6, 13, 17, 18, 19, 31, 38, 40 ptoms, back pain(32.5%) was the 4. Group averaged brain deactivation induced by unilateral(right side) eletro-acupunture stimulation on Sp6 activates Brodman Area 3, 4, 18, 21, 36, 38, 39. 5. Brain region activated by motor stimulation activates Brodman Area 3, 4, 6, 18, 19.

• Clinical Psychopharmacology and Neuroscience
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• 제16권4호
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• pp.494-496
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• 2018

No previous reports have described a case in which deep brain stimulation elicited an acute mood swing from a depressive to manic state simply by switching one side of the bilateral deep brain stimulation electrode on and off. The patient was a 68-year-old woman with a 10-year history of Parkinson's disease. She underwent bilateral subthalamic deep brain stimulation surgery. After undergoing surgery, the patient exhibited hyperthymia. She was scheduled for admission. On the first day of admission, it was clear that resting tremors in the right limbs had relapsed and her hyperthymia had reverted to depression. It was discovered that the left-side electrode of the deep brain stimulation device was found to be accidentally turned off. As soon as the electrode was turned on, motor impairment improved and her mood switched from depression to mania. The authors speculate that the lateral balance of stimulation plays an important role in mood regulation. The current report provides an intriguing insight into possible mechanisms of mood swing in mood disorders.

• 대한임상검사과학회지
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• 제45권4호
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• pp.170-179
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• 2013

There is a correct way to avoid any sequale in the central motor area during neurosurgery procedures. A clear way to find the circumference of the central sulcus, central motor, and sensory areas by giving cortical electrical stimulation to the central motor area immediate after surgery is proposed. Looking at patients who underwent brain surgery September 2009 to July 2013, the central sulcus and speech areas around the central area of the brain was investigated, using the practices of either a localized brain map check or a direct cortical electrical stimulation test. Brain maps localized around the surgical site through functional movement or speech areas were identified. Accurate tests done during surgery without damage to motor neurons or after surgery were conducted smoothly. Although successful brain map test localization can be accomplished, there are some factors that can interfere. The following phenomena can reverse the phase: (1) the first sensory / motor in the case of patients severe nerve damage; (2) placement of the electrode on top of the vessel; (3) presence of a brain tumor near the brain cortex; (4) use of anesthesia if patient cooperation is difficult; and (5) location of the electrode position and stimulus is inappropriate.

• 의료법학
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• 제23권2호
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• pp.119-139
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• 2022

뇌에 전기적·자기적 자극을 가하는 뇌자극기술은 신경학적·정신학적 장애에 대해 다양한 범위에 걸쳐 상당한 치료 가능성을 보여준다. 뇌자극기술은 침습 여부에 따라 침습적 기술과 비침습적 기술로 구분되는데, 뇌심부자극술(이하, DBS)은 대표적인 침습적 뇌자극기술에 속한다. 현재 DBS는 식약처 고시인 "의료기기 품목 및 품목별 등급에 관한 규정"에 따라 4등급 의료기기로 분류되어 몇몇 질환에서 안정된 치료법으로 사용되고 있다. 동시에 날로 그 기술이 발전하여 다양한 방향에서 이용방법이 논의되고 있다. 반면, 이와 관련한 법적 규제에 대한 논의는 상대적으로 적은 편이다. 이러한 배경에서 본 글은 DBS의 기술 및 효과와 안전성을 간략하게 소개한 이후, DBS 이용에서 고려할 수 있는 주요한 법적 쟁점을 이용 목적별로, 즉 치료목적, 임상연구 목적, 표준적 치료법이 아니나 다른 치료법이 없는 경우, 향상 목적으로 구분하여 논의하고, 어떠한 목적의 이용이든 DBS 이용에 따른 법적 책임의 문제에서 새로이 공통적으로 부상하고 있는 쟁점-위험·이익평가, 의사의 설명의무, 환자의 동의능력, 기기의 조정, 보험의 보장-을 소개하고 논의한다.

• The Korean Journal of Physiology and Pharmacology
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• 제18권2호
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• pp.103-108
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• 2014

Head restraining is an experimental technique that firmly secures the animal's head to a fixation apparatus for the precise control and sensing of behaviors. However, procedural and surgical difficulties and limitations have been obstructing the use of the technique in neurophysiological and behavioral experiments. Here, we propose a novel design of the head-restraining apparatus which is easy to develop and convenient for practical use. Head restraining procedure can be completed by sliding the head mounter, which is molded by dental cement during implantation surgery, into the port, which serves as matching guide rails for the mounter, of the fixation bar. So neither skull-attached plates nor screws for fixation are needed. We performed intracranial self stimulation experiment in rats using the newly designed device. Rats were habituated to acclimatize the head-restraint environment and trained to discriminate two spatially distinguished cues using a customized push-pull lever as an operandum. Direct electrical stimulation into the medial forebrain bundle served as reward. We confirmed that head restraining was stable throughout experiments and rats were able to learn to manipulate the lever after successful habituation. Our experimental framework might help precise control or sensing of behavior under head fixed rats using direct electrical brain stimulation as a reward.

• 대한통합의학회지
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• 제6권2호
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• pp.117-123
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• 2018

Purpose : The purpose of this study was to investigate the effect of increased brain activity on the muscle endurance and the effect of brain activation through the combination of transcranial direct current stimulation and aerobic exercise on elderly woman. Methods : To investigate the effect of the muscle endurance on right leg, muscle endurance was evaluated by measuring the surface EMG of the muscles of the rectus femoris, biceps femoris, tibialis anterior, and gastrocnemius muscle. Results : There was a significant difference in the pre and post comparisons of muscle endurance on rectus femoris, biceps femoris, tibialis anterior muscle (p<.05). Difference of Combination of transcranial direct current stimulation and aerobic exercise group median frequency was smaller than control group (p<.05). There was not a significant difference in the pre and post comparisons of muscle endurance on biceps femoris, and gastrocnemius muscle. Difference of Combination of transcranial direct current stimulation and aerobic exercise group median frequency was showed a similar pattern. Conclusion : Through these results, It was found that increasing the brain activity by the transcranial direct current stimulation improves the exercise capacity on the elderly women. Combination of transcranial direct current stimulation and aerobic exercise maybe applied as an effective treatment for improving muscular endurance.

• PNF and Movement
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• 제5권1호
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• pp.9-17
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• 2007

Purpose : The purpose of this study was to test the effect of balance training for proprioceptive and vestibular sensory stimulation and therapeutic environment on expression of BDNF after traumatic brain injury in the rat. Subject : Twelve Sprague-Dawley rats were randomly assigned into group I and group II. After traumatic brain injury, group I was housed in standard cage for 7 days. Group II was housed in therapeutic cage after balance training for 7 days. Method : Traumatic brain injury was induced by weight drop model and after operation they were housed in individual standard cages for 24 hours. After 7th day, the rats were sacrificed and cryostat coronal sections were processed individually in goat polyclonal anti-BDNF antibody. The morphologic characteristics and the BDNF expression were investigated in injured hemisphere section from immunohistochemistry using light microscope. Result : Immunohistochemical response of BDNF in lateral nucleus, purkinje cell layer, superior vestibular nucleus and pontine nucleus appeared very higher in group II than in group I Conclusion : The present result revealed that simultaneously application of balance training for proprioceptive and vestibular sensory stimulation input and therapeutic environment in traumatic brain injured rats is enhance expression of BDNF and it is facilitates neural plasticity.

• 생물정신의학
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• 제24권4호
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• pp.167-174
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• 2017

Based on advances in biotechnology and neuroscience, neuromodulation is poised to gain clinical importance as a treatment modality for psychiatric disorders. In addition to old-established electroconvulsive therapy (ECT), clinicians are expected to understand newer forms of neurostimulation, such as deep brain stimulation (DBS), vagus nerve stimulation (VNS), repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS). Given the growing interest in non-invasive neuromodulation technologies, clinicians may seek sufficient information about neuromodulation to inform their clinical practice. A growing literature suggests that applications of non-invasive neuromodulation have evidence particularly for indications where treatments are currently insufficient, such as drug-resistant depression. However, positive neuromodulation studies require replication, and the precise interactions among stimulation, antidepressant medication, and psychotherapy are unknown. Further studies of long-term safety and the impact on the developing brain are needed. Non-invasive neuromodulatory devices could enable more individualized treatment. However, do-it-yourself (DIY) stimulation kits require a better understanding of the effects of more frequent patterns of stimulation and raise concerns about clinical supervision, regulation, and reimbursement. Wide spread enthusiasm for therapeutic potential of neuromodulation in clinical practice settings should be mitigated by the fact that there are still research gaps and challenges associated with non-invasive neuromodulatory devices.

• 한국전자파학회논문지
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• 제27권5호
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• pp.482-485
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• 2016

본 논문에서는 쥐 뇌의 감각 피질을 자극하기 위해 변조신호를 이용하여 경두개 자기자극(TMS) 동물실험을 수행하였다. 제안한 TMS 시스템은 인버터, 변압기, 커패시터, 가변 인덕터, 자극 코일로 구성되어 쥐 뇌의 감각피질에 약 1.5 mT의 자기장이 생기도록 시스템을 설계하였다. 자극 신호는 구형파 변조되었으며, 반송 주파수는 85~91 kHz의 범위로 변화시키며, 자극 효과를 관찰하였다. 자극 결과 반송 주파수가 89 kHz 미만일 때에는 자극의 효과를 볼 수 없었고, 반송 주파수가 89 kHz 이상일 때에는 압력 자극에 반응하는 역치 값이 낮아지는 효과를 볼 수 있었다.

• The Korean Journal of Pain
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• 제34권2호
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• pp.156-164
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• 2021

Several types of pain occur following spinal cord injury (SCI); however, neuropathic pain (NP) is one of the most intractable. Invasive and non-invasive brain stimulation techniques have been studied in clinical trials to treat chronic NP following SCI. The evidence for invasive stimulation including motor cortex and deep brain stimulation via the use of implanted electrodes to reduce SCI-related NP remains limited, due to the small scale of existing studies. The lower risk of complications associated with non-invasive stimulation, including transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), provide potentially attractive alternative central neuromodulation techniques. Compared to rTMS, tDCS is technically easier to apply, more affordable, available, and potentially feasible for home use. Accordingly, several new studies have investigated the efficacy of tDCS to treat NP after SCI. In this review, articles relating to the mechanisms, clinical efficacy and safety of tDCS on SCI-related NP were searched from inception to December 2019. Six clinical trials, including five randomized placebo-controlled trials and one prospective controlled trial, were included for evidence specific to the efficacy of tDCS for treating SCI-related NP. The mechanisms of action of tDCS are complex and not fully understood. Several factors including stimulation parameters and individual patient characteristics may affect the efficacy of tDCS intervention. Current evidence to support the efficacy of utilizing tDCS for relieving chronic NP after SCI remains limited. Further strong evidence is needed to confirm the efficacy of tDCS intervention for treating SCI-related NP.