• Annals of Clinical Neurophysiology
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• v.2 no.1
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• pp.13-20
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• 2000

Background and Objective : Visual evoked potentials(VEPs) is considered to be a reliable diagnostic procedure for examining patients with anterior visual pathways. Some abnormalities in the recordings on monocular stimulation have been said to indicate retrochiasmal lesion, but less consistent results have been reported. This study is to evaluate the positive predictability of VEP for the detection of retrochiasmal lesion. Methods : We reviewed VEPs that could be interpreted as indicative of a retrochiasmal lesions, based on amplitude or latency asymmetry recorded on the left(O1) and right(O2) occipital regions. Bilateral absent VEPs on both recording(O1 and O2) without evidence of prechiasmal lesion were included. During 5 years, we identified 31 patients who met the above criteria and who had undergone magnetic resonance imaging(MRI) of brain(one patient underwent computerized tomography). Twenty three patients underwent pattern reversal VEPs and others underwent flash goggle VEPs. Results : Brain imagings were abnormal in 29 and were normal in 2. Of the 29 abnormal scans, lesions in posterior visual pathway were detected in 21 scans(predictive value=68%). The predictive value was not significantly different between flash goggle VEP(75%) and pattern reversal VEP(68%). The predictive value was higher in patient with visual field defect(100%) than those without visual field defect(25%). The pathologic nature of lesion also showed close relations to the predictive value. VEPs is usually paradoxically lateralized(78%), but not in all patients. Conclusion : VEPs abnormalities suggesting retrochiasmal lesion were usually corresponded with brain MRI findings. Diagnostic reliability could be increased when considering the visual field defect and nature of lesion. Therefore, the authors suggest that VEPs studies could be useful in evaluating the patients with the retrochismal lesion.

• The Journal of the Korea institute of electronic communication sciences
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• v.16 no.1
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• pp.89-94
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• 2021

In this paper, we presented the results of analysis with data obtained through EEG measurements to confirm the effect of musical stimulus when performing mathematical tasks. While the subject was solving a mathematical task, favorite and unfavorite music classified according to the subject's preference were presented as musical stimulus and the tasks were divided into memorization task and procedure task. The data measured in the EEG experiments was divided into theta waves, SMR waves and mid-beta waves which are the frequency bands related to concentration to compare the relative power spectrum values. In our results, in the case of comparing no music with favorite music and no music with unfavorite music, a significant difference was observed in the several channels, and the average difference was shown in the channels F3 and F4 of the frontal lobe. In that channels, the power was found to be greater when the music was presented than the case where there was no music. Depending on the subject's preference, it was confirmed that favorite music showed greater brain activity than unfavorite music.

• Biomolecules & Therapeutics
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• v.5 no.3
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• pp.239-245
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• 1997

Trimetoquinol (TMQ) and its analogs are known to have thromboxane $A_2$ antagonistic action. We also reported that GS389, chemically similar to TMQ, has competitive antagonistic action in rat aorta and human platelets. In the present study, we investigated the pharmacological characteristics of GS283 and GS 386, analogs of GS389, using vascular smooth muscle, human platelets and rat brain homogenates. In isolated pig coronary artery (PCA), both of GS283 and GS386 relaxed U46619-contracted rings in concentration dependent manner. Pretreatment with several concentrations of GS283 and GS386 shifted the dose-response curves to the right, and reduced of maximum contration dose-dependently. Furthermore, GS283 and GS386 strongly inhibited $Ca^{2+}$ -induced contraction in the PCA. In human platelets, U46619- and A23187-induced platelet aggregation was inhibited by GS283 and GS386, concentration-dependently. Anti-platelet aggregation was related to the compound\`s ability to inhibit ATP release at each stimulation. In rat brain homogenates, receptor-binding assay resulted that both GS283 and GS386 have a relative affinity to $\alpha$-adrenergic receptor. Taken together. we concluded that the mechamism of action of GS283 and GS86 is not related with in TXA$_2$ receptor but concerned with calcium antagonistic action and a-blocking action.n.

• Journal of the Korean Society of Physical Medicine
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• v.18 no.3
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• pp.47-53
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• 2023

PURPOSE: A visual feedback method was proposed to induce brain stimulation in a stroke patient, and among them, there was a treatment using a mirror. On the other hand, mirror therapy focuses only on the functional changes in body movements, and analysis of neurophysiological mechanisms of brain activity is lacking. In addition, studies on evaluating the activity and response generated in specific brain regions during visual feedback training using mirrors are insufficient. METHODS: Fifteen healthy adults (male: 10, female: 5, Years: 23.33 ± 1.23), who were right-handed were recruited. By attaching the C3, Cz, and C4 channels in the sensorimotor cortex using an electroencephalogram, training was performed under the conditions without mirror-based visual feedback (No-condition) and with visual feedback (Tasks-condition). At this time, the immediate activity of the mu-rhythm in response to training was separated and evaluated. RESULTS: The tasks-condition of C3, Cz, and C4 channels activated the relative mu-rhythm rather than the no-condition, and all showed significant differences (p < .05). In addition, in all channels at the start time, the tasks-condition was more active than the no-condition (p < .05). The activity of the cortical response was higher in the tasks-condition than in the no-condition (p < .05). CONCLUSION: The mu-rhythm activity can be evaluated objectively when visual feedback using a mirror is applied to healthy subjects, and a basic analysis protocol is proposed.

• The Journal of the Korea Contents Association
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• v.11 no.4
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• pp.273-282
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• 2011

This study was to investigate the effect of improve forelimb sensorimotor function and neurotrophic factor(GAP-43) expression when differing an application time of tDCS in ischemic brain injury rat model(pre, $1^{st}$, $7^{th}$, $14^{th}$). Focal ischemic brain injury was induced in 80 Sprague-Dawley rats through middle cerebral artery occlusion(MCAO) by 'Longa' method. And then experimental groups were randomly divided into four groups; GroupI: MCAO induction, GroupII: application of tDCS(10 min) after MCAO induction, GroupIII: application of tDCS(20 min) after MCAO induction, GroupIV: application of tDCS(30 min) after MCAO induction. Modified limb placing test and single pellet reaching test were performed to test forelimb sensorimotor function. And the histological examination was also observed through the immunohistochemistric response of GAP-43(growth-associated protein-43) in the cerebral cortex. In modified limb placing test, groupIII(p<0.05) showed significantly improve than the other groups on $14^{th}$). day. In single pellet reaching test, groupIII(p<0.01) and groupIV(p<0.05) significantly improved on $14^{th}$) day. And in immunohistochemistric response of GAP-43, group III showed significantly positive response than the other groups on $14^{th}$ day. These results suggest that the intensity(0.1 mA)/time(20 min) condition of tDCS application has a significant impact on the sensorimotor functional recovery in focal ischemic brain injury rat models.

• Sleep Medicine and Psychophysiology
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• v.26 no.2
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• pp.75-85
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• 2019

A lucid dream is defined as a dream during which a dreamer is aware that she/he is dreaming. The existence of lucid dream has long been known in the literature, but it hasn't been long before it has received attention in sleep medicine. Although many studies have been conducted since validation of the lucid dream in polysomnography by Steven LaBerge in the 1980s, the neuroscience of lucid dreams is still not fully understood. Here the neuroscientific literature on lucid dreaming, including electroencephalographic, neuroimaging, pharmacological and brain stimulation studies, are reviewed. Also this review gives an overview on how lucid dreams are used in clinical and nonclinical areas, ranging from nightmare therapy to research on consciousness and creative problem solving.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2000.04a
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• pp.265-270
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• 2000

본 연구에서는 EEG 반응을 통하여 향이 인간에 미치는 영향을 평가하였다. 24-26세의 8명의 남성 피험자를 대상으로 국제 기준 전극법에 따라 19 부위에서 EEG를 기록하여 분석하였다. 실험에 사용한 향은 Rose oil bulgarian, Lemon oil misitano, Jasmin abs, Laverder iol france (KIMEX co. Ltd) 등 4가지의 천연오일을 사용하였다. 향에 대한 선입견을 배제하고 각 피실험자별로 주관적 평가를 통하여 가장 쾌하게 느낀 향이 제시되었을 때의 뇌파와 무향 상태 뇌파에서 $\alpha$/$\beta$ 대역의 power spectrum 비를 구하여 비교하였다. 무향 상태에 비해 각 피실험자별로 가장 쾌하게 느낀 향을 제시했을 때 F3, Fz, F4, T4 부분에서 $\alpha$/$\beta$ 대역의 power spectrum 비의 통계적으로 유의한 증가를 관찰할 수 있었으며 이는 $\alpha$/$\beta$ 대역의 power spectrum 비가 향의 쾌도를 측정하는 하나의 새로운 척도가 될 수 있음을 시사한다.

• Sleep Medicine and Psychophysiology
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• v.24 no.2
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• pp.79-85
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• 2017

Targeted memory reactivation (TMR) is a method whereby cues associated with previous learning are used to externally reactivate aspects of this learning. Research findings demonstrate that TMR can be a useful tool to enhance memory consolidation during sleep in both animals and humans, especially in the declarative/spatial domain. Neurocognitive processing during sleep with covert cueing via auditory or olfactory stimulation can benefit memory storage. These beneficial effects on memory consolidation during sleep are associated with the activation of memory-related brain areas. The purpose of the present review is to provide a short overview of the findings of studies that adopted the TMR method of sleep-dependent memory consolidation and to suggest the potential applications of TMR in variable areas.

• Proceedings of the Korean Society of Medical Physics Conference
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• 1999.11a
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• pp.427-428
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• 1999

• Clinical and Experimental Pediatrics
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• v.54 no.6
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• pp.241-245
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• 2011

Tuberous sclerosis complex (TSC) is a genetic multisystem disorder that results from mutations in the TSC1 or TSC2 genes, and is associated with hamartomas in several organs, including subependymal giant cell tumors. The neurological manifestations of TSC are particularly challenging and include infantile spasms, intractable epilepsy, cognitive disabilities, and autism. The TSC1- and TSC2-encoded proteins modulate cell function via the mammalian target of rapamycin (mTOR) signaling cascade, and are key factors in the regulation of cell growth and proliferation. The mTOR pathway provides an intersection for an intricate network of protein cascades that respond to cellular nutrition, energy levels, and growth factor stimulation. In the brain, TSC1 and TSC2 have been implicated in cell body size, dendritic arborization, axonal outgrowth and targeting, neuronal migration, cortical lamination, and spine formation. The mTOR pathway represents a logical candidate for drug targeting, because mTOR regulates multiple cellular functions that may contribute to epileptogenesis, including protein synthesis, cell growth and proliferation, and synaptic plasticity. Antagonism of the mTOR pathway with rapamycin and related compounds may provide new therapeutic options for TSC patients.