• Title/Summary/Keyword: boron-dose enhancer

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Feasibility of Intra-Operative BNCT Using Accelerator-Based Near-Threshold $^7Li(p,n)^7$Be Direct Neutrons

  • Tanaka, Kenichi;Kobayashi, Tooru;Nakagawa, Yoshinobu;Sakurai, Yoshinori;Ishikawa, Masayori;Hoshi, Masaharu
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2002.09a
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    • pp.157-160
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    • 2002
  • The dosage of intra-operative BNCT using near-threshold $^{7}$ Li(p,n)$^{7}$ Be direct neutrons was evaluated with the calculation method validated with the phantom experiment. The production of both neutrons by near-threshold $^{7}$ Li(p,n)$^{7}$ Be and gamma rays by $^{7}$ Li(p,p'gamma)$^{7}$ Li in a Li target was calculated using Lee's method and their transport in the phantom was calculated with MCNP-4B. As a result, the region satisfying the requirements of the protocol in intra-operative BNCT for brain tumors in Japan was acknowledged to be comparable to present BNCT, for the proton energy of 1.900 MeV for example. A boron-dose enhancer (BDE) introduced in this study to increase $^{10}$ (n,$\alpha$)$^{7}$ Li dose in a living body was effective. The void used to increase doses in deep regions was also valid with the BDE. It was found that intra-operative BNCT using near-threshold $^{7}$ Li(p,n)$^{7}$ Be direct neutrons is feasible.

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