Proceedings of the Korean Society of Medical Physics Conference (한국의학물리학회:학술대회논문집)

Korean Society of Medical Physics (한국의학물리학회)
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Feasibility of Intra-Operative BNCT Using Accelerator-Based Near-Threshold $^7Li(p,n)^7$Be Direct Neutrons

  • Tanaka, Kenichi (Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka) ;
  • Kobayashi, Tooru (Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka) ;
  • Nakagawa, Yoshinobu (National Kagawa Children's Hospital, Zentsuji-cho, Zentsuji, Kagawa) ;
  • Sakurai, Yoshinori (Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka) ;
  • Ishikawa, Masayori (Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi-ku, Hiroshima) ;
  • Hoshi, Masaharu (Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi-ku, Hiroshima)
  • Published : 2002.09.01
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Abstract

The dosage of intra-operative BNCT using near-threshold $^{7}$ Li(p,n)$^{7}$ Be direct neutrons was evaluated with the calculation method validated with the phantom experiment. The production of both neutrons by near-threshold $^{7}$ Li(p,n)$^{7}$ Be and gamma rays by $^{7}$ Li(p,p'gamma)$^{7}$ Li in a Li target was calculated using Lee's method and their transport in the phantom was calculated with MCNP-4B. As a result, the region satisfying the requirements of the protocol in intra-operative BNCT for brain tumors in Japan was acknowledged to be comparable to present BNCT, for the proton energy of 1.900 MeV for example. A boron-dose enhancer (BDE) introduced in this study to increase $^{10}$ (n,$\alpha$)$^{7}$ Li dose in a living body was effective. The void used to increase doses in deep regions was also valid with the BDE. It was found that intra-operative BNCT using near-threshold $^{7}$ Li(p,n)$^{7}$ Be direct neutrons is feasible.

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