• Maxillofacial Plastic and Reconstructive Surgery
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• v.18 no.3
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• pp.515-527
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• 1996

The most serious problem resulting from estrogen deficiency induce osteo porosis. Recently, they make efforts to inquire a relation between hematopoietic organ and bone loss due to estrogen deficiency. Estrogen have an effect on growth and formation of skeletal system, and inhibit bone resorption under the influence of osteoblast and osteoclast, and basically inhibit the increase of hematopoietic progenitor and immune factor connected with bone resorption and prevent the osteoid formation. The purpose of this article was to observe the change of spleen and effect on hematopoietic function following estrogen administration. In this study, female rats of 150g weight was ovariectomized, after 70 days, experimental group was injected estrogen at interval of a week and sacrificed on 1, 2, 3, 4, 6 weeks. Control group was sacrificed after ovariectomy on 11, 12, 13, 14, 16 weeks without estrogen injection, and normal rats were sacrificed for harvest of spleen and femur. Paraffin sections and H&E stain was performed, and observed under light microscope. The obtained results were as follows. 1. From 11 to 12 weeks at bone marrow of control group, hematopoietic cells were decreased in comparison with normal group, and lipid infiltration was seen, and irregular bone remodelling was seen after 13 weeks. From 14 to 16 weeks, there were more decreased hematopoietic cells and lipid degeneration, and lipid degeneration of hematopoietic cells appeared. 2. All the bone marrow of experimental group, the structure of hematopoietic cells with decreased lipid infiltration was recovered from 2 weeks of estrogen adminstration and maintained to 6 weeks. 3. At spleen of control group, borders of white and red pulp was not well demarcated, and size of white pulp was decreased. 4. At spleen of experimental group, borders between white and red pulp have been well demarcated from 3 weeks of estrogen adminstration relatively, and white pulp was increased with distinct border. From above findings, we could regarded that estrogen deficiency due to ovariectomy influenced on hematopoietic cells of bone marrow and spleen, and histologic recovery of hematopoietic cells were observed after 3 weeks of estrogen adminstration even if it was not reach to normal group.

• Journal of Digital Convergence
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• v.11 no.4
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• pp.57-69
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• 2013

Progresses in ICT make the processing and exchange of personal data across international borders often necessary and relatively easy. The challenge lies in protecting fundamental rights and freedoms of individuals, notably the right to privacy and the right to personal information, while encouraging the free and secure flow of information across borders for the continued expansion of online transactions. The key to establishing a functioning international solution for personal data protection is to strike a right balance between the two camps which currently dominate the debate - the advocates of individual privacy rights on one side exemplified by the EU, and the proponents of self-regulation and economic efficiency on the other, represented by the U.S. In the face of a growing tension between the two sides each equipped with their own ideals, a practical solution may lie in utilizing established institutions of standardization such as ISO and IEC as a ground upon which an agreement can take its root.

• The Journal of Korean Academy of Prosthodontics
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• v.28 no.1
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• pp.25-41
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• 1990

The purpose of this study was to evaluate and compare the dimensional changes of relined dentures with a light-curing resin, a heat-curing resin, and a direct, hard reline resin. And also to measure the transverse strength, impact strength, surface hardness of the three resins used in relining. The surface textures of three resins also of evaluated by using scanning electron microscope. Through analyses on the data from this study, the following conclusions were obtained. 1. Impact strength of heat-curing resin was highest, and direct, hard reline resin higher, light-curing resin lowest. 2. Transverse strength of heat-curing resin was highest, and direct, hard reline resin and light-curing resin was lower and not signiicantly different. 3. Surface hardness of light-curing resin was lighest, heat-curing resin higher, and direct, hard reline resin was lowest. 4. After storage of the relined dentures for 1 day and 1 week in water at room temperature, linear shrinkage of distance between the reference points in the maxillary base relined with direct, hard reline resin was lowest, and those relined with light-curing resin and heat-curing resin were lower and were not significantly different. 5. After storage for 4 weeks in orator at room tempeature, linear shrinkage of distance between ridge crests of dentures relined with heat-curing resin was highest and that of distance between denture borders was not significantly different. 6. The dimensional changes of relined dentures during storage in water was not significant except those of distance between denture borders relined with light-curing resin at 1 day and 1 week storage in water. 7. At low magnification (x40) of SEM examination, the surface textures of three resins were similar except light-curing resin which had some defects. At high magnification (x200), the surface textures of hard, direct reline resin were smooth with little defects, but those of heat-curing resin and light-curing resin w ere irregular.

• Journal of the Korean Institute of Educational Facilities
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• v.27 no.2
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• pp.35-47
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• 2020

The need for communication is emphasized in decision making, design methods and processes for the educational environment that contain new curricula and learning methods. In this study, we tried to find the direction and agenda of learner-centered environment restructuring through the 'user-integrated platform' in which various subjects related to school space environment understand each other's position and overcome the barriers and prejudices of each sector. The project was planned in a 'bottom-up process' method that uncovered the singularities of the previous stage and led the main contents of the next stage. The various subjects who participated in the project shared their own experiences and different positions regarding the school space. At the workshop, the topics of the participating teams were divided into two categories. The teams in the category of the 'school culture and space' insisted innovation of 'the school culture' as a premise for the restructuring of the 'school space', and proposed schools with different interpretations of 'authority and rules of school', 'the meaning of learning and play' and 'the main character of school. The teams in the category of the 'school borders and spaces' focused on 'communication' and proposed schools containing 'emotional care of students', 'borders between schools and villages', 'village community schools', and 'interspace and niche time'. After the workshop, we were able to derive the direction and architectural strategy of the school space restructuring by analyzing the works of the participants. Through this study, we confirmed the possibility of translating user's ideas into the professional domain through careful planning, preparation, facilitation, and analysis in Participatory Design.

• Parasites, Hosts and Diseases
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• v.53 no.2
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• pp.177-187
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• 2015

Merozoite surface proteins (MSPs) of malaria parasites play critical roles during the erythrocyte invasion and so are potential candidates for malaria vaccine development. However, because MSPs are often under strong immune selection, they can exhibit extensive genetic diversity. The gene encoding the merozoite surface protein-3 (MSP-3) of Plasmodium falciparum displays 2 allelic types, K1 and 3D7. In Thailand, the allelic frequency of the P. falciparum msp-3 gene was evaluated in a single P. falciparum population in Tak at the Thailand and Myanmar border. However, no study has yet looked at the extent of genetic diversity of the msp-3 gene in P. falciparum populations in other localities. Here, we genotyped the msp-3 alleles of 63 P. falciparum samples collected from 5 geographical populations along the borders of Thailand with 3 neighboring countries (Myanmar, Laos, and Cambodia). Our study indicated that the K1 and 3D7 alleles co-existed, but at different proportions in different Thai P. falciparum populations. K1 was more prevalent in populations at the Thailand-Myanmar and Thailand-Cambodia borders, whilst 3D7 was more prevalent at the Thailand-Laos border. Global analysis of the msp-3 allele frequencies revealed that proportions of K1 and 3D7 alleles of msp-3 also varied in different continents, suggesting the divergence of malaria parasite populations. In conclusion, the variation in the msp-3 allelic patterns of P. falciparum in Thailand provides fundamental knowledge for inferring the P. falciparum population structure and for the best design of msp-3 based malaria vaccines.

• Journal of KIISE:Software and Applications
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• v.32 no.7
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• pp.625-635
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• 2005

In this paper, we propose a hybrid approach for segmenting the lungs efficiently and automatically in chest CT images. The proposed method consists of the following three steps. first, lungs and airways are extracted by two- and three-dimensional automatic seeded region growing and connected component labeling in low-resolution. Second, trachea and large airways are delineated from the lungs by two-dimensional morphological operations, and the left and right lungs are identified by connected component labeling in low-resolution. Third, smooth and accurate lung region borders are obtained by refinement based on image subtraction. In experiments, we evaluate our method in aspects of accuracy and efficiency using 10 chest CT images obtained from 5 patients. To evaluate the accuracy, we Present results comparing our automatic method to manually traced borders from radiologists. Experimental results show that proposed method which use connected component labeling in low-resolution reduce processing time by 31.4 seconds and maximum memory usage by 196.75 MB on average. Our method extracts lung surfaces efficiently and automatically without additional processing like hole-filling.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.2
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• pp.223-228
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• 2019

Recently, the United States has been trying to strengthen its cybersecurity by upgrading its position as an Unified Combatant Command that focuses on the Cyber Command in the United States, strengthening operations in cyberspace, and actively responding to cyber threats. Other major powers are also working to strengthen cyber capabilities, and they are working to strengthen their organization and power. The world demands economic power for its own interests rather than its own borders. But Cyber World is a world without borders and no defense. Therefore, a cyber weapon system is necessary for superiority in cyberspace (defense, attack) for national cybersecurity. In this paper, we analyze operational procedures for cyber weapons operation. And we design cyber weapons to analyze and develop the best cyber weapons to lead victory in cyberwarfare. It also conducts cyber weapons research to solve the confrontation between Cyber World.

• Journal of Korea Trade
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• v.23 no.7
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• pp.96-112
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• 2019

Purpose - "Trade Facilitation" aims the easier flow of trade across borders, driven not only by effective customs administration, the efficiency of appropriate authorities, but also by telecommunications, the quality of infrastructures and competent logistics. Facilitating trade will help lower trade development costs as well as improve economic development and enhance economic benefits for emerging economies at a time when imports and exports are sent in and out across borders several times in the form of intermediate and final products. Not only that, globalization is being accelerated, which in turn increases competitiveness and this makes logistics one of the key factors when it comes to international trade. Highly efficient logistics services promote product movement, ensure product safety and delivery speed, and reduce trade costs between countries. The purpose of this study is, by using the LPI indices based on gravity model estimates, to analyze the impact of each LPI component on trade with the 20 biggest exporting countries of Northeast Asian countries-Korea, Japan, and China-which account for 19.05% of global exports. Design/methodology - Also, this study statistically analyzes the impact of trade on Northeast Asian countries' top 20 exporting countries, using the LPI indices relevant to Trade Facilitation based on the gravity model estimates. Findings - As a result, it was turned out that the distance, GDP, and the LPI components have relevant impact on the trade exports of all three countries but demonstrated little relation to the demographic perspective. Originality/value - The study also found we can increase the trade volume by improving three countries' trade partners' LPI indices since Korea, Japan, and China share most of their 20 biggest trade partners.

• Molecules and Cells
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• v.44 no.11
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• pp.805-829
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• 2021

CCCTC-binding factor (CTCF) critically contributes to 3D chromatin organization by determining topologically associated domain (TAD) borders. Although CTCF primarily binds at TAD borders, there also exist putative CTCF-binding sites within TADs, which are spread throughout the genome by retrotransposition. However, the detailed mechanism responsible for masking the putative CTCF-binding sites remains largely elusive. Here, we show that the ATP-dependent chromatin remodeler, chromodomain helicase DNA-binding 4 (CHD4), regulates chromatin accessibility to conceal aberrant CTCF-binding sites embedded in H3K9me3-enriched heterochromatic B2 short interspersed nuclear elements (SINEs) in mouse embryonic stem cells (mESCs). Upon CHD4 depletion, these aberrant CTCF-binding sites become accessible and aberrant CTCF recruitment occurs within TADs, resulting in disorganization of local TADs. RNA-binding intrinsically disordered domains (IDRs) of CHD4 are required to prevent this aberrant CTCF binding, and CHD4 is critical for the repression of B2 SINE transcripts. These results collectively reveal that a CHD4-mediated mechanism ensures appropriate CTCF binding and associated TAD organization in mESCs.

• International Journal of Computer Science & Network Security
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• v.23 no.2
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• pp.111-125
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• 2023

Due to the car's central role in modern life, the industry has become more fiercely competitive, with each manufacturer doing everything it can to attract buyers with features like plush interiors, comprehensive warranties, and helpful customer service departments. Customers may not have the luxury of buying a new car, so they will have to buy a used car. Nevertheless, in most cases, the customer (car driver) may be deceived about the vehicle information and history and thus will be confused in making his/her decision to purchase. In addition, after all attempts to obtain vehicle information (plate number, model, year of manufacture, number of maintenance times, accidents, etc.), the customer's many attempts may fail. In general, the government records and verifies the information of all cars, even those that pass through their borders. However, there might still be some trouble in obtaining this information. From this standpoint, we will design a website that makes it easier for car drivers, car companies and governments to carry out all the above-mentioned processes. It will also allow users, whether a driver or a car company, to inquire about all vehicle information through detailed and integrated reports on its condition since its entry into the Kingdom of Saudi Arabia until the present time, in addition to information supported by numbers and statistics to ensure the integrity and reliability of the information. This platform will save the trouble of searching for car information for drivers and car companies. It will also help governments keep track of the information of all cars entering and leaving the Kingdom of Saudi Arabia, which will contribute to facilitating the process of viewing the history of any car that has previously entered the Kingdom's borders.