• 한국의상디자인학회지
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• 제16권4호
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• pp.217-228
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• 2014

The purpose of this study is to grasp inconveniences and improvements by examining wearing condition and satisfaction of protective clothing targeting 114 Korean farmers and to suggest basic data for enhancement of pattern and wearing satisfaction of protective clothing by understanding problems of pesticide-proof clothing through comparative analysis on the size of its commercial products. Most of male subjects were in charge of spraying pesticide, whereas female were most likely to play an assistant role to hold the hose of pesticide applicator. Both of female and male subjects were very aware of the harmful effect of pesticide on human body and tried to take off the clothes immediately after spraying it to reduce possible damage caused by pesticide. As a result of examining wearing condition, the farmers avoided wearing protective clothing because that it feels hot, stuffy, and uncomfortable to move. This hesitant response of wearing the clothing was not shown significantly in case of female subjects who play an assistant role for spraying. Although the farmers wore protective equipments such as mask or gloves in a proper way as compared to protective clothing, they seemed to choose alternative way rather than best way to block pesticide completely. The satisfaction regarding to the fitting of protective clothing which the subjects showed low in all items of upper-lower clothes except waistline. It is necessary to improve the functionality such as relief from heat stress and convenience for movement rather than design or economic in protective clothing development. As a result of comparing the size of five kinds of commercial protective clothing, the farmers got confused to choose the product since designation method of size across companies showed a significant difference in an identical clothing size. In addition, the sizing system developed on a basis of a well-built man has become a hindering factor in wearing satisfaction of female farmers.

• 한국정보통신학회논문지
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• 제9권8호
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• pp.1632-1642
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• 2005

항만정보시스템의 기능과 항만유형과는 관련성이 있는 것일까? 본 연구에서는 선진항만들의 유형과 정보시스템 기능 분석을 통하여 관련성을 규명하고자 하였다. 항만들은 자산의 소유와 운영의 주체에 따라 국유제, 공영자치제, 지방자치제(지방정부자치제) 및 사유제의 4가지로 유형으로 구분된다. 유형에 따른 항만들의 주요활동도 달라진다. 국유제와 지방자치제의 경우는 행정처리 기능에 중점을 두고 있는 반면, 공영자치제와 사유제는 고객서비스 강화에 중점을 두고 있다. 항만의 유형과 정보시스템과의 상관관계를 조사한 결과 국유제, 지방자치제 항만에는 업무처리 중심의 시스템이 발달하여 있으며, 사유제 및 공영자치제 항만에는 고객서비스를 최우선으로 하는 커뮤니티 시스템과 e-Business 시스템이 발달되어 있었다. 항만유형별 정보시스템의 차이는 부산항만정보시스템의 개선에 시사점을 던져주고 있다. 그동안 국유제 항만으로서 운영되던 부산항이 공영자치제 유형의 운영방식으로 변경됨에 따라 항만정보시스템도 추세에 따라 개선되어야 한다. 본 연구에서 제안하는 방법으로 3단계 방법을 제안하였다. 제 1단계가 미러링(Mirroring) 단계로서 항만운영을 안정화시키는 단계이며, 제 2단계에서는 커뮤니티 시스템을 구축하여 고객의 서비스를 제고시키는 협업화 단계로 설정하였으며, 제 3단계는 부가가치창출을 위한 수익형 시스템을 개발하는 e-Business 개발단계로 설정하였다.

• 대한약침학회지
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• 제18권1호
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• pp.72-78
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• 2015

Objectives: The stomach is a sensitive digestive organ that is susceptible to exogenous pathogens from the diet. In response to such pathogens, the stomach induces oxidative stress, which might be related to the development of both gastric organic disorders such as gastritis, gastric ulcers, and gastric cancer, and functional disorders such as functional dyspepsia. This study was accomplished to investigate the effect of Ganoderma lucidum pharmacopuncture (GLP) on chronic gastric ulcers in rats. Methods: The rats were divided into 4 groups of 8 animals each: the normal, the control, the normal saline (NP) and the GLP groups. In this study, the modified ethanol gastritis model was used. The rats were administrated 56% ethanol orally every other day. The dose of ethanol was 8 g/kg body weight. The normal group received the same amount of normal saline instead of ethanol. The NP and the GLP groups were treated with injection of saline and GLP respectively. The control group received no treatment. Two local acupoints CV12 (中脘) and ST36 (足三里) were used. All laboratory rats underwent treatment for 15 days. On last day, the rats were sacrificed and their stomachs were immediately excised. Results: Ulcers of the gastric mucosa appeared as elongated bands of hemorrhagic lesions parallel to the long axis of the stomach. In the NP and GLP groups, the injuries to the gastric mucosal injuries were not as severe as they were in the control group. Wound healings of the chronic gastric ulcers was promoted by using GLP and significant alterations of the indices in the gastric mucosa were observed. Such protection was demonstrated by gross appearance, histology and immunehistochemistry staining for Bcl-2-associated X (BAX), B-cell lymphoma 2 (Bcl-2) and Transforming growth factor-beta 1 (TGF-${\beta}1$). Conclusion: These results suggest that GLP at CV12 and ST36 can provide significant protection to the gastric mucosa against an ethanol induced chronic gastric ulcer.

• 감성과학
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• 제12권2호
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• pp.169-180
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• 2009

본 연구에서는 입체 영상이 가지는 특성과 시청환경의 특성에 따라 입체 영상을 시청할 때 발생할 수 있는 시각적 피로도를 체계적으로 살펴보기 위해 깊이방향의 운동속도와 응시거리 각각을 입체 영상과 시청환경의 대표적인 특성으로 삼고 각 요인에 의해 발생되는 시각적 피로도를 측정하였다. 시각적 피로도는 눈통증 요인, 시각적 스트레스, 어지러움 요인, 신체 통증 요인, 상흐림 요인으로 구성된 피로도 측정도구를 이용하여 주관적인 시각적 피로도를 측정하였다. 실험 1에서는 깊이 방향의 운동속도를 변화시킨 자극을 40분간 제시하면서 10분, 20분, 40분에 시각적 피로도를 측정하였다. 측정결과 전체 피로도 점수는 시청시간이 증가함에 따라 높아졌지만 운동 속도에 따른 차이를 보이지 않았다. 다섯 개의 하위척도들 중 어지러움 하위척도 점수에 서만 운동 속도가 증가할수록 증가하는 것으로 나타났다. 실험 2에서는 동일한 입체 영상을 응시거리만 변화시켜가면서 시각적 피로도를 측정하였다. 전체 피로도 점수는 시청시간이 증가함에 따라 높아졌지만 응시거리에 따른 차이는 발견되지 않았다. 다섯 개의 하위 척도들 중 상흐림 하위척도 점수에서만 응시거리가 멀어질수록 감소하는 것으로 나타났다. 이러한 결과는 입체 영상의 특성이나 시청환경에 따라 시각피로도가 변화될 수 있음을 보여주며, 시각피로도를 발생시키는 요인에 따라 각기 다른 종류의 시각피로도가 발생할 수 있음을 보여준다.

• Applied Biological Chemistry
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• 제50권1호
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• pp.63-67
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• 2007

본 연구에서는 석곡(Dendrobium nobile Lindl.) 추출물에 대한 신경세포 보호 효과를 확인하기 위하여 $H_{2}O_{2}$에 의해 유도된 스트레스 상태의 PC12 세포주에서 MTT-dye reduction assay와 LDH release assay를 이용하였다. MTT reduction assay 결과, 스트레스 상태에서는 47%의 생존율을 보인데 반하여 석곡 추출물 50${\mu}$g/ml 농도로 처리하였을 때 99.5%의 높은 세포 생존율을 확인할 수 있었다. 이 결과는 LDH release assay 에서도 일치하는 결과를 확인하였다. 그리고 광학 현미경을 이용한 형태학적 변화를 관찰한 결과에서도 신경돌기의 출현 유도를 통한 신경세포 생존을 확인 할 수 있었다. 또한 핵의 변화에 미치는 영향을 관찰한 결과 정상 세포의 핵은 타원형의 온전한 핵 모양을 나타낸 반면 산화적 손상을 입은 세포는 apoptotic body가 핵 주변에 나타나는 전형적인 apoptosis를 나타내었고 석곡 추출물을 처리한 결과 핵의 condersation현상과 fragmentation이 현저히 감소함을 확인 할 수 있었다. 그리고 $H_{2}O_{2}$에 의한 capase-3의 활성은 석곡 추출물을 50${\mu}$g/ml 처리 후 약 1.1배 이하로 감소함을 보였다.

• The Journal of Korean Physical Therapy
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• 제15권1호
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• pp.82-95
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• 2003

Our health is intimately connected to the health of our environment. The contemporary world view which sees a radical distinction between humans as subjects and world as object can obscure our recognition of how much we rely on nature for health and survival. Indigenous traditions and contemporary scholars remind us that we live in a universe in which all things are connected, and in which nature continues to offer its gifts in co-creative partnership for the health and wellbeing of all. Living in awareness of our relationship with nature enables us to open more to the experience of nature's nurturing. Many complementary therapies derive from ancient practices that involve nature in healing partnership. Essential oils have been used for thousands of years. Hippocrates claimed that the way to health was through aromatic baths and massages. Much anecdotal evidence exists regarding aromatherapeutic positive effects on recipients. Aromatherapy is a branch of complementary or alternative therapy which is increasing in popularity, yet has scant scientific credibility. Aromatherapy should be defined as treatment using odors and practised as such. However, essential oils are usually used in conjunction with therapeutic massage and often combined with counselling of some kind. Aromatherapy complements and enhances the therapeutic powers of massage. Massage is one of the most wonderful ways to relax and is throughly beneficial to health. Massage can help unknot tense and aching muscles and other minor symptoms of stress, leaving patients fresh and energized. As the use of aromatherapy within a health care setting has grown so rapidly in recent years, and will continue to do so, the need for suitable training has become apparent. No health service can afford the risk of having staff who are inadequately trained in the practice of aromatherapy using essential oils incorrectly on those in a state of ill-health, especially if the essential oils used are not to a standard suitable for therapeutic use. Training to an acceptable level in aromatic therapy is essential for safety and effectiveness. Knowledge of the nature and make-up of essential oils, their effect on the body and the emotions, and how, when, and where to apply them is imperative in order for them to be beneficial to a patient's health. In order to achieve best practice, further research is necessary to explore the use of aromatherapy in the management of multiple disorder.

• 동의생리병리학회지
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• 제20권4호
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• pp.936-941
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• 2006

To prevent human body injury from oxidative stress, antioxidants are very important and many research about antioxidants are generally being conducted. Hydrogen peroxide$(H_20_2)$ that is one of vitality oxygen species has been seen that cause various diseases, DNA damage and gene change. We have already known that the inhibition effect of Zizania latifolia Radix, Rhizoma on apoptosis induced by $H_2O_2$ in Neuro2A cell. And the purpose of this study was that we made a comparative study on the inhibition effect of apoptosis in Neuro2A cell on the region of Zizania latifolia(Radix, Rhizoma, Herba). Neuro2A cells were cultivated in RPMI(GibcoBRL) with 5% FBS and treated with $H_2O_2$ and Zizania latifolia(Radix, Rhizoma, Herba). Separately we measured the cell viability and analyzed DNA fragmentation. Activity of PARP, Cytochrome C, caspase-9, caspase-3, p53, p21, Bax and Bcl-2 in the cell was examined by using western blot. The results obtained were as Follows: The cell viability in all of Zizania latifolia (Radix, Rhizoma, Herba) treatment (60ug/m1<) decreased significantly compared with that of none treatment(p<0.001). Zizania latifolia Radix increased cell viability was most effective of three regions. But we had no significant difference among three regions. All of Zizania latifolia (Radix, Rhizoma, Herba) increased cell viability about twice as much as that being injury by $H_2O_2$,(Zizania Latifolia (Radix, nhizoma, Herba) 20ug/m1, $H_2O_2$ 200uM, p<0.001). DNA fragmentation developed by $H_2O_2$, but was not developed in all of Zizania latifolia (Radix, Rhizoma, Herba) treatment. PARP, Cytochrome C, caspase-9 and caspase-3 activated all by $H_2O_2$ but were not activated in all of Zizania latifolia (Radix, Rhizoma, Herba) treatment. P53, P2l and Bax activated by $H_2O_2$, and Bcl-2 got into inactivation. But the opposite results appeared in all of Zizania latifolia (Radix, Rhizoma, Herba) treatment. In conclusion, these results suggest that all of Zizania latifolia (Radix, Rhizoma, Herba) inhibit the development of DNA fragmentation and apoptosis by $H_2O_2$and the antioridant action of all of Zizania latifolia (Radix, Rhizoma, Herba) is effective.

• 대한예방한의학회지
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• 제15권1호
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• pp.49-69
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• 2011

Objective : The object of this study was to observe the effects of Lonicerae Flos (LF) aqueous extracts on lipopolysaccharide (LPS)-induced rat acute lung injury. Method : Five different dosages of LF extracts were orally administered once a day for 28 days before LPS treatments, and then all rats were sacrificed after 5 hour-treatment of LPS. Eight groups of 16 rats each were used in the present study. The following parameters caused by LPS treatment were observed ; body weights, lung weights, pulmonary transcapillary albumin transit, arterial gas parameters (pH, $PaO_2$ and $PaCO_2$) bronchoalveolar lavage fluid (BALF) protein lactate dehydrogenase (LDH), and proinflammatory cytokines tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-$1{\beta}$ (IL-$1{\beta}$) contents, total cell numbers, neutrophil and alveolar macrophage ratios, lung malondialdehyde (MDA), myeloperoxidase (MPO), proinflammatory cytokines TNF-${\alpha}$ and IL-$1{\beta}$ contents. In addition, the histopathologic changes were observed in the lung in terms of luminal surface of alveolus, thickness of alveolar septum, number of polymorphonuclear neutrophils. Result : As results of LPS-injection, dramatical increases in lung weights, pulmonary transcapillary albumin transit increases, increases in $PaCO_2$, decreases in pH of arterial blood and $PaO_2$, increases of BALF protein, LDH, TNF-${\alpha}$ and IL-$1{\beta}$ contents, total cells, neutrophil and alveolar macrophage ratios, TNF-${\alpha}$ and IL-$1{\beta}$ contents increases were detected with decreases in LSA and increases of alveolar septum and PMNs numbers, respectively as compared with intact control. These are means that acute lung injuries (resembling acute respiratory distress syndrome) are induced by treatment of LPS mediated by inflammatory responses, oxidative stress and related lipid peroxidation in the present study. However, these LPS-induced acute lung injuries were inhibited by 28 days continuous pretreatment of 250 and 500mg/kg of LF extracts. Because of lower three dosages of LF treated groups, 31.25 and 62.5 and 125mg/kg did not showed any favorable effects as compared with LPS control, the effective dosages of LF in LPS-induced acute lung injuries in the present study, is considered as about 125mg/kg. The effects of 250mg/kg of LF extracts showed almost similar effects with ${\alpha}$-lipoic acid 60mg/kg in preventing LPS-induced acute lung injuries. Conclusion : It seems that LF play a role in protecting the acute respiratory distress syndrome caused by LPS.

• 한국식품과학회지
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• 제46권5호
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• pp.622-629
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• 2014

생쥐에서의 으름의 열매 추출물의 경구 투여가 알코올로 인한 급성 간독성 상태에서 간보호 효과에 대한 영향을 조사 하였다. 즉, 생쥐 (C57BL/6)에게 1주간 으름 열매 추출물을 투여 하고 희생 전 알코올의 경구 투여를 통해 급성 알코올 간독성을 유발한 후 간 조직 형상, 간 기능 지표(ALT, AST), 간 세포내 GSH 합성 효소(GCLM, GCLC, GSS)의 mRNA 발현량, GSH 농도의 측정, 산화 스트레스 지표인 NOX4의 mRNA 발현량과 염증 반응 지표인 TNF-${\alpha}$의 mRNA 발현량을 조사 하였다. 그 결과, 으름 열매 추출물의 경구 투여는 알코올로 유발된 급성 간독성 상태에서 간 조직내 지방의 축적을 완화 하였고, 혈청 AST, ALT 수치를 개선하였으며, 간조직 내 항산화 물질인 GSH의 농도를 증가시켰다. 더불어 활성산소기를 생성하는 NOX4의 mRNA 발현을 억제 하는 것으로 분석되었으며 염증 반응 지표인 TNF-의 mRNA 발현도 억제 하는 것으로 분석되었다. 따라서 으름의 열매 추출물은 알코올로 유발된 산화 스트레스, 염증 반응에 대한 간보호 효과 가능성을 나타내는 것으로 판단된다.

• 한국산학기술학회논문지
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• 제15권5호
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• pp.2996-3006
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• 2014

본 연구는 대학생들의 개인적 특성, 가정생활, 학교생활 및 건강관련행위 특성에 따른 자아존중감, 사회적지지 및 우울수준을 파악하고, 특히 자아 존중감 및 사회적지지와 우울과의 관련성을 규명하고자 실시하였다. 조사대상은 대전 충청지역에 소재하고 있는 4년제 대학에 재학 중인 남녀 대학생 471명으로 하였으며, 자료 수집은 2013년 4월 23일부터 약 2주에 걸쳐 표준화된 자기기입식 설문지를 사용하여 수집하였다. 연구결과, 조사대상자들의 자아존중감과 사회적지지에 따른 우울 수준은 자아존중감이 낮을수록(p=0.000), 사회적지지가 낮을수록(p=0.000) 우울수준이 유의하게 높았다. 조사대상자들의 자아존중감과 사회적지지는 우울수준과 유의한 음의 상관관계를 보였으며, 사회적 지지와 자아존중감은 유의한 양의 상관관계를 보였다. 위계적 다중회귀분석 결과, 조사대상자들의 우울수준에 영향을 미치는 요인으로는 성별, 연령, 체형에 대한 스트레스 유무, 주관적인 경제 상태, 공부시간, 자아존중감 및 사회적지지가 유의한 요인으로 지적되었으며 이들의 설명력은 23.8%이었다. 위와 같은 결과는 조사대상 대학생들의 우울수준은 자아존중감 및 사회적 지지와 유의한 관련성이 있음을 시사하고 있으며, 특히 우울수준은 사회적지지에 의해 더 큰 영향을 받고 있음을 알 수 있다.