• Journal of the Korean Society of Food Science and Nutrition
• /
• v.36 no.5
• /
• pp.548-553
• /
• 2007

This study was designed to investigate effects of KH-305 on erectile dysfunction in hyperlipidemic rat. KH-305 has been evaluated for antihyperlipidemic and antierectile dysfunction effects on experimental hyperlipidemic rats induced by high cholesterol-diet. After oral administration of KH-305 water extract (50, 100, 200, 300 mg/kg) to hyperlipidemic rats for 8 weeks, the variables including body weight, total cholesterol, HDL-, and LDL-cholesterol levels in serum, the expression of eNOS and nNOS in penis were measured. Also, erectile function was determined by the measurements of intracavernosal pressure (ICP) and maximal arterial pressure (MAP) after electrical stimulation of the cavernosal nerve. Oral administration of KH-305 extracts significantly inhibited the increase of serum total cholesterol and LDL-cholesterol levels and the decrease of serum HDL-cholesterol level in hyperlipidemic rats induced by high fat diet. The penile expression level of the two enzymes (eNOS, nNOS) were increased significantly after oral administration of the KH-305 extracts. Erectile function after 10 volts stimulation was significantly decreased in the hyperlipidemic rat compared with the normal rat, but increased in KH-305 group compared with hyperlipidemic group. These results suggest that KH-305 is effective for erectile dysfunction in hyperipidemia.

• Korean Journal of Community Nutrition
• /
• v.19 no.6
• /
• pp.513-526
• /
• 2014

Objectives: This study was conducted to investigate the effect of low sodium diet education program on dietary habits, diet quality, and measures of obesity in overweight or obese middle-aged women. Methods: Subjects were 81 individuals aged 45 years or over, who completed an 8-week nutrition education. The subjects were divided into a normal group (N = 30) and an overweight-obese group (N = 51) according to the BMI. The effects were evaluated by anthropometric measurement, biochemical analysis, questionnaire, and diet records before and after the program. Results: Overweight-obese group showed significant decreases in weight (p < 0.0001), BMI (p < 0.0001), percent of body fat (p = 0.0087), waist circumference (p < 0.0001), systolic (p = 0.0003) and diastolic blood pressure (p = 0.0261). Nutrients intakes were not different between the two groups and only sodium intake was decreased after education. Total score of general dietary habits, dietary behavior related to sodium intake, dietary diversity score (DDS), diet variety score (DVS), and diet quality index-international (DQI-I) were improved in both groups compared to the baseline. Overweight-obese group showed significant improvement in 'having fruits everyday', 'having fish everyday', 'trying to eat many kinds of food', 'eating less broth when eating soup, stew, and noodles', 'eating less kimchi and salt-fermented vegetable', and 'propensity to think that dishes should be pretty seasoned'. In addition, moderation of empty calories food (p = 0.0064) and macronutrient ratio (p = 0.0004) were improved in the overweigh-obese group, but in the normal group, the results did not reach statistical significance. Conclusions: These results suggested that low sodium diet education program may contribute to obesity management by improving diet quality and dietary habits in middle-aged women.

• Journal of Animal Science and Technology
• /
• v.47 no.4
• /
• pp.555-564
• /
• 2005

This study was conducted to investigate the effect of dietary supplementation of zeolite on growth performance, carcass characteristics and fecal ammonia gas release in the finishing pigs. A total of 120 crossbred finishing pigs (50.2$\pm$1.4kg, Landrace$\time$Yorkshire$\time$Duroc) were assigned to 4 treatments and randomly divided into 12 groups. They were divided between early finishing period (50~80kg) and late finishing period (80-120kg). Finishing pigs were fed on a basal diet supplemented with 0, 1, 2 and 4% levels of zeolite. Average daily gain and feed conversion were significantly (P<0.05) improved by the dietary supplementation of 4% zeolite compared with other treatments during overall period. In the finishing periods, ammonia gas emission was reduced (P<0.05) in 4% zeolite treatment more than that of the other treatments. Carcass weight and back fat thicknesses were not affected by zeolite treatments. But, the appearance of A grade pork was increased by the dietary supplementation of 4% zeolite. Feed cost was linearly decreased by increasing the supplementation of zeolite. According to this study, 4% supplement of zeolite is suitable for the improvement of carcass quality and feed conversion, the reduction of fecal ammonia gas emission and feed cost per body weight gain.

• Journal of Animal Science and Technology
• /
• v.59 no.8
• /
• pp.18.1-18.8
• /
• 2017

Background: In 2006, the European Union (EU) has decided to forbid use of antibiotics as growth promoters. Although many researches had been conducted about fiber source as alternatives of antibiotics, there are still lack of reports in the literature about the optimum level of sugar beet pulp supplementation, affecting growth performance and nutrient digestibility in weaning pigs. Therefore, different level of sugar beet pulp was added to diets to determine the effects of sugar beet pulp supplementation on growth performance, nutrient digestibility, fecal microflora, blood profile and incidence of diarrhea in weaning pigs. Methods: A total of 200 weaning pigs [$(Yorkshire{\times}Landrace){\times}Duroc$], averaging $9.01{\pm}1.389kg$ of initial body weight were, allotted to 5 treatments in a randomized complete block (RCB) design. Each treatment was composed of 4 replicates with 10 pigs per pen. The treatments were control treatment: Corn-SBM basal diet + ZnO (phase 1: 0.05%; phase 2; 0.03%) and four different levels of sugar beet pulp were supplemented in Corn-SBM basal diet (3, 6, 9 or 12%). Two phase feeding programs (phase 1: 1-2 weeks; phase 2: 3-5 weeks) were used for 5 week of growth trial. Results: In feeding trial, there were no significant differences in growth performance and incidence of diarrhea among treatments. The E.coli counts were not significantly different among dietary treatments but linear response was observed in Lactobacillus counts as sugar beet pulp supplementation increased (P < 0.05). In addition, IGF-1, IgA and IgG were not affected by dietary treatments. However, the BUN concentration was decreased when pigs were fed the treatments of diets with SBP compared to that of control treatment (P < 0.05). In nutrient digestibility, crude fiber and NDF digestibilities were improved as the sugar beet pulp increased (P < 0.05). However, digestibilities of crude ash, crude fat, crude fiber and nitrogen retention were not affected by dietary sugar beet pulp levels. Conclusion: This experiment demonstrated that sugar beet pulp can be supplemented in weaning pigs' diet instead of ZnO to prevent postweaning diarrhea without any detrimental effect on growth performance.

• Journal of Microbiology and Biotechnology
• /
• v.14 no.4
• /
• pp.722-729
• /
• 2004

Leptin is an adipocyte-secreted hormone and its plasma levels correlate with total body fat mass, however, it also plays a regulatory role in immunity, inflammation, and hematopoiesis. Chemokine is known as a chemoattractant cytokine in inflammatory reaction, but its role in leptin reaction has not been well studied. In this study, the direct effect of leptin on the expression of chemokine mRNAs and lipopolysaccharide (LPS)-induced chemokine KC mRNA in mouse peritoneal macrophages was investigated. Leptin did not induce the expression of lymphotactin, RANTES, eotaxin, MIP-1$\beta$, MIP-1$\alpha$, MIP-2, MCP-1, IP-10, TCA-3, and KC mRNA in mouse peritoneal macrophages, and had no direct effect on the expression of these LPS-induced chemokine mRNAs except KC mRNA. The synergistic effect of leptin on the expression of LPS-induced KC mRNA occurred late in the time course of response to LPS. The increased expressions of Ob-Rb mRNA and leptin receptor protein were detected during the LPS treatment. Leptin produced a substantial increase in the stability of the LPS-induced KC mRNA, and the synergistic effect of leptin on LPS-induced KC mRNA expression was further augmented by cycloheximide (CHX). Pyrrolidine dithiocarbamate (PDTC) did not block the synergistic effect of leptin on LPS-induced KC mRNA expression in mouse peritoneal macrophages. These data suggest that although leptin has no direct effect on the expression of lymphotactin, RANTES, eotaxin, MIP-1$\beta$, MIP-1$\alpha$, MIP-2, MCP-1, IP-10, TCA-3, and KC mRNA in mouse peritoneal macrophages, the synergistic effect of leptin on the expression of LPS-induced KC mRNA has the possibility that LPS might induce the expression of the Ob-Rb receptor or an unknown gene(s) that sensitizes macrophages to the synergistic function of leptin. Therefore, further studies are necessary to examine leptin as a regulatory factor of chemokine production.

• Proceedings of the Korea Society of Poultry Science Conference
• /
• 2001.11a
• /
• pp.61-63
• /
• 2001

Two experiments were conducted to investigate the feeding influence of wood vinegar and mixed with probiotics on performance and physiological related of broiler chicks for five weeks. Diets contained 21.5%, 3,100kcal/kg and 19.0% CP, 3,100kcal/kg ME for starting and finishing period, respectively. In Expt 1, Four levels of wood vinegar(0, 0.05, 0.10, 0.20%) were fed into two hundred forty chicks with four replicates. In Expt 2, 0, 0.1% wood vinegar(W), 0, 0.1% lactobacillus casei(L) and bacillus subtilis (B) were applied to 2${\times}$2${\times}$2 facotrial design for eight treatments with four replicates. Weight gain, feed intake, feed cholesterol were detected at five weeks old in each experiment. In Expt 1, Weight gain of chicks fed 0.1% wood vinegar(WV) was increased upto 1645.8g, but was not significantly different. However, chicks fed 0.2% WV showed the highest gain and siginificantly different compared to that of control (P＜0.05) for finishing period. Feed intake also showed similar tendency with weight gain. There were no statistical difference in feed conversion. Abdominal fat seemed to be decreased in WV supplemental groups, whereas ND antibody titer tended to increase in those treatments. In Expt 2, 0, 0.1% WV, lactobacillus, bacillus were combined with each other(W$\sub$0/L$\sub$0/B$\sub$0/, W$\sub$0/L$\sub$1/B$\sub$0/, W$\sub$0/L$\sub$0/B$\sub$1/, W$\sub$0/L$\sub$1/B$\sub$1/, W$\sub$1/L$\sub$0/B$\sub$0/, W$\sub$1/L$\sub$1/B$\sub$0/, W$\sub$1/L$\sub$1/ B$\sub$0/, W$\sub$1/L$\sub$0/B$\sub$1/, W$\sub$1/L$\sub$1/B$\sub$1). WV supplemental groups significantly improved feed conversion of all treatments(P＜0.05). There were no interaction in weight gain and feed intake. Total cholesterol was signficantly decreased in WV plus lactobacillus and ladtobacillus plus bacillus treatments. Liver to body ratio(%) of lactobacillus plus WV significantly decreased compared to that of other treatments. The results of these experiments showed that wood vinegar tended to improve the performance of broiler chicks, but was not effect in its combination with lactobacillus or bacillus treatments.

• Korean Journal of Poultry Science
• /
• v.32 no.3
• /
• pp.165-170
• /
• 2005

This experiment was conducted to compare the influences of dietary dried persimmon by-product(DPB) on performance, blood cholesterol and fatty acid composition in broiler chicks. Diets contained 21.5 and $19\%$ CP for the starting and finishing period, respectively. The ME was 3,100kcal/kg in diets for both starter and finisher diets. One hundred sixty chicks were assigned to 4 treatments with 4 replicates at different levels of dried persimmon by-product. Treatments were consisted of 0(control), 1(T1), 3(T2) and $5\%$ (T3) DPB. Body weight gain was higher in treatment groups fed the starter diet but was the lowest in T3 for finishing period. Feed efficiency was not significantly different. In proximate composition, crude fat of chicken meat were increased in diets by addition of DPB than control, but moisture and crude ash was no significantly different. The total cholesterol, HDL, and triglyceride of treatment groups was higher than control. The LDL of control was higher than treatment groups. In fatty acid composition, oleic acid contents of treatment groups were higher than control, whereas stearic, linoleic acid contents lower in meat composition than control. In conclusion, dietary supplementation of DPB at $3\%$ level tended to improve growth performance of broiler chicks.

• Korean Journal of Poultry Science
• /
• v.31 no.3
• /
• pp.151-155
• /
• 2004

This experiment was conducted to investigate the influence of dietary supplementation of granite porphyry (GP) on growth performances and meat sensory quality in commercial broiler chicks. A total of four hundred-fifty 5-day-old male broiler chicks were divided into 15 pens and fed one of five experimental diets for 5 weeks; 0% GP with antibiotics (Control), 1% GP with or without antibiotics, and 2% GP with or without antibiotics. Final body weight and daily weight gain of all GP supplemented groups were slightly higher than those of control. Feed conversion rate was improved in GP 1 % supplemented groups, although there was no significant difference. Feeding antibiotics in addition to GP did not influence the growth parameters. Relative weights of liver and abdominal fat tended to be reduced in broiler chickens fed GP supplemented diets. Feeding of 2% GP diet resulted in a significant improvement in meat sensory quality in terms of taste and tenderness(P < 0.05), but the effect of the 1% GP on meat sensory quality was not significant. The results of this study indicate that GP could be used as a favorable feed additive for production of sensory-enhanced broiler meats.

• Journal of Preventive Medicine and Public Health
• /
• v.30 no.4 s.59
• /
• pp.729-740
• /
• 1997

To determine the relationship between hypertension and nutrient intake cross-sectional study were performed in a rural area. Adult resident over 30-year-old age were measured blood pressure and body mass index(BMI), and interviewed about food in-take for the previous 24 hours. 250 men and 297 women participated the survey. Significant correlation was showen in men between mean systolic blood pressure and protein density. Significant correlation with mean diastolic blood pressure was showen on protein density, protein energy(%), calcium density and energy-adjusted protein in men. We analysed risk factor for hypertension adjust the effect of age, BMI, sex and family history by multiple logistic regression. Protein density(odds ratio=3.18), fat density(odds ratio=1.94) and energy-adjusted protein(odds ratio=1.01) intake were positively associated with hypertension but sodium density(odds ratio=0.73) was showen to have inverse relationship.

• Journal of The Korean Society of Grassland and Forage Science
• /
• v.39 no.4
• /
• pp.272-280
• /
• 2019

The present study was designed to determine the effect of barn or cycle of grazing on changes of biochemical metabolites in prepartum and changes of milk composition in postpartum of dairy cows. For this purpose, a total of sixteen 25 months old Holstein primiparous dairy cows were allocated in two groups (n=8) with an average body weight of 571.61 ± 35.30 kg (Barn) and 578.10 ± 39.20 kg (Grazing). The study was conducted from June 2018 to October 2018. Results revealed that barn raised dairy cows had a higher increase in their serum albumin and calcium level on day 14 prepartum. However, the level of palmitic acid, saturated fatty acid increased significantly, and the level of fat, oleic acid, γ-linoleic acid, arachidonic acid and unsaturated fatty acids decreased significantly in barn raised dairy cow's milk on day 14 postpartum. There were no significant differences observed with respect to all other biochemical metabolites, fatty acids and minerals between barn raised and cycle grazing dairy cows during prepartum and postpartum. Our study results could serve to a better understanding of barn raised cow with respect to changes of biochemical metabolites in prepartum and changes of milk composition, fatty acids and minerals content in grazing dairy cows in postpartum for estimating their physiological status.