• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4405-4409
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• 2014

Reactive oxygen species (ROS), highly reactive molecules, are produced by living organisms as a result of normal cellular metabolism and environmental factors, and can damage nucleic acids and proteins, thereby altering their functions. The human body has several mechanisms to counteract oxidative stress by producing antioxidants. A shift in the balance between oxidants and antioxidants in favor of oxidants is termed as "oxidative stress". Paradoxically, there is a large body of research demonstrating the general effect of oxidative stress on signaling pathways, less is known about the initial and direct regulation of signaling molecules by ROS, or what we term the "oxidative interface." This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival (MAP kinases and PI3 kinase), ROS homeostasis, and antioxidant gene regulation (Ref-1 and Nrf-2). This review also deals with classification as well as mechanisms of formation of free radicals, examining their beneficial and deleterious effects on cellular activities and focusing on the potential role of antioxidants in preventing and repairing damage caused by oxidative stress. A discussion of the role of phytochemical antioxidants in oxidative stress, disease and the epigenome is included.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.11
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• pp.1569-1576
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• 2013

The study was conducted to evaluate the effect of vitamin E and zinc supplementation on energy metabolites, lipid peroxidation, and milk production in peripartum Sahiwal cows. For this, thirty-two pregnant dry Sahiwal cows were selected at sixty days prepartum and divided into four groups viz control, $T_1$, $T_2$, and $T_3$ of eight each. Group $T_1$ were supplemented with zinc at 60 ppm/d/cow, group $T_2$ were supplemented with vitamin E at 1,000 IU/d/cow and group $T_3$ were supplemented with combination of vitamin E at 1,000 IU/d/cow and zinc at 60 ppm/d/cow during d 60 prepartum to d 90 postpartum. Blood samples were collected on d -60, -45, -30, -15, -7, -3, 0, 3, 7, 15, 30, 45, 60, 90, and 120 with respect to day of parturition and analysed for glucose, non esterified fatty acid, and thiobarbituric acid reactive substance. Body condition score was maintained significantly better (p<0.05) in $T_3$ than in the control, $T_1$ and $T_2$ groups. Overall glucose level was higher (p<0.05) in $T_3$ than control, $T_1$, and $T_2$ groups. Levels of nonesterified fatty acid, and thiobarbituric acid reactive substance were lower (p<0.05) in $T_3$ than control, $T_1$, and $T_2$ groups. Milk yield was higher (p<0.05) in $T_3$ than control, $T_1$, and $T_2$ groups. In conclusion, the present study indicated that the supplementation of vitamin E and zinc in peripartum Sahiwal cows enhanced milk production by reducing negative energy balance.

• Korean Journal of Community Nutrition
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• v.15 no.1
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• pp.73-82
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• 2010

This study was conducted to investigate the effects of a weight control programs on BMI, nutrition knowledge, physical fitness and stress level of adult obese women. The subjects of this study were 36 adult obese women aged 30-65 years whose BMI were above $23\;kg/m^2$. The weight control program for obese women included nutritional education, exercise and cognitive behavioral therapy for 12 weeks. The BMI of the subjects was significantly decreased (p < 0.001) from $27.1\;kg/m^2$ to $26.4\;kg/m^2$ after the 12 weeks of the weight control program. In addition, the weight of body fat was significantly decreased (p < 0.001) and % body fat was significantly decreased (p < 0.05) from 35.4% to 34.9% after completion of the weight control program. In addition, nutritional knowledge (p < 0.001) and eating behavior scores (p < 0.01) were significantly increased. However, the food intake scores were not changed after the program. Stress levels of the adult obese women were significantly decreased (p < 0.001) from 85.63 to 66.88 and also obesity stress levels were significantly decreased (p < 0.01) after the weight control program. In the physical fitness levels of the subjects, muscle endurance (p < 0.05) and ability of balance (p < 0.01) were significantly improved after completion of the weight control program. There were positive significant correlations between general stress and obesity stress level (p < 0.05), and negative correlations between stress level and food intake score (p < 0.05). These results showed that the weight control program for adult obese women may be effectively used to improve weight reduction, physical fitness and stress levels.

• The Korean Journal of Food And Nutrition
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• v.22 no.4
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• pp.577-586
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• 2009

Aging is associated with decreased energy expenditure, thermogenesis and energy requirements. Maintenance of physical fitness of the elderly has been reported to reduce the rate at which the basal metabolic rate, muscle strength, skeletal muscle mass and bone density deteriorate. Skeletal muscle disease is known to increase the risk of physical disability and psychological problems. This study was conducted to investigate changes in disability, emotional problems, body compositions, obesity indices and nutrient intake levels according to physical fitness with the elderly in rural areas. According to the results, physical fitness was negatively related with Activities of Daily Living(ADL, p<0.05), Instrumental Activities of Daily Living(IADL, p<0.001), Body Mass Index(BMI, p<0.001) and abdominal obesity(p<0.05), while it showed a positive correlation with the General Self Efficacy Scale(GSES)(p<0.001) and nutrient intake(p<0.05). When changes in these factors were compared according to the range of quartile of the Fullerton Advanced Balance Scale(FAB Scale), GSES(Q1=35.3, Q2=43.5, Q3=53.2, Q4=51.9, p<0.001), BMI(Q1=36.1%, Q2=34.7%, Q3=33.2%, Q4=28.6%, p<0.01), abdominal obesity(Q1=1.02, Q2=0.99, Q3=0.97, Q4=0.94, p<0.001) and nutrient intake(Q1=71.1%, Q2=75.4%, Q3=80.6%, Q4=80.2%, p<0.05) differed significantly. Taken together, these results suggested that better physical fitness would lead to a reduction in negative factors including physical disability and obesity indices, but to an increase in positive factors such as GSES and nutrient intake. The results of this study are expected to be used as basic data for the development of programs to promote the health of the elderly in a local society.

• The Journal of Internal Korean Medicine
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• v.23 no.2
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• pp.292-297
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• 2002

Fire is known as one of the most common causes of stroke. Chest fever with dysphoria caused by heat in the stomach is one of the fire symptoms, meaning feeling oppressed in the chest. We observed two stroke patients who had chest fever with dysphoria. These patients' clinical symptoms were headache, thirst, heat in the upper part of the body and constipation. They were diagnosed as Chest fever with dysphoria. It is assumed that Exuberance of Yang causes heat. We treated them with Yangkyuksanhoa-tang(凉膈散火湯) based on Dong Ui Su Se Bo Won for about 2 weeks. During this period, we observed that their symptoms of heat in the upper part of the body and constipation had been improved. We suggest that Yangkyuksanhoa-tang makes the balance between water and fire, and improves chest fever with dysphoria of stroke patients.

• Journal of Korean Academy of Rural Health Nursing
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• v.4 no.2
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• pp.103-109
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• 2009

Purpose: This study was conducted to test the effect of a 5 weeks health education program on stroke for rural elderly people. Methods: A total of 55 rural elders in Kok Sung County were participated in the health education on stroke program. Descriptive statistics, and paired t-test were used for statistical analysis with SPSS 12.0. Results: The results are summarized as follows : Mean age was 67.3 years and 88.2% of participants were female. The mean pre-test scores for knowledge of stroke were 0.35 and post-test, 0.85 (p< .001). Percentage of accurate response rates of warning signs of stroke were sudden dizziness pre-test 45.5% post-test 80.0%, sudden trouble speaking or understanding, pre-test 27.3% post-test 41.8%, sudden trouble walking, loss of balance or coordination, pre-test 32.7% post-test 70.9%, sudden numbness or weakness of the arm or leg, especially on one side of the body, pre-test 47.3% post-test 72.7%, sudden confusion, pre-test 27.3% post-test 81.8%, sudden numbness or weakness of the face especially on one side of the body, pre-test 40.0% post-test 76.4%, sudden severe headache with no known cause, pre-test 40.0% post-test 70.9%, Sudden trouble seeing in one or both eyes, pre-test 38.1% post-test 66.0%, nausea or vomiting pre-test 16.4% post-test 43.6%. The increases after the health education on stroke were statistically significant. Conclusions: Health education on stroke for rural elderly people are needed and should focus on community health care programs, especially for those who are older, had a low level of education, and low socio-economical status.

• Journal of Nutrition and Health
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• v.26 no.1
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• pp.21-33
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• 1993

This balance study was performed to investigate nutritional effects of guar gum and calcium supplement for 8 weeks. 36 male rate of Sprague-Dawley strain weighing 50g were blocked into six groups : 5CN, 5GN, 5CS, 5GS, FFN, 10GN. Food intake, body weight gains, FER, PER, bioavailabity of energy, protein, fat, Ca and P, and Ca & P content of femur and kidney was measured. The results obtained in this study were summarized as follows: (1) Feed intake, weight gains, FER, PER and bioavailabilities of protein and P and the contents of Ca & P in femur of 5GB were significantly higher than 5CN and 5CS (p<0.05) but was not significant different with those 5GN. Fat bioavailabilities of 5GS was significantly lower than 5CN and 5GN (p<0.05) but was not significant different with those of 5CS. Ca contents of kidney of 5GS was significantly higher than 5CN and 5GN(p<0.05) but was not significant different with those of 5SC. (2) According to guar gum levels feed intake. FER and PER were not sifgnificantly different among groups but body weight gains, bioavailabilities of energy, protein, fat and Ca, Ca & P content of femur was significantly decreased (p<0.05). Bioavailabilities of P was significantly increased according to the guar gum levels (p<0.05). Ca contents in Kidney of 10GN was significantly higher those of 5GN(p<0.05) but P contents in kidney was not significant difference by guar gum levels. Therefore 5% supplemental guar gum in diet of obese man and diebetics could be recommended. But it should be careful in using 10% guar gum in diet.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.8
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• pp.1234-1240
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• 1999

The nutritive value of rumen contents and barley mixture (4:1 w/w; RCB) was evaluated and the effect of their feeding on growth performances in Najdi lambs was studied. A metabolism trial was conducted with 16 rams divided into four dietary groups. The diets were: a whole-mixed control diet and three diets where RCB was incorporated at the rates of 25, 50 and 100%, replacing an equal amount of control diet. The results showed that there was a depression (p<0.05) in DM digestibility for the 100% RCB diet in comparison with other diets. The digestibility of CP was higher(p<0.05) for the 25% RCB diet as compared to the control diet; there was a trend for a small (p>0.05) decrease in digestibility as level of RCB increased. Lambs in all studied diets were in positive nitrogen balance; the differences between diets were not significant. A total of 45 lambs were allotted into three groups and used to evaluate the effect of dietary inclusion of RCB (0, 25 and 50%) on growth performance and carcass traits. Daily DM intake, final body weight, carcass weight and dressing percentage were not different among treatments. Average weight gain and ether extract (EE) in 9-11th control joint were higher (p<0.05) in lambs fed control diet than those fed RCB diets. The substitution of RCB for 50% of control diet exhibited 11.8% reduction in feeding cost for each kg of body weight gain.

• Journal of Nutrition and Health
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• v.37 no.2
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• pp.100-107
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• 2004

This study was performed to evaluate the effect of dietary protein source and sulfur amino acid content on bone metabolism in ra. Thirty male rats (body weight 145$\pm$2g) were divided into three groups. The rats in the first group were fed on casein 20% diet as animal protein source and those in the second group were fed on soy 20% diet as plant protein source. Sulfur amino acid ratio of these group was 1.07:1. The rats in the third group were fed on soy 20% diet and the sulfur amino acid were supplemented with the amount contained as much in the soy 20% diet. All rats were fed on experimental diet and deionized water ad libitum for 9 weeks, The total body, spine, femur bone mineral density and bone mineral content were measured using Dual Energy X-ray Absorptiometry Calcium, phosphate, pyridinoline, creatinine in urine and calcium, phosphate, alkaline phosphatase, osteocalcin in serum were measured. During the experimental period, plant protein (soy protein) group had a lower urinary Ca excretion, urine pyridinoline ＆ crosslinks value and had a higher Ca efficiency in total bone and femur bone mineral density than animal protein (casein) group. There were no significant differences in serum calcium, phosphate, alkaline phosphatase and osteocalcin among the three groups of the rats. The findings from this study demonstrated that plant protein (soy protein) is beneficial of bone mineral density because it had a higher Ca efficiency in total bone and femur bone mineral density than animal protein (casein). However, the supplementation of sulfur amino acid on soy results were consistent with prior studies that dietary sulfur amino acid load had a negative effect on calcium balance. The rats fed sulfur amino acid supplementation diet increased urinary calcium excretion and decreased calcium efficiency for total and femur mineral density. Therefore, dietary protein source and sulfur amino acid content influence bone metabolism. (Korean J Nutrition 37(2): 100-107, 2004)

• Korean Journal of Adult Nursing
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• v.22 no.3
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• pp.260-270
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• 2010

Purpose: The main question is systematic review of the published in Korea and foreign countries on warming therapy for surgical patients. Methods: The researchers searched at Medline, CINAHL, KERIS, Adult Nursing Association, Korean Society of Nursing Science, Korean Academy of fundamentals of Nursing, and National Assembly Library web site for the published on warming therapy for surgical patients from 1980 to 2008. Words for search were operation/surgery, warming, operation/surgery and warming. Studies were included randomized controlled trial, and there were no restrictions regarding operative phase and outcome measures. Results: 36 published researches that met the criteria were mostly published in foreign countries between 2000 and 2008 and focused on surgery with general anesthesia. Sample size ranged from 21 to 60 subjects, age range between 21 and 60 years of age. Thirty different warming therapies were reported, fifty-two different dependent variables. Outcome indicators included active external warming, intra-operative, and body temperature. 'Positive effects' and 'no effects' equaled. The most frequently reported 'positive effects' were body temperature, shivering, and acid-base balance. No effects were more likely to be heart rate, blood pressure, and hemodynamics. Conclusion: Many types of warming therapy, are reported in the literature with little information about the efficacy of each, many different dependant variables were studied. There were no consistent reports as to length of time used for warming procedures. Overall, the effects of warming therapy are inconsistent. And additional research must be down before any particular method of warming can be used with confidence as to its effectiveness. Attention must be made as to the research design, better measurement of the dependent variables. This review may serve as a base.