• BMB Reports
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• v.41 no.7
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• pp.523-528
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• 2008

BMI-1026 is a synthetic aminopyrimidine compound that targets cyclin dependent kinases (cdks) and was initially designed as a potential anticancer drug. Even though it has been well documented that BMI-1026 is a potent cdk inhibitor, little is known about the cellular effects of this compound. In this study, we examined the effects of BMI-1026 treatment on inducing premature senescence and then evaluated the biochemical features of BMI-1026-induced premature senescence. From these experiments we determined that BMI-1026 treatment produced several biochemical features of premature senescence and also stimulated expression of mitogen activated protein kinase (MAPK) family proteins. BMI-1026 treatment caused nuclear translocation of activated Erk1/2 and the formation of senescence associated heterochromatin foci in 5 days. The heterochromatin foci formation was perturbed by inhibition of Erk1/2 activation.

• Knee surgery & related research
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• v.30 no.4
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• pp.319-325
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• 2018

Purpose: Body mass index (BMI) is often used to predict surgical difficulty in patients receiving total knee arthroplasty (TKA); however, BMI neglects variation in the central versus peripheral distribution of adipose tissue. We sought to examine whether anthropometric factors, rather than BMI alone, may serve as a more effective indication of surgical difficulty in TKA. Materials and Methods: We prospectively enrolled 67 patients undergoing primary TKA. Correlation coefficients were used to evaluate the associations of tourniquet time, a surrogate of surgical difficulty, with BMI, pre- and intraoperative anthropometric measurements, and radiographic knee alignment. Similarly, Knee Injury and Osteoarthritis Outcome Score (KOOS) was compared to BMI. Results: Tourniquet time was significantly associated with preoperative inferior knee circumference (p=0.025) and ankle circumference (p=0.003) as well as the intraoperative depth of incision at the quadriceps (p=0.014). BMI was not significantly associated with tourniquet time or any of the radiographic parameters or KOOS scores. Conclusions: Inferior knee circumference, ankle circumference, and depth of incision at the quadriceps (measures of peripheral obesity) are likely better predictors of surgical difficulty than BMI. Further study of alternative surgical indicators should investigate patients that may be deterred from TKA for high BMI, despite relatively low peripheral obesity.

• The Research Journal of the Costume Culture
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• v.25 no.2
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• pp.175-191
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• 2017

The purpose of this study is to analyze the body mass index(BMI) and foot characteristics of senior-generation women and to use those values to develop a standard shoe last for producing shoes that best fit the foot of senior-generation women. In order to develop a standard shoe last that reflects the BMI and foot characteristics of senior-generation women, I analyzed the morphometric characteristics of feet by conducting descriptive statistics for each item. The foot characteristics based on BMI were analyzed by conducting ANOVA and Duncan's tests via the foot's measured values. Subsequently, I developed a standard shoe last reflecting the BMI and the foot characteristics of senior-generation women by applying all those values. Senior-generation women showed significant differences among three groups based on BMI-normal weight, overweight, and obese-in all the items except for medial ball width and toe 5 angle. Through these values, I realized that as the value of the BMI becomes higher, the size of the foot becomes larger. This suggests that as a woman's weight increases or decreases, her shoes need to be replaced as well as her clothes. Deviations in the toe-side parts of the shoe could cause deformation of the foot. If someone keeps wearing shoes produced using a shoe last with a large deviation, she risks developing foot conditions like hallux valgus. This situation points to the need for shoe manufacture that utilizes a standard shoe last that reflects the BMI and foot characteristics of the senior generation.

• Journal of Korean Medicine Rehabilitation
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• v.24 no.4
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• pp.61-70
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• 2014

Objectives The purpose of this study was to investigate the characteristics in obesity classification group of college students having health checkup by analyzing their BMI and blood test and determine the association between factors contributing to obesity and obesity according to BMI. Methods A group of 2992 test subjects took their medical examination and their body composition, height, weight, blood pressure were measured and blood test was done. With these results we diagnosed obesity, and analysed relationship between obesity and cholesterol, triglyceride, LDL (low density lipoprotein)-cholesterol, HDL (high density lipoprotein)-cholesterol, liver function, renal function and blood pressure. Results 1. Overweight individuals showed high total cholesterol, LDL-cholesterol, triglyceride, GOT (glutamic oxalacetic transaminase), GPT (glutamic pyruvate transaminase), Urea-nitrogen, Creatinine and low HDL-cholesterol. 2. BMI showed a significant association with other factors. BMI has a negative correlation with sex and HDL-cholesterol. BMI had positive correlations with other factors. 3. There was no relation between BMI and sex. Those six factors, liver function, cholesterol, blood pressure, kidney function, neutral fat, and blood sugar were related to BMI. Conclusions There was a significant relation between college students' BMI and their liver function, cholesterol, blood pressure, kidney function, neutral fat, and blood sugar. The diseases related to liver function, cholesterol, blood pressure, kidney function, neutral fat, and blood sugar were clearly associated with obesity.

• Journal of the Korean Home Economics Association
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• v.44 no.10
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• pp.67-77
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• 2006

This study was performed investigate eating behaviors and their association with obesity in Korean elderly people. A total of 9,408 (male 4,487, female 4,921) Korean adults aged 40 to 69 years were interviewed and examined from May 2001 to Feb 2002. The subjects were classified into 4 weight status groups based on body mass index (BMI, $kg/m^2$): under weight, BMI<18.5; normal, $18.5{\leq}BMI\leq24.9$; overweight, $25.0{\leq}BMI\leq29.9$; obesity, $BMI\geq30.0$. Anthropocentric parameters, eating behavior, and preference of cooking method and taste were examined. In male, distribution of weight status by BMI was under weight 2.4%, normal 58.1%, over weight 36.7%, obesity 2.8%. As the BMI increased, the rate of skipping meal, snacks, and eating out were increased and the rate of eat alone was decreased. When compared according to the weight status by BMI, the frequency of the steamed, roasted, fried, seasoned, and soup intake rates were increases in the cooking methods and preference of greasy taste was increased by degree of obesity. In female, distribution of weight status by BMI was under weight 1.4%, normal 52.8%, over weight 38.6%, obesity 7.2%. There were differences in the rate of eating out, snacks, the frequency of fried food intake rates, and preferences of salty, hot, greasy taste according to the weight groups by BMI. In this results, we suggests that keep regular meal and keep away from the high-fat, salty, stimulative foods for prevent and administer the obesity in Korean adults meal and female.

• Journal of Preventive Medicine and Public Health
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• v.40 no.1
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• pp.45-50
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• 2007

Objectives : The aim of this study was to investigate the relationship between the contributions of macronutrients to the total energy intakes and Body Mass Indices (BMI, $kg/m^2$) of Korean women. Methods : We used dietary records data from 115 healthy Korean women, ages 20 and over, who completed four 3-day dietary records between February 2003 and March 2004. For the calculation of nutrients we used a dietary assessment program developed by the Korean Nutritional Society. Macronutrient intakes were estimated by averaging individual total daily intakes in four 3-day dietary records. Subjects were categorized into three Body Mass Index (BMI) groups : underweight (BMI < 20), normal (20 $\leq$ BMI < 25), and overweight (BMI $\geq$ 25) group. Results : The total energy intakes were not different among the three BMI groups. Similarly, other macronutrient intakes such as protein, fat, carbohydrate, vegetable protein, animal protein, saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids were not different. From the multivariate nutrient density model, substituting polyunsaturated fatty acid for carbohydrate was positively associated with BMI in women aged 20 to 49 ($\beta=2.31$, p<0.01). In women aged 50 and over, substituting animal protein for carbohydrate was positively associated with BMI ($\beta=0.549$, p=0.04). Conclusions : No single macronutrient was associated with BMI when all subjects were combined. However, when stratified by age, polyunsaturated fatty acid intake in younger women, and animal protein intake in older women, were positively associated with BMI. In the future, we recommend a larger study to confirm these results.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3437-3441
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• 2012

Background: Oncogenic Bmi-1 (B-lymphoma Moloney murine leukemia virus insertion region-1) belongs to the Polycomb-group (PcG) family of proteins and plays an important role in the regulation of proliferation, senescence, cell cycle and apoptosis, chromosome stability, activation of gene transcription. Methods: To clarify the roles of Bmi-1 in tumourigenesis and progression of gastric carcinomas, it was examined by immunohistochemistry (IHC) and real-time RT-PCR in gastric carcinomas, dysplasia, intestinal metaplasia (IM), and gastritis with a comparison of its expression with clinicopathological parameters of carcinomas. Results: There was gradually increased Bmi-1 protein expression from gastritis, IM, dyplasia to carcinoma (p<0.001). Bmi-1 expression was positively linked to tumor size, depth of invasion, lymph node metastasis and worse prognosis of carcinomas (p<0.001), but not to age or sex of carcinoma patients (p>0.05). There was higher Bmi-1 protein expression in intestinal-type carcinomas than diffuse-type ones (p<0.001). At mRNA level, Bmi-1 protein expression was increased from gastritis, IM, dysplasia and carcinoma (p<0.001). Bmi-1 overexpression was observed in gastric carcinoma with larger diameter, deeper invasion, lymph node metastasis, and intestinal-type carcinoma (p<0.05). Conclusion: These findings indicate that up-regulated Bmi-1 expression is positively linked to pathogenesis, growth, invasion, metastasis and differentiation of gastric carcinomas. It was considered as a promising marker to indicate the aggressive behaviors and prognosis of gastric carcinomas.

• International Journal of Oral Biology
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• v.33 no.4
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• pp.217-221
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• 2008

Bicuculline is one of the most commonly used $GABA_A$ receptor antagonists in electrophysiological research. Because of its poor water solubility, bicuculline quaternary ammonium salts such as bicuculline methiodide (BMI) and bicuculline methbromide are preferred. However, a number of studies have shown that BMI has non-$GABA_A$ receptor-mediated effects. The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) is implicated in the processing of nociceptive signaling. In this study, we investigated whether BMI has non-GABA receptor-mediated activity in Vc SG neurons using a whole cell patch clamp technique. SG neurons were depolarized by application of BMI ($20{\mu}M$) using a high $Cl^-$ pipette solution. GABA ($30-100{\mu}M$) also induced membrane depolarization of SG neuron. Although BMI is known to be a $GABA_A$ receptor antagonist, GABA-induced membrane depolarization was enhanced by co-application with BMI. However, free base bicuculline (fBIC) and picrotoxin (PTX), a $GABA_A$ and $GABA_C$ receptor antagonist, blocked the GABA-induced response. Furthermore, BMI-induced membrane depolarization persisted in the presence of PTX or an antagonist cocktail consisting of tetrodotoxin ($Na^+$ channel blocker), AP-5 (NMDA receptor antagonist), CNQX (non-NMDA receptor antagonist), and strychnine (glycine receptor antagonist). Thus BMI induces membrane depolarization by directly acting on postsynaptic Vc SG neurons in a manner which is independent of $GABA_A$ receptors. These results suggest that other unknown mechanisms may be involved in BMI-induced membrane depolarization.

• Journal of Digital Convergence
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• v.14 no.2
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• pp.519-527
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• 2016

This research aims at investigating the measures of agreement between BMI classification standard and that of 9-point contour drawing rating scale(CDRS), verifying their usefulness for the application to the filed, examining university students' substantial understanding of their bodies, and offering correct information regarding the distorted recognition of their bodies. In order to examine the measures of agreement between the classification standard of BMI and that of CDRS, and the women university students' recognition of their body images depending on BMI, Cross tabulation was carried out, and ${\chi}^2$, Spearman rank correlation coefficient and kappa statistics were calculated. As the analysis results, the classification standards of CDRS and BMI judged by general female college students showed statistically the correlation was high with ${\rho}=.719$(p<.001) and an average level of confirmity with ${\kappa}=.506$(p<.001). Based on these results, regarding body shape, sizes and shapes according to racial characteristics need to be controlled later.

• Korean Journal of Clinical Laboratory Science
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• v.42 no.3
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• pp.129-135
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• 2010

This study was performed to determine the risk factors associated with increased body mass index (BMI) in 672 heavy industry men workers. Subjects were examined in March, 2010 to September, 2010 in Gyeongnam province. Height, weight, systolic blood pressure, and diastolic blood pressure were measured. And fasting blood glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride levels were measured by Olympus AU 680, and their BMIs calculated. Age, smoking statue, and alcohol drinking of the workers were surveyed by questionnairs. The mean total cholesterol levels were $190.06{\pm}36.62mg/dL$, HDL-cholesterol $53.65{\pm}11.92mg/dL$, LDL-cholesterol $104.28{\pm}30.31mg/dL$, triglyceride $151.11{\pm}99.53mg/dL$, and fasting blood glucose $96.92{\pm}19.53mg/dL$. Mean systolic blood pressure was $126.08{\pm}13.78mmHg$, and diastolic blood pressure $71.88{\pm}10.45mmHg$. Subjects were categorized into two BMI groups, BMI ${\geq}23$ and BMI ${\leq}22.9$. The subjects with BMI of 23 or above had significantly higher levels of LDL-cholesterol, systolic blood pressure, and triglyceride, with lower levels of HDL-cholesterol. BMI showed the highest level at the age of thirties, increasing with age. BMI of smokers was higher than BMI of non-smokers, not showing a link between alcoholics and non alcoholics. In conclusion, age, systolic blood pressure, and HDL-cholesterol are mostly relevant to the increase of BMI in this study.