• 한국잠사곤충학회지
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• 제48권1호
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• pp.25-27
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• 2006

누에장려품종 중 혈당강하제 개발에 적합한 품종 결정을 위하여 DNJ 함량을 정량한 결과, 봄에 사육한 금옥잠이 5.45 mg/gDW으로 DNJ 함량이 가장 높았다. 또한 누에 유전자원 원종 66품종의 DNJ 함량을 결정한 결과, 품종간 DNJ 함량 차이가 매우 큰 것으로 밝혀져, 혈당 강하제용 누에 육종시 기초자료가 될 수 있으며, 또한 DNJ 함량이 낮은 품종은 DNJ 축적 기작 연구에 많은 도움이 될 것으로 사료된다.

• Clinical and Experimental Pediatrics
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• 제54권8호
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• pp.340-344
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• 2011

Purpose: Brain natriuretic peptide (BNP) has been considered a biochemical marker for myocarditis in Kawasaki disease. We performed this study to determine its quantitative significance. Methods: We attempted to correlate log-transformed BNP concentrations (log-BNP) and clinical, laboratory, and echocardiographic variables in 81 children with Kawasaki disease. Stepwise multiple linear regression analysis was used to determine the variables independently associated with log-BNP concentration. Results: Serum C-reactive protein level (P<0.0001), serum alanine aminotransferase concentration (P =0.0032), white blood cell count (P=0.0030), and left ventricular mass index (P=0.0024) were positively related with log-BNP, and hemoglobin level (P<0.0001), serum albumin level (P<0.0001), $Na^+$ concentrations (P<0.0001), left ventricular fractional shortening (P=0.0080), and peak early diastolic tissue velocity of the left ventricular basal lateral segment (P=0.0045) were negatively related to the log-BNP concentration. Multiple regression analysis showed that serum albumin concentration ($R_2$=0.31, P=0.0098) and left ventricular mass index ($R_2$=0.09, P=0.0004) were significantly associated with the log-BNP concentration. Conclusion: Elevated BNP levels during the acute phase of Kawasaki disease may be attributable to cardiac dysfunction associated with the increase in left ventricular mass, and log-BNP concentration may be a quantitative biochemical marker of myocarditis in Kawasaki disease.

• 대한핵의학회지
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• 제17권2호
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• pp.1-17
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• 1983

The purpose of this study is to investigate the effects of thyroid hormone on the left ventricular(LV) volume arid function in man with untreated hyperthyroidism and to determine the effects of successful therapy for thyrotoxicosis on the ventricular pathophysiology. In the present study, equilibrium radionuclide cardiac angiography was performed and LV volume index, ejection phase indexes of LV performance, serum thyroid hormone levels and other hemodynamic parameters were measured in 28 normal subjects and 39 patients with hyperthyroidism before treatment and again every 4 weeks for the first 2 months after the initiation of effective therapy. The results obtained were as follows; 1) In the untreated hyperthyroid state heart rate, blood volume, cardiac index and stroke volume index($97{\pm}14$ beats/min, $73.5{\pm}11.8ml/kg,\;6.9{\pm}1.4\;l/min/m^2$ and $77.6{\pm}13.8ml/m^2$, respectively) were increased significantly compared to those in normal control($74{\pm}12beats/min$, $66.6{\pm}14.8ml/kg,\;3.8{\pm}1.2\;l/min/m^2$ and $56.6{\pm}13.2ml/m^2$ respectively). $(Mean{\pm}SD)$ 2) There was a significant increase in LV end-diastolic volume index in patients with hyperthyroidism ($30.5{\pm}7.5$ for hyperthyroid group compared to a normal control of $22.2{\pm}6.5$; p<0.001), whereas end-systolic volume index remained unchanged $9.6{\pm}3.6\;and\;8.8{\pm}3.3$ respectively).3) In patients with hyperthyroidism, LV ejection fraction was $70.0{\pm}5.6%$, fractional shortening $32.9{\pm}5.1%$, mean velocity of circumferential fiber shortening(mean Vcf) $1.34{\pm}0.31$ circ/sec and maximum ejection rate $3.47{\pm}0.80$. All the ejection phase indexes were significantly greater than those in normal control($65.2{\pm}5.7%,\;28.8{\pm}3.2%,\;0.88{\pm}0.37$ circ/see and $2.27{\pm}0.50$, respectively; p<0.001). 4) Effective therapy produced significant decrease in all the values of serum thyroid hormone concentrations(p<0.00l), hemodynamic parameters(p<0.001), end-diastolic volume index(p<0.01) and ejection phase indexes of LV contractility in patients with hyperthyroidism and after one to two months, when the patients were euthyroid, these measurements were in the range of normal. 5) A significant linear correlation between mean Vcf and serum thyroxine level(r=0.63, p<0.001) as well as between mean Vcf and serum triiodothyronine level(r=0.62, p<0.001) was found. The lesser degree of correlation was also noted between other ejection phase indexes and serum thyroid hormone concentrations. The results indicate that the major effects of excess thyroid hormone on the LV in human beings with hyperthyroidism are an enhancement of LV function and an increase in LV enddiastolic volume and that these effects cause predictable reversible cardiac alteration which are changed dramatically and immediately after effective therapy.

• 한국의류학회지
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• 제16권4호
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• pp.405-416
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• 1992

This study was performed to investigate correlation between total body weight loss and local sweat rate and to find out any possible method that can estimate total body weight loss judging from local sweat rate. Twelve adult females were kept at 44 $\pm1^{\circ}C$, 50 ${\pm}5\%$ R.H. (1) Physiological responses such as total body weight loss, local sweat rate, rectal temperature, skin temperature, blood pressure and pulse, (2) micro climate inside garment and (3) subjective sensation were examined. Two types of garment such as long-sleeves with long pants (Type I) and half·sleeves with short pants (Type II) were used to observe the effect of garment types on sweating response. Both clothing weight was equal (132$\pm$3 g/$m^{2}$). The results were as follows: 1. Regardless of the different types, total body weight loss was more interrelated with the sweat rate on forehead than any other parts of the body. Except the forehead, different parts of body with different types of garment influenced on body weight loss quite differently. 2. Total body weight loss was more interrelated with the weight gain of garment than the local sweat rate. 3. Under the environment of 44$\pm1^{\circ}C,\;50{\pm}5\%$R.H., body weight loss during 1 hour of subject clothed and silted was 275.2 g/hr and weight loss per body surface area was 178.9 g/$m^{2}/hr$ Garment types have no influences on total body weight loss. 4. Local sweat rate (mg/7.07 $cm^{2}/hr$) was 208.0,191.0, 133.0, 115.0,81 0, 75.1 and 66.3 on scruff, breast, forehead, forearm, thigh, upper arm, leg respectively No evidence has been found that garment types influenced on local sweat rate (p<0.1). 5. No interrelationships between rectal temperature and total body weight loss, local skin temperature and total body weight loss, and local skin temperature and local sweat rate were found. From this study, some possible method that we can estimate total body' weight loss judging from weight loss of garment. But considering the fact that clothing design factor, the physical characteristics of fabric and environmental factor such as humidity and wind velocity should be concerned in weight loss of garment, it should be studied further whether the total body weight loss can be estimated properly from the weight loss of garment. This experiment suggest that different parts of body with different types of garment can influence on body weight loss quite differently. Therefore, in order to get more precise results, more studies under the diversity of garment types should be done in the near future.

• 대한한방내과학회지
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• 제27권2호
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• pp.416-428
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• 2006

Objectives : Arterial stiffness and pulse pressure are related to cardiovascular and cerebrovascular survival and longevity. This study is aimed at examining the effects of Chungpyesagan-tang on arterial stiffness and Pulse pressure in acute stroke Patients. Methods: The subject of this study was acute strike Patients within 1 week after ictus, with Cardio-ankle vascular index(CAVI) higher than 9.0. They were divided into two groups: A treatment group (n=44) and a control group(n=46). For two weeks, Chungpyesagan-tang was given to the former, other herbal medicines to the latter. used for stroke patients for the control group for 2 weeks. At the end of first and second week, CAVI, pulse Pressure, National Institute of Health stroke scale(NIHSS), Modified Barthel Index(MBI) were measured. Serum lipid Profile, aspartate transaminase(AST), alanine transaminase(ALT). blood urea nitrogen(BUN), creatinine were also measured at the end of the study. Results : After 2 weeks, CAVI and Pulse Pressure in Chungpyesagan-tane group were significantly tower than those in the control group(P<0.05). NIHSS and MBI were improved in both groups. But there was no significant difference between the treatment group and the control group in terms of the NIHSS and MBI. Conclusions : We suggest Chungpyesagan-tanghas desirable effects on arterial stiffness and Pulse Pressure of acute stroke patients. It can improve morbidity and mortality of patients on the basis of influencing vascular stiffness and increased pulse pressure.

• 대한수의학회지
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• 제39권1호
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• pp.230-239
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• 1999

Digital color doppler ultrasonographic system(DCDUS) has a lot of diagnostic functions. One of these is a detection of low velocity vessels in the organs of abdominal cavity. The purpose of study was to determine the clinical usefulness of DCDUS. Interlobar artery resistive index(RI), pulsatility index(PI) and systolic diastolic ratio(SDr) were measured for diagnosis of obstructed urinary tract. RI, PI and SDr were a measure of intrarenal blood flow impedance. This study was consisted of 2 groups. The normal group was studied in 16 normal adult dogs and the study group was studied 7 dogs with surgically induced, unilateral ureteral obstruction. In the study group, parameters were checked in normal condition and on 1, 2, 3, 5, 7 and 10th day after ligation. The result were summarized as follows. In the normal group, RI, PI and SDr of the left kidney was $0.65{\pm}0.04$, $1.25{\pm}0.12$ and $292.45{\pm}29.40$, respectively. RI, PI and SDr of the right kidney were $0.64{\pm}0.05$, $1.28{\pm}0.20$ and $282.25{\pm}37.26$, respectively. In the study group, RI of the left kidney induced ligation was increased significantly on 1, 2, 3, 5, 7 and 10th day. RI of the left kidney on 1, 2, 3, 5, 7 and 10th day were $0.75{\pm}0.05$, $0.71{\pm}0.03$, $0.74{\pm}0.04$, $0.74{\pm}0.02$, $0.73{\pm}0.02$ and $0.73{\pm}0.04$, respectively. PI of the left kidney was increased significantly on 1, 3, 5 and 7th day. PI of the left kidney on 1, 3, 5 and 7th day were $1.57{\pm}0.21$, $1.54{\pm}0.24$, $1.60{\pm}0.15$ and $1.60{\pm}0.26$, respectively. SDr of the left kidney increased significantly on 1, 2, 3, 5 and 7th day. SDr of the left kidney on 1, 2, 3, 5 and 7th day were $412.18{\pm}86.69$, $352.14{\pm}47.05$, $399.77{\pm}65.54$, $369.43{\pm}48.34$ and $365.57{\pm}22.46$, respectively(p<0.05). In the study group, RI of the left kidney was more increased than that of the right kidney on 1, 2, 3, 5, 7 and 10th day. PI of the left kidney was more increased than that of the right kidney on 1, 3, 5, and 7th day. SDr of the left kidney was more increased than that of the right kidney on 1, 2, 3, 5 and 7th day(p<0.05). RI was effective in the diagnosis of an acute unilateral ureteral obstruction. PI and SDr were insufficient in the diagnosis of an acute unilateral ureteral obstruction.

• 한국임상수의학회지
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• 제31권5호
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• pp.367-370
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• 2014

본 연구는 개에서 건삭파열로 유발한 급성 이첨판 폐쇄부전 모델의 혈류역학적 변화를 관찰하는 것이다. 이 연구는 10마리의 정상 심장기능을 가진 비글견에서 실시되었다. 직접혈압측정법과 Swan-Ganz 카테터를 통해 건삭을 실험적으로 파열시키는 기간동안 혈류역학적 지표 변화를 진행하였다. 이첨판 폐쇄부전 모델을 만들기 위해 5번 늑간으로 접근하여 관절경에 사용하는 작은 훅나이프를 사용하여 건삭을 파열하였다. 수술 중 칼라 도플러 영상 검사를 통해 이첨판 역류를 확인하였다. 혈류역학적 지표를 측정한 결과 폐모세혈관쇄기압은 유의적으로 증가하였지만, 평균동맥압, 정맥압, 폐동맥압, 심박출량, 심박출 지수는 건삭 파열 후에 유의적으로 감소한다는 것을 발견하였다. 이것은 건산파열로 인해 좌심실로 부터 역류된 혈액이 좌심방에 과부하를 일으킨다는 것을 나타내는 것이다. 본 연구를 통해 개에서 급성 이첨판 폐쇄부전 모델을 만드는데 있어 건삭파열방법이 효과적인 것을 알 수 있었고, 이첨판 역류 유발 후 시간이 지나면 만성 이첨판 부전증으로 진행할 수 있을 것으로 생각되며, 차후 판막의 만성적 변화 양상을 연구하는데 도움을 줄 수 있을 것으로 생각됩니다.

• 한국식품저장유통학회지
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• 제22권6호
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• pp.859-866
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• 2015

무기이온이 풍부한 생식물 중 버려지는 부산물을 이용하여 미네랄 확보를 위한 발효최적조건을 설정하고 발효물에 함유된 미네랄 여과 및 정제 조건을 확립하였다. 생식물 가공 후 부산물을 활용하여 다량의 미네랄을 확보하고, 생식물 미네랄 배지조성을 위하여 백미 도정 후의 현미부산물인 미강을 고체 발효시켜 열수추출한 결과 칼륨 2,019.2 mg/100 g을 포함한 미네랄을 얻을 수 있었다. 추출물에 대한 순차적인 여과로 칼륨 1,769.70 mg/100 g을 포함한 미네랄을 확보하여 정제한 후 미네랄을 염수와 치환하기 위한 조건을 확립하기 위하여 유량과의 상관관계를 알아본 결과 유량이 변화하여도 전기투석효과에 영향이 없었으며, 유속이 200 mL/L로 빠를 때 생산제품인 정제수실 반응액이 농도가 낮게 나타났다. 인가전류와의 상관관계에서는 전류를 높게 인가할수록 전기투석효과가 높게 나타났고, 그 증가곡선도 역포물선으로 인가전류가 높을수록 효율이 높음을 나타냈다. 시간과의 상관관계 결과 90분 이내에 95%의 추출액 이온이 정제수로 회수 되었으며 비례적으로 추출 이온별 농도의 변화가 있었다. 정제수실의 이온 농축수에 정제염수실에서 조성된 수산화나트륨을 혼합하여 pH 7.4 의 안전한 염화화합물을 조성할 수 있게 되었다. 전기투석 공정의 원리를 이용하여 생식물 발효 조성액에 함유된 미네랄을 정제염수와 이온치환하여 나트륨 함량 40% 대비 최저 5.7%~최고 30%까지 나트륨이 감량된 소금을 제조하여 미네랄 저염소금 개발 가능성을 확인할 수 있었다.

• 한국산학기술학회논문지
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• 제20권6호
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• pp.390-395
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• 2019

수중운동치료는 물의 저항을 이용하여 충분한 운동 효과를 낼 수 있어서 관절염이나 재활치료를 받아야하는 환자들에게 긍정적인 효과를 가진다. 하지만 효과에 대한 국내 연구는 미비한 실정이고, 그 효과에 대한 근본적인 원인규명은 아직까지 확실하지 않다. 따라서 본 연구에서는 수중운동 효과의 근본적인 원인을 파악하기 위해 실제 환경과 비슷한 조건으로 Unsteady fluid flow simulation을 진행했다. 해석 모델은 실제 손을 모델링하였고, 손가락 마디에 가해지는 압력변동을 the methods of computational fluid로 분석했다. 손의 수중운동 시, 피부 표면속도와 유동 저항에 의하여 손가락 사이에 다양한 크기의 와류가 발생한다. 와류에 의해 약 -500Pa부터 +500Pa 정도의 압력이 가해지고, 방향을 전환하는 부분에서는 최소 -2000Pa에서 최대 +2000Pa까지의 양압과 음압이 지속적으로 반복됐다. 또한 손가락 마디마다 20Hz ~ 70Hz의 진동수를 가진 압력 변동이 지속적으로 가해졌다. 이러한 지속적인 압력 변동은 손가락 마디에 직접적인 마사지 효과를 제공하고, 관련 부위의 혈액순환에 긍정적인 영향을 미친다고 판단된다.

• 대한소아치과학회지
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• 제50권3호
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• pp.334-346
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• 2023

이 연구의 목적은 Skeletal maturity indicator (SMI) 및 Middle phalanx of the third finger (MP3)와 혈청 Insulin-like growth factor-1 (IGF-1) 및 Insulin-like growth factor binding protein-3 (IGFBP-3)의 상관 관계를 통해 골격적 성숙도의 예측 지표로 사용될 수 있는지 알아보는 것이다. 2018년 1월부터 2022년 12월까지 아주대학교 치과병원 및 소아청소년과에 내원한 만 7세 이상 17세 이하 환자 205명의 의무기록을 후향적으로 분석하였다. 혈청 IGF-1 농도는 SMI 6 - 8, MP3 - G에서 가장 높았고(p < 0.0001) 혈청 IGFBP-3 농도는 SMI 9 - 10, MP3 - I에서 가장 높았다(p = 0.010, 0.030). SMI, MP3와 혈청 IGF-1 농도 간 비교적 높은 Pearson 상관계수를 나타냈다(r = 0.698, 0.622, p < 0.0001). 혈청 IGF-1는 소아청소년의 골격적 성숙도를 평가하는 보조적 수단으로 활용될 수 있을 것이며 임상적으로는 472 ㎍/L에서 510.63 ㎍/L의 범위를 최대성장기로 고려할 수 있다.