• Journal of Biomedical Engineering Research
• /
• v.45 no.1
• /
• pp.49-55
• /
• 2024

Accurate measurement of blood pressure is essential for classifying an individual's disease, identifying blood pressure-related risks, and managing health. Due to the environmental and health hazards of mercury sphygmomanometers, automatic sphygmomanometers using the oscillometric method are widely used in hospitals as well as in general homes, and have established themselves as a practical standard sphygmomanometer. In this study, we developed a blood pressure simulator using an actuator that provides simulated pressure to an automatic blood pressure cuff. The developed blood pressure simulator adopts an arm-shaped cylindrical shape similar to the situation in which a person measures blood pressure with an automatic blood pressure monitor, and implements a method of transmitting pressure to the cuff using a pressure plate. Accuracy was evaluated through the mean and standard deviation of the difference with the commercialized blood pressure simulator BP PUMP 2, and reproducibility was confirmed using two automatic blood pressure monitors. The developed blood pressure simulator enables automatic blood pressure monitoring in a simple manner and also meets the evaluation standards for accuracy and reproducibility. In the future, as a standardized blood pressure simulator, it is expected to be of great help in evaluating and verifying the performance of automatic blood pressure monitors by supplementing precise hardware and software and building a blood pressure database.

• Journal of fish pathology
• /
• v.30 no.2
• /
• pp.115-134
• /
• 2017

A total number of 668 apparently healthy fish were obtained from farm to study the effect of two heavy metals (Copper and Mercury) on histopathology of liver, kidney, spleen, gills and muscles also residues in muscles. The $LC_{50}$/96 hr. of Cu and Hg were estimated and fish exposed to 1/2 $LC_{50}$ for 7 days and for 1/10 $LC_{50}$ for 8 weeks from each product separately. Histopathological findings in acute and chronic mercuric chloride toxicity revealed degeneration and necrosis in the glomeruli, interstitium tissue and epithelium lining renal tubules. The tubular epithelium became necrotic at several places. Eosinophilic hyaline droplets is exist in the cytoplasm of the necrosed cells. Degenerative changes and hyperactivity in melanomachrophage center was seen in the spleen together with some necrotic areas. Necrosis and aggregation of melanomachrophage were seen in the hepatic cells, Hepatic cells showed vacuolar degeneration in the hepatic cells. Gills showed loss in the lamellae of the filaments associated with edema, inflammatory cells infiltration and haemorrhages in the arch. The sarcoplasm of the bundles of the skeletal muscle showed granular degeneration and focal inflammatory cells infiltration between the hyalinized bundles. Mercury residues obtained from these studies in the acute toxicity were 0.22 ppm/gm in the 2nd day, 0.411 ppm/gm in the $5^{th}$ day ended with 0.96 ppm/gm in the $7^{th}$ day. In chronic toxicity it was 1.1320, 1.7140, 2.3620 and 3.5640 ppm/gm respectively from the $2^{nd}$ to the $8^{th}$ week of exposure. In acute and chronic copper toxicity, there was degenerative changes in renal tubules. Melanophores aggregation in the wall of the blood vessels of the spleen and depletion of some of the melanophores in the melanomachrophage were seen together with necrosis in some areas. Congested Mvs (Micro vessels) and vacuolation of hepatocytes were observed. Some areas of hemorrhage and melanophores vacuolar degeneration in the liver were seen. There was mitosis in some areas with displesia of hepatopancreatic cells and eosinophilic granular cells aggregation. Zymogen granules disappeared and there were dyplastic hepatocytes. Congestion in the blood vessels of the gill filaments, associated with massive number of granular eosinophilic cells infiltration were seen in the base of the filaments. There were sever vacuolization and hyalinization in the skeletal muscle bundles. Detection of residues of copper sulfate revealed increase of the amount of copper measured in ppm/gm comparing to the normal control starting from 0.60 ppm/g in the $2^{nd}$ day, 0.67 ppm/g in the $5^{th}$ day and 0.67 ppm/g in the $7^{th}$ day. Result obtained in chronic copper sulfate toxicity revealed gradual increase of the amount of copper which ranged from 0.18 ppm/g at the $2^{nd}$ week to 0.21 ppm/g in the $8^{th}$ week of exposure.

• Journal of Magnetics
• /
• v.16 no.4
• /
• pp.449-452
• /
• 2011

A wrist wearable cuffless pulsimeter with a portable and small size apparatus using Hall effect is fabricated. The analysis of the pulse wave measured by the testing product of pulsimeter is done to measure the pulse rate and blood pressure. The blood pressure obtained by the puslimeter is compared with the practical values measured by electronic or mercury liquid blood pressure meters. The detail analysis of a pulse wave measured by a wrist wearable cuffless pulsimeter detecting the changes of the magnetic field can be used to develop a new diagnostic algorithm of blood pressure applying for oriental medical apparatus.

• Journal of Biomedical Engineering Research
• /
• v.13 no.3
• /
• pp.189-194
• /
• 1992

As people's income and intake of animal fat rapidly increase, so does choresterol concentration in blood. Thus diseases such as non-insulin-dependent diabetes mellitus(NIDDM)myocardial infraction, high blood pressure, cerebral stroke resulting from atherosclerosis rapidly increase recently. It is very difficult to diagnose atherosclerosis early since its progress is so slow and there is no sypmtoms in the beginning of the disease. In this study a mechanical characteristic, compliance, of the lower leg arteries was measured noninvasively. Changes of blood volume and pressure were measured using impedance plethysmgraphy and mercury sphygmomanometer, respectively. The compliance was calculated by dividing the change of blood volume by the change of pulse pressure ( systolic-diastolic pressure ) . Subjects were 24 asymptomatic persons ranging (rom 30 Ic 58yeras and 14 diabetics from 41 to 59years. The compliances, mean, and systolic pressures were statistically analyzed using a t-test be- tween the healthy and diabetic groups. The average compliance of the healthy and diabetic group was measured 2.79 and 1.82U1/mmHg/cm, respectively and these were significantly different(p<0.01). It was also found that the compliance is a better parameter in differentiating the vascular disease than mean or systolic blood pressure.

• Journal of the Korean Chemical Society
• /
• v.57 no.5
• /
• pp.568-573
• /
• 2013

A selective and sensitive method for simultaneous determination of copper in blood by adsorptive differential pulse cathodic stripping voltammetry is presented. The procedure involves an adsorptive accumulation of Cu(II)-ETSC (4- ethyl-3-thiosemicarbazide) on a hanging mercury drop electrode, followed by a stripping voltammetry measurement of reduction current of adsorbed complex at about -715 mV. The optimum conditions for the analysis of copper (II) ion are : pH 10.3, concentration of 4-ethyl-3-thiosemicarbazide $3.25{\times}10^{-6}$ M and an accumulation potential of -100 mV. The peak current is proportional to the concentration of copper over the range 0.003-125 ng/mL with a detection limit of 0.001 ng/mL and an accumulation time of 60 s. Moreover, with the use of the proposed method, there is a considerable improvement in the detection limit, the linear dynamic range and the deposition time, compared with the methods of adsorptive stripping voltammetry for the determination of copper. The developed method was validated by analysis of whole blood certified reference materials.

• Journal of the Korean Magnetics Society
• /
• v.20 no.3
• /
• pp.106-113
• /
• 2010

In order to get the precise blood pressure and pulse number in the cuffless status, the wrist wearable pulsimeter with a portable and small size apparatus using by Hall device is developed. The regression analysis of the pulse wave measured by the testing product of pulsimeter is conducted two equations of the blood pressure algorithm. The estimated values of blood pressure obtained by the cuffless pulsimeter during 5 s are compared with the practical values measured by electronic or mercury liquid blood pressure meters. The standard deviation of the estimated value and the practical value for the high blood pressure and the low blood pressure were 12.1 and 5.9, respectively, which have the neighborhood values of BP International Standard. The detail analysis of a pulse wave measured by cuffless wrist wearable detecting the changes of the magnetic field can be used to develop a new diagnostic algorithm of blood pressure applying for oriental medical apparatus like as the wrist wearable pulsimeter.

• Journal of the Korean Society of Physical Medicine
• /
• v.10 no.1
• /
• pp.63-69
• /
• 2015

PURPOSE: Low-intensity exercise with transient restriction of blood flow to muscle could be an alternative rehabilitation method which avoids the problems associated with conventional high-intensity exercise. However, the mechanism of low-intensity exercise with transient restriction of blood flow is not clearly known. Thus, the purpose of this study was to investigate the mechanism of improvement of muscular function after low-intensity exercise with transient restriction of blood flow using H-reflex analysis. METHODS: Twenty one healthy young adults with no medical history of neurological or musculoskeletal disorder voluntarily participated in this study. The ${\alpha}$-motor neuron excitability of the triceps surae was assessed using the H-reflex. The amplitude of the M-wave and H-reflex were measured across three conditions: rest, after low-intensity exercise without restriction of blood flow and after low-intensity exercise with restriction of blood flow. The subjects performed low-intensity ankle plantar flexion exercise at their own pace for one minute without or with transient restriction of blood flow achieved by a sphygmomanometer cuff on popliteal fossa at a pressure of 120mm of mercury(120 mmHg). RESULTS: No significant changes of the excitability of the ${\alpha}$-motor neuron were obtained across three different conditions. CONCLUSION: This study found that low-intensity exercise with transient restriction of blood flow did not influence to ${\alpha}$-motor neuron excitability of the triceps surae. From the results, I could come to the conclusion that further study will be required.

• Environmental Analysis Health and Toxicology
• /
• v.21 no.3 s.54
• /
• pp.229-238
• /
• 2006

Although, mercury (Hg) is not a naturally abundant element in the environment, residues frequently occur in many environmental compartments because of widespread contamination from industrial and agricultural practices. This research evaluated Hg-B concentrations of general population who was not occupationally exposed. And also evaluates the association between life factor and health effect with Hg-B concentration of general adult through interrelationship estimation and index about kidney function and oxidative damage that appeared by questionnaire survey and medical examination. Average concentration of Hg-B was 3.19 $\mu$g/L (ND$\sim$8.64 $\mu$g/L), and persons who exceed mercury exposure level (5 $\mu$g/L) presented in WHO (1990) appeared by 16 (7.0%). High-risk group (smoking and meat main intake group) had significantly higher Hg-B concentration than low-risk group (non-smoking and vegetable diet main intake group) (p < 0.05, low-risk group: 3.30 $\mu$g/L (ND$\sim$8.64 $\mu$g/L), high-risk group: 4.27 $\mu$g/L (ND$\sim$7.84 $\mu$g/L).

• Research in Community and Public Health Nursing
• /
• v.7 no.1
• /
• pp.170-177
• /
• 1996

신체의 활력을 측정하는 혈압은 다른 어느 측정치보다 변동이 심하고 정상적으로 변할 수 있는 생리적 현상이어서 정확하게 측정하기란 쉽지 않다. 1mmHg 차이의 혈압일지라도, 특히 큰 집단일 경우, 연구목적에서 그 결과를 크게 왜곡 시킬 수 있다. (Wright & dore, 1970). 혈압 측정에는 직접적 방법과 간접적 방법이 있다. 이 중 간접적 방법은 임상분야와 연구분야에서 실제로 넓게 사용되고 있을 분만 아니라 신체로의 직접적 침투하는 방법도 아니고 가격 또한 비싸지 않다. 그러나, 간접적 측정 방법은 혈압에 영향을 끼치는 많은 요인들인 관찰자 편견, 확장기음의 청취음 선택, 관찰자와 환자 사이의 상호관계 때문에 방법론적으로 문제제기가 되기도 한다. 이런 요인을 최소화하기 위하여 가장 타당도가 높은 측정도구의 선택이 필요하다. 도시지역의(Ease Baltimore) 고혈압을 가진 젊은 흑인 남성(연령별/성별/종속별/거주지역) 중 수축기 혈압이 140mmHg 이고 확장기 혈압이 90mmHg인 사람, 또는 확장기 혈압이 90mmHg인 사람, 또는 혈압하강제를 먹고 있는 사람 200명을 대상으로 훈련받은 community health worker(CHW)에 의해 Random-Zero Sphygmdmanometer(RZS)와 Digit Automatic Device(DAD)로 혈압을 측정하게 하였다. 이 중 36명을 무작위 추출하여 regular Mercury Sphygmdmanometer (RMS)로 혈압을 측정하게 했다. Bland 와 Altman에 의해 제기된 두측정값의 차이에 대한 scattergram(일치도 검증법)과 AAMI(Association for the Advancement of Medical Instrument) 기준, BHS 기준, Central Tendency와 숫자선호도로 검증되었다. AAMI와 BHS 기준에 의하면 확장기 혈압에서 RZS와 DAD의 일치도와 평균을 중심으로 더 넓게 퍼져있어 낮은 일치도를 보였으며 또 DAD와 RMS의 혈압치는 숫자 선호도를 볼 수 있는데 특히 RMS는 더 뚜렷하게 나타났는데 확장기 혈압의 최빈치(30.6)는 100mmHg이었다. 혈압치들이 가장 가까이 "0"점으로 치우쳐져 있었다. RZS의 Central tendency는 DAD와 RMS보다 뚜렷하였다. 결론적으로 RZS는 이 연구목적으로 가장 적절함을 보여준다.

• Journal of Preventive Medicine and Public Health
• /
• v.45 no.6
• /
• pp.353-363
• /
• 2012

Methylmercury is a hazardous substance that is of interest with regard to environmental health, as inorganic mercury circulating in the general environment is dissolved into freshwater and seawater, condensed through the food chain, ingested by humans, and consequently affects human health. Recently, there has been much interest and discussion regarding the toxicity of methylmercury, the correlation with fish and shellfish intake, and methods of long-term management of the human health effects of methylmercury. What effects chronic exposure to a low concentration of methylmercury has on human health remains controversial. Although the possibility of methylmercury poisoning the heart and blood vessel system, the reproductive system, and the immune system is continuously raised and discussed, and the carcinogenicity of methylmercury is also under discussion, a clear conclusion regarding the human health effects according to exposure level has not yet been drawn. The Joint FAO/WHO Expert Committee on Food Additives proposed to prepare additional fish and shellfish intake recommendations for consumers based on the quantified evaluation of the hazardousness of methylmercury contained in fish and shellfish, methylmercury management in the Korea has not yet caught up with this international trend. Currently, the methylmercury exposure level of Koreans is known to be very high. The starting point of methylmercury exposure management is inorganic mercury in the general environment, but food intake through methylation is the main exposure source. Along with efforts to reduce mercury in the general environment, food intake management should be undertaken to reduce the human exposure to methylmercury in Korea.