• Journal of Ginseng Research
• /
• v.44 no.2
• /
• pp.179-193
• /
• 2020

Ginseng products on the market show high variability in their composition and overall quality. This becomes a challenge for both consumers and health-care professionals who are in search of high-quality, reliable ginseng products that have a proven safety and efficacy profile. The botanical extract standardization is of crucial importance in this context as it determines the reproducibility of the quality of the product that is essential for the evaluation of effectiveness and safety. This review focuses on the well-characterized and standardized ginseng extract, G115, which represents an excellent example of an herbal drug preparation with constant safety and efficacy within the herbal medicinal products. Over the many decades, extensive preclinical and clinical research has been conducted to evaluate the efficacy and safety of G115. In vitro and in vivo studies of G115 have shown pharmacological effects on physical performance, cognitive function, metabolism, and the immune system. Furthermore, a significant number of G115 clinical studies, most of them double-blind placebo-controlled, have reinforced the findings of preclinical evidence and proved the efficacy of this extract on blood glucose and lipid regulation, chronic obstructive pulmonary disease, energy, physical performance, and immune and cognitive functions. Clinical trials and 50 years of presence on the market are proof of a good safety profile of G115.

• Journal of Nutrition and Health
• /
• v.28 no.9
• /
• pp.862-871
• /
• 1995

This study was designed to investigate the effectiveness of ginseng intakes in modifying serum lipid profiles and plasma clotting factors. The participants in this study were 47 normal healthy volunteers(men 24, women 23) with an age range of 35-49 years and a mean age of 41 years residing in Taejon. Based on the diet intakes, subjects were classed into one of three groups : control, vegetarian, and ginseng consumed over 3-4 years. There was no significant difference in their physical characteristics. Dietary calorie intakes were not significantly different in subjects. The ratio of energy intake in the control and ginseng consumed group was 63-64% : 20-21% : 15-16%(Cho : Fat : Pro), but 70-73% : 13-14% :14-15%(Cho : Fat : Pro) in the vegetarians. The intakes of animal food in the vegetarian was significantly lower than the control and ginseng consumed group in men. The ratio of P/S(1.27) was the highest in the vegetarians. Venous blood samples were taken for serum lipid profiling, plasma clotting assay and platelet function. The concentration of serum triglyceride in the men ginseng group is significantly lower than those of the men control group. Serum lipid profiles values of the men ginseng group, such as total cholesterol and phospholipid were lower those of the men control group, but higher those of the men vegetarian group. the serum lipid profile in the women were not significant, but total cholesterol, triglyceride and LDL cholesterol levels in the ginseng groups were low. The concentration of HDL cholesterol was not significantly different. Platelet cell count and platelet aggregation were low in the ginseng groups. APTT(Activated Partial thromboplastin time) was significantly elongated in ginseng groups in the normal range. In seems that the major beneficial effects of ginseng intakes in especially men were on the blood concentrations of triglyceride, total cholesterol and elongation of plasma clotting time.

• Journal of Ginseng Research
• /
• v.42 no.3
• /
• pp.264-269
• /
• 2018

Panax ginseng, also called Asian or Korean ginseng, has long been traditionally used in Korea and China to treat various diseases. The major active ingredients of P. ginseng are ginsenosides, which have been shown to have a variety of therapeutic effects, including antioxidation, anti-inflammatory, vasorelaxation, antiallergic, antidiabetic, and anticancer. To date, approximately 40 ginsenoside components have been reported. Current research is concentrating on using a single ginseng compound, one of the ginsenosides, instead of the total ginseng compounds, to determine the mechanisms of ginseng and ginsenosides. Recent in vitro and in vivo results show that ginseng has beneficial effects on cardiac and vascular diseases through efficacy, including antioxidation, control of vasomotor function, modulation of ion channels and signal transduction, improvement of lipid profiles, adjustment of blood pressure, improvement in cardiac function, and reduction in platelet adhesion. This review aims to provide valuable information on the traditional uses of ginseng and ginsenosides, their therapeutic applications in animal models and humans, and the pharmacological action of ginseng and ginsenosides.

• The Korean Journal of Food And Nutrition
• /
• v.25 no.4
• /
• pp.1075-1080
• /
• 2012

본 연구는 안전하면서 효율적으로 비만을 개선시키는데 도움이 될 수 있는 식품소재로 목이버섯을 선정하여 복부 비만이 있는 중년 여성의 골밀도 및 혈청지질농도에 미치는 영향에 대하여 알아보고자 하였다. 30~50대의 복부비만 여성 30명에게 4주 동안 대조군은 목이버섯을 섭취시키지 않았고, 실험군은 목이버섯을 식사와 함께 섭취하도록 하였다. 실험 전 후 골밀도(T-score, Z-score), 총 콜레스테롤, HDL-콜레스테롤, LDL-콜레스테롤, 중성지방을 측정하였다. 연구결과, 목이버섯 섭취군과 대조군 간에 T-score와 Z-score는 유의한 차이를 보이지 않았지만, 목이버섯 섭취군의 혈청 총 콜레스테롤, LDL-콜레스테롤 및 중성지방 수준이 대조군에 비해 유의하게 감소되었다.

• Clinical Nutrition Research
• /
• v.12 no.1
• /
• pp.40-53
• /
• 2023

Differential bitterness perception associated with genetic polymorphism in the bitter taste receptor gene taste 2 receptor member 38 (TAS2R38) may influence an individual's food preferences, nutrition consumption, and eventually chronic nutrition-related disorders including cardiovascular disease. Therefore, the effect of genetic variations on nutritional intake and clinical markers needs to be elaborated for health and disease prevention. In this study, we conducted sex-stratified analysis to examine the association between genetic variant TAS2R38 rs10246939 A > G with daily nutritional intake, blood pressure, and lipid parameters in Korean adults (males = 1,311 and females = 2,191). We used the data from the Multi Rural Communities Cohort, Korean Genome and Epidemiology Study. Findings suggested that the genetic variant TAS2R38 rs10246939 was associated with dietary intake of micronutrients including calcium (adjusted p = 0.007), phosphorous (adjusted p = 0.016), potassium (adjusted p = 0.022), vitamin C (adjusted p = 0.009), and vitamin E (adjusted p = 0.005) in females. However, this genetic variant did not influence blood glucose, lipid profile parameters, and other blood pressure markers. These may suggest that this genetic variation is associated with nutritional intake, but its clinical effect was not found. More studies are needed to explore whether TAS2R38 genotype may be a potential predictive marker for the risk of metabolic diseases via modulation of dietary intake.

• Journal of the Korean Dietetic Association
• /
• v.12 no.2
• /
• pp.118-126
• /
• 2006

The purpose of this study was to estimate sugar intake and relation between it and blood lipid profiles in Korean adult according to age. The 346 subjects were measured anthropometric assessment, dietary intake using 24-hour recall method, and serum lipid profiles. The average age of the subjects of 20-49, 50-64, over 65 years were 40.8, 57.0, 70.2 years, respectively. The mean height and weight were significantly decreased with increment of age(p<0.001, p<0.01). The mean energy, food, and sugar intakes of the age groups were decreased with increment of age(p<0.05, p<0.001, p<0.001), that is, 1649.8 ㎉/1253.6 g/36.1 g for 20~49 years, 1555.4 ㎉/1157.0 g/31.4 g for 50~64 years, 1404.4 ㎉/893.5 g/17.1 g for over 65 years. The major foods consumed sugar of the age groups were watermelon, sugar, ice cream for 20-49 years, watermelon, sugar, peach for 50-64 years, watermelon, sugar, kimchi for over 65 years. Carbohydrate intake of the subject adjusted age provided significantly negative correlation with serum HDL-cholesterol(p<0.05). However, there was not significant correlation between sugar intake and serum lipid profile. Based on these results, further studies on effects on blood lipid of sugar and carbohydrate intakes were needed for proper carbohydrate intake.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.34 no.6
• /
• pp.825-832
• /
• 2005

This study was conducted to investigate the effect of extract of Fomes fomentarius (FF) on blood glucose, lipid profile, antioxidant enzymes and immune cells in streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley rats were divided into control, STZ-induced diabetic group (DM), STZ plus FF water extract treated group (DM-FW 200) and STZ plus FF methanol extract treated group (DM-FM 200). FW (200 mg/kg BW) and FM (200 mg/kg BW) were orally administered once a day for 14 days. Admdinistering FW and FM to STZ-induced diabetic rats lowered the blood glucose level. The supplementation of FW and FM suppressed the increase in the total cholesterol and triglyceride levels in the serum and liver of the diabetic rats. The high density lipoprotein-cholesterol level and glutathione peroxidase activity were higher in the FF-sup-plemented group compared to the diabetic group. Administering FW and FM increased the suppress in the serum complement component C3, whole blood B-cell, T-cell, helper T cell and suppressor T cell of the diabetic rats. Therefore, it could be suggested that FW and FM are alleviated the diabetic complication through enhancing the hyperglycemia and preventing diabetic complications.

• Journal of the Korean Applied Science and Technology
• /
• v.29 no.2
• /
• pp.214-223
• /
• 2012

This study was carried out to investigate the feeding effects of microcapsulated inulin (MI) from Jerusalem artichoke (Helianthus tuberosus L.) on blood lipid, fatty acid composition and cholesterol of egg in laying hens. Hyline brown layers of 25 weeks old were subjected to one of the following treatments for 4 weeks: a control group without MI, 800 ppm, 900 ppm, and 1,000 ppm. Compared with control group, levels of triacylglyceride and cholesterol in blood and egg cholesterol decreased significantly in groups MI groups. Egg saturated fatty acid was lower in MI groups than control group but not unsaturated fatty acid was significantly high in MI groups as compared to the group without MI. The results suggest that the addition of microcapsulated inulin to a laying hens' diet can improve egg quality by reducing blood lipids.

• Research in Community and Public Health Nursing
• /
• v.14 no.2
• /
• pp.200-210
• /
• 2003

Purpose: This quasi-experimental study was performed to investigate the effects of a health promotion program(HPP) on self-efficacy, healthy lifestyle and blood lipid profile in employees with hyperlipidemia. Methods: The subjects were forty-three employees who were diagnosed as having hyperlipidemia during routine health examination at two worksites in Seoul in 2001. Of the forty-three subjects, thirty were allocated to the experimental group and the remaining thirteen were allocated to the control group. Data were collected from September 24, 2001 to March 16, 2002. The HPP was applied to the experimental group for 11 weeks and included health education, diet counseling, watching videos, conference, and so on. The health education included information about exercise, smoking cessation, and abstinence from drinking alcohol and seven sessions of hyperlipidemia education. The experimental group was requested to keep a daily health promotion lifestyle diary. This diary was analyzed by a dietician and subjects were instructed based on the results. As for data analyses, wilcoxon signed rank test and wilcoxon rank sum test and x2-test were carried out using SAS program. Results: 1. Self-efficacy scores of the experimental group were significantly more increased than those of the control group (experimental: 5.86 10.80, control: -4.04 11.91, p=0.018). 2. Healthy lifestyle scores of the experimental group were significantly more increased than those of the control group (experimental: 0.19 0.26, control: -0.05 0.29, p=0.024). 3. Blood total cholesterol values of the experimental group were significantly more decreased than those of the control group (experimental: -13.07 30.10mg/dl, control: 10.00 26.57mg/dl, p=0.033). 4. Blood triglyceride values of the experimental group were significantly more decreased than those of the control group (experimental: -29.17 192.40mg/dl, control: 63.31 107.53mg/dl, p=0.050). Conclusion: These findings indicate that the HHP could be effective in improving self-efficacy, healthy lifestyle and blood HDL cholesterol and decreasing blood total cholesterol in employees with hyperlipidemia. Therefore, the HHP could be suggested as an effective nursing intervention for employees in the worksite by ultimately preventing cerebral and cardiac vessel complications related to hyperlipidemia.

• Advances in Traditional Medicine
• /
• v.10 no.3
• /
• pp.165-172
• /
• 2010

The present study investigated the effect of silymarin, a flavonoid, on streptozotocin (STZ) - induced diabetic dyslipidaemia in rats. Experimental diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg). Silymarin (25 mg/kg and 50 mg/kg) was orally administered to diabetic rats for a period of 15 days. Blood glucose levels, serum lipid profile and liver glycogen levels were estimated following the established procedures. Biochemical observations were supplemented with histological examination of liver sections. Oral administration of silymarin to diabetic rats significantly (P < 0.001) decreased the blood glucose levels ($259.99{\pm}23.64$ vs. $99.90{\pm}2.62$ [25 mg] & $89.17{\pm}3.32$ [50 mg]). The most interesting finding was the significant (p < 0.001) increase in HDL-cholesterol levels ($26.99{\pm}0.61$ vs. $40.55{\pm}0.52$ [25 mg] & $41.12{\pm}0.37$ [50 mg]) whereas, there was a significant decrease in serum total cholesterol (TCh), triglycerides (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) cholesterol levels observed in silymarin treated diabetic rats. STZ treatment caused significant degeneration of liver parenchyma, which was normalized to near normal morphology by administration of silymarin. The findings indicate that silymarin effectively improved the overall lipid profile and restored the glycogen stores in the liver of STZ-induced diabetic rats, in a dose dependent manner. The results indicate existence of abnormalities in lipid metabolism in STZ-induced diabetic rats and suggest a protective effect of silymarin in this animal model.