• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1475-1478
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• 2008

We have investigated the blood sucking phenomena of a female mosquito. The main objective of this study is to understand the mosquito's blood sucking mechanism and eventually to develop a bio-mimic technology that can be used to resolve the problem encountered in the transport of infinitesimal biological fluids in various bio-chips and microchips. At first, the consecutive velocity fields of blood-sucking flow in a proboscis were measured using a micro-particle image velocimetry (PIV) system employed with a high-speed camera. The velocity signals of the blood-sucking flow in the proboscis represent a periodic pulsatile flow pattern and spectral analysis on the velocity waveform shows a clear peak at 6.1 Hz.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.363-367
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• 1996

In general, the physiological systems have shown nonlinear complex phenomena. This study analyzes nonlinear characteristics of the flow of peripheral blood vessel dynamics in physiological systems using chaos theory. We performed this study by means of several quantity methods and power spectrum. The quantity methods are a phase space reconstruction and a poincare's map. And the power spectrum method is a conventional linear analysis. Experimental data have been acquired from examining 10 diabetic patients, and 10 control subjects in initial stable state. In acquisition experminetal data, we anlysized the differences of nonlinear characteristics between diabetic group and control group. The results of quality analysis methods showed the flow of peripheral blood vessel had the nonlinear and chaotic characteristics, screening a strange attractor on reconstructed phase space. In conclusion, the flow dynamics of peripheral blood vessel had a chaotic behavior of nonlinear dynamic systems, dynamic system, and differences of characteristic of nonlinear dynamic system.

• 순환기질환의공학회:학술대회논문집
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• 2005.12a
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• pp.35-36
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• 2005

• Journal of the Korea Institute of Information and Communication Engineering
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• v.24 no.11
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• pp.1411-1416
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• 2020

In this paper, we propose a method of extraction analysis of blood flow area on color doppler ultrasonography by using 4-directional contour tracking and K-Means algorithm. In the proposed method, ROI is extracted and a binarization method with maximum contrast as a threshold is applied to the extracted ROI. 4-directional contour algorithm is applied to extract the trapezoid shaped region which has blood flow area of brachial artery from the binarized ROI. K-Means based quantization is then applied to accurately extract the blood flow area of brachial artery from the trapezoid shaped region. In experiment, the proposed method successfully extracts the target area in 28 out of 30 cases (93.3%) with field expert's verification. And comparison analysis of proposed K-Means based blood flow area extraction on 30 color doppler ultrasonography and brachial artery blood flow ultrasonography provided by a specialist yielded a result of 94.27% accuracy on average.

• Journal of Mechanical Science and Technology
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• v.15 no.5
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• pp.613-622
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• 2001

Interaction of blood flow and leaflet behavior in a bileaflet mechanical heart valve was investigated using computational analysis. Blood flows of a Newtonian fluid and a non-Newtonian fluid with Carreau model were modeled as pulsatile, laminar, and incompressible. A finite volume computational fluid dynamics code and a finite element structure dynamics code were used concurrently to solve the flow and structure equations, respectively, where the two equations were strongly coupled. Physiologic ventricular and aortic pressure waveforms were used as flow boundary conditions. Flow fields, leaflet behaviors, and shear stresses with time were obtained for Newtonian and non-Newtonian fluid cases. At the fully opened phase three jets through the leaflets were found and large vortices were present in the sinus area. At the very final stage of the closing phase, the angular velocity of the leaflet was enormously large. Large shear stress was found on leaflet tips and in the orifice region between two leaflets at the final stage of closing phase. This method using fluid-structure interaction turned out to be a useful tool to analyze the different designs of existing and future bileaflet valves.

• Journal of the Korean Society of Physical Medicine
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• v.10 no.1
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• pp.63-69
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• 2015

PURPOSE: Low-intensity exercise with transient restriction of blood flow to muscle could be an alternative rehabilitation method which avoids the problems associated with conventional high-intensity exercise. However, the mechanism of low-intensity exercise with transient restriction of blood flow is not clearly known. Thus, the purpose of this study was to investigate the mechanism of improvement of muscular function after low-intensity exercise with transient restriction of blood flow using H-reflex analysis. METHODS: Twenty one healthy young adults with no medical history of neurological or musculoskeletal disorder voluntarily participated in this study. The ${\alpha}$-motor neuron excitability of the triceps surae was assessed using the H-reflex. The amplitude of the M-wave and H-reflex were measured across three conditions: rest, after low-intensity exercise without restriction of blood flow and after low-intensity exercise with restriction of blood flow. The subjects performed low-intensity ankle plantar flexion exercise at their own pace for one minute without or with transient restriction of blood flow achieved by a sphygmomanometer cuff on popliteal fossa at a pressure of 120mm of mercury(120 mmHg). RESULTS: No significant changes of the excitability of the ${\alpha}$-motor neuron were obtained across three different conditions. CONCLUSION: This study found that low-intensity exercise with transient restriction of blood flow did not influence to ${\alpha}$-motor neuron excitability of the triceps surae. From the results, I could come to the conclusion that further study will be required.

• Journal of Biomedical Engineering Research
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• v.28 no.2
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• pp.178-186
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• 2007

This study is attempted to correct an error of electronic blood pressure meter with an optical sensor. In general, for a hospitalized patient, ECG, blood pressure, oxygen saturation, and respiration are basically measured to monitor the patient's condition. Opening of a blood vessel after it is occluded by pressurizing the cuff influences the blood flow of peripheral blood vessels as well as oscillation changes in the cuff. Blood vessels are occluded and peripheral blood flow disappears at cuff pressure above the examinee's blood pressure, while blood vessels are opened and peripheral blood flow appears again at cuff pressure under the examinee's blood pressure. Then Disappear-Appear Point Length(DAPL) of peripheral blood flow can be judged with the signal of peripheral blood flow, thus is available as a factor of error correction for electronic blood pressure meter. Also, systolic or diastolic blood pressure can be corrected with Appear-Point-Pressure(APP) of cuff pressure at a point where blood flow occurs and Appear-Maximum Pressure(AMP) of cuff pressure at the maximum amplitude point of peripheral blood flow after peripheral blood flow appears again. For verification, 27 examinees were selected, and their blood value was obtained through experimental procedure of 4 stages including induction of blood pressure change. The examinees were divided into two groups of experimental group and control group, regression analysis was conducted for experimental group, and correction of a blood pressure error was verified with optical signal by applying the regression equation calculated in experimental group to control group. As an experimental result, mean of the whole measurement errors was 5mmHg or more, which did not meet the standard fur blood pressure meter. As a result of correcting blood pressure measurements with data of DAPL, APP, and AMP as drawn out of PPG signal, systolic blood pressure, mean blood pressure, and diastolic blood pressure were $-0.6{\pm}4.4mmHg,\;-1.0{\pm}3.9mmHg$ and $-1.3{\pm}5.4mmHg$, respectively, indicating that mean of the whole measurement errors was greatly improved, and standard deviation was decreased.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.3 s.168
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• pp.154-161
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• 2005

In this study, the leaflet motion of a mechanical heart valve and the characteristics of two-dimensional transient blood flow in an elastic blood vessel have been numerically investigated by using fluid-structure interaction method. Here, blood has been assumed as a Newtonian, incompressible fluid. Pressure profiles have been used as boundary conditions at the ventricle and the aorta. As a result, closing motion of the leaflet is faster than opening one. While opening angles of leaflet grow up, vortex is detected at the sinus and backward of the leaflets. When the leaflet is fully closed, vortex is detected at the ventricle and at that moment maximum displacement of the elastic blood vessel is observed in the vicinity of the sinus region. Maximum displacement is caused in association with the blood flow that is oriented toward the elastic blood vessel.

• Journal of Biomedical Engineering Research
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• v.21 no.4
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• pp.353-362
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• 2000

Minimization of hemolysis is one of the key factors for successful axial flow blood pumps. It is, however, difficult to estimate the hemolytic performance of axial flow blood pumps without experiments. Instead, the Computational Fluid Dynamics(CFD) analysis enables the prediction of hemolysis. Three-dimensional fluid dynamics of axial flow pumps with different impellers were analyzed using the CFD software, FLOTRAN. The turbulence model k-$\varepsilon$ was used. The changes in turbulent kinetic energy applied to each particle (red blood cell) flowing through the pumps were computed and displayed by the particle trace method (particle spacing of 10 msec). Also, the Reynolds shear stress was calculated from the turbulent kinetic energy. The shear stress was higher behind the impellers than elsewhere. The CFD analysis could predict in vitro results of hemolysis and also the areas where hemolysis occurred. The CFD analysis was found to be a useful tool for designing less hemolytic rotary blood pumps.

• Proceedings of the KOSOMBE Conference
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• v.1995 no.05
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• pp.113-116
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• 1995

Steady and physiological flows of a Newtonian fluid and blood in the bifurcated arterial vessel are numerically simulated. Distributions of velocity, pressure and wall shear stress in the bifurcated arterial vessel are calculated to investigate the differences between steady and physiological flows. For the given Reynolds number physiological flow characteristics of a Newtonian fluid and blood in the bifurcated arterial vessel are quite different from those of steady flows. No flow separation or flow reversal in the bifurcated region in the downstream after stenosis appears during the acceleration phase. Also, no recirculation region is seen for steady flows. However, during the deceleration phase the flow began to exhibit flow reversal, which is eventually extended to the entire wall region.