• 생약학회지
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• 제51권1호
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• pp.1-29
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• 2020

Diabetes mellitus, commonly known as diabetes, is a group of metabolic disorders characterized by high blood sugar levels over a prolonged period. Diabetes has been found to show many acute complications such as cardiovascular disease, stroke, chronic kidney disease, foot ulcer and damage to eyes. Korean ginseng (Panax ginseng) has been traditionally known to normalize the functional deficiencies of the lung, spleen and stomach, and thus improve the secretion of body fluids, thereby quenching thirst, suggesting it to be effective in the treatment of diabetes. Experimental studies (in vitro and in vivo) have recently shown that Korean ginseng and its extracts exhibit antidiabetic effects, and also insulin secretion and sensitizing effects related to blood glucose control. Moreover, clinical trials on antidiabetic effects of Korean ginseng have been reported to show blood glucose control, improvement of insulin resistance, reduction of postprandial blood glucose level and improvement of serum lipids (TG, TC, LDL-C). These will be critically examined by means of in vitro studies, cell experiment, animal models and human trials with a focus on understanding of molecular mechanisms.

• Mass Spectrometry Letters
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• 제13권1호
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• pp.2-10
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• 2022

Metabolomics makes it possible to analyze the interrelationships between various signaling molecules based on the metabolic pathways involved by using high-resolution devices. This approach can also be used to obtain large-scale metabolic information to identify the relevant pathways for disease diagnosis and prognosis and search for potential biomarkers. In the fields of medicine and forensics, hair analysis is used to detect various metabolites in the body. Hair can be harvested readily in a noninvasive manner and is easier to transport and store than blood and urine. Another advantage from a forensic viewpoint is that hair reflects all the components of body fluids. In addition, because of the unique coating structure of hair, it can be used for measurements without changing or destroying its adsorbed components. In this review, the pretreatments for hair analysis, instrumental conditions and clinical applications are discussed. Especially, the clinical use of hair metabolomics in the diagnosis of various diseases and the limitations of the technique are described.

• Journal of Yeungnam Medical Science
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• 제3권1호
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• pp.193-199
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• 1986

1984년 10월부터 1986년 5월까지 영남대병원 임상병리과에 의뢰된 132예의 복수액과 늑막액의 진단적가치를 설정하기위한 연구로서 총 LD, LD 동위효소의 활성도, 생화학 및 혈액학적 검사, 세포진검사 등의 소견을 연구한 결과 다음과 같은 결론을 얻었다. 1. 복수액은 총 LD활성도 및 단백양으로 여출액의 감별이 가능하였다. 2. 복수액과 늑막액의 악성삼출액은 LD2가 염증성 삼출액에 비하여 증가되었고(P<0.01), 혈청에 비하여 LD4가 증가되어(P<0.05) 통계적 유의성을 나타내었다. 3. 늑막액과 복수액의 염증성 삼출액은 LD5가 증가하여 혈청과 악성삼출액에 비하여 의의성 있는(P<0.05) 증가를 나타내었다. 4. 복수액에서는 염증성 삼출액의 총 LD양은 악성삼출액에 비해 유의한 증가를 보여 총 LD활성도에 의한 삼출액의 구별이 가능하였으나 늑막액에서는 악성 삼출액과 결핵성 삼출액의 총 LD 활성도 차이의 통계적 유의성은 없었다. 5. 총 LD 및 LD5동위효소의 삼출액에서 백혈구수와 상관관계가 성립하지 않았다.

• 한국산학기술학회논문지
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• 제17권11호
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• pp.563-572
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• 2016

본 연구는 종합병원 간호사의 주사바늘이나 날카로운 상처 경험과 혈액 및 체액의 접촉 경험을 알아보고, 표준주의지침 이행도에 대한 영향요인을 파악하기 위하여 시도되었다. 연구대상자는 C도에 소재하는 3개의 종합병원에서 근무하는 간호사 144명으로 표준주의지침 인지도, 이행도, 안전환경 및 태도에 대해 설문조사로 자료수집을 하였다. 지난 1년 동안 주사바늘이나 날카로운 기구 등에 의한 상처 경험은 대상자의 40.3%에서 보고되었고, 평균 경험 횟수는 1.01회였다. 또한 지난 1년 동안 환자의 혈액, 체액 및 상처의 접촉 경험은 대상자의 29.2%가 경험하였고, 평균 1.06회를 경험하였으며, 이러한 접촉종류는 혈액(22.9%)이 가장 많았다. 표준주의지침 인지도는 총 4점 만점 중에 3.77점, 이행도는 3.45점으로 전반적으로 높았으나, 표준주의지침에 대한 이행도는 인지도보다 더 낮았다. 표준주의지침 이행도는 인지도 및 안전환경과 유의한 상관관계를 보였다. 표준주의지침 이행도에 영향을 미치는 요인은 인지도와 안전환경이었으며, 이들 변수의 설명력은 16.6%로 나타났다. 이에 표준주의지침의 이행도를 높이기 위해서는 임상실무에서 병원감염의 예방을 위해 표준주의지침의 체계적이고 지속적인 교육을 통해 표준주의지침에 대한 인지도를 높이고, 더 나아가 병원의 지지적인 안전환경 증진이 필요하다.

• Nutrition Research and Practice
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• 제6권2호
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• pp.126-131
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• 2012

The purpose of this study was to determine the effects of beverage temperature and composition on weight retention and fluid balance upon voluntary drinking following exercise induced-dehydration. Eight men who were not acclimated to heat participated in four randomly ordered testing sessions. In each session, the subjects ran on a treadmill in a chamber maintained at $37^{\circ}C$ without being supplied fluids until 2% body weight reduction was reached. After termination of exercise, they recovered for 90 min under ambient air conditions and received one of the following four test beverages: $10^{\circ}C$ water (10W), $10^{\circ}C$ sports drink (10S), $26^{\circ}C$ water (26W), and $26^{\circ}C$ sports drink (26S). They consumed the beverages ad libitum. The volume of beverage consumed and body weight were measured at 30, 60, and 90 min post-recovery. Blood samples were taken before and immediately after exercise as well as at the end of recovery in order to measure plasma parameters and electrolyte concentrations. We found that mean body weight decreased by 1.8-2.0% following exercise. No differences in mean arterial pressure, plasma volume, plasma osmolality, and blood electrolytes were observed among the conditions. Total beverage volumes consumed were $1,164{\pm}388$, $1,505{\pm}614$, $948{\pm}297$, and $1,239{\pm}401$ ml for 10W, 10S, 26W, and 26S respectively ($P$ > 0.05). Weight retention at the end of recovery from dehydration was highest in 10S ($1.3{\pm}0.7kg$) compared to 10W ($0.4{\pm}0.5kg$), 26W ($0.4{\pm}0.4kg$), and ($0.6{\pm}0.4kg$) ($P$ < 0.005). Based on these results, carbohydrate/electrolyte-containing beverages at cool temperature were the most favorable for consumption and weight retention compared to plain water and moderate temperature beverages.

• 한방안이비인후피부과학회지
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• 제16권3호
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• pp.1-37
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• 2003

The epistaxis is commonplace and temporary disease in the field of ENT. In most cases, it is a slight illness, but sometimes, it leads to death because of copious bleeding. The first treatment of epistaxis is stoping hemorrhage, but the real state of treatment in oriental medical is not thoroughgoing enough. So we referred to oriental medical journals and sundry records about etiology and remedy of epistaxis, we got this results. 1. The etiology of epistaxis was mostly bleeding due to heat in the blood by dysfunction of Jang and Bu Gi, there were affection wind-cold by exopathogen, spleen heat to liver, excessive fire of lung meridian, stagnated fire-heat of upper Cho, excessive drinking, bruise and so on. 2. The treatment was used much to remove heat from the blood and activating blood, in case of getting no better, it's used to enriching the blood or clear Gi. 3. The internal remedy of epistaxis was the most used 20times SeogakJihwangtang(犀角地黃湯) to remove heat from the blood and activating blood, and used Jihwangtang(地黃湯), Samhwangbohyultang(三黃補血湯), Jiyuksan(止육散), hueksinsan(黑神散), etc. The drugstuffs were the most used 51times Radix Rehmanniae Preparata((生地黃) to clear heat and remove heat from the blood, produce the body fluids, yin, and used Radix Paeoniae Alba(芍樂) and Radix Glycyrrhizae(甘草), Radix Angelicae Gignatis(當歸), Radix Scutellariae(黃岑), Rhizoma Coptidis(黃連) and Fructus Gardeniae(梔子), etc. 4. The external medical treatment of epistaxis was the most used 16times spraying the granular medication into the cavity and attaching Allii Bulbus(大蒜) to center of the sole or binding the middle finger, etc.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제42권
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• pp.12.1-12.9
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• 2020

Coronavirus is an enveloped virus with positive-sense single-stranded RNA. Coronavirus infection in humans mainly affects the upper respiratory tract and to a lesser extent the gastrointestinal tract. Clinical symptoms of coronavirus infections can range from relatively mild (similar to the common cold) to severe (bronchitis, pneumonia, and renal involvement). The disease caused by the 2019 novel coronavirus (2019-nCoV) was called Covid-19 by the World Health Organization in February 2020. Face-to-face communication and consistent exposure to body fluids such as blood and saliva predispose dental care workers at serious risk for 2019-nCoV infection. As demonstrated by the recent coronavirus outbreak, information is not enough. During dental practice, blood and saliva can be scattered. Accordingly, dental practice can be a potential risk for dental staff, and there is a high risk of cross-infection. This article addresses all information collected to date on the virus, in accordance with the guidelines of international health care institutions, and provides a comprehensive protocol for managing possible exposure to patients or those suspected of having coronavirus.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2010년 춘계학술대회논문집
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• pp.214-220
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• 2010

This article described that a high Reynolds number version of a turbulence model was modified by using drag reduction to analyze the turbulent flows of non-Newtonian fluid with visco-elastic viscosity and it was applied hemodynamics which was representative of visco-elastic fluid. The turbulence characteristics of visco-elastic fluid was expanded viscous sublayer region and buffer layer region by drag reduction phenomenon and also Newtonian turbulence models does not predict because viscosity was related with shear rate of fluid flow. Hence numerical simulation using a modified turbulence model was conducted under the same conditions that were applied to obtain the experiment results and previous turbulence models and then the numerical investigation of turbulent blood flow in the stenosed artery bifurcation under periodic acceleration of the human body.

• Journal of Chest Surgery
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• 제41권4호
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• pp.536-539
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• 2008

52세 여자는 승용차 조수석에 앉아가다가 타차와 충돌후 다발성 늑골골절과 혈기흉과 함께 다량의 출혈을 야기한 우측 전완의 절단에 가까운 손상을 입었다. 응급실에 도착시 명료하지 못한 의식과 저혈압의 소견을 보였다. 혈액량 감소 쇼크로 판단되어 다량의 혈액과 수액을 급속수액주입기(레벨 1)를 이용하여 좌측 쇄골하정맥관을 통해 주입하였다. 폐좌상의 소견이 호전되었을 때 일반 흉부 X선 사진의 좌폐야에 이물질이 확인되었다. 폐동맥조영술에서 15 cm 정도의 이물질이 좌측 폐기저동맥에 있었다. 경피적 중재시술을 통해 혈관 겸자로 잡아 제거할 수 있었다.

• 농업과학연구
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• 제48권2호
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• pp.251-264
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• 2021

Bovine respiratory syncytial virus (BRSV) and bovine viral diarrhea virus (BVDV) are the main viral contributors to bovine respiratory disease (BRD) with high mortality and morbidity. BRD control measures include vaccination that modulates immunological profiles reflected in blood cells, serum, and body secretions, such as milk. This study evaluated the immune responses to an inactivated BRD vaccine in lactating cows reared in a natural environment on a dairy farm. The cows were intramuscularly inoculated with the vaccine, and serum, blood, and milk were collected pre-and post-vaccination. Our study revealed a prominent increase in BRSV-specific antibodies both in serum and milk, while the change in BVDV-specific antibodies was insignificant. Serum interleukin (IL)-1β and IL-6 levels significantly decreased, but this change was not reflected in milk. Evaluation of pattern recognition receptors (PRRs) via RT-qPCR revealed downregulation of nucleotide-binding oligomerization domain 2 (NOD2). The concentrations of BRSV antibodies, BVDV antibodies, IL-2, and IL-17A in serum and milk were strongly correlated, implying a concurrent influence on both body fluids. Thus, immunological factors modulated as a result of vaccination generally measured in serum were reflected in milk, demonstrating the suitability of milk evaluation as an alternative approach for immunological observations. Furthermore, the correlation between BRSV antibodies and NOD2 and that between BVDV antibodies and toll-like receptor (TLR) 2, TLR3, TLR4, and TLR5 imply the possible role of PRRs for the assessment of the immune response developed in immunized cows reared on the farm.