• 한국통신학회논문지
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• 제23권9A호
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• pp.2345-2354
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• 1998

디지털 카메라의 핵심 부품인 CCD(charge couple device) 소자의 해상도는 촬영된 영상의 화질에 결정적인 요인으로 작용하며 제품 제조 원가에서도 큰 비중을 차지한다. 낮은 해상도의 소자로부터 보다 높은 해상도의 화질을 얻기 위한 많은 연구가 진행되어왔다. 본 논문에서는 에일리어싱 성분을 가우시안 저역 필터로 제거한 후, 최소 자승 스플라인보간과 경계 모델에 기반한 비선형 보간을 사용함으로써 확대된 저해상도 영상의 계단 현상, 블록화 현상등을 줄이는 동시에, 선형 보간시 나타나는 경계주변의 울림현상(ringing effect) 번짐현상(blur effect)을 최소화한다.

• Archives of Pharmacal Research
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• 제8권4호
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• pp.267-272
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• 1985

Pyrantal pamoate's anthelmintic activity is due to its action as a neuromuscular blocking agent. It is generally well tolerated. Transient rises in SGOT levels have been reported in the drug-treated patients. Decreased levels of serum alkaline phosphatase post treatment were found in yound dogs. The present study was performed to investigate the possible toxic effects of pyrantal pamoate in pregnant mice progenies. The drug was given in different doses to these mothers in the first, second and third trimester. Serum alkaline phosphatase, SGOT and SGPT of one or two month old offspring were monitored. SGOT levels showed an increase in some doses in one and two month old offspring where alkaline phosphatase showed a decrease in some doses in one and two month old offspring. The latter effect may be due to osteoblastic alkaline phosphatase inhibition. The effect on SGOT levels, however, was difficult to explain, but may be due to a toxic effect on liver cells or cardiac muscles.

• Molecules and Cells
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• 제26권5호
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• pp.462-467
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• 2008

TPA is known to cooperate with an activated Ras oncogene in the transformation of rodent fibroblasts, but the biochemical mechanisms responsible for this effect have not been established. In the present study we used c-fos promoter-luciferase constructs as reporters, in transient transfection assays, in NIH3T3 cells to assess the mechanism of this cooperation. We found a marked synergistic interaction between TPA and a transfected v-Ha-ras oncogene in the activation of c-fos promoter and SRE. SRE has binding sites for TCF and SRF. A dominant-negative Ras (ras-N17) inhibited the TPA-Ras synergy by blocking the PKC-MAPK-TCF pathway. Dominant-negative RhoA and Rac1 (but not Cdc42Hs) inhibited the TPA-Ras synergy by blocking the Ras-Rho-SRF signaling pathway. Constitutively active $PKC{\alpha}$ and $PKC{\varepsilon}$ showed synergy with v-Ras. These results suggest that the activation of two distinct pathways such as Ras-Raf-ERK-TCF pathway and Rho-SRF pathway are responsible for the induction of c-fos by TPA and Ras in mitogenic signaling pathways.

• 한국해양공학회지
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• 제33권6호
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• pp.573-580
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• 2019

A submerged breakwater is a coastal structure built under water with excellent landscape. The depth of the crest of the breakwater should be maintained at more than a certain level in order for the submerged breakwater to control waves properly. This means that the effect of blocking waves deceases sharply at high tide in coastal areas with large tidal differences. In this study, we proposed a Tide-Adapting Submerged Breakwater (TA-SB) to overcome this problem, and then we conducted hydraulic model experiments to evaluate the performance of the TA-SB for controlling waves. The experimental results showed that the tapered wings attached to the crest of the TA-SB helped induce forced breaking waves. In particular, they were very effective in blocking waves and attenuating wave energy at high tide. In addition, the wave control performance of the proposed TA-SB was far superior to the Tide-Adapting Low-Crested Structure (TA-LCS) of the previous study.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2016년도 제50회 동계 정기학술대회 초록집
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• pp.162-162
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• 2016

We present multifunctional indium tin oxide (ITO) thin films formed at room temperature by a normal sputtering system equipped with a plasma limiter which effectively blocks the bombardment of energetic negative oxygen ions (NOIs). The ITO thin film possesses not only low resistivity but also high gas diffusion barrier properties even though it is deposited on a plastic substrate at room temperature without post annealing. Argon neutrals incident to substrates in the sputtering have an optimal energy window from 20 to 30 eV under the condition of blocking energetic NOIs to form ITO nano-crystalline structure. The effect of blocking energetic NOIs and argon neutrals with optimal energy make the resistivity decrease to $3.61{\times}10-4{\Omega}cm$ and the water vapor transmission rate (WVTR) of 100 nm thick ITO film drop to $3.9{\times}10-3g/(m2day)$ under environmental conditions of 90% relative humidity and 50oC, which corresponds to a value of ~ 10-5 g/(m2day) at room temperature and air conditions. The multifunctional ITO thin films with low resistivity and low gas permeability will be highly valuable for plastic electronics applications.

• BMB Reports
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• 제50권8호
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• pp.417-422
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• 2017

Cisplatin is the most effective and widely used chemotherapeutic agent for many types of cancer. Unfortunately, its clinical use is limited by its adverse effects, notably bone marrow suppression leading to abnormal hematopoiesis. We previously revealed that neuropeptide Y (NPY) is responsible for the maintenance of hematopoietic stem cell (HSC) function by protecting the sympathetic nervous system (SNS) fibers survival from chemotherapy-induced bone marrow impairment. Here, we show the NPY-mediated protective effect against bone marrow dysfunction due to cisplatin in an ovarian cancer mouse model. During chemotherapy, NPY mitigates reduction in HSC abundance and destruction of SNS fibers in the bone marrow without blocking the anticancer efficacy of cisplatin, and it results in the restoration of blood cells and amelioration of sensory neuropathy. Therefore, these results suggest that NPY can be used as a potentially effective agent to improve bone marrow dysfunction during cisplatin-based cancer therapy.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권9호
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• pp.4467-4486
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• 2016

Discrete cosine transform (DCT) based JPEG standard significantly improves the coding efficiency of image compression, but it is unacceptable event in serious blocking artifacts at low bit rate and low efficiency of high-definition image. In the light of all phase digital filtering theory, this paper proposes a novel transform based on discrete sine transform (DST), which is called all phase discrete sine biorthogonal transform (APDSBT). Applying APDSBT to JPEG scheme, the blocking artifacts are reduced significantly. The reconstructed image of APDSBT-JPEG is better than that of DCT-JPEG in terms of objective quality and subjective effect. For improving the efficiency of JPEG coding, the structure of JPEG is analyzed. We analyze key factors in design and evaluation of JPEG compression on the massive parallel graphics processing units (GPUs) using the compute unified device architecture (CUDA) programming model. Experimental results show that the maximum speedup ratio of parallel algorithm of APDSBT-JPEG can reach more than 100 times with a very low version GPU. Some new parallel strategies are illustrated in this paper for improving the performance of parallel algorithm. With the optimal strategy, the efficiency can be improved over 10%.

• 한국재료학회지
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• 제26권8호
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• pp.417-421
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• 2016

We improve the energy conversion efficiency (ECE) of a dye sensitized solar cell (DSSC) by preparing a working electrode (WE) with localized surface plasmon resonance (LSPR) by inducing Au thin films with thickness of 0.0 to 5.0 nm, deposited via sputtering. Field emission scanning electron microscopy and atomic force microscopy were used to characterize the microstructure of the blocking layer (BL) of the Au thin films. Micro-Raman measurement was employed to confirm the LSPR effect, and a solar simulator and potentiostat were used to evaluate the photovoltaic properties, including the impedance and the I-V of the DSSC of the Au thin films. The results of the microstructural analysis confirmed that nano-sized Au agglomerates were present at certain thicknesses. The photovoltaic results show that the ECE reached a value of 5.34% with a 1-nm thick-Au thin film compared to the value of 5.15 % without the Au thin film. This improvement was a result of the increase in the LSPR of the $TiO_2$ layer that resulted from the Au thin film coating. Our results imply that the ECE of a DSSC may be improved by coating with a proper thickness of Au thin film on the BL.

• 한국컴퓨터산업학회논문지
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• 제4권10호
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• pp.571-580
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• 2003

인터넷 유해정보를 차단하기 위해서는 차단목록에 의한 차단 방안을 기반으로 한 차단 프로그램이 많이 사용되고 있다. 그러나 차단목록에 의한 차단 방안은 클라이언트 PC의 성능 저하와 같은 문제점들을 발생시킨다. 본 논문에서는 차단목록에 의한 차단 방안의 문제점들을 극복할 수 있는 효율적인 방안을 제안한다. 클라이언트/서버 환경에서 차단목록을 차단목록서버에 두고, 웹 사용자의 사이트 재방문 패턴을 이용한 허용목록을 클라이언트 PC에 도입하는 것이다. 간 논문의 실험에서, 제안하는 방안은 클라이언트 PC의 성능 저하를 초래하지 않으면서 차단목록에 의한 차단 방안보다도 상당한 속도 향상을 보여 준다.

• BMB Reports
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• 제45권2호
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• pp.108-113
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• 2012

Protopine is an isoquinoline alkaloid contained in plants in northeast Asia. In this study, we investigated whether protopine derived from Hypecoum erectum L could suppress lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages (Raw 264.7 cells). Protopine was found to reduce nitric oxide (NO), cyclooxygenase-2 (COX-2), and prostaglandin $E_2$ ($PGE_2$) production by LPS-stimulated Raw 264.7 cells, without a cytotoxic effect. Pre-treatment of Raw 264.7 cells with protopine reduced the production of pro-inflammatory cytokines. These inhibitory effects were caused by blocking phosphorylation of mitogen-activated protein kinases (MAP kinases) and also blocking activation of a nuclear factor kappa-light-chain-enhancer of activated B cells (NF-${\kappa}B$).