• 한국임상수의학회지
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• 제20권3호
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• pp.406-409
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• 2003

We found seventeen dairy cattle with the abnormal signs in cardiovascular and gastrointestinal systems after feeding of the yew foilage. Among them three cattle were dead due to yew poisoning. Among the remaining fourteen dairy cattle, four cattle showed similar symptoms as did dead cattle. Although the remaining ten dairy cattle did not show any abnormal signs, we conducted a therapy of forced magnesium sulfate infusion because the yew consumption might have been occurred in all cattle. As a result of the therapy, we could not found further signs of yew poisoning. The performance of the therapy and the treatment procedures adapted by the therapy could be concluded as follows: The cardioselective toxicity and inhibition of peristaltic activity by the taxine in yew foilage might be involved in the symptoms of acute poisoning as anorexia, dullness, muscle tremor, dyspnea, and sudden death. We also performed the dose response relationship of taxine to the range of clinical symptoms and examined recovery performances. Through the autopsy of the cattle, we could confirm the presence of yew foilages that might have caused the poisoning in the gastrointestinal tract. However, we could not identify further abnormalities in other organs. In this case report, we demonstrated that practice of the forced magnesium sulfate infusion in yew poisoning was helpful for the attenuating the taxine poisoning by blocking the further proceeding of the toxic effect.

• Animal cells and systems
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• 제16권6호
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• pp.462-468
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• 2012

Urodeles including newt and salamander have remarkable regenerative capacity during the postembryonic life span. Some of the unique features are the formation of the well-developed wound epidermis and the active dedifferentiation process in the early phase of regeneration. These are regarded as key events for the successful regeneration since no further regenerative activity is possible without them. In this study, we investigated the role of retinoic acid (RA) in salamander limb regeneration by blocking RA synthesis using disulfiram, an inhibitor of aldehyde dehydrogenase that oxidizes retinal to RA. Disulfiram treatment resulted in delaying the limb regeneration processes via inhibition of wound epidermis formation and dedifferentiation process. When RA was administered after disulfiram treatment, the inhibitory effect of disulfiram was rescued. In addition, disulfiram treatment after the dedifferentiation stage resulted in the mild retardation of limb regeneration, suggesting that RA might also be involved in the blastema outgrowth. Furthermore, salamander MMP-9 gene expression was also inhibited by disulfiram treatment. Collectively, our findings indicate that endogenous RA may play an important role(s) in the early phase of limb regeneration by regulating the expression of molecules responsible for the modification of intracellular and extracellular environment during salamander limb regeneration.

• 대한안전경영과학회지
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• 제14권2호
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• pp.83-89
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• 2012

In this study, FDS fire simulation experiments and measured wind speed by applying the exterior installation portion for blocking the spread of the fire was investigated. As a result, aluminum composite panels installed in the lower and the upper part of the panel to remove all the lower side, and then the maximum wind speed 0.24 m/s and the upper side 0.58 m/s were measured. In the FDS, the measured wind speed difference air currents are approximately 3.7 times in 12 seconds, the occurrence of 17 seconds early moment wind 2.2 m/s was measured from. Before and after the fire occurred in early of the air velocity about 39 seconds was 3.5 times difference. Such air currents caused by the temperature of the building but also by the building height was found. Turbulent flame of fire by expanding the vertical extent of damage become greatly important factor. Therefore, through the exterior installation portion of the block that can delay the spread of fire is expected that this should be taken.

• 한국물환경학회지
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• 제22권1호
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• pp.140-144
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• 2006

This study was performed to investigate the effect of organic characteristics and feed water solution chemistry on membrane fouling index such as Silt Density Index (SDI) and Modified Fouling Index (MFI). Specifically, Aldrich humic acids (AHA) and Suwannee river humic acids (SHA) were used in SDI/MFI experiments. Higher SDI values were observed with increasing organic concentration. AHA with larger molecular weight (MW) and SUVA (${\approx}UV_{254}/TOC$) resulted in higher SDI values, compared to SHA. The feed solution chemistry (i.e, pH, ionic strength, and hardness) also affects SDI values to some degree. In particular, SDI increased with increasing hardness ($Ca^{2+}$) concentration for AHA. Unlike SDI, the MFI developed on the basis of particle cake filtration theory, was not accurately assessed due to internal fouling by organics such as pore adsorption and subsequent pore blocking.

• Elastomers and Composites
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• 제51권1호
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• pp.24-30
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• 2016

Sole in the footwear usually modified with foaming agent on the polymer resin to improve the lightweightness and crush-cushion effect. In this study, we investigated rheological properties for polymer resin filled with the different type and concentration of foaming agent, capsule type foaming agent and organo-chemical foaming agent, under the time sweep test. Curing times of each polymer resin with different kind of foaming agent are delayed than reference material (epoxy resin with curing agent). In case of adding capsule type foaming agent, however, there is appropriate concentration to reduce the curing time, relatively. When foaming agent is activated, foaming force inflates the sample in contrast to condensation force of curing and then axial normal force develop to the (+) direction. Interestingly, by increase concentration of foaming agent, there is a specific point to break down the axial normal force development. The reason for this phenomenon is that coalescence of foams induce the blocking of axial normal force development.

• 지역연구
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• 제8권2호
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• pp.11-26
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• 1992

In spite of her abundant natural resources for tourist industry, Kangreung and Sokcho area became lagged in economic development during the national industrialization. The major purpose of this study is to exactly purpose of this study is to exactly measure the impacts of tourist industry on regional development. Through the regional input-output analysis, we found some critical facts: (1) Input coefficients are relatively high in those industries as fish products, food and drink products, and printing and publishing. (2) Input coefficients are high in fiber and apparel products, and other manufac-turing. (3) Induced production effects are high in chemical and coal products, fish products, food and fish products, printing and publishing, and public administration for Sokcho. (4) As for the induced employment effect, food and lodging, other services, wholesale and retail show high coefficients. (5) As for the location quotients, food and lodging, fish products, transportation and ware housing are identified as basic industries. Through the questionnaire survey, we also found some important facts: (1) Residents tend to evaluate employment effects higher than the income effects from resort-related development. (2) Pollution, forest demolition, general price increase, and traffic congestions are more serious than ever reported. (3) Willingness to participate in resort development is high, but is discouraged by the lack of regional capital. Based on these findings, we suggest some future directions of tourist industry: (1) blocking the leakage of income produced in tourist and tourist industry, (2) connection between fishery and tourist industry, (3) development of tourist route, and (4) administrative reshuffling that helps joint development between private and public sectors.

• The Korean Journal of Physiology and Pharmacology
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• 제19권3호
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• pp.211-218
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• 2015

The present study showed that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibited lipopolysaccharide (LPS)-induced morphological changes in the mouse RAW264.7 macrophage cell line. We also showed that silymarin inhibited the nuclear translocation and transactivation activities of nuclear factor-kappa B (NF-${\kappa}B$), which is important for macrophage activation-associated changes in cell morphology and gene expression of inflammatory cytokines. BAY-11-7085, an NF-${\kappa}B$ inhibitor, abrogated LPS-induced morphological changes and NO production, similar to silymarin. Treatment of RAW264.7 cells with silymarin also inhibited LPS-stimulated activation of mitogen-activated protein kinases (MAPKs). Collectively, these experiments demonstrated that silymarin inhibited LPS-induced morphological changes in the RAW264.7 mouse macrophage cell line. Our findings indicated that the most likely mechanism underlying this biological effect involved inhibition of the MAPK pathway and NF-${\kappa}B$ activity. Inhibition of these activities by silymarin is a potentially useful strategy for the treatment of inflammation because of the critical roles played by MAPK and NF-${\kappa}B$ in mediating inflammatory responses in macrophages.

• 한국주조공학회지
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• 제30권5호
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• pp.179-186
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• 2010

To elucidate the effects of alloying elements on the characteristics of microstructure and high temperature oxidation of cast austenitic stainless steel, a thermodynamic calculation, a cyclic oxidation test, a X-ray diffraction, a scanning electron microscopy-back scattered electron, a electron probe microanalysis were conducted. The thermodynamic calculation for the effect of vanadium (V) addition on the formation of various precipitates leads to a decrease of chromium (Cr)-rich $M_{23}C_6$ carbides due to the formation of M (C, N) carbo-nitrides containing V and / or niobium (Nb). The V added alloy increased the resistance to high temperature oxidation due to a decrease of Cr-depleted zone deteriorating the oxidation resistance and due to the V-enriched oxide layer formed in inner oxide layer blocking the outward transport of cations.

• Archives of Pharmacal Research
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• 제29권1호
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• pp.67-72
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• 2006

The abnormal proliferation of aortic vascular smooth muscle cells (VSMCs) plays a central role in the pathogenesis of atherosclerosis and restenosis after angioplasty and possibly also in the development of hypertension. The present study was designed to examine the inhibitory effects and the mechanism of luteolin 7-glucoside (L7G) on the platelet-derived growth factor (PDGF)-BB-induced proliferation of VSMCs. L7G significantly inhibited the PDGF-BB-induced proliferation and the DNA synthesis of the VSMCs in a concentration-dependent manner. Pre-incubation of the VSMCs with L7G significantly inhibited the PDGF-BB-induced extracellular signal-regulated kinase 1/2 (ERK1/2), Akt and the phospholipase C $(PLC)-{\gamma}1$ activation. However, L7G had almost no affect on the phosphorylation of $PDGF-{\beta}$ receptor tyrosine kinase, which was induced by PDGF-BB. These results suggest that L7G inhibits the PDGF-BB-induced proliferation of VSMCs via the blocking of $(PLC)-{\gamma}1$, Akt, and ERK1/2 phosphorylation.

• 안보군사학연구
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• 통권5호
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• pp.173-202
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• 2007

After successful nuclear tests Pakistan launched a more severe surprise attack toward India than before. It is highly possible that North Korea will adopt this Pakistan military strategy if it is armed with nuclear weapons. The North Korean forces armed, with nuclear bombs could make double its war capability through strengthening aggressive force structure and come into effect on blocking reinforcement of the US forces at the initial phase of war time. Therefore we may regard that Pyongyang's nuclear arming is a major one of various factors which increase possibility of waging a conventional warfare or a nuclear war. North Korea's high self-confidence after nuclear arming will heighten tension on the Korean Peninsula via aggressive military threat or terror toward South Korea, and endeavor to accomplish its political purpose via low-intensity conflicts. For instance, nuclear arming of the Pyongyang regime enforces the North Korean forces to invade the Northern Limit Line(NLL), provoke naval battles at the West Sea, and occupy one or two among the Five Islands at the West Sea. In that case, the South Korean forces will be faced with a serious dilemma. In order to recapture the islands, Seoul should be ready for escalating a war. However it is hard to imagine that South Korea fights with North Korea armed with nuclear weapons. This paper concludes that the Pyongyang regime after nuclear arming strongly tends to occupy superiority of military strategy and wage military provocations on the Korean Peninsula.