• IMMUNE NETWORK
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• v.20 no.4
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• pp.29.1-29.20
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• 2020

The development of refractory tumor cells limits therapeutic efficacy in cancer by activating mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival. Benzimidazole anthelmintics have broad-spectrum action to remove parasites both in human and veterinary medicine. In addition to being antiparasitic agents, benzimidazole anthelmintics are known to exert anticancer activities, such as the disruption of microtubule polymerization, the induction of apoptosis, cell cycle (G2/M) arrest, anti-angiogenesis, and blockage of glucose transport. These antitumorigenic effects even extend to cancer cells resistant to approved therapies and when in combination with conventional therapeutics, enhance anticancer efficacy and hold promise as adjuvants. Above all, these anthelmintics may offer a broad, safe spectrum to treat cancer, as demonstrated by their long history of use as antiparasitic agents. The present review summarizes central literature regarding the anticancer effects of benzimidazole anthelmintics, including albendazole, parbendazole, fenbendazole, mebendazole, oxibendazole, oxfendazole, ricobendazole, and flubendazole in cancer cell lines, animal tumor models, and clinical trials. This review provides valuable information on how to improve the quality of life in patients with cancers by increasing the treatment options and decreasing side effects from conventional therapy.

• Journal of Korean Tunnelling and Underground Space Association
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• v.16 no.6
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• pp.553-560
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• 2014

The road tunnel install a vent for the purpose of ventilation and smoke control. Ventilation equipment capacity(number of jet fans) depends on from the condition that of the pressure and ventilation resistance. Pressure and the resistance under operating vehicle have affected on the drag coefficient. The drag coefficient of the tunnel have affected by the blockage effect and slipstream effects. However, when calculating the ventilation fan, are not properly consider taking into account such effects. Therefore, ventilation force may have been slightly overestimated. This paper describes the drag coefficient through a numerical analysis to calculate the equivalent resistance area that reflects the vehicle distance, and examined the equivalent resistance area. The ventilation coefficient corresponding to the result heavy vehicle mixing ratio of the present study was not clear. Equivalent resistance area had reduced by about 86% compared to the road design handbook current standards. Also it had analyzed and reduced to 62.2% compared to Korea Highway Corporation ventilation design criteria ratio, which is the old standard.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.69-73
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• 2014

The effects of erlotinib combined with celecoxib in a lung cancer xenograft model were here explored with a focus on possible mechanisms. A xenotransplanted lung cancer model was established in nude mice using the human lung cancer cell A549 cell line and animals demonstrating tumour growth were randomly divided into four groups: control, erlotinib, celecoxib and combined (erotinib and celecoxib). The tumor major axis and short diameter were measured twice a week and after 40 days tissues were collected for immunohistochemical analyses of Bcl-2 and Bax positive cells and Western-blotting analyses for the epidermal growth factor recepto (EGFR), P-EGFR, and cyclooxygenase-2 (COX-2). Tumor size in the combined group was smaller than in the others (p<0.01) and the percentage of Bcl-2 positive cells was fewer in most cases (p<0.01), while that of Bax positive cells was greater than in the erlotinib and celecoxib groups (P>0.05). Western blotting showed decreased expression of P-EGFR and COX-2 with both erlotinib and celecoxib treatments, but most pronouncedly in the combined group (P<0.05). Simultaneous blockage of the EGFR and COX-2 signal pathways exerted stronger growth effects in our human xenotransplanted lung cancer model than inhibition of either pathway alone. The anti-tumor effects were accompanied by synergetic inhibition of tumor cell apoptosis, activation of p-EGFR and expression of COX-2.

• Journal of computational fluids engineering
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• v.11 no.3 s.34
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• pp.52-58
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• 2006

A numerical investigation is made of air flow in a spinner equipment used for cleanning and drying flat display panels. A unique feature of the spinner under question is the placement of a torus plate cover over the rotating plate. The turbulent flow is driven by rotation of a large disk and suction by the exhaust system connected to vacuum chamber. The flow is modelled as an axisymmetric two-dimensional flow and computation is conducted by using the FLUENT package with a version of k-$\varepsilon$ turbulence model. The required capacity of the exhaust system is assessed numerically. The usefulness of the cover in controlling air flow circulation is examined. A computational trouble shooting is attempted to resolve the problem of panel rising which occurred in real experiment.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.22 no.8
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• pp.1052-1063
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• 1998

The performance database of small-sized centrifugal compressors is needed for the design of high performance machines and also for the verification of design tools and analysis software. An impeller is designed, manufactured and tested. The effects of several parameters on the evaluation of performance are investigated and the performance test of parallel diffuser is also carried out. The proper estimation of static pressure, total temperature and blockage at the impeller exit is important for performance evaluation. 4 method in cooperation with 3-D calculation is suggested. The measured performances are in a good agreement with the predicted results. However, there are some discrepancies in efficiency.

• Development and Reproduction
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• v.17 no.2
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• pp.111-119
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• 2013

Golden hamsters reproduce in a limited time of a year. Their sexual activities are active in summer but inactive in winter during which day length does not exceed night time and environmental conditions are severe to them. The reproductive activities are determined by the length of light in a day (photoperiod). Melatonin is synthesized and secreted only at night time from the pineal gland. Duration of elevated melatonin is longer in winter than summer, resulting in gonadal regression. The present study aimed at the influences of continuous melatonin treatments impinging on the gonadal function in male golden hamsters. Animals received empty or melatonin-filled capsules for 10 weeks. They were divided into long photoperiod (LP) and short photoperiod (SP). All the animals maintained in LP (either empty or melatonin-filled capsules) showed large testes, implying that melatonin had no effects on testicular functions. Animals housed in SP displayed completely regressed testes. But animals kept in SP and implanted with melatonin capsules exhibited blockage of full regression by SP. These results suggest that constant release of melatonin prohibits the regressing influence of SP.

• 한국전산유체공학회:학술대회논문집
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• 2000.05a
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• pp.91-98
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• 2000

The three-dimensional unsteady compressible Full Navier-Stokes equation solver with sliding multi-block method has been applied to analyze three dimensional characteristics of the flow field and compression wave around the high speed train which Is entering into a tunnel. The numerical scheme of AF + ADI was used to efficiently solve Navier-Stokes equations in the curvilinear coordinate system. The vortex formation around the nose region was found and the generation of compression wave due to the blockage effects was observed ahead of the train in the form of plane wave. The three dimensional characteristics of the flow field compared to the analytic results were discussed in detail. The variation of pressure of tunnel wall surface and velocity profile of the train are identified as the train enters into a tunnel. The changes in aerodynamic forces and streamlines of each specific sections are also discussed and presented.

• Journal of computational fluids engineering
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• v.5 no.3
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• pp.23-31
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• 2000

The three-dimensional unsteady compressible Full Navier-Stokes equation solver with sliding multi-block method has been applied to analyze three dimensional characteristics of the viscous flow field and compression wave around the high speed train which is entering into a tunnel. The numerical scheme of AF + ADI was used to efficiently solve Navier-Stokes equations in the curvilinear coordinate system. The vortex formation owing to the viscous interaction around the train was found and the generation of compression wave due to the blockage effects was observed ahead of the train in the form of plane wave. The three dimensional characteristics of the flow field compared to the analytic results were discussed in detail. The variation of pressure of tunnel wall surface and velocity profile of the train are identified as the train enters into a tunnel. The changes in aerodynamic forces and streamlines of each specific sections are also discussed.

• The Korean Journal of Ecology
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• v.17 no.4
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• pp.425-434
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• 1994

After two highly weathered soils were treated with glucose, ammonium nitrate, monobasic potassium phosphate and biocides, and incubated for 4 or 6 weeks, adsorption tests were carried out to determine their effect on P adsorption. Glucose addition generally decreased P adsorption. The addition stimulated microbial activity, which might contribure to the reduced adsorption, probably through chelation and anion competition. Consistent endency was not observed with N treatment. Addition of P initially decreased P adsorption, probably through blockage of adsorption sites. Biocides generally decreased adsorption, probably because the microbes that 몬 been killed. Soil 1 with naturally lower levels of C and higher levels of aluminium adsorbed more P than soil 2. These results suggest that in highly weathered soils, which are low in available P and high in exchangeable Al, cultivation techniques which increase soil organic matter will also result in higher levels of plant-available P.

• Proceedings of the KSME Conference
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• 2002.08a
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• pp.707-708
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• 2002

Catheters are used to measure translesional pressure gradients in the stenosed coronary arteries. Catheter insertions during coronary angioplasty cause flow obstructions. A narrowed flow cross section with catheter present effectively introduced a tighter stenosis than the enlarged residual stenoses after balloon angiplasty. In general, the form of stenoses are no uniform. Sometimes, these are occurred the irregularly eccentricity If the analyses are conducted for uniform stenosed artery, the results will be underestimated. Thus, in this study, three dimensional computer simulations are conducted to investigate the flow blockage effects due to the catheter insertion during the coronary angioplasty. The results for the eccentric stenosed artery are compared with those of the concentric stenosed artery.