• Journal of Veterinary Clinics
• /
• v.38 no.1
• /
• pp.32-35
• /
• 2021

Three dogs (a 30-month-old spayed female English bulldog; a 12-month-old castrated male English bulldog; a 19-month-old castrated male Shar-pei dog) were presented to the Dana Animal Hospital Eye Center with clinical signs of blepharospasm, epiphora, and ocular discharge (serous to mucopurulent) in one or both eyes. Through ophthalmic examination, the dogs (5 eyes) were diagnosed with trichiasis caused by upper and lower eyelid entropion, including the lateral canthus. To correct upper and lower eyelid entropion, modification using a combination of the Stades forced granulation method for upper eyelid entropion and Hotz-Celsus procedure for lower eyelid entropion was performed in all cases. At the last follow-up, mean 274 days after surgery, clinical signs disappeared and no recurrences of entropion were observed in any of the 3 dogs (5 eyes). Therefore, the combination of the Stades forced granulation method and Hotz-Celsus procedure may be an effective treatment for trichiasis caused by upper and lower eyelid entropion in dogs.

• Journal of Acupuncture Research
• /
• v.40 no.2
• /
• pp.97-110
• /
• 2023

This review aimed to examine and analyze trends of clinical research using case studies on facial spasms in Korean medicine. Seven web databases were searched for case studies on facial spasms using Korean and English search terms. Case studies were selected using the exclusion and inclusion criteria. Overall, 13 case studies were selected, analyzed, and classified according to the publication year and journal, study participants, cause, treatment methods, pattern identification, evaluation methods, improvement, and side effects. Case studies reporting on various treatment methods in Korean medicine, including acupuncture and pharmacopuncture for facial spasms, have been published since 2000. In addition, studies on new treatment methods in Korean medicine for facial spasm have been published. Combination therapy is the most common method used in Korean medicine-based case studies; therefore, future studies on single treatment are necessary. Most of the case studies on Korean medicine reported improved symptoms and patient satisfaction with the Korean medicine treatment method. No side effects were reported, except for facial swelling and bruising, indicating that Korean medicine treatment methods for facial spasm were safe and effective. Therefore, the Korean medicine treatment methods for facial spasm can be actively used in clinical practice and future research.

• Journal of Veterinary Clinics
• /
• v.24 no.4
• /
• pp.640-643
• /
• 2007

A 3-month-old female mixed breed cat was referred to the veterinary medical teaching hospital of Seoul National University with ocular discharge and blepharospasm of both eyes. On ophthalmic examination, the patient was diagnosed as multiple ocular defects : eyelid coloboma, keratoconjunctivitis sicca, persistent pupillary membrane, uveal cyst, incipient cataract and choroidal hypoplasia. On histopathologic examination, choroidal hypoplasia was confirmed.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
• /
• v.23 no.2
• /
• pp.111-118
• /
• 2012

Botulinum toxin is a potent neurotoxin that is produced by the bacterium Clostridium botulinum. The agent causes muscle paralysis by preventing the release of acetylcholine at the neuromuscular junction of striated muscle. Botulinum toxin A (Botox, AllerganInc., Irvine, California) is the most potent of seven distinct toxin subtypes that are produced by the bacterium. The toxin was initially used clinically in the treatment of strabismus caused by hypertonicity of the extraocular muscles and was sub-sequently described in the treatment of multiple disorders of muscular spasticity and dystonia. In treating patients with Botox for blepharospasm, Carruthers and Carruthers [5] noticed an improvement in glabellar rhytids. This ultimately led to the introduction and development of Botox as a mainstay in the treatment of hyperfunctional facial lines in the upper face. Since its approval by the U.S. Food and Drug Administration for the treatment of facial rhytids (2002), botulinum toxin A has expanded into wide-spread clinical use. Forehead, glabellar, and periocular rhytids are the most frequently treated facial regions. Indications for alternative uses for Botox in facial plastic and reconstructive surgery are expanding. These include a variety of well-established procedures that use Botox as an adjunctive agent to enhance results. In addition, Botox injection is finding increased usefulness as an independent modality for facial rejuvenation and rehabilitation. The agent is used beyond its role in facial rhytids as an effective agent in the management of dynamic disorders of the face and neck. Botox injection allows the physician to precisely manipulate the balance between complex and conflicting muscular interactions, thus resetting their equilibrium state and exerting a clinical effect. This article will address some of the new and unique indications on Botox injection in the face (the lower face and neck, combination with fillers). Important points in terms of its clinical relevance will be stressed, such as an understanding of functional facial anatomy, the importance of precise injections, and correct dosing all are critical to obtaining natural outcomes.

• Journal of Korean Neurosurgical Society
• /
• v.48 no.2
• /
• pp.134-138
• /
• 2010

Objective : Meige syndrome is the combination of blepharospasm and oromandibular dystonia. We assessed the surgical results of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) in patients with medically refractory Meige syndrome. Methods : Eleven patients were retrospectively analyzed with follow-ups of more than 12 months. The mean follow-up period was $23.1{\pm}6.4$ months. The mean age at time of surgery was $58.0{\pm}7.8$ years. The mean duration of symptoms was $8.7 {\pm}7.6$ years. DBS electrodes were placed under local anesthesia using microelectrode recording and stimulation. After $2.4{\pm}1.3$ days of trial tests, the stimulation device was implanted under general anesthesia. Patients were evaluated using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). Results : BFMDRS total movement scores improved by 59.8%, 63.5%, 74.1%, 74.5%, and 85.5% during the immediate postoperative period of test stimulation, 3, 6, 12, and 24 months (n = 5) after surgery, respectively. The BFMDRS total movement scores were reduced gradually and the results reached statistical significance in the postoperative period (test period, p < 0.001; 3 months, p < 0.001; 6 months, p = 0.003; 12 months, p < 0.001; 24 months, p = 0.042). There was no statistical difference between 12 months and 24 months. BFM subscores improved by 63.3% for the eyes, 80.9% for the mouth, 68.4% for speech/swallowing, and 87.9% for the neck at 12 months after surgery. The adverse effects were insignificant. Conclusion : The bilateral GPi-DBS can be effective for the treatment of intractable Meige syndrome without significant side effects.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• v.24 no.2
• /
• pp.90-95
• /
• 2013

Botulinum toxin, a neurotoxin, is known to be an inhibitor of cholinergic neuromuscular transmission. Recently, it was reported that the administration of botulinum toxin is effective for the treatment of focal neurological motor disorders such as cervical dystonia, blepharospasm, hemifacial spasm, spasmodic dysphonia, and writer's cramp. Several case studies reported that the botulinum toxin was administered for the treatment of motor tic or vocal tic. It was found that this toxin reduces the frequency and severity of the tic as well as the premonitory urge and symptoms. In our case study, a noticeable decrease of motor tic symptom was observed after an intramuscular injection of 300mg of botulinum toxin in an 18-year-old patient with Tourette's disorder who showed only a little improvement of motor tic and vocal tic symptoms after treatment with antipsychotic drugs for several years. This case is reported in our study and literature survey was undertaken for reviewing similar cases. In our study, an 18-year-old boy diagnosed with Tourette's disorder based on Diagnostic and Statistical Manual of Mental Disorders, fourth edition presented with the following scores : the Clinical Global Impression scale, Yale Global Tic Severity Scale (motor/vocal/severity), Premonitory Urge Score, Korean Attention-Deficit Hyperactivity Disorder Rating scale, and Kovac Depression scale which were performed prior to the treatment were 5, 21/5/50, 100, 17, and 18 points, respectively. Two weeks after the injection of botulinum toxin, the scores were 4, 17/5/40, 50, 16, and 19 points, respectively. Eight weeks after the injection of botulinum toxin, they had become 3, 15/5/30, 25, 16, and 20 points, respectively, which clearly indicates a noticeable decrease of motor tic symptom.

• Korean Journal of Oriental Medicine
• /
• v.3 no.1
• /
• pp.215-228
• /
• 1997

Extrapyramidal movement disorders are divided descriptively into hypokinesias(such as parkinsonism), characterized by poverty and slowness of movement : hyperkinesias(such as chorea, athetosis, dystonia, ballism, etc.), manifested by abnormal involuntary movement. Chorea refers to widespread arrythythmic movements of a forcible, rapid, jerky, restless type Choreic movements are noted for their irregularity and variability. They are generally continuous, may be simple or quite elaborate, and affect any part of the body. Dystonla refers to abnormally increased muscular tone that causes fixed abnormal postures. Some patients with dystonia also have shifting postures, resulting from irregular, forceful twisting movement that affect trunk and produce bizarre, grotesque movements and positions of the body. The most frequent and familiar type of focal dystonia is spasmodic torticollis. It consists of an involuntary turning of the head to one side - intermittent at first, then gradually worsening to the point of being more or loss continuous. The combination of blepharospasm and oromandibular dystonia is sometimes refered to as Meige's syndrome. We report two patients with dystonia and chorea in cerebral infarction at basal ganglia. We have experienced good improvement by the oriental medicine and acupuncture treatment.'rho acupuncture points of LI 4, ST 36, TE 3, GB 34, GB 41, LR 3, GB 39 were used. The therapies of herb-medicine were treated by Zibu-Ganshen(滋補肝腎), Huoxue-Xifeng-Tongluo(活血息風通絡).

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.19 no.3 s.31
• /
• pp.171-179
• /
• 2006

Objective : The purpose of this study is to investigate outpatients of ophthalmologic disease who had visited to Hospital of Oriental Medicine. Method : We analyzed statistics study in 590 patients, who had visited to the Dept. of dermatology, ophthalmology & otorhinolayngology Hospital of Oriental Medicine Dongeui University from January, 1998 to July , 2006. Result : The results were as follows. 1. Distributions of sex : male 45.42%, female 54.58%. 2. The age distributions of patients showed highest in 51-60 years, followed by 41-50 years, 61-70 years in order. 3. The yearly distributions of patients showed highest in 2004, followed by 2005, 2002 in order. The seasonal distributions of patients showed highest in summer, followed by spring, winter, autumn in order. The monthly distributions of patients showed highest in August, followed by June, March in order. 4. The frequency of chief complaint showed highest in visual disorder, followed by dry eye, blepharospasm, squint in arch order. Visual disorder and dry eye were the most common ophthalmologic disease, irrespective of age. 5. The Distribution of past history showed highest in ophthalmologic disease, followed by circulatory disease, digestive disease in order. The Distribution of ophthalmologic diseases showed highest in retinal disease, followed by lens-induced ocular disease, disease of the optic nerve in order. 6. The number of times in treatment : 1-20 times(84.07%), 21-40 times(7.97%). 7. In the treatment method, a major portion of treatment methods was acupuncture & herbal medicine treatment, followed by acupuncture, consulting, herbal medicine treatment in order.

• The Korea Journal of Herbology
• /
• v.38 no.5
• /
• pp.97-103
• /
• 2023

Objectives : These days many people tend to prefer spicy taste. The purpose of this study was to find out the relationship between prefer spicy and physical symptoms. Methods : We examined the subjective physical condition of patients who visited L/C clinic during the period between January and June 2023 by conducting a survey. The survey was completed voluntarily, and the anonymity and confidentiality of the research data were strictly protected, and it was stated that patients could withdraw at any time if they did not want to participate. Patients who refused to complete the survey and patients with limited capacity to give consent were excluded. The survey took about 10 minutes to complete. We analyzed 248 cases who answered the survey and found that 66 patients had a high spicy preference. Results : As a result, participants with high spicy taste preference tended to have general body symptoms such as fever, sweat, and thirst; digestive symptoms such as belching, constipation, bloody stools, and abdominal distension; genitourinary symptoms such as yellowish urine, urinary retention, white fluor albus, and premenstrual tension; and neuromuscular symptoms such as edema, blepharospasm, and cold hands. Conclusion : People who have general body symptoms, digestive symptoms, genitourinary symptoms and neuromuscular symptoms described above should try to eat as little spicy food as possible and make sure they get a good balance of the five flavors.

• Journal of Veterinary Science
• /
• v.24 no.4
• /
• pp.59.1-59.13
• /
• 2023

Background: Rocuronium bromide has been evaluated as a mydriatic agent in birds, but the species applied were limited and the dose and effect were variable. Objective: This study aims to evaluate the efficacy of topical rocuronium bromide as mydriatics in 4 species according to horizontal palpebral fissure length: Feral pigeon (Columba livia), Common kestrel (Falco tinnunculus), Northern boobook (Ninox japonica), and Eurasian eagle owl (Bubo bubo). Methods: A total of 32 birds (8 for each species) were included as pre-releasing examination. Rocuronium bromide was instilled in one randomly selected eye of each bird based on palpebral fissure length criteria (0.5 mg/50 µL for pigeons, 1 mg/100 µL for kestrels and boobook owls, and 2 mg/200 µL for eagle owls). The contralateral eye was used as control and treated with normal saline. After instillation of the drug, pupil diameter, pupillary light reflex, intraocular pressure, heart rate, and respiratory rate were evaluated at 10 min intervals up to 180 min and at 30 min intervals up to 360 min. Results: Statistically significant mydriasis was obtained in all birds (p < 0.001). However, in boobook and eagle owls, marked mydriasis persisted until 360 min. Side effects including corneal erosion and lower eyelid paralysis were common, which was observed in 26/32 birds. Blepharospasm was also noted during this study. No systemic adverse signs were observed. Conclusions: Rocuronium bromide could be a good mydriatics option for 4 species of birds, however, further studies are needed to find lowest effective dose to reduce drug-related side effects.