• 한국결정성장학회지
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• 제20권5호
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• pp.237-242
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• 2010

Mg-BCP(Mg Substituted BCP)를 제조하기 위하여 $Ca(NO_3)_2{\cdot}4H_2O$(Katayama chemical, Japan)과 $(NH_4)_2{\cdot}HPO_4$ (Junsei chemical, Japan), $Mg(NO_3)_2{\cdot}6H_2O$(Junsei chemical, Japan)를 출발물질로 공침법(co-precipitation process)을 이용하여 합성하였다. 제조된 분말의 마그네슘의 첨가에 따른 분말의 분광학적 특성은 FT-IR(MAGNA-IR 560, Nicolet)을 통하여 분석하였으며, SEM(S-4200, Hitachi)을 통하여 미세구조를 분석하였다. XRD 회절피크의 면적적분강도를 Integral Analysis (Rigaku, Japan)를 이용하여 HAp와 ${\beta}$-TCP의 비율을 확인하였다. 1.0 wt% 마그네슘이 첨가된 BCP 샘플의 경우 Hank's solution에서의 2주 침적 후 표면에 침상의 HAp로 추정되는 결정이 성장하였다. 이러한 미세구조의 변화는 생활성을 가지는 마그네슘의 첨가가 BCP 조직 내에서 표면의 활성을 증가시켜 결정의 성장을 촉진시킨 것으로 판단된다.

• Archives of Pharmacal Research
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• 제15권3호
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• pp.246-250
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• 1992

Acetaminophen (AAP) and ranitidine (RT) were coadministered orally to nine rats, and the possible contribution of the gastric emptying to the plasma concentration profiles of them was examined. The drugs showed multiple plasma peaks similar to the respective ones after separated administration of each durg. IT Implies that there is no significant interaction between AAP and RT in terms of the gastric emptying or drug absorption. There were no significant linear correlations of the peak patterns (peak height and peak time) between AAP andd RT. It is contrary to the expectation from the biphasic gastric emptying (BGE) theory previously suggested for AAP and RT. The BGE theory. Therefore, seemed to have some draw-backs in explaining satisfactorily the multiple plasma peaks of AAP and RT. Two more doubts raised previously against the BGE theory were also discussed.

• Bulletin of the Korean Chemical Society
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• 제33권10호
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• pp.3203-3207
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• 2012

The nucleophilic substitution reactions of diisopropyl chlorothiophosphate (5) with X-pyridines have been kinetically studied in MeCN at $35.0^{\circ}C$. The Hammett and Br$\ddot{o}$nsted plots for the substituent X variations in the nucleophiles show biphasic concave upwards with a break point at X = 3-Ph. The pyridinolysis rate of 5 exhibits great negative deviation from the Taft plot. A concerted $S_N2$ mechanism is proposed involving a change of the attacking direction of the X-pyridines from a frontside attack with the strongly basic pyridines to a backside attack with the weakly basic pyridines.

• 대한한의학회지
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• 제39권3호
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• pp.101-109
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• 2018

Objectives: To report the effect of Sajaehyangbu-hwan on a polycystic ovary syndrome(PCOS) patient with anovulation. Methods: The patient with PCOS was treated by Sajaehyangbu-hwan twice a day. The patient measured basal body temperature(BBT) and took a urine luteinizing hormone test(LH test) for three months to predict ovulation. Results: Two ovulations were observed in BBT and LH test results within three months and the typical biphasic BBT pattern was established. Conclusions: Sajaehyangbu-hwan has an effect on establishing obvious biphasic pattern in BBT of the patient with PCOS and the anovulation caused by PCOS.

• Journal of Korean Neurosurgical Society
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• 제42권1호
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• pp.67-70
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• 2007

Synovial sarcomas are rare soft tissue malignancies arising from tendons, tendon sheaths, and bursal structures. These tumors usually develop in the extremities of adolescents and young adults. Uncommonly, these tumors may arise in the head and neck approximately 9% of all synovial sarcomas. Most common sites of head and neck synovial sarcomas are hypopharynx and surrounding structures of paranasal sinuses. However, frontal bone without involving paranasal sinus is extremely rare. We report a case of biphasic synovial sarcoma of the frontal bone discuss the clinical and pathologic features of this case with the literature review.

• Bulletin of the Korean Chemical Society
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• 제32권12호
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• pp.4179-4184
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• 2011

The nucleophilic substitution reactions of bis(2,6-dimethylphenyl) chlorophosphate (5), containing the four ortho-methyl substituents, with X-pyridines are investigated kinetically in MeCN at $65.0^{\circ}C$. The free energy correlations for substituent X variations in the nucleophiles exhibit biphasic concave upwards with a breakpoint at a X = 3-Cl. Unusual positive ${\rho}_X$ (= +5.40) and negative ${\beta}_X$ (= -0.83) values are obtained with the weakly basic pyridines. The pyridinolysis rate of 5 is hundreds times slower compared to that of bis(phenyl) chlorophosphate because of the steric hindrance of the four ortho-methyl substituents in the two phenyl rings. Ion-pair mechanism is proposed and positive ${\rho}_X$ and negative ${\beta}_X$ values are substantiated by an imbalance of the transition state.

• Bulletin of the Korean Chemical Society
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• 제32권12호
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• pp.4387-4391
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• 2011

The kinetic studies on the pyridinolysis of diisopropyl thiophosphinic chloride have been carried out in acetonitrile at $55.0^{\circ}C$. The free energy correlations for substituent X variations in the X-pyridines are biphasic concave upwards with a break point at X = 3-Ph. A concerted SN2 mechanism is proposed with a change of the attacking direction of the X-pyridine from a frontside attack for the strongly basic pyridines to a backside attack for the weakly basic pyridines. The factors to determine the rates and thio effects on the rates for the pyridinolyses of thiophophinic chloride, chlorothiophosphate, phosphinic chloride, phosphonochloridothioate, and chlorophosphate systems are briefly reviewed on the basis of the magnitude of the positive charge of the reaction center P atom and steric effects of the two ligands.

• Bulletin of the Korean Chemical Society
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• 제34권11호
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• pp.3372-3376
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• 2013

The kinetic studies on the reactions of ethyl methyl (2) and ethyl propyl (4) chlorothiophosphates with X-pyridines have been carried out in acetonitrile at $35.0^{\circ}C$. The free energy correlations with X show biphasic concave upwards with a break point at X = H (2) and 3-Ph (4), respectively. A stepwise mechanism with a rate-limiting leaving group expulsion from the intermediate is proposed based on the magnitudes of selectivity parameters for both substrates. The considerably large values of ${\beta}_X$ = 1.50(2) and 1.44(4) with strongly basic pyridines and relatively small values of ${\beta}_X$ = 0.43(2) and 0.36(4) with weakly basic pyridines are interpreted as a change of the attacking direction of the X-pyridines from a frontside to a backside attack toward the chloride leaving group.

• Journal of Pharmaceutical Investigation
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• 제21권4호
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• pp.201-213
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• 1991

There are many drugs reproted to show unusual pharmacokinetic behavior by producing a significant secondary peak in the plasma concentration-time curve after oral administration. The drugs are ranitidine, cimetidine, acetaminophen, aspirin, furosemide, bumetanide, piretanide, veralipride, sobrerol, penicillamine and doxycycline etc. Enterohepatic circulation-, two absorption site-, biphasic gastric emptying-, tissue deposition- and multi-fraction absorption theories have been suggested for the mechanisms of this phenomenon. Here, the theories were reviewed and critisized for their validity as a possible mechanism of the multiple peak phenomenon.

• Bulletin of the Korean Chemical Society
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• 제33권3호
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• pp.1085-1088
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• 2012