Journal of Pharmaceutical Investigation
- Volume 21 Issue 4
- /
- Pages.201-213
- /
- 1991
- /
- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
Mechanisms of Multiple Peak Phenomenon in the Plasma Profile of Drugs Following Oral Administration
경구투여된 약물의 혈장중 농도곡선에 나타나는 다중피크 현상의 해석
- Shim, Chang-Koo (College of Pharmacy, Seoul National University) ;
- Lee, Hye-Weon (College of Pharmacy, Seoul National University)
- Published : 1991.12.20
Abstract
There are many drugs reproted to show unusual pharmacokinetic behavior by producing a significant secondary peak in the plasma concentration-time curve after oral administration. The drugs are ranitidine, cimetidine, acetaminophen, aspirin, furosemide, bumetanide, piretanide, veralipride, sobrerol, penicillamine and doxycycline etc. Enterohepatic circulation-, two absorption site-, biphasic gastric emptying-, tissue deposition- and multi-fraction absorption theories have been suggested for the mechanisms of this phenomenon. Here, the theories were reviewed and critisized for their validity as a possible mechanism of the multiple peak phenomenon.
Keywords