• Environmental Engineering Research
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• 제24권3호
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• pp.501-512
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• 2019

The seasonal effects on the biostability of drinking water were investigated by comparing the seasonal variation of assimilable organic carbon (AOC) in full-scale water treatment process and adsorption of AOC by three filling materials in lab-scale column test. In full-scale, pre-chlorination and ozonation significantly increase $AOC_{P17\;(Pseudomonas\;fluorescens\;P17)}$ and $AOC_{NOX\;(Aquaspirillum\;sp.\;NOX)}$, respectively. AOC formation by oxidation could increase with temperature, but the increased AOC could affect the biostability of the following processes more significantly in winter than in warm seasons due to the low biodegradation in the pipes and the processes at low temperature. $AOC_{P17}$ was mainly removed by coagulation-sedimentation process, especially in cold season. Rapid filtration could effectively remove AOC only during warm seasons by primarily biodegradation, but biological activated carbon filtration could remove AOC in all seasons by biodegradation during warm season and by adsorption and bio-regeneration during cold season. The adsorption by granular activated carbon and anthracite showed inverse relationship with water temperature. The advanced treatment can contribute to enhance the biostability in the distribution system by reducing AOC formation potential and helping to maintain stable residual chlorine after post-chlorination.

• 폴리머
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• 제28권1호
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• pp.86-91
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• 2004

생체 이식용 재료로서 제한된 용도를 갖는 기존의 스폰지를 대체하기 위해 히드록시에틸 메타크릴레이트 및 메타크릴산염이 높은 단량체 농도에서 단독 또는 공중합하여 생체적합성 및 생체안정성이 향상된 수화젤을 합성하고 이들의 세포 독성, 세포 부착성, 및 조직 적합성 등을 고찰하였다. 히드록시에틸 메타크릴레이트의 투입 몰비가 증가할수록 세포 독성은 감소하여 0.05의 투입 몰비에서는 거의 세포 독성을 나타내지 않았다. 메타크릴산염이 0.01의 몰비로 투입된 수화젤이 가장 우수한 세포 부착 및 퍼짐을 보인 반면, 메타크릴산염이 0.05 투입된 수화젤은 낮은 세포 부착을 보였다. 메타크릴산염이 공중합된 수화젤은 이식 후 8주가 경과하여도 특별한 이물질 반응의 소견을 보이지 않았다. 따라서 높은 단량체 농도에서 히드록시에틸 메타크릴레이트와 메타크릴산염을 적절한 단량체 투입비로 공중합하여 제조한 수화젤은 탁월한 생체적합성 및 생체안정성을 갖는 생체 이식용 재료로 사용될 수 있다고 사료된다.

• 한국산업융합학회 논문집
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• 제20권2호
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• pp.169-176
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• 2017

Dental implants are required to have biomechanical functions and biostability in order to perform authoring, pronunciation, and aesthetic functions in the oral cavity. In terms of biostability, pure titanium for medical have good biostability and no rejection in the alveolar bone. with appropriate strength in terms of strength as well as biocompatibility. In recent years, various surgical methods and devices have been developed to improve the convenience and safety of the procedure. However, as the number of procedures increases, the screw loosening of the abutment screw connecting the artificial root and the abutment There are many reports of artificial root and abutment fracture. Fig. 1 is an example of a case where the upper part of the abutment screw is arbitrarily modified to remove the abutment by the abutment fracture due to the loosening of the abutment screw. The fundamental cause of abduction of the abutment screw is caused by the slight movement due to the lowering of the retention force of the abutment screw. It is necessary to minimize loosening of the abutment screw to avoid problems such as fracture during the period of using the implant. The purpose of this study is to investigate the structure of the abutment screw to prevent the loosening of the abutment screw by forming 0.5mm slot.

• 대한환경공학회지
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• 제27권2호
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• pp.158-162
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• 2005

이 연구에서는 대규모 나노여과 정수처리 시스템의 각 단계의 생물학적 안정성과 공정내의 AOC를 측정하고자 한다. 나노 여과 정수처리 시스템은 미 플로리다 주 남부의 Plantation 시의 $45,400\;m^3$/day (12 mgd) 규모의 연수화 시설에서 연구하였으며, 표면 대수층의 유기물이 많은 지하수를 원수로 이용하였다. 유입원수의 평균 AOC 농도는 158 g/L acetate-C이다. 전처리(산과 스케일 방지제첨가) 후 AOC농도는 12.7% 가량 증가하였는데, 이는 전처리 과정에서 투입된 화학물들이 생물학적 안정성을 저감시킬 수 있음을 의미한다. 전체적으로 나노여과공정은 63.4%와 94.8% 의 AOC 및 DOC 제거효율을 보였다. 특히 1단계에서의 AOC 제거율 (68%)이 2단계에서의 제거율 (58%)보다 다소 높았는데 이는 높은 회수율과 산 전처리과정이 있는 대규모 나노 공정 2단계에서 흔히 형성되는 낮은 pH 높은 이온강도 및 경도 등의 화학적 환경에 기인한다고 사료된다.

• 한국환경보건학회지
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• 제32권6호
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• pp.539-542
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• 2006

The objective of this paper is to compare the applicability of assimilable organic carbon (AOC) or biodegradable dissolved organic carbon (BDOC) for quantifying biodegradable organic material (BOM) and bio-stability in distribution systems for a variety of finished waters. The study the data is derived from was part of an AWWARF and Tampa Bay Water tailored collaboration project to determine the effect of blending different waters on distribution system water quality. Seven different finished waters were produced from surface, ground, or brackish water on site and fed 18 independent pilot distribution systems (PDSs), either as single finished water or as a blend of several finished waters. AOC and BDOC have often been used as indicators of bacterial regrowth potential in distribution systems. In this study, AOC was the more useful assay of the two for the BOM concentrations observed in the PDSs. BDOC did not distinguish BOM while AOC did at the low BOM levels from many of the advanced treatments (e.g. RO, $O^3/BAC$). AOC in contrast allowed much more meaningful calculations of the consumption or production of AOC as the blends passed through the PDSs even for very low BOM blends. In addition, meaningful trends corresponding to changes in heterophic plate count (HPC) were observed for AOC but not for BDOC. Moreover, AOC stability was associated with waters produced from advanced membrane treatment.

• 한국재료학회지
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• 제20권3호
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• pp.132-136
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• 2010

This study examined the biostability and drug delivery efficiency of g-$Fe_2O_3$ magnetic nanoparticles (GMNs) by cytotoxicity tests using various tumor cell lines and normal cell lines. The GMNs, approximately 20 nm in diameter, were prepared using a chemical coprecipitation technique, and coated with two surfactants to obtain a water-based product. The particle size of the GMNs loaded on hangamdan drugs (HGMNs) measured 20-50 nm in diameter. The characteristics of the particles were examined by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-TEM) and Raman spectrometer. The Raman spectrum of the GMNs showed three broad bands at 274, 612 and $771\;cm^1$. A 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay showed that the GMNs were non-toxic against human brain cancer cells (SH-SY5Y, T98), human cervical cancer cells (Hela, Siha), human liver cancer cells (HepG2), breast cancer cells (MCF-7), colon cancer cells (CaCO2), human neural stem cells (F3), adult mencenchymal stem cells (B10), human kidney stem cells (HEK293 cell), human prostate cancer (Du 145, PC3) and normal human fibroblasts (HS 68) tested. However, HGMNs were cytotoxic at 69.99% against the DU145 prostate cancer cell, and at 34.37% in the Hela cell. These results indicate that the GMNs were biostable and the HGMNs served as effective drug delivery vehicles.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1992년도 춘계학술대회
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• pp.105-107
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• 1992

• 대한의용생체공학회:의공학회지
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• 제39권3호
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• pp.140-145
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• 2018

Cancer is a major burden of human disease worldwide. Current chemotherapy has severe side effects because the drugs affect whole body nonspecifically. In addition, the drugs to reach cancer cells are very limited. Over the last two decades, Drug Delivery System (DDS) using nanoparticles has suggested promising results to improve current limitations. In this study, we prepared PLGA nanoparticles with different charge properties and observed their stability and internalization effect to cancer cells. Results using Dynamic Light Scattering (DLS) and Fourier Transform Infrared Spectroscopy (FTIR) confirmed the size and chemical composition of the nanoparticles. The stability of the nanoparticles in pH buffers were variable depending on charge properties. The nanoparticles showed different cytotoxicity and internalization effects to MCF-7 human breast cancer cells. In conclusion, we demonstrated the importance of delicately engineered nanoparticles for better DDS in cancer.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.39-42
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• 1997

Biostabilities of the iron oxide MRI contrast agent were evaluated using the cytotoxicity test and the animal test. Six experimental groups (35, 17, 5, 3.4, 1.7, 0.9 mg of iron oxide/10ml) and a control group were prepared for the cytotoxicity test. The cell count of higher concentration than 5 mg/10m1 become decrease significantly after 4-days incubation. Iron oxide was injected into the right vein of the two fully grown rabbits with the concentration of 0.5 or 0.9mg/kg of body weight respectively. Blood samples were collected and analyzed in turn after 30min, 1, 2, 4, 8, 16, 30, 60, 90days injection. The body temperature and weight of rabbits were measured simultaneously. The result of blood and serum analyses and the body temperature shows that there was no significant variation with respect to the sampling term and the dosage within this experimental conditions.

• 산업기술연구
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• 제43권1호
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• pp.25-31
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• 2023

Stretchable and flexible electronics that comply with dynamic movements and micromotion of the human tissues can enable real-time monitoring of physiologic signals onto the human skin and in the brain, respectively. Especially, gallium based liquid metal stretchable electronics can offer human-interactive biosensors to monitor various physiologic parameters. However, the liquid-like nature, surface oxidation and contamination by organic materials, and low biostability of the liquid metals have still limited the long-term use as bioelectronics. Here we introduced electrochemical deposition without oxidation pathways to overcome these practical challenges in liquid metal bioelectronics. CNT/PDDA composite with reduction way and PEDOT:BF₄ with oxidation way under organic solvent are suggested as rationally designed material engineering approaches. We confirmed that the structures with the soft, flexible, and stretchable liquid metal platform can successfully detect dopamine with a high sensitivity and selectivity, record neural signals including action potentials without scar formation, and monitor physiologic signals such as EMG and ECG.