• BMB Reports
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• 제40권4호
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• pp.532-538
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• 2007

Mouse ficolin A is a plasma protein with lectin activity, and plays a role in host defense by binding carbohydrates, especially GlcNAc, on microorganisms. The ficolin A subunit consists of an N-terminal signal peptide, a collagen-like domain, and a C-terminal fibrinogen-like domain. In this study, we show that ficolin A can be synthesized and oligomerized in a cell and secreted into culture medium. We also identify a functionally relevant signal peptide of ficolin A by using MS/MS analysis to determine the N-terminal sequence of secreted ficolin A. When the signal peptide of mouse ficolin A was fused with enhanced green fluorescent protein (EGFP), EGFP was released into HEK 293 cell medium, suggesting that the signal peptide can efficiently direct ficolin A secretion. Moreover, our results suggest that the signal peptide of ficolin A has potential application for the production of useful secretory proteins.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.387-390
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• 1997

Electrogastrography(EGG), the cutaneous recording of the myoelectrical activity of the stomach using surface electrodes, is attractive due to its non-invasiveness. We propose feasible methods to detect tile gastric contraction by vector analysis of the surface EGG signals obtained from three paired electrodes. The amplitude and direction of the calculated EGG vector were analyzed and compared with the gastric contraction signals such as the strain gauge signal from the gastric serosa in dog. From the vector analysis of the EGG signal, we found a typical change of the amplitude and direction of the EGG vector, which can indicate occurrences of the gastric contraction.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 춘계학술대회
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• pp.3-5
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• 1996

Electrogastrography(EGG) is the technique by which gastric myoelectrical activity is recorded noninvasively, from electrodes on the abdominal skin. This gastric myoelectrical activity consists of two type signals : 1) slow wave, which is gastric basal rhyemic activity and is not closely related to gastric contraction 2) spike wave, which is generated only during contraction of the stomach. Despite many attempts made over the decades, analysis of surface EGG has not led to identification of the spike wave (gastric contraction) that would help the clinician to diagnose functional or organic diseases of the stomach. In this paper, we propose a feasible methods to detect gastric contraction by frequency-domain signal analysis of surface ECG signal. Synchronous measurement of gastric pressure by the antropyloric manometry with surface EGG established feasibility of this method.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1994년도 춘계학술대회
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• pp.60-62
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• 1994

In this paper, we present a signal analysis workstation in which the user can scrutinize and quantify biological signals, observe the effects of various signal processing algorithms on them, and eventually get some interpretation of clinical use. Within the system, the user can also access all the information in the central data base, such as patient personal information, biological signal information, and insert his interpretation results obtained into the data base after his careful observation. The software system is designed in an object-oriented paradigm, and written in C++ as a window-based application program.

• 한국의류학회지
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• 제39권3호
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• pp.369-378
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• 2015

Various forms of wearable bio-signal monitoring systems have been developed recently. Acquisition of stable bio-signal data for health care purposes needs to be unconscious and continuous without hindrance to the users' daily activities. The garment type is a suitable form of a wearable bio-signal monitoring system; however, motion artifacts caused by body movement degrade the signal quality during the measurement of bio-signals. It is crucial to stabilize the electrode position to reduce motion artifacts generated when in motion. The problems with motion artifacts remain unresolved despite their significant effect on bio-signal monitoring. This research creates a foundation for the design of garment-type wearable systems for everyday use by finding a method to reduce motion artifacts through modular design. Two distinct garment-type wearable systems (tee-shirt with a motion artifact-reducing module (MARM) and tee-shirt without a MARM) were designed to compare the effects of modular design on the measurement of heart activity in terms of electrode position displacement, signal quality index value, and morphological quality. The tee-shirt with MARM showed superior properties and yielded higher quality signals than the tee-shirt without MARM. In addition, the tee-shirt with MARM showed a better repeatability of the heart activity signals. Therefore, a garment design with MARM is an efficient way to acquire stable bio-signals while in motion.

• 대한의용생체공학회:의공학회지
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• 제28권4호
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• pp.494-502
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• 2007

Ubiquitous location based services (u-LBS) will be interested to an important services. They can easily recognize object position at anytime, anywhere. At present, many researchers are making a study of the position recognition and tracking. This paper consists of postion recognition and user identification system. The position recognition is based on location under services (LBS) using a signal strength map, a database is previously made use of empirical measured received signal strength indicator (RSSI). The user identification system automatically controls instruments which is located in home. Moreover users are able to measures body signal freely. We implemented the multi-hop routing method using the Star-Mesh networks. Also, we use the sensor devices which are satisfied with the IEEE 802.15.4 specification. The used devices are the Nano-24 modules in Octacomm Co. Ltd. A RSSI is very important factor in position recognition analysis. It makes use of the way that decides position recognition and user identification in narrow indoor space. In experiments, we can analyze properties of the RSSI, draw the parameter about position recognition. The experimental result is that RSSI value is attenuated according to increasing distances. It also derives property of the radio frequency (RF) signal. Moreover, we express the monitoring program using the Microsoft C#. Finally, the proposed methods are expected to protect a sudden death and an accident in home.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1995년도 추계학술대회
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• pp.105-108
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• 1995

• 재활복지공학회논문지
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• 제7권2호
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• pp.27-34
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• 2013

기존의 u-헬스케어 시스템의 생체 신호 측정 단말기는 단말기에서 하나의 생체 신호를 측정하여 평가하는 것이 대부분이고, 복합된 기능의 단말기이더라도 사용자의 선택에 의해서 생체 신호를 측정하도록 되어 있다. 본 논문에서는 이러한 문제점을 해결하고, u-헬스케어 시스템에 적용하기 위한 멀티 생체신호 측정 무선 단말기를 구현하였다. 구현된 단말기는 4개의 적외선 센서를 사용하여 맥박수를 측정하고, 2개의 전극을 이용하여 피부전도도를 측정하고, 3축 가속도 센서를 사용하여 운동량을 측정하였다. 뿐만 아니라, 생체신호 데이터를 무선으로 전송하기 위해 지그비를 이용하여 PC 또는 휴대단말기로 전송할 수 있는 통신 패킷 프레임을 제안한다. 무선 단말기를 구현하여 실제 테스트한 결과 맥박 수는 2회 이내의 오차 범위를 가지고, 운동량은 약 85.6%, 84.7%의 신뢰도를 보였으며, 피부전도도는 사용자의 신체 상태에 따라 변화함을 알 수 있었다.

• 대한의용생체공학회:의공학회지
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• 제34권3호
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• pp.105-110
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• 2013

Respiratory signal is one of the important physiological information indicating the status and function of the body. Recent studies have provided the possibility of being able to estimate the respiratory signal by using a change of PWV(pulse width variability), PRV(pulse rate variability) and PAV(pulse amplitude variability) in the PPG (photoplethysmography) signal during daily life. But, it is not clear whether the respiratory monitoring is possible even during sleep. Therefore, in this paper, we estimated the respiration from PWV, PRV and PAV of PPG signals during sleep. In addition, respiration rates of the estimated respiration signal were calculated through a time-frequency analysis, and errors between respiration rates calculated from each parameter and from reference signal were evaluated in terms of 1 sec, 10 sec and 1 min. As a result, it showed the errors in PWV(1s: $36.38{\pm}37.69$ mHz, 10s: $36.53{\pm}38.16$ mHz, 60s: $30.35{\pm}38.72$ mHz), in PRV(1s: $1.45{\pm}1.38$ mHz, 10s: $1.44{\pm}1.37$ mHz, 60s: $0.45{\pm}0.56$ mHz), and in PAV(1s: $1.05{\pm}0.81$ mHz, 10s: $1.05{\pm}0.79$ mHz, 60s: $0.56{\pm}0.93$ mHz). The errors in PRV and PAV are lower than that of PWV. Finally, we concluded that PRV and PAV are more effective than PWV in monitoring the respiration in daily life as well as during sleep.

• 대한의용생체공학회:의공학회지
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• 제26권6호
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• pp.399-406
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• 2005

In these days, HIS(Hospital Information System) raise the quality of medical services by effective management of medical records. As computing environment was developed, it is possible to search information quickly. But, standard medical data exchange is not completed between medical clinic and another organ so far. In case of patient transfer, past medical record was not efficiently transmitted. It be feasible treatment delay or medical accident. It is trouble that medical records is transferred by a person and communicate with each other. Extensible Markup Language (XML) is a simple, very flexible text format derived from SGML. Originally designed to meet the challenges of large-scale electronic publishing, XML is also playing an increasingly important role in the exchange of a wide variety of data on the Web and elsewhere. Form in system of company product, relative organs that handle bio-signal data is each other dissimilar and integration and to transmit to supplement bottleneck this research uses XML. In this study, it is discussed about sharing of medical data using XML web technology to standard medical record between hospital and relative organization The data structure model was designed to manage bio-signal data and patient record. We experimented about data transmission and all-in-one between different systems (one make use of MS-SQL database system and the other manage existent bio-signal data in itself form in file in this research). In order to search and refer medical record, the web-based system was implemented. The system that can be shared medical data was tested to estimate the merits of XML. Implemented XML schema confirms data transmission between different data system and integration result.