• Journal of Sensor Science and Technology
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• v.14 no.1
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• pp.7-15
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• 2005

A sensor and measuring system were implemented to measure both uroflow and urophonography signal during urination for diagnose the lower urinary tract symptom. The implemented system was composed of the uroflow sensor using the load-cell, the urophonography measurement sensor so as stethoscope type, pre-processing part for sensors signal detection, amplifier and filter, system control parts and PC measurement program. A simulator of the lower urinary system that is experimental equipment implemented for evaluate the developed system. The two signals were measured using implemented system and analyzed these signal by means of time domain and frequency domain for extraction of the characteristic parameter which can most effectively reflected by the occlusion of the lower urinary system. Furthermore two signals were measured and analyzed with the subject of 5 healthy adult for clinical application possibility of the implemented system. As a result, the most influence bandwidth of effect according to occlusion of the lower urinary system is $253{\sim}282$ Hz of the urophonography signal.

• Journal of Korea Multimedia Society
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• v.23 no.5
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• pp.625-632
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• 2020

In the diagnosis of lung cancer, the tumor size is measured by the longest diameter of the tumor in the entire slice of the CT. In order to accurately estimate the size of the tumor, it is better to measure the volume, but there are some limitations in calculating the volume in the clinic. In this study, we propose an algorithm to segment lung cancer by applying a custom loss function that combines focal loss and dice loss to a U-Net model that shows high performance in segmentation problems in chest CT images. The combination of values of the various parameters in custom loss function was compared to the results of the model learned. The purposed loss function showed F1 score of 88.77%, precision of 87.31%, recall of 90.30% and average precision of 0.827 at α=0.25, γ=4, β=0.7. The performance of the proposed custom loss function showed good performance in lung cancer segmentation.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.9 no.1
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• pp.125-130
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• 2005

Background and purpose: We evaluated the reliability of two electrodermal measurement devices on meridian skin areas; Electro Acupuncture according to Dr. Voll (EAV) method and newly developed MIR-1. Methods: Eighteen volunteers were tested repeatedly on the same condition with each device. To explore the intra-rater, inter-rater, and test-retest reliabilities, one rater tested each subject twice in succession, then the other rater tested the subject in a row. Finally, retests on the subjects with each device were performed 1 week later. The reliability was determined by Pearson correlation and intraclass correlation statistics. Results: EAV method showed poor reliability, while MIR-1 showed good reliability. Conclusion: It is suggested that further research on the reliability and useful device in both fields of clinical practice and biomedical research.

• Biomedical Science Letters
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• v.17 no.3
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• pp.173-176
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• 2011

Free-living Acanthamoeba are eukaryotic protozoan organisms that are widely distributed in the air, water, etc such as environment. Acanthamoeba ingest the Escherichia coli which will replicate in cytoplasm of Acanthamoeba. Bacterial pathogenicity or virulence is one of important determinant factors to survive in free-living Acanthamoeba and otherwise Acanthamoebic pathogenicity is also an important factor for their interactions. Bacterial association with pathogenic strain of Acanthamoeba T1 and T4 was lower about two times than non-pathogenic T7. Bacterial invasion percentages into T1 were higher about three times than T7 but bacterial survival in T7 was increased as T1. The capsule-deletion mutant exhibited limited ability for invasion/uptake by and survival inside pathogenic Acanthamoeba T4. E. coli-outer membrane protein A (OmpA) decreased bacterial association with A. castellanii by about three times and it had higher effects than lipopolysaccharides (LPS). Under favorable conditions, the mutants were not survived in Acanthamoeba up to 24 h incubation. Therefore, this review will report pathogenic and non-pathogenic Acanthamoeba strains interactions with E. coli and its several mutants, i.e., capsule, OmpA and LPS.

• Journal of Biomedical Engineering Research
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• v.31 no.1
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• pp.40-49
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• 2010

A rule weight -based fuzzy classification model is proposed to analyze the patterns of admission-discharge of patients as a previous research for differential diagnosis of dyspnea. The proposed model is automatically generated from a labeled data set, supervised learning strategy, using three procedure methodology: i) select fuzzy partition regions from spatial distribution of data; ii) generate fuzzy membership functions from the selected partition regions; and iii) extract a set of candidate rules and resolve a conflict problem among the candidate rules. The effectiveness of the proposed fuzzy classification model was demonstrated by comparing the experimental results for the dyspnea patients' data set with 11 features selected from 55 features by clinicians with those obtained using the conventional classification methods, such as standard fuzzy classifier without rule weights, C4.5, QDA, kNN, and SVMs.

• Journal of Biomedical Engineering Research
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• v.38 no.2
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• pp.82-88
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• 2017

Enlargement of the lateral ventricles have been identified as a surrogate marker of neurological disorders. Quantitative measure of the lateral ventricle from MRI would enable earlier and more accurate clinical diagnosis in monitoring disease progression. Even though it requires an automated or semi-automated segmentation method for objective quantification, it is difficult to define lateral ventricles due to insufficient contrast and brightness of structural imaging. In this study, we proposed a fully automated lateral ventricle segmentation method based on a graph cuts algorithm combined with atlas-based segmentation and connected component labeling. Initially, initial seeds for graph cuts were defined by atlas-based segmentation (ATS). They were adjusted by partial volume images in order to provide accurate a priori information on graph cuts. A graph cuts algorithm is to finds a global minimum of energy with minimum cut/maximum flow algorithm function on graph. In addition, connected component labeling used to remove false ventricle regions. The proposed method was validated with the well-known tools using the dice similarity index, recall and precision values. The proposed method was significantly higher dice similarity index ($0.860{\pm}0.036$, p < 0.001) and recall ($0.833{\pm}0.037$, p < 0.001) compared with other tools. Therefore, the proposed method yielded a robust and reliable segmentation result.

• Proceedings of the KIEE Conference
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• 2006.07d
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• pp.2161-2162
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• 2006

In this study, we developed five mobile units and an integrated system which can manage vital signs from each unit using Bluetooth wireless communication. The five kinds of mobile unit were so designed that each has different function to be applied according to the condition of patient properly. The mobile units can measure ECG signal of single or 12 channel, blood pressure, pulse and SpO2 signal from a patient. Also, to reduce the uncomfortable measurement, several types of units such as belt type, wrist type and necklace type were designed. Our proposed system can integrate and monitor several biological signals from different patient by using Bluetooth wireless communication simultaneously. The developed system was evaluated in the simulated emergent situation and showed the system can monitor 5 patients in maximum according to the data quality. It showed the possibilities that the developed system can be used effectively for emergency situation or in- or out-hospital transport of patient. In future, with the combination of mobile communication technique, a patient who is in emergency situation can be provided with proper first-aid and a doctor can pile information of patient and give better diagnosis and treatments.

• Journal of Sensor Science and Technology
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• v.20 no.6
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• pp.434-438
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• 2011

A portable surface plasmon resonance(SPR) based immunosensor using thiolated protein G and protein G was developed for the detection of immunoglobulin G(IgG). The protein G has specific affinity with Fc fragment of IgG and was thiolated by 2-Iminothiolane for introduction of thiol groups. Anti-IgG, bovine serum albumin(BSA), and IgG have been sequently injected after surface modification of gold sensor chip with protein G and thiolated protein G. The output signal was increased with the injection of each protein and the actual signal was measured by subtracting signal of reference channel from signal of sample injected channel. The experimental results showed the higher detection capability of IgG using thiolated protein G compared with protein G. From these results, we can conclude that the current surface modification technique and the portable SPR sensor system can be applied to various immunosensors for diagnosis.

• Clinical and Experimental Pediatrics
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• v.59 no.sup1
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• pp.76-79
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• 2016

Tracheoinnominate artery fistula is a rare, fatal complication of tracheostomy, and prompt diagnosis and management are imperative. We report the case of tracheoinnominate artery fistula after tracheostomy in a 14-year-old boy with a history of severe periventricular leukomalacia, hydrocephalus, cerebral palsy, and epilepsy. The tracheoinnominate artery fistula was successfully treated with a stent graft insertion via the right common femoral artery. Endovascular repair of the tracheoinnominate artery fistula via stent grafting is a safe, effective, and minimally invasive treatment for patients in poor clinical conditions and is an alternative to traditional open surgical treatment.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.11a
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• pp.379-382
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• 2002

Lately, intensifying screen of the $CaWO_4$ is used to medical treatment and diagnosis of the image. In this paper, we investigated transmission fraction and mass attenuation coefficient of $CaWO_4$ screen about diagnostic x-ray of low energy using MCNP 4C code. Experimentally, for 0.9 mm-$CaWO_4$ screen, the absorbable rate of diagnostic x-ray is more than 95%. according to kVp, the experimental value of mass attenuation coefficient is in a1most agreement with an corrected estimate value of MCNP and the deviation of experimental values is less than ${\pm}7%$. Using the MCNP code through this paper, we can make an estimate of signal and design for construction of the CaWO4/a-Se based digital x-ray image detector and make a good use of the foundation data for development of other materials.